EC Number |
Activating Compound |
Reference |
---|
6.1.1.2 | chuangxinmycin |
- |
704281 |
6.1.1.2 | glyceraldehyde 3-phosphate dehydrogenase |
the oxidized form of glyceraldehyde 3-phosphate dehydrogenase interacts with both full-length and mini tryptophanyl-tRNA synthetase and specifically stimulates the aminoacylation potential of mini, but not full-length tryptophanyl-tRNA synthetase. In contrast, reduced glyceraldehyde 3-phosphate dehydrogenase does not bind to tryptophanyl-tRNA synthetase and does not influence their aminoacylation activity |
661186 |
6.1.1.2 | heme |
- |
703734 |
6.1.1.2 | heme |
enhances activity |
702375 |
6.1.1.2 | heme |
R135H/E438A double mutant |
703734 |
6.1.1.2 | hemin |
heme can interact strongly with Zn2+-depleted full-length TrpRS, but not the Zn2+-bound enzyme, with a stoichiometric heme:protein ratio of 1:1 to enhance the aminoacylation activity significantly, involvement of heme in regulation of TrpRS aminoacylation activity, overview |
672219 |
6.1.1.2 | hygromycin |
- |
704281 |
6.1.1.2 | indolmycin |
- |
704281 |
6.1.1.2 | interferon gamma |
strong upregulation of the alternatively spliced truncated mini enzyme form |
650116 |
6.1.1.2 | interferon gamma |
strongly stimulates and regulates the expression of the enzyme isoforms via 2 specific interferon-gamma-sensitive promoters that are additionally regulated by the interferon regulatory factor 1 |
653395 |