3.4.23.44 D75E no maturation cleavage 137317 3.4.23.44 D75N no maturation cleavage 137317 3.4.23.44 D75T no maturation cleavage 137317 3.4.23.44 D75V no maturation cleavage 137317 3.4.23.44 N363T drastically slowed cleavage 137317