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EC Number Activating Compound Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 1.14.11.27ascorbate required for optimal activity 662947
Display the word mapDisplay the reaction diagram Show all sequences 1.14.11.27ascorbate stimulation 688966
Display the word mapDisplay the reaction diagram Show all sequences 1.14.11.27fisetin fisetin induces DNA damage via critical transcription factor RFXAP/KDM4A-dependent histone H3K36 demethylation, thus causing inhibition of proliferation in pancreatic adenocarcinoma (PDAC). Fisetin inhibits cell proliferation and induces DNA damage and S-phase arrest in PDAC. Expression of RFXAP and other DNA-damage response genes is upregulated by fisetin. RFXAP targets KDM4A. Overexpression of RFXAP upregulates KDM4A and attenuates methylation of H3K36, impairing DNA repair and enhancing the DNA damage induced by fisetin 764436
Display the word mapDisplay the reaction diagram Show all sequences 1.14.11.27HP1a H3K36 demethylation activity of the fly dKDM4A is dramatically stimulated upon HP1a association 701212
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