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Results 1 - 8 of 8
EC Number Activating Compound Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.92acyldepsipeptide acyldepsipeptides in addition to opening the axial pore directly stimulate ClpP activity through cooperative binding 732563
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.92acyldepsipeptide allow the protease to degrade folded native proteins in the absence of its cognate chaperones 683473
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.92acyldepsipeptides ADEP series 2, 3, 4 as well as two other synthesized derivatives, IDR-10001 and IDR-10011, which incorporate N-methylalanine instead of the more rigid homoproline in the depsipeptide core structure. All five compound are active against Mycobacterium tuberculosis, ADEP2 is the most active 717738
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.92ATP stimulates proteolytic activity of ClpP in heart mitochondria of muscle creatine kinase mutants 697889
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.92ClpX ClpX binding stimulates ClpP cleavage of peptides larger than a few amino acids and enhances ClpP active-site modification. Stimulation requires ATP binding but not hydrolysis by ClpX 717989
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.92more carbonyl cyanide m-chloro phenylhydrazone and 2,4-dinitrophenol induce the heat-shock-like response, cellular level of the heat shock regulator protein sigma-32 also increases 696989
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.92more ClpP3/R complex stimulates the steady-state ATPase activity of ClpC 698890
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.92more frataxin deficiency causes significant upregulation of both mitochondrial Lon and ClpP proteases in the cardiac mouse model for Friedreich ataxia. ClpP protein level is progressively enhanced, with ca. 3fold, 3.5fold and 4.5fold increases at 5, 7 and 10 weeks of age in muscle creatine kinase mutants, respectively, despite no change in mRNA levels 697889
Results 1 - 8 of 8