EC Number   |
Activating Compound |
Reference |
|---|
   3.4.19.12 | 2-mercaptoethanol |
active-site thiol is very sensitive to oxidation and requires reductants |
35003 |
| 3.4.19.12 | 4-hydroxy-2-alkenal |
modification of UCH-L1 promotes direct interactions between UCH-L1 and tubulin |
680081 |
| 3.4.19.12 | 4-hydroxy-2-nonenal |
modification of UCH-L1 promotes direct interactions between UCH-L1 and tubulin |
680081 |
| 3.4.19.12 | Adrm1 |
recruits Uch37 to the proteasome. Binds the carboxy-terminal tail of Uch37. Following binding, Adrm1 relieves Uch37 autoinhibition, accelerating the hydrolysis of ubiquitin-7-amido-4-methylcoumarin |
682066 |
| 3.4.19.12 | DTT |
active-site thiol is very sensitive to oxidation and requires reductants |
35003 |
| 3.4.19.12 | DTT |
inactivated in absence of DTT |
36451 |
| 3.4.19.12 | DTT |
required, hydrolase activity of UCH-L1 in vitro is decreased when reducing dithiothreitol is omitted from the reaction buffer |
710082 |
| 3.4.19.12 | ethyl 1-[N-(4-methylphenyl)-N-(methylsulfonyl)alanyl]-4-piperidinecarboxylate |
- |
710080 |
| 3.4.19.12 | H2O2 |
- |
682794 |
| 3.4.19.12 | more |
6-hydroxydopamine induces oxidative stress in human neuroblastoma SH-SY5Y cells. UCH-L1 is an oxidative-stress-reporting biomarker |
681102 |
