EC Number   |
Activating Compound |
Reference |
|---|
   3.5.3.15 | dithiothreitol |
activates |
209414 |
| 3.5.3.15 | dithiothreitol |
enhances activity, maximal activation at 2 mM |
209412 |
| 3.5.3.15 | hydrogen carbonate |
physiological levels of hydrogen carbonate upregulate citrullination by recombinant PAD2/4 and endogenous PADs in neutrophils. The impact of hydrogen carbonate is independent of calcium and pH |
753665 |
| 3.5.3.15 | lipid vesicle |
binding of substrate myelin basic protein to lipid vesicles, consisting of 7.8% phosphatidylserine and 92.2% phosphatidylcholine, increases deimination activity, but in the 40 amino acid residue C-terminal region, where the arginyl residues are no longer deiminated, while they are deiminated in aqueous solution |
688741 |
| 3.5.3.15 | more |
activity is increased by hypoxic conditions |
663848 |
| 3.5.3.15 | more |
ionomycin induces PADI4 expression |
684511 |
| 3.5.3.15 | more |
overexpression of PAD2 increases expression of PAD4 but not other PAD enzymes |
697573 |
| 3.5.3.15 | more |
overexpression of PAD2 increases expression of PAD4 enzyme |
697573 |
| 3.5.3.15 | more |
smoking increases peptidylarginine deiminase 2 enzyme expression in human lungs and increases citrullination in BAL cells |
695607 |
