EC Number   |
Activating Compound |
Reference |
|---|
   3.4.22.62 | (2S)-1-([2-[(2S)-2-aminopropanoyl]-1-(prop-2-en-1-yl)hydrazinyl]carbonyl)-N-(diphenylmethyl)pyrrolidine-2-carboxamide (non-preferred name) |
- |
731452 |
| 3.4.22.62 | (2S)-1-([2-[(2S)-2-aminopropanoyl]-1-(prop-2-yn-1-yl)hydrazinyl]carbonyl)-N-(diphenylmethyl)pyrrolidine-2-carboxamide (non-preferred name) |
- |
731452 |
| 3.4.22.62 | (2S)-1-([2-[(2S)-2-aminopropanoyl]-1-benzylhydrazinyl]carbonyl)-N-(diphenylmethyl)pyrrolidine-2-carboxamide (non-preferred name) |
- |
731452 |
| 3.4.22.62 | (2S)-1-([2-[(2S)-2-aminopropanoyl]-1-methylhydrazinyl]carbonyl)-N-(diphenylmethyl)pyrrolidine-2-carboxamide (non-preferred name) |
- |
731452 |
| 3.4.22.62 | (2S)-1-([2-[(2S)-2-aminopropanoyl]hydrazinyl]carbonyl)-N-(diphenylmethyl)pyrrolidine-2-carboxamide (non-preferred name) |
- |
731452 |
| 3.4.22.62 | adenosine |
extracellular adenosine induces apoptosis by activating caspase-9 and caspase-3 in association with mitochondrial damage via A2a adenosine receptors, induction dose-dependent (1-20 mM) and time-dependent (24-72 h) |
699289 |
| 3.4.22.62 | APAF-1 |
caspase-9 and Apaf-1 bind to each other via their respective NH2-terminal CED-3 homologous domains in the presence of cytochrome c and dATP, an event that leads to caspase-9 activation |
647425 |
| 3.4.22.62 | APAF-1 |
caspase-9, Bcl-Xl and Apaf-1 form a ternary complex. Caspase-9 likely represents a direct downstream target of Agaf-1 and its activation appears critical for the propagation of death signals |
647421 |
| 3.4.22.62 | APAF-1 |
interaction with APAF-1 promotes auto-cleavage and activation of caspase-9 |
697186 |
| 3.4.22.62 | APAF-1 |
proteolytic activity of caspase-9 in a complex with APAF-1 is several orders of magnitude higher than that of the free enzyme. Thus, this complex functions as a holoenzyme in which caspase-9 is the catalytic subunit and APAF-1 its allosteric regulator |
647419 |
