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EC Number Activating Compound Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.561,2-benzenedithiol 4-5fold activation 669537
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.561,3-benzenedithiol 6fold activation 669537
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.562-mercaptoethanol half-maximal activation at 1.4 mM 669537
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.562-methoxyestradiol increases the enzyme activity 2fold at 100 nM 697054
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.563-[(dodecylthiocarbonyl)methyl]glutarimide - 731262
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.564,4-thiobisbenzenethiol 4-5fold activation 669537
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.56actinomycin D significantly activates caspase-3 695622
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.56arachidonic acid - 695963
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.56azinomycin epoxide i.e. (2S,3S)-benzyl 3,4-epoxy-2-(3-methoxy-5-methyl-1-naphthoyloxy)-3-methylbutanamide, leads to activation and apoptosis in THP-1 cells in a p53-independent manner, while human apoptosis signal-regulating kinase 1, ASK1, is highly required for caspase-3 activation by (2S,3S)-benzyl 3,4-epoxy-2-(3-methoxy-5-methyl-1-naphthoyloxy)-3-methylbutanamide, transient expression of the dominant-negative human ASK1 with kinase-dead domain in THP-1 cells abolishes the caspase-3 activating effect of azinomycin epoxide, overview 697769
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.56C2-ketoCer i.e. (2S,4E)-2-acetylamino-3-oxo-4-octadecen-1-ol, a ceramide analogue, activates caspase-3 and induces apoptosis 700544
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