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Results 1 - 4 of 4
EC Number Activating Compound Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 1.13.11.8more allosteric rate enhancement in the presence of non-substrate protocatechuate-like aldehydes such as vanillin 741768
Display the word mapDisplay the reaction diagram Show all sequences 1.13.11.8more impact of alpha-subunit Phe103alpha mutations on allosteric activation of alternate substrate dioxygenation by vanillin compared to the wild-type enzyme, overview 743708
Display the word mapDisplay the reaction diagram Show all sequences 1.13.11.8Vanillin heteroallosteric activation of LigAB by vanillin at an allosteric binding site in LigAB, regulatory feed-forward activation mechanism, kinetics, overview. Vanillin is the pre-pre-substrate of LigAB. Enhancement by vanillin is specific to protocatechuate. Glu86b is directly involved in a hydrogen bond network through the carboxylate with Ndelta of His127b, believed to be the catalytic base that performs the initial substrate deprotonation. The His127b methylene also contributes a small fraction to the identified allosteric binding pocket 741768
Display the word mapDisplay the reaction diagram Show all sequences 1.13.11.8Vanillin like the wild-type enzyme, F103T and F103V alpha-subunit point mutants also exhibit allosteric activation for the dioxygenation of protocatechuate and gallate, respectively 743708
Results 1 - 4 of 4