EC Number   |
Activating Compound |
Reference |
|---|
    1.5.1.20 | A23187 |
treatment of cells results in increase in enzyme mRNA and protein |
687772 |
| 1.5.1.20 | homocysteine |
treatment of cells results in increase in enzyme mRNA and protein |
687772 |
| 1.5.1.20 | inositol-requiring enzyme-1 |
the induction of MTHFR was also observed after overexpression of inositol-requiring enzyme-1 |
687772 |
| 1.5.1.20 | more |
induction of MTHFR is observed after overexpression of inositol-requiring enzyme IRE1 and is inhibited by a dominant-negative mutant of IRE1. Tranfection of c-Jun and its activators LiCl and sodium valproate increase MTHFR expression, whereas inhibitor of c-Jun SP600125 reduces activation |
687772 |
| 1.5.1.20 | more |
transfection of c-Jun and two activators of c-Jun (LiCl and sodium valproate) increase MTHFR expression, MTHFR mRNA is up-regulated by endoplasmic reticulum stress |
687772 |
| 1.5.1.20 | S-adenosylmethionine |
stimulates |
437724 |
| 1.5.1.20 | thapsigargin |
treatment of cells results in increase in enzyme mRNA and protein |
687772 |
| 1.5.1.20 | tunicamycin |
treatment of cells results in increase in enzyme mRNA and protein |
687772 |
| 1.5.1.20 | Valproic acid |
300 mg/kg treatment increases MTHFR promoter activity 2.5fold and MTHFR mRNA and protein 3.7fold |
687925 |
