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EC Number Activating Compound Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.1.11.22-mercaptoethanol required 133964
Display the word mapDisplay the reaction diagram Show all sequences 3.1.11.2more the sliding DNA beta-clamp forms in vivo and in vitro complexes with XthA in Mycobacterium tuberculosis. The beta-clamp stimulates the activities of XthA primarily by increasing its affinity for the substrate and its processivity. Additionally, loading of the beta-clamp onto DNA is required for activity stimulation. Reduction in XthA activity stimulation is observed in the presence of beta-clamp binding peptides supporting that direct interactions between the proteins are necessary to cause stimulation. The inclusion of beta-clamp in the reaction mixture substantially enhanced the exonuclease activity with an about 8fold stimulation in the hydrolysis of the labelled strand 751601
Results 1 - 2 of 2