EC Number   |
Activating Compound |
Reference  |
|---|
   2.7.11.30 | actividin |
activates Smad2 phosphorylation via type I receptor kinases |
663984 |
| 2.7.11.30 | TGF-beta |
i.e. transforming growth factor-beta, interacts with and activates type I transforming growth factor-beta receptor |
663984 |
| 2.7.11.30 | SARA protein |
i.e. Smad anchor for receptor activation protein, binding site for co-modulator Smad4, modulates self-association of partially phosphorylated Smad2 preventing premature release of monophosphorylated substrate, interaction with Smad2 via the Smad2 MH2 domain |
664036 |
| 2.7.11.30 | TGF-beta |
binds to and activates TbetaRI receptor kinase that phosphorylates Smad2 |
664036 |
| 2.7.11.30 | actividin |
TGF-beta receptor I and ALK7 possess an actividin receptor-binding domain |
664282 |
| 2.7.11.30 | nodal |
- |
664282 |
| 2.7.11.30 | TGF-beta |
- |
664318, 664715, 665532 |
| 2.7.11.30 | actividin |
binds and activates the type I receptor ALK7 |
664721 |
| 2.7.11.30 | more |
increased D-glucose and palmitate concentrations increase the ALK7 enzyme expression in INS-1 cells |
664721 |
| 2.7.11.30 | TGF-beta |
binds and activates the TGF-family receptor kinases of type I and type II, e.g. type I receptor ALK7 |
664721 |
