EC Number   |
Activating Compound |
Reference |
|---|
   1.2.4.4 | (S)-2-chlorophenylpropionic acid |
- |
739536 |
| 1.2.4.4 | 5-fluorouracil |
in male rats administered with 4 doses of 5-FU, 150 mg/kg b.wt. each, 5-FU treatment causes an increase in branched-chain alpha-keto acid dehydrogenase complex BCKDH activity that results mainly from increased dephosphorylation of the complex and is associated with an increase of phosphatase PPM1K mRNA level and reduction of BDK and dehydrogenase E1 mRNA levels |
763049 |
| 1.2.4.4 | Activator protein |
a protein in rat liver and kidney mitochondria that reactivates phosphorylated branched-chain complex without dephosphorylation |
349045 |
| 1.2.4.4 | alpha-Chloroisocaproate |
- |
673938 |
| 1.2.4.4 | alpha-Chloroisocaproate |
activates through release of branched-chain alpha-keto acid dehydrogenase kinase from the BCKD complex |
662695 |
| 1.2.4.4 | alpha-Chloroisocaproate |
activation of the enzyme complex in intact cell and tissue preparations |
349052 |
| 1.2.4.4 | alpha-Ketoisocaproate |
activates through release of branched-chain alpha-keto acid dehydrogenase kinase from the BCKD complex |
662695 |
| 1.2.4.4 | alpha-Ketoisocaproate |
promotes dissociation of the BCKDH kinase from the BCKDH complex, consistent with activation of BCKDH complex |
675567 |
| 1.2.4.4 | alpha-ketoisovalerate |
activates through release of branched-chain alpha-keto acid dehydrogenase kinase from the BCKD complex |
662695 |
| 1.2.4.4 | bezafibrate |
i.e. 2-[4-[2-(4-chlorobenzamido)ethyl]phenoxy]-2-methylpropanoic acid. In rats treated with 5, 10, 20 mg/kg bezafibrate mean enzyme actual activity is 1.9, 2.9, and 4.3fold higher than in the control group, respectively. Enzymatic total activity increases by 1.3 and 1.6fold in rats treated with 10 and 20 mg/kg bezafibrate |
723788 |
