EC Number   |
Activating Compound |
Reference |
|---|
    4.2.1.3 | cysteine |
enzyme activity increases 2-4fold in presence of both Fe2+ and cysteine. 0.1-1 mM Fe2+ and 0.05-0.5 mM cysteine |
650272 |
| 4.2.1.3 | Fe4-S4 cluster |
active enzyme contains an iron-sulfur cluster |
704048, 704318 |
| 4.2.1.3 | ferric ammonium citrate |
increases activity and gene expression |
666327 |
| 4.2.1.3 | hemin |
increases activity and gene expression |
666327 |
| 4.2.1.3 | lipoic acid |
causes an increase in cardiac enzyme activity at doses of 35 and 70 mg/kg of 1.3 and 2.4fold in the animals |
696162 |
| 4.2.1.3 | menadione sodium bisulfite |
causes a modest activation of IRP-1 to bind to iron resonsive elements within 15-30 min. Menadione-induced oxidative stress leads to post-translational inactivation of both genetic and enzymatic functions of IRP-1 by a mechanism that lies beyond the classical Fe-S cluster switch and exerts multiple effects on cellular iron metabolism |
651975 |
| 4.2.1.3 | more |
acetyl-CoA-driven acetylation leads to about 45% activation. The increase in activity is a result of increased maximal velocity |
747087 |
| 4.2.1.3 | more |
the maximal activity requires the presence of sulfhydryl compounds in the medium |
696168 |
