EC Number   |
Activating Compound |
Reference |
|---|
   1.1.1.B40 | 17alpha,20beta-dihydroxy-4-pregnen-3-one |
activates in immature testis |
668426 |
| 1.1.1.B40 | dexamethasone |
after application of dexamethasone, 11beta-HSD1 mRNA increases in muscle of both diabetic and control subjects, whereas 11beta-HSD2 mRNA decreases. 11beta-HSD1 activity increases in diabetic subjects, but not in controls, whereas 11beta-HSD2 activity does not change in either group |
687961 |
| 1.1.1.B40 | more |
interleukin-1beta or tissue necrosis factor-alpha simultaneously increase 11beta-HSD1 expression and down-regulate 11beta-HSD2 |
700178 |
| 1.1.1.B40 | more |
the enzyme is induced by cortisol |
668426 |
| 1.1.1.B40 | more |
the JNK inhibitor SP600125 has no effect on 11beta-HSD2 enzyme activity |
742040 |
| 1.1.1.B40 | prostaglandin E2 |
stimulation of progesterone production and of 11beta-hydroxysteroid dehydrogenase activity via the prostaglandin E receptor 2-cAMP signalling pathway in luteinizing granulosa cells |
693380 |
| 1.1.1.B40 | U0126 |
the ERK1/2 inhibitor activates 11beta-HSD2 enzyme activity 3fold |
742040 |
