EC Number   |
Activating Compound |
Reference |
|---|
   2.1.1.57 | 2',3',5'-tri-O-acetyladenosine |
about 20% increased activity at 0.1 mM |
704920 |
| 2.1.1.57 | 2',3',5'-tri-O-acetyladenosine |
about 50% increased activity at 0.1 mM |
704920 |
| 2.1.1.57 | 3-deazaadenosine |
about 10% increased activity at 0.1 mM |
704920 |
| 2.1.1.57 | 5'-deoxy-5'-(methylthio)adenosine |
about 75% increased activity at 0.1 mM |
704920 |
| 2.1.1.57 | 5'-deoxy-5'-methylthioadenosine |
about 10% increased activity at 0.1 mM |
704920 |
| 2.1.1.57 | 5'-S-isobutylthio-5'-deoxyadenosine |
about 60% increased activity at 0.1 mM |
704920 |
| 2.1.1.57 | ATP-dependent RNA DHX15 helicase |
the enzyme acts poorly on capped RNA molecules whose 5'-terminal residues are base-paired to form secondary structure. However, the enzyme uses its G-patch domain to form a strong complex with ATP-dependent RNA, which significantly improves the efficiency of cap1 methylation of such RNAs |
757922 |
| 2.1.1.57 | nsp10 protein |
nsp10 acts as an essential trigger to activate the 2'-O-methyltransferase activity of nsp16. The region of amino acids 42120 in nsp10 is needed for stimulating the nsp16 2'-O-methyltransferase activity |
721104 |
| 2.1.1.57 | nsp10 protein |
nsp16 carries RNA cap 2'-O-methyltransferase activity only in the presence of its interacting partner nsp10 |
719892 |
| 2.1.1.57 | nsp10 protein |
nsp16 requires non-structural protein nsp10 as a stimulatory factor to execute its methyltransferase activity by binding both S-adenosyl-L-methionine and RNA substrate |
720879 |
