EC Number   |
Activating Compound |
Reference |
|---|
    1.13.11.31 | 13-hydroperoxy-octadecadienoic acid |
- |
706032 |
| 1.13.11.31 | 2-arachidonoylglycerol |
activates 12(S)-HETE production in vivo |
687143 |
| 1.13.11.31 | alpha-Naphthol |
slight activation of enzyme activity at 0.25 mM, but not at 0.5 mM |
690148 |
| 1.13.11.31 | ATP |
2 mM ATP + 1 mM CaCl2 stimulate approximately 2fold |
395411 |
| 1.13.11.31 | beta-boswellic acid |
0.03 mM, in the absence of Ca2+ |
676096 |
| 1.13.11.31 | more |
a significant increase of 12-lipoxygenase enzyme activity in presence of arachidonic acid under GSH depletion induced by glutamate in C6 glimoa cells, overview |
688759 |
| 1.13.11.31 | more |
dihydroceramide has no effect |
705902 |
| 1.13.11.31 | more |
the enzyme is induced by the epidermal growth factor, EGF |
686569 |
| 1.13.11.31 | more |
the potent vasoconstricting and pro-inflammatory hormone angiotensin II (Ang II) led to increases in leukocyte-type 12-LO mRNA and protein levels, as well as increased enzyme activity |
743718 |
