6.3.3.4	H447A	the mutant shows severely reduced turnover number compared to the wild type enzyme	
6.3.3.4	additional information	disruption mutant, complete loss of clavulanic acid production, accumulation of N2-(carboxyethyl)-L-arginine, but no effect on synthesis of penicillin or cephamycin	
6.3.3.4	V446A	the mutant shows reduced turnover number compared to the wild type enzyme	
6.3.3.4	V446G	the mutant shows strongly reduced turnover number compared to the wild type enzyme