6.1.1.1 tyrosine-tRNA ligase - 6.1.1.10 methionine-tRNA ligase - 6.1.1.11 serine-tRNA ligase - 6.1.1.12 aspartate-tRNA ligase - 6.1.1.13 D-alanine-poly(phosphoribitol) ligase - 6.1.1.14 glycine-tRNA ligase - 6.1.1.15 proline-tRNA ligase - 6.1.1.16 cysteine-tRNA ligase - 6.1.1.17 glutamate-tRNA ligase - 6.1.1.18 glutamine-tRNA ligase - 6.1.1.19 arginine-tRNA ligase - 6.1.1.2 tryptophan-tRNA ligase - 6.1.1.20 phenylalanine-tRNA ligase - 6.1.1.21 histidine-tRNA ligase - 6.1.1.22 asparagine-tRNA ligase - 6.1.1.23 aspartate-tRNAAsn ligase - 6.1.1.24 glutamate-tRNAGln ligase - 6.1.1.25 lysine-tRNAPyl ligase deleted 6.1.1.26 pyrrolysine-tRNAPyl ligase - 6.1.1.27 O-phospho-L-serine-tRNA ligase - 6.1.1.3 threonine-tRNA ligase - 6.1.1.4 leucine-tRNA ligase - 6.1.1.5 isoleucine-tRNA ligase - 6.1.1.6 lysine-tRNA ligase - 6.1.1.7 alanine-tRNA ligase - 6.1.1.8 D-alanine-sRNA sythetase deleted 6.1.1.9 valine-tRNA ligase - 6.1.1.B3 glutamyl-Q-tRNA(Asp) ligase preliminary BRENDA-supplied EC number 6.1.2.1 D-alanine-(R)-lactate ligase - 6.1.2.2 nebramycin 5' synthase - 6.1.3.1 olefin beta-lactone synthetase - 6.2.1.1 acetate-CoA ligase - 6.2.1.10 carboxylic acid-CoA ligase (GDP-forming) - 6.2.1.11 biotin-CoA ligase - 6.2.1.12 4-coumarate-CoA ligase - 6.2.1.13 acetate-CoA ligase (ADP-forming) - 6.2.1.14 6-carboxyhexanoate-CoA ligase - 6.2.1.15 arachidonate-CoA ligase - 6.2.1.16 acetoacetate-CoA ligase - 6.2.1.17 propionate-CoA ligase - 6.2.1.18 citrate-CoA ligase - 6.2.1.19 long-chain-fatty-acid-protein ligase - 6.2.1.2 medium-chain acyl-CoA ligase - 6.2.1.20 long-chain-fatty-acid-[acyl-carrier-protein] ligase - 6.2.1.21 phenylacetate-CoA ligase deleted, included in EC 6.2.1.30 6.2.1.22 [citrate (pro-3S)-lyase] ligase - 6.2.1.23 dicarboxylate-CoA ligase - 6.2.1.24 phytanate-CoA ligase - 6.2.1.25 benzoate-CoA ligase - 6.2.1.26 O-succinylbenzoate-CoA ligase - 6.2.1.27 4-hydroxybenzoate-CoA ligase - 6.2.1.28 3alpha,7alpha-Dihydroxy-5beta-cholestanate-CoA ligase - 6.2.1.29 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate-CoA ligase deleted, identical to EC 6.2.1.7 6.2.1.3 long-chain-fatty-acid-CoA ligase - 6.2.1.30 phenylacetate-CoA ligase - 6.2.1.31 2-furoate-CoA ligase - 6.2.1.32 anthranilate-CoA ligase - 6.2.1.33 4-chlorobenzoate-CoA ligase - 6.2.1.34 trans-feruloyl-CoA synthase - 6.2.1.35 acetate-[acyl-carrier protein] ligase - 6.2.1.36 3-hydroxypropionyl-CoA synthase - 6.2.1.37 3-hydroxybenzoate-CoA ligase - 6.2.1.38 (2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA synthase - 6.2.1.39 [butirosin acyl-carrier protein]-L-glutamate ligase - 6.2.1.4 succinate-CoA ligase (GDP-forming) - 6.2.1.40 4-hydroxybutyrate-CoA ligase (AMP-forming) - 6.2.1.41 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate-CoA ligase - 6.2.1.42 3-oxocholest-4-en-26-oate-CoA ligase - 6.2.1.43 2-hydroxy-7-methoxy-5-methyl-1-naphthoate-CoA ligase - 6.2.1.44 3-(methylthio)propionyl-CoA ligase - 6.2.1.45 E1 ubiquitin-activating enzyme - 6.2.1.46 L-allo-isoleucine-holo-[CmaA peptidyl-carrier protein] ligase - 6.2.1.47 medium-chain-fatty-acid-[acyl-carrier-protein] ligase - 6.2.1.48 carnitine-CoA ligase - 6.2.1.49 long-chain fatty acid adenylyltransferase FadD28 - 6.2.1.5 succinate-CoA ligase (ADP-forming) - 6.2.1.50 4-hydroxybenzoate adenylyltransferase FadD22 - 6.2.1.51 4-hydroxyphenylalkanoate adenylyltransferase FadD29 - 6.2.1.52 L-firefly luciferin-CoA ligase - 6.2.1.53 L-proline-[L-prolyl-carrier protein] ligase - 6.2.1.54 D-alanine-[D-alanyl-carrier protein] ligase - 6.2.1.55 E1 SAMP-activating enzyme - 6.2.1.56 4-hydroxybutyrate-CoA ligase (ADP-forming) - 6.2.1.57 long-chain fatty acid adenylase/transferase FadD23 - 6.2.1.58 isophthalate-CoA ligase - 6.2.1.59 long-chain fatty acid adenylase/transferase FadD26 - 6.2.1.6 glutarate-CoA ligase - 6.2.1.60 marinolic acid-CoA ligase - 6.2.1.61 salicylate-[aryl-carrier protein] ligase - 6.2.1.62 3,4-dihydroxybenzoate-[aryl-carrier protein] ligase - 6.2.1.63 L-arginine-[L-arginyl-carrier protein] ligase - 6.2.1.64 E1 NEDD8-activating enzyme - 6.2.1.65 salicylate-CoA ligase - 6.2.1.66 glyine---[glycyl-carrier protein] ligase - 6.2.1.67 L-alanine---[L-alanyl-carrier protein] ligase - 6.2.1.68 L-glutamate---[L-glutamyl-carrier protein] ligase - 6.2.1.69 L-cysteine-[L-cysteinyl-carrier protein] ligase - 6.2.1.7 cholate-CoA ligase - 6.2.1.70 L-threonine-[L-threonyl-carrier protein] ligase - 6.2.1.71 2,3-dihydroxybenzoate-[aryl-carrier protein] ligase - 6.2.1.72 L-serine-[L-seryl-carrier protein] ligase - 6.2.1.73 L-tryptophan-[L-tryptophyl-carrier protein] ligase - 6.2.1.74 3-amino-5-hydroxybenzoate-[acyl-carrier protein] ligase - 6.2.1.75 indoleacetate-CoA ligase - 6.2.1.76 malonate-CoA ligase - 6.2.1.8 oxalate-CoA ligase - 6.2.1.9 malate-CoA ligase - 6.2.1.B1 O-succinylbenzoate-CoA ligase (ADP-forming) preliminary BRENDA-supplied EC number 6.2.1.B10 2-(imidazol-4-yl)acetate-CoA ligase preliminary BRENDA-supplied EC number 6.2.1.B11 carboxylic acid-CoA ligase (NDP-forming) preliminary BRENDA-supplied EC number 6.2.1.B13 3-phenylpropionic acid-CoA ligase preliminary BRENDA-supplied EC number 6.2.1.B3 OPC-8:CoA ligase preliminary BRENDA-supplied EC number 6.2.1.B4 glycine:[acyl-carrier protein] ligase (AMP forming) preliminary BRENDA-supplied EC number 6.2.1.B5 L-alanine:[acyl-carrier protein] ligase (AMP forming) preliminary BRENDA-supplied EC number 6.2.2.1 thioglycine synthase - 6.2.2.2 oxazoline synthase - 6.2.2.3 thiazoline synthase - 6.3.1.1 aspartate-ammonia ligase - 6.3.1.10 adenosylcobinamide-phosphate synthase - 6.3.1.11 glutamate-putrescine ligase - 6.3.1.12 D-aspartate ligase - 6.3.1.13 L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase - 6.3.1.14 diphthine-ammonia ligase - 6.3.1.15 8-demethylnovobiocic acid synthase - 6.3.1.16 carbapenam-3-carboxylate synthetase transferred to EC 6.3.3.6 6.3.1.17 beta-citrylglutamate synthase - 6.3.1.18 gamma-glutamylanilide synthase - 6.3.1.19 prokaryotic ubiquitin-like protein ligase - 6.3.1.2 glutamine synthetase - 6.3.1.20 lipoate-protein ligase - 6.3.1.21 phosphoribosylglycinamide formyltransferase 2 - 6.3.1.3 phosphoribosyl-glycinamide synthetase transferred to EC 6.3.4.13 6.3.1.4 aspartate-ammonia ligase (ADP-forming) - 6.3.1.5 NAD+ synthase - 6.3.1.6 glutamate-ethylamine ligase - 6.3.1.7 4-methyleneglutamate-ammonia ligase - 6.3.1.8 glutathionylspermidine synthase - 6.3.1.9 trypanothione synthase - 6.3.2.1 pantoate-beta-alanine ligase (AMP-forming) - 6.3.2.10 UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase - 6.3.2.11 carnosine synthase - 6.3.2.12 dihydrofolate synthase - 6.3.2.13 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-2,6-diaminopimelate ligase - 6.3.2.14 enterobactin synthase - 6.3.2.15 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diamino-pimelate-D-alanyl-D-alanine ligase deleted 6.3.2.16 D-alanine-alanyl-poly(glycerolphosphate) ligase - 6.3.2.17 tetrahydrofolate synthase - 6.3.2.18 gamma-glutamylhistamine synthase - 6.3.2.19 ubiquitin-protein ligase deleted. The ubiquitinylation process is now known to be performed by several enzymes in sequence, starting with EC 6.2.1.45 (ubiquitin-activating enzyme E1) and followed by several transfer reactions, including those of EC 2.3.2.23 (E2 ubiquitin-conjugating enzyme) and EC 2.3.2.27 (RING-type E3 ubiquitin transferase) 6.3.2.2 glutamate-cysteine ligase - 6.3.2.20 indoleacetate-lysine synthetase - 6.3.2.21 ubiquitin-calmodulin ligase deleted. The reaction is performed by the sequential action of EC 6.2.1.45 (ubiquitin-activating enzyme E1), several ubiquitin transferases and finally by EC 2.3.2.27 [ubiquitin transferase RING E3 (calmodulin-selective)] 6.3.2.22 diphthine-ammonia ligase transferred to EC 6.3.1.14 6.3.2.23 homoglutathione synthase - 6.3.2.24 tyrosine-arginine ligase - 6.3.2.25 tubulin-tyrosine ligase - 6.3.2.26 N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase - 6.3.2.27 aerobactin synthase deleted, now covered by EC 6.3.2.38 N2-citryl-N6-acetyl-N6-hydroxylysine synthase, and EC 6.3.2.39, aerobactin synthase 6.3.2.28 L-amino-acid alpha-ligase transferred to EC 6.3.2.49 6.3.2.29 cyanophycin synthase (L-aspartate-adding) - 6.3.2.3 glutathione synthase - 6.3.2.30 cyanophycin synthase (L-arginine-adding) - 6.3.2.31 coenzyme F420-0:L-glutamate ligase - 6.3.2.32 coenzyme gamma-F420-2:alpha-L-glutamate ligase - 6.3.2.33 tetrahydrosarcinapterin synthase - 6.3.2.34 coenzyme F420-1:gamma-L-glutamate ligase - 6.3.2.35 D-alanine-D-serine ligase - 6.3.2.36 4-phosphopantoate-beta-alanine ligase - 6.3.2.37 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-D-lysine ligase - 6.3.2.38 N2-citryl-N6-acetyl-N6-hydroxylysine synthase - 6.3.2.39 aerobactin synthase - 6.3.2.4 D-Alanine-D-alanine ligase - 6.3.2.40 cyclopeptine synthase - 6.3.2.41 N-acetylaspartylglutamate synthase - 6.3.2.42 N-acetylaspartylglutamylglutamate synthase - 6.3.2.43 [amino group carrier protein]-L-2-aminoadipate ligase - 6.3.2.44 pantoate-beta-alanine ligase (ADP-forming) - 6.3.2.45 UDP-N-acetylmuramate-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate ligase - 6.3.2.46 fumarate-(S)-2,3-diaminopropanoate ligase - 6.3.2.47 dapdiamide synthase - 6.3.2.48 L-arginine-specific L-amino acid ligase - 6.3.2.49 L-alanine-L-anticapsin ligase - 6.3.2.5 phosphopantothenate-cysteine ligase (CTP) - 6.3.2.50 tenuazonic acid synthetase - 6.3.2.51 phosphopantothenate-cysteine ligase (ATP) - 6.3.2.52 jasmonoyl-L-amino acid ligase - 6.3.2.53 UDP-N-acetylmuramoyl-L-alanine-L-glutamate ligase - 6.3.2.54 L-2,3-diaminopropanoate-citrate ligase - 6.3.2.55 2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate synthase - 6.3.2.56 staphyloferrin B synthase - 6.3.2.57 staphyloferrin A synthase - 6.3.2.58 D-ornithine-citrate ligase - 6.3.2.59 3-methyl-D-ornithine---L-lysine ligase - 6.3.2.6 phosphoribosylaminoimidazolesuccinocarboxamide synthase - 6.3.2.60 glutamate---[amino group carrier protein] ligase - 6.3.2.61 tubulin-glutamate ligase - 6.3.2.62 beta-tubulin-glutamate ligase - 6.3.2.7 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase - 6.3.2.8 UDP-N-acetylmuramate-L-alanine ligase - 6.3.2.9 UDP-N-acetylmuramoyl-L-alanine-D-glutamate ligase - 6.3.2.B1 oligomer L-amino acid ligase deleted, replaced by EC 6.3.2.30 6.3.2.B10 L-asparagine:L-amino acid ligase preliminary BRENDA-supplied EC number 6.3.2.B11 beta-citrylglutamate synthase preliminary BRENDA-supplied EC number 6.3.2.B15 3-[[[(2R,3R)-3-carboxyoxiran-2-yl]carbonyl]amino]-L-alanine-L-valine ligase preliminary BRENDA-supplied EC number 6.3.2.B16 L-valine-specific L-amino acid ligase preliminary BRENDA-supplied EC number 6.3.2.B19 [LysW]-C-terminal-L-glutamate ligase preliminary BRENDA-supplied EC number 6.3.2.B2 murein peptide ligase preliminary BRENDA-supplied EC number 6.3.2.B23 3-formyl-tyrosine ligase preliminary BRENDA-supplied EC number 6.3.2.B24 beta-tubulin-glutamate ligase deleted, replaced by EC 6.3.2.62, beta-tubulin-glutamate ligase 6.3.2.B3 tubulin-glutamate ligase deleted, replaced by EC 6.3.2.61, tubulin-glutamate ligase 6.3.2.B4 polyglycylase preliminary BRENDA-supplied EC number 6.3.3.1 phosphoribosylformylglycinamidine cyclo-ligase - 6.3.3.2 5-formyltetrahydrofolate cyclo-ligase - 6.3.3.3 dethiobiotin synthase - 6.3.3.4 (carboxyethyl)arginine beta-lactam-synthase - 6.3.3.5 O-ureido-D-serine cyclo-ligase - 6.3.3.6 carbapenam-3-carboxylate synthase - 6.3.3.7 Ni-sirohydrochlorin a,c-diamide reductive cyclase - 6.3.4.1 GMP synthase transferred to EC 6.3.5.2 6.3.4.10 biotin-[propionyl-CoA-carboxylase (ATP-hydrolysing)] ligase - 6.3.4.11 biotin-[methylcrotonoyl-CoA-carboxylase] ligase - 6.3.4.12 glutamate-methylamine ligase - 6.3.4.13 phosphoribosylamine-glycine ligase - 6.3.4.14 biotin carboxylase - 6.3.4.15 biotin-[biotin carboxyl-carrier protein] ligase - 6.3.4.16 carbamoyl-phosphate synthase (ammonia) - 6.3.4.17 formate-dihydrofolate ligase - 6.3.4.18 5-(carboxyamino)imidazole ribonucleotide synthase - 6.3.4.19 tRNAIle-lysidine synthase - 6.3.4.2 CTP synthase (glutamine hydrolysing) - 6.3.4.20 7-cyano-7-deazaguanine synthase - 6.3.4.21 nicotinate phosphoribosyltransferase - 6.3.4.22 tRNAIle2-agmatinylcytidine synthase - 6.3.4.23 formate-phosphoribosylaminoimidazolecarboxamide ligase - 6.3.4.24 tyramine-L-glutamate ligase - 6.3.4.25 2-amino-2'-deoxyadenylo-succinate synthase - 6.3.4.3 formate-tetrahydrofolate ligase - 6.3.4.4 adenylosuccinate synthase - 6.3.4.5 argininosuccinate synthase - 6.3.4.6 urea carboxylase - 6.3.4.7 ribose-5-phosphate-ammonia ligase - 6.3.4.8 imidazoleacetate-phosphoribosyldiphosphate ligase - 6.3.4.9 biotin-[methylmalonyl-CoA-carboxytransferase] ligase - 6.3.5.1 NAD+ synthase (glutamine-hydrolysing) - 6.3.5.10 adenosylcobyric acid synthase (glutamine-hydrolysing) - 6.3.5.11 cobyrinate a,c-diamide synthase - 6.3.5.12 Ni-sirohydrochlorin a,c-diamide synthase - 6.3.5.13 lipid II isoglutaminyl synthase (glutamine-hydrolysing) - 6.3.5.2 GMP synthase (glutamine-hydrolysing) - 6.3.5.3 phosphoribosylformylglycinamidine synthase - 6.3.5.4 asparagine synthase (glutamine-hydrolysing) - 6.3.5.5 carbamoyl-phosphate synthase (glutamine-hydrolysing) - 6.3.5.6 asparaginyl-tRNA synthase (glutamine-hydrolysing) - 6.3.5.7 glutaminyl-tRNA synthase (glutamine-hydrolysing) - 6.3.5.8 aminodeoxychorismate synthase transferred to EC 2.6.1.85 6.3.5.9 hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) - 6.4.1.1 pyruvate carboxylase - 6.4.1.2 acetyl-CoA carboxylase - 6.4.1.3 propionyl-CoA carboxylase - 6.4.1.4 methylcrotonoyl-CoA carboxylase - 6.4.1.5 geranoyl-CoA carboxylase - 6.4.1.6 acetone carboxylase - 6.4.1.7 2-oxoglutarate carboxylase - 6.4.1.8 acetophenone carboxylase - 6.4.1.9 coenzyme F430 synthetase - 6.5.1.1 DNA ligase (ATP) - 6.5.1.2 DNA ligase (NAD+) - 6.5.1.3 RNA ligase (ATP) - 6.5.1.4 RNA 3'-terminal-phosphate cyclase (ATP) - 6.5.1.5 RNA 3'-terminal-phosphate cyclase (GTP) - 6.5.1.6 DNA ligase (ATP or NAD+) - 6.5.1.7 DNA ligase (ATP, ADP or GTP) - 6.5.1.8 3'-phosphate/5'-hydroxy nucleic acid ligase - 6.5.1.9 cyclic 2,3-diphosphoglycerate synthase - 6.5.1.B1 2'-5' RNA ligase (NTP-independent) preliminary BRENDA-supplied EC number 6.5.1.B3 2'-5' RNA ligase (GTP-activated) preliminary BRENDA-supplied EC number 6.6.1.1 magnesium chelatase - 6.6.1.2 cobaltochelatase - 6.7.1.1 3-amino-2-hydroxy-4-methoxybenzoate diazotase -