EC Number |
Activating Compound |
Reference |
---|
1.1.1.284 | pyrazole |
no effect |
287866 |
1.1.1.284 | pyrazole |
stimulates |
287866 |
1.1.1.284 | more |
formaldehyde induces the enzyme expression |
686818 |
1.1.1.284 | formaldehyde |
in the presence of NAD+ and initial absence of NADH, ADH3-mediated S-nitrosoglutathione reduction is triggered by the presence of formaldehyde |
696092 |
1.1.1.284 | NADH |
increasing intracellular NADH levels are likely to trigger S-nitrosoglutathione reduction |
697214 |
1.1.1.284 | more |
the GSNOR1/HOT5/PAR2 protein level, other than its steady-state mRNA level, is induced by paraquat |
703110 |
1.1.1.284 | glutathione |
dependent on |
742700 |
1.1.1.284 | S-nitrosoglutathione |
i.e. GSNO, kinetic activation of GSNOR by its substrate S-nitrosoglutathione (GSNO). Enzyme GSNOR kinetic analysis data results in nonhyperbolic behavior that was successfully accommodated by the Hill-Langmuir equation with a Hill coex0ecient of +1.75, indicating that the substrate, GSNO, is acting as a positive allosteric affector. GSNO activates GSNOR by binding to an allosteric site comprised of the residues Asn185, Lys188, Gly321, and Lys323 |
762616 |