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Results 1 - 10 of 22 > >>
EC Number
Activating Compound
Commentary
Reference
actividin
activates Smad2 phosphorylation via type I receptor kinases
actividin
binds and activates the type I receptor ALK7
actividin
TGF-beta receptor I and ALK7 possess an actividin receptor-binding domain
actividin A
required for activity in a complex formed with ALK4 and ActRIIB or ActRII, identification of the functional binding site
actividin B
required for activity in a complex formed with ALK4 and ActRIIB or ActRII, identification of the functional binding site
ALK5
is important for ALK1/TGF-beta signaling
growth differentiation factor-9
i.e. GDF-9, interacts with bone morphogenetic protein type II receptor, and activates type I actividin receptor-like kinase 5, ALK5, GDF-9 belongs to the TGF-beta family, no stimulation of receptors ALK1, ALK2, ALK3, and ALKA6 by GDF-9
more
increased D-glucose and palmitate concentrations increase the ALK7 enzyme expression in INS-1 cells
nodal
-
SARA protein
i.e. Smad anchor for receptor activation protein, binding site for co-modulator Smad4, modulates self-association of partially phosphorylated Smad2 preventing premature release of monophosphorylated substrate, interaction with Smad2 via the Smad2 MH2 domain
Results 1 - 10 of 22 > >>