EC Number   |
Activating Compound |
Reference |
|---|
   2.7.11.30 | nodal |
- |
664282 |
| 2.7.11.30 | TGF-beta |
- |
664318, 664715, 665532 |
| 2.7.11.30 | TGF-beta |
a potent regulator of cell proliferation, differentiation, motility, and apoptosis, binds to and activates serine/threonine receptors that phosphorylate Smad2 and Smad3 |
665554 |
| 2.7.11.30 | actividin |
activates Smad2 phosphorylation via type I receptor kinases |
663984 |
| 2.7.11.30 | TGF-beta |
activates the TGF-beta receptor by direct binding |
666512 |
| 2.7.11.30 | TGF-beta |
activates the TGF-beta type I receptor kinase by binding, affects BGN and GADDbeta45 expression in PANC-1 and M-63 cells via ALK5 and Smad phosphorylation/activation, overview |
665640 |
| 2.7.11.30 | TGF-beta |
activates the type II and type I membrane receptors, e.g. ALK1 and ALK5 |
666312 |
| 2.7.11.30 | TGF-beta 3 |
binds and activates ALK5 |
665699 |
| 2.7.11.30 | TGF-beta |
binds and activates the TGF-beta receptor kinase, promotes transforming growth in advanced carcinogenesis, influences transcription activity of cells |
666443 |
| 2.7.11.30 | TGF-beta |
binds and activates the TGF-beta receptor, treatment of cells with TGF-beta increaes the production of matrix proteins |
665481 |
