1.1.3.12 H460A site-directed mutagenesis, the mutant shows highly reduced activity compared to the wild-type enzyme 724467 1.1.3.12 H460A/H462A inactive 724979 1.1.3.12 H460A/H462A site-directed mutagenesis, inactive mutant 724467 1.1.3.12 H462A site-directed mutagenesis, the mutant shows highly reduced activity compared to the wild-type enzyme 724467