4.2.1.120 A460G site-directed mutagenesis, the mutant shows highly reduced enzyme activity and forms tetramers 746825 4.2.1.120 C103A site-directed mutagenesis of a catalytic residue, inactive mutant with monomeric, dimeric, or tetrameric subunit composition compared to wild-type 746825 4.2.1.120 C299A site-directed mutagenesis of a catalytic residue, inactive mutant with monomeric, dimeric, or tetrameric subunit composition compared to wild-type 746825 4.2.1.120 C99A site-directed mutagenesis of a catalytic residue, inactive mutant with monomeric, dimeric, or tetrameric subunit composition compared to wild-type 746825 4.2.1.120 E257Q site-directed mutagenesis, inactive mutant forming tetramers 746825 4.2.1.120 E455Q site-directed mutagenesis, inactive mutant forming tetramers 746825 4.2.1.120 H292C site-directed mutagenesis of a catalytic residue, inactive mutant with dimeric or tetrameric subunit composition compared to wild-type 746825 4.2.1.120 H292E site-directed mutagenesis of a catalytic residue, inactive mutant with tetrameric subunit composition compared to wild-type 746825 4.2.1.120 K300Q site-directed mutagenesis, the mutant shows highly reduced enzyme activity and forms tetramers 746825 4.2.1.120 M149S site-directed mutagenesis, the mutant shows highly reduced enzyme activity and forms tetramers 746825