EC Number   |
Activating Compound |
Reference |
|---|
   3.1.6.2 | 17beta estradiol |
exposure to 17beta estradiol causes 9% increase of estrone 3-sulfate sulfatase activity in mammary myoepithelial cells after 6 days, but 70% reduction in MCF-7 cells |
656646 |
| 3.1.6.2 | 1alpha,25-dihydroxyvitamin D3 |
upregulation of enzyme activity. In HL-60 cell, stimulation is augmented by retinoid X-receptor agonists, blocked by retinoid X-receptor specific antagonists, and retinoic acid receptor specific agonists and antagonist have no effect. In NB-4 cell, upregulation is unaffected by the specific classical nuclear vitamin D receptor and retinoid X-receptor antagonists, but is blocked by a plasma-membrane associated vitamin D receptor antagonist and increases by plasma-membrane associated vitamin D receptor agonists |
665806 |
| 3.1.6.2 | ascorbic acid |
activates |
656643 |
| 3.1.6.2 | Digitonin |
activates |
656643 |
| 3.1.6.2 | estrone |
slightly activates |
656643 |
| 3.1.6.2 | glutathione |
oxidized form, 5 mM, 187% of initial activity |
681650 |
| 3.1.6.2 | glutathione |
slightly activates |
656643 |
| 3.1.6.2 | Insulin |
human recombinant insulin, 30% activation at 10 ng/ml |
656370 |
| 3.1.6.2 | interleukin 6 |
plus tumor necrosis factor alpha, increases STS activity in mock transfected MCF-7 cells and further increases STS activity in transfected MCF-7 cells, activation occurs independently of STS promoter and enhancer elements, may activate via a post-translational modification of STS or by increasing substrate availability |
656640 |
| 3.1.6.2 | interleukin-1 |
in cultured MCF-7 cells |
135619 |
