2.3.1.56 G286E small reduction in activity 486162 2.3.1.56 I114T strong reduction of the acetylation activity 486162 2.3.1.56 K268R slightly increased activity 486162 2.3.1.56 additional information nucleic acid substitutions C282T and C481T have no effect on activity 486162 2.3.1.56 R197Q moderate reduction of acetylation activity 486162 2.3.1.56 R64Q moderate reduction of acetylation activity 486162