3.4.21.101 D348A production of a 64000 Da precursor protein which is not processed to active enzymes under acidic conditions, no catalytic acticity detected 3.4.21.101 DELTA192 pro-region mutant enzyme 3.4.21.101 S169A production of a 64000 Da precursor protein which is not processed to active enzymes under acidic conditions, no catalytic acticity detected 3.4.21.101 S79A production of a 64000 Da precursor protein which is not processed to active enzymes under acidic conditions, no catalytic acticity detected