EC Number   |
Activating Compound |
Reference |
|---|
   3.4.22.36 | adapter protein Asc |
is important for caspase-1 activation during Legionella pneumophila infection, mechanism, overview. Activation of caspase-1 through Asc does not require the flagellin-sensing pathway involving the host nucleotide-binding domain and leucine-rich repeat-containing protein Ipaf, NLRC4. Asc-dependent caspase-1 activation is inhibited by high extracellular potassium levels |
698235 |
| 3.4.22.36 | alendronate |
a nitrogen-containing bisphosphonate, activates caspase-1, activation is inhibited by clodronate. Pretreatment of cells with alendronate augments interleukin-1beta production stimulated by Toll-like receptor ligands, augmentation is inhibited by clodronate |
701307 |
| 3.4.22.36 | anthrax lethal toxin |
rapidly activates caspase-1/interleukin-1beta-converting enzyme and induces extracellular release of interleukin-1beta and interleukin-18 |
669224 |
| 3.4.22.36 | ATP |
- |
709953 |
| 3.4.22.36 | cathepsin B |
cathepsin B can effectively cleave and activate pro-caspase-1 in a cell-free system only at an acidic pH and in THP-1 monocytic cells after stimulation with the microbial toxin nigericin |
708598 |
| 3.4.22.36 | chromogranin A |
chromogranin A can activate pro-caspase-1 in microglia |
708598 |
| 3.4.22.36 | Ipaf |
i.e. host nucleotide-binding domain and leucine-rich repeatcontaining protein Ipaf or NLRC4, Ipaf-dependent activation is unaffected by potassium treatment |
698235 |
| 3.4.22.36 | lipopolysaccharide |
- |
709953 |
| 3.4.22.36 | monosodium urate |
- |
709953 |
| 3.4.22.36 | more |
activation of caspase-1 in macrophages occurs independently of Nalp3 and proteasome activity |
698235 |
