EC Number   |
Activating Compound |
Reference |
|---|
   3.6.5.5 | 1-O-(1,2-di-O-palmitoyl-sn-glycerol-3-benzyloxyphosphoryl)-D-myo-inositol 3,4,5-triphosphate |
activates the GTPase activity of dynamin, specific for D-5 phosphoinositides, activation mechanism, activates also in the presence of 100-130 mM NaCl, the interactions are mediated by the dynamin pleckstrin homology domain |
659859 |
| 3.6.5.5 | 1-O-(1,2-di-O-palmitoyl-sn-glycerol-3-benzyloxyphosphoryl)-D-myo-inositol 3,4,5-triphosphate |
activates, binds to the pleckstrin homology domain |
644191 |
| 3.6.5.5 | actin |
actin filaments bind purified Drp1 and increase GTPase activity in a manner that is synergistic with the mitochondrial protein Mff, suggesting a role for direct Drp1/actin interaction |
756570 |
| 3.6.5.5 | actin |
actin filaments increase Drp1's GTPase activity eith a 3.5fold increase. The assembly of filaments of actin is the signal to Drp1 to accumulate on mitochondria and for fission |
756570 |
| 3.6.5.5 | amphiphysin |
stimulation of dynamin GTPase activity |
670136 |
| 3.6.5.5 | anionic liposome |
potent stimulation of dynamin GTPase activity at low ionic strength, activator interacts with the highly basic C-terminal proline/arginine-rich domain of dynamin via ionic interactions that are essentially abrogated at physiologic ionic strength |
659859 |
| 3.6.5.5 | antibodies |
stimulate by crosslinking through the C-terminal proline-rich domain of dynamin |
644189 |
| 3.6.5.5 | Arc/Arg3.1 |
enhances dynamin polymerization and GTPase activity. The activity-regulated cytoskeleton-associated protein, Arc, is an immediate-early gene product implicated in various forms of synaptic plasticity. Arc promotes endocytosis of AMPA type glutamate receptors and regulates cytoskeletal assembly in neuronal dendrites. Bacterially-expressed His6-Arc facilitates the polymerization of Dyn2 and stimulates its GTPase activity under physiologic conditions (37°C and 100 mM NaCl). At lower ionic strength Arc also stabilizes preformed Dyn2 polymers against GTP-dependent disassembly, thereby prolonging assembly-dependent GTP hydrolysis catalyzed by Dyn2. Arc also increases the GTPase activity of Dyn3, an isoform of implicated in dendrite remodeling, but does not affect the activity of Dyn1, a neuron-specific isoform involved in synaptic vesicle recycling. Analysis of recombinant full-length mouse Arc and of His6-tagged fragments, including Arc-N (residues 1-227), Arc-C (residues 228-396), and Arc-(DELTA195-214). While residues 195-214 may contribute to dynamin binding, additional binding determinants are likely to be present in the N-terminal portion of Arc. Arc stimulates the assembly-dependent GTPase activity of isozymes Dyn2 and Dyn3. The effect of Arc on GTPase activity of dynamin mirrors its effect on dynamin assembly as measured by turbidity |
756073 |
| 3.6.5.5 | Arc/Arg3.1 |
enhances dynamin polymerization and GTPase activity. The activity-regulated cytoskeleton-associated protein, Arc, is an immediate-early gene product implicated in various forms of synaptic plasticity. Arc promotes endocytosis of AMPA type glutamate receptors and regulates cytoskeletal assembly in neuronal dendrites. Bacterially-expressed His6-Arc increases the GTPase activity of Dyn3, an isoform of implicated in dendrite remodeling. Analysis of recombinant full-length mouse Arc and of His6-tagged fragments, including Arc-N (residues 1-227), Arc-C (residues 228-396), and Arc-(DELTA195-214). Arc stimulates the assembly-dependent GTPase activity of isozymes Dyn2 and Dyn3. The effect of Arc on GTPase activity of dynamin mirrors its effect on dynamin assembly as measured by turbidity |
756073 |
| 3.6.5.5 | cardiolipin |
Drp1 binding to anionic lipids such as cardiolipin increases its GTPase activity |
756570 |
