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Results 1 - 2 of 2
EC Number Activating Compound Commentary Reference
Show all pathways known for 1.5.3.16Display the word mapDisplay the reaction diagram Show all sequences 1.5.3.16HIV-1 Tat Tat-induced SMO activation, involving the polyamine-sensitive subtype of the NMDA receptor, the activation is completely prevented by the NMDAR antagonist MK-801. Mechanism, overview 725069
Show all pathways known for 1.5.3.16Display the word mapDisplay the reaction diagram Show all sequences 1.5.3.16N1,N11-diethylnorspermine polyamine analogue with clinical relevance as an experimental anticancer agent. Treatment of human C-28/I2 chondrocytes rapidly induces spermidine/spermine N1-acetyltransferase and spermine oxidase activities, and down-regulates ornithine decarboxylase. The treatment does not provoke cell death and caspase activation when given alone for 24 h, but causes a caspase-3 and -9 dependent apoptosis in chondrocytes further exposed to cycloheximide. The simultaneous addition of N1,N11-diethylnorspermine and cycloheximide rapidly increases caspase activity in C-28/I2 cells in the absence of spermidine/spermineN1-acetyltransferase and spermine oxidase induction or significant reduction of polyamine levels 712558
Results 1 - 2 of 2