EC Number |
Activating Compound |
Reference |
---|
2.7.1.138 | A23187 |
calcium ionophore, 216% activation of ceramide kinase in A549 lung adenocarcinoma cells |
640970 |
2.7.1.138 | Ca2+ |
1 mM, stimulatory effect in the absence of Mg2+ |
662592 |
2.7.1.138 | Calcium |
- |
691938 |
2.7.1.138 | Calmodulin |
binding site is located at residues 422-435, which form a amphipathic helical wheel, motif 1-8-14, calmodulin is involved in the Ca2+-dependent activation of ceramide kinase as a calcium-sensor |
662431 |
2.7.1.138 | interleukin-1 beta |
187% activation of ceramide kinase in A549 lung adenocarcinoma cells |
640970 |
2.7.1.138 | Mg2+ |
3 mM, highly dependent on Mg2+ |
662592 |
2.7.1.138 | more |
(2R)-isomers of (2S)-substrates are stimulatory |
662592 |
2.7.1.138 | more |
the enzyme is induced by the calcium triggers interleukin-1beta and IgE/Ag due to calcium mobilization |
661860 |
2.7.1.138 | peroxisome proliferator-activated receptor beta |
upregulation of CERK through activation of peroxisome proliferator-activated receptor beta (PPARbeta) results in decreased intracellular ceramide levels and increased cell survival with less cell death |
692307 |
2.7.1.138 | Phorbol esters |
e.g. PMA |
661860 |