EC Number   |
Activating Compound |
Reference |
|---|
    1.6.5.2 | 1,1'-(E)-ethene-1,2-diylbis(2-methoxybenzene) |
at 12.5 micromol, induces quinone reductase to a greater extent than resveratrol |
692171 |
| 1.6.5.2 | 1,2-dithiole-3-thione |
induces enzyme expression |
694519 |
| 1.6.5.2 | 1,3-dimethoxy-2-[(E)-2-(4-methoxyphenyl)ethenyl]benzene |
at 12.5 micromol, induces quinone reductase to a greater extent than resveratrol |
692171 |
| 1.6.5.2 | 1-(3,4-dihydroxybenzyl)-1,2,3,4-tetrahydro-6,7-isoquinolinediol |
up-regulation of enzyme upon exposure to L-dopa and tetrahydropapaveroline |
674023 |
| 1.6.5.2 | 1-methoxy-2-[(E)-2-(4-methoxyphenyl)ethenyl]benzene |
at 6.3 micromol is 1.8 times more effective than resveratrol as a quinone reductase inducer |
692171 |
| 1.6.5.2 | 1-methoxy-3-[(E)-2-(4-methoxyphenyl)ethenyl]benzene |
at 12.5 micromol, induces quinone reductase to a greater extent than resveratrol |
692171 |
| 1.6.5.2 | 2-mercaptoethanol |
stimulates |
394351 |
| 1.6.5.2 | 2-methoxy-5-[(E)-2-(4-methoxyphenyl)ethenyl]phenol |
at 12.5 micromol, induces quinone reductase to a greater extent than resveratrol |
692171 |
| 1.6.5.2 | 3-nitrobenzanthrone |
increases protein level and enzymatic activity of NQO1. Up to a 2.5fold increase in NQO1 activity with menadione as substrate in tissues of rats treated with 3-nitrobenzanthrone |
695203 |
| 1.6.5.2 | 3H-1,2-dithiole-3-thione |
significantly increases cellular NQO1 activity and mRNA levels. Induces NQO1 in a concentration-dependent manner. In SH-SY5Y cells, 2fold induction of cellular NQO1 with 0.01 mM and 3-5.5fold induction of NQO1 with 0.05 and 0.1 mM. 4.5fold increase of NQO1 mRNA between 12 and 24 h after treatment. 40% induction of cellular NQO1 after treatment of primary human neurons at a concentration of 0.01 mM |
691553 |
