EC Number   |
Activating Compound |
Reference |
|---|
   3.1.3.64 | EDTA |
maximally active in the presence of EDTA |
646448, 646449 |
| 3.1.3.64 | EDTA |
optimum at 1.5-3 mM |
646448 |
| 3.1.3.64 | EGTA |
activation, optimum at 1.5-3 mM |
646448 |
| 3.1.3.64 | more |
myotubularin-related protein 6 is activated up to 28fold in the presence of phosphatidylserine liposomes, myotubularin-related protein 6 activity in the presence of myotubularin-related protein 9 and assayed in phosphatidylserine liposomes increases 84fold |
698920 |
| 3.1.3.64 | myotubularin-related protein 9 |
myotubularin-related protein 9 increases the binding of myotubularin-related protein 6 to phospholipids without changing the lipid binding profile, myotubularin-related protein 9 increases the 3-phosphatase activity of myotubularin-related protein 6 up to 6fold, myotubularin-related protein 9 potentiates the effects of myotubularin-related protein 6 on apoptosis |
698920 |
| 3.1.3.64 | octyl glucoside |
- |
646449 |
| 3.1.3.64 | octyl glucoside |
biphasic dependence of activity on octyl glucoside |
646448 |
| 3.1.3.64 | phosphatidylinositol 3-phosphate |
substrate is a weak allosteric activator of MTM1 capable of binding at a regulatory site on the monomeric enzyme, no physiological activator |
646451 |
| 3.1.3.64 | phosphatidylinositol 4-phosphate |
phosphatidylinositol 4-phosphate increases myotubularin-related protein 6 activity in the presence of myotubularin-related protein 9 in 100% phosphatidylserine |
698920 |
| 3.1.3.64 | phosphatidylinositol 5-phosphate |
allosteric activator, phosphatidylinositol 5-phosphate and increases myotubularin-related protein 6 activity in the presence of myotubularin-related protein 9 in 100% phosphatidylserine |
698920 |
