5.6.1.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18303116&form=6&db=m SPAS-1 (stimulator of prostatic adenocarcinoma-specific T cells)/SH3GLB2: A prostate tumor antigen identified by CTLA-4 blockade. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1 5.6.1.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21681775&form=6&db=m Aberrant expression of katanin p60 in prostate cancer bone metastasis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 5.6.1.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33192306&form=6&db=m The lncRNA MALAT1/miR-30/Spastin Axis Regulates Hippocampal Neurite Outgrowth. diagnostic usage,unassigned 3,0 5.6.1.1 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16240363&form=6&db=m Spastin mutations in sporadic adult-onset upper motor neuron syndromes. causal interaction,ongoing research,unassigned 4,2,0 5.6.1.1 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18608088&form=6&db=m Heterozygous S44L missense change of the spastin gene in amyotrophic lateral sclerosis. ongoing research,unassigned 1,0 5.6.1.1 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21865889&form=6&db=m Microtubule-Severing ATPase Spastin in Glioblastoma: Increased Expression in Human Glioblastoma Cell Lines and Inverse Roles in Cell Motility and Proliferation. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0 5.6.1.1 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17868079&form=6&db=m Analysis and mapping of CACNB4, CHRNA1, KCNJ3, SCN2A and SPG4, physiological candidate genes for porcine congenital progressive ataxia and spastic paresis. ongoing research,therapeutic application,unassigned 2,1,0 5.6.1.1 Azoospermia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24913027&form=6&db=m Lack of association of KATNAL1 gene sequence variants and azoospermia in humans. causal interaction,ongoing research,unassigned 2,2,0 5.6.1.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26642432&form=6&db=m Adseverin mediates RANKL-induced osteoclastogenesis by regulating NFATc1. ongoing research,unassigned 2,0 5.6.1.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20068098&form=6&db=m Activity of the kinesin spindle protein inhibitor ispinesib (SB-715992) in models of breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,4 5.6.1.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22123335&form=6&db=m Phase I dose-escalation and pharmacokinetic study of ispinesib, a kinesin spindle protein inhibitor, administered on days 1 and 15 of a 28-day schedule in patients with no prior treatment for advanced breast cancer. causal interaction,therapeutic application,unassigned 1,4,0 5.6.1.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25763370&form=6&db=m Targeting Cell Cycle Proteins in Breast Cancer Cells with siRNA by Using Lipid-Substituted Polyethylenimines. causal interaction,ongoing research,therapeutic application,unassigned 1,3,3,0 5.6.1.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29103029&form=6&db=m Tumor tissue katanin P60 expression correlates with lymph node metastasis and worse prognosis in patients with breast cancer: A cohort study. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 5.6.1.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29552132&form=6&db=m The role of katanin p60 in breast cancer bone metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 5.6.1.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30223388&form=6&db=m Katanin P80 expression correlates with lymph node metastasis and worse overall survival in patients with breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 5.6.1.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11568009&form=6&db=m Expression of scinderin in megakaryoblastic leukemia cells induces differentiation, maturation, and apoptosis with release of plateletlike particles and inhibits proliferation and tumorigenesis. causal interaction,ongoing research,unassigned 1,4,0 5.6.1.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34502304&form=6&db=m The Aneugenicity of Ketone Bodies in Colon Epithelial Cells Is Mediated by Microtubule Hyperacetylation and Is Blocked by Resveratrol. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 5.6.1.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24330498&form=6&db=m Expression of EPHRIN-A1, SCINDERIN and MHC class I molecules in head and neck cancers and relationship with the prognostic value of intratumoral CD8+ T cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0 5.6.1.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25174406&form=6&db=m Suppression of scinderin modulates epithelial?mesenchymal transition markers in highly metastatic gastric cancer cell line SGC?7901. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 5.6.1.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25605484&form=6&db=m Downregulation of Kinesin spindle protein inhibits proliferation, induces apoptosis and increases chemosensitivity in hepatocellular carcinoma cells. causal interaction,ongoing research,unassigned 4,1,0 5.6.1.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30034938&form=6&db=m Scinderin is a novel transcriptional target of BRMS1 involved in regulation of hepatocellular carcinoma cell apoptosis. causal interaction,therapeutic application,unassigned 3,1,0 5.6.1.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32194697&form=6&db=m Scinderin suppresses cell proliferation and predicts the poor prognosis of hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,1,1 5.6.1.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32631334&form=6&db=m Katanin P60: a potential biomarker for lymph node metastasis and prognosis for non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 5.6.1.1 Cerebellar Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15667412&form=6&db=m Hereditary spastic paraplegia with cerebellar ataxia: a complex phenotype associated with a new SPG4 gene mutation. causal interaction,unassigned 4,0 5.6.1.1 Cerebellar Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30599301&form=6&db=m A Japanese family with a novel nonsense mutation in the spastin gene associated with both cerebellar ataxia and cognitive impairment. causal interaction,unassigned 4,0 5.6.1.1 Choriocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15683985&form=6&db=m Selection of choriocarcinoma-associated genes using bioinformatics. diagnostic usage,unassigned 1,0 5.6.1.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31736743&form=6&db=m Aberrant Scinderin Expression Correlates With Liver Metastasis and Poor Prognosis in Colorectal Cancer. causal interaction,diagnostic usage,unassigned 3,1,0 5.6.1.1 Congenital Abnormalities http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24990491&form=6&db=m Association between an alternative promoter polymorphism and sperm deformity rate is due to modulation of the expression of KATNAL1 transcripts in Chinese Holstein bulls. unassigned - 5.6.1.1 Decompression Sickness http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28436967&form=6&db=m Microtubule minus-end regulation at spindle poles by an ASPM-katanin complex. ongoing research,therapeutic application,unassigned 2,1,0 5.6.1.1 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12925368&form=6&db=m Subtle cognitive impairment but no dementia in patients with spastin mutations. causal interaction,unassigned 3,0 5.6.1.1 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19652142&form=6&db=m Dementia in SPG4 hereditary spastic paraplegia: clinical, genetic, and neuropathologic evidence. causal interaction,therapeutic application,unassigned 1,1,0 5.6.1.1 Dermatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24664804&form=6&db=m A newly recognized 13q12.3 microdeletion syndrome characterized by intellectual disability, microcephaly, and eczema/atopic dermatitis encompassing the HMGB1 and KATNAL1 genes. unassigned - 5.6.1.1 Developmental Dysplasia of the Hip http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28213129&form=6&db=m Cyclic compressive stress-induced scinderin regulates progress of developmental dysplasia of the hip. unassigned - 5.6.1.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11723204&form=6&db=m A large family with hereditary spastic paraparesis due to a frame shift mutation of the spastin (SPG4) gene: association with multiple sclerosis in two affected siblings and epilepsy in other affected family members. causal interaction,unassigned 1,0 5.6.1.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16828199&form=6&db=m Spastin in the human and mouse central nervous system with special reference to its expression in the hippocampus of mouse pilocarpine model of status epilepticus and temporal lobe epilepsy. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 5.6.1.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17868079&form=6&db=m Analysis and mapping of CACNB4, CHRNA1, KCNJ3, SCN2A and SPG4, physiological candidate genes for porcine congenital progressive ataxia and spastic paresis. ongoing research,therapeutic application,unassigned 2,1,0 5.6.1.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33023587&form=6&db=m A novel phenotype of 13q12.3 microdeletion characterized by epilepsy in an Asian child: a case report. causal interaction,unassigned 4,0 5.6.1.1 Epilepsy, Temporal Lobe http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16828199&form=6&db=m Spastin in the human and mouse central nervous system with special reference to its expression in the hippocampus of mouse pilocarpine model of status epilepticus and temporal lobe epilepsy. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 5.6.1.1 Gait Disorders, Neurologic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24381312&form=6&db=m Gene dosage-dependent rescue of HSP neurite defects in SPG4 patients' neurons. causal interaction,therapeutic application,unassigned 3,1,0 5.6.1.1 Genetic Diseases, Inborn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22773755&form=6&db=m Microtubule-targeting drugs rescue axonal swellings in cortical neurons from spastin knock-out mice. causal interaction,unassigned 1,0 5.6.1.1 Genetic Diseases, Inborn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25506442&form=6&db=m A new case of 13q12.2q13.1 microdeletion syndrome contributes to phenotype delineation. causal interaction,therapeutic application,unassigned 2,1,0 5.6.1.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21865889&form=6&db=m Microtubule-Severing ATPase Spastin in Glioblastoma: Increased Expression in Human Glioblastoma Cell Lines and Inverse Roles in Cell Motility and Proliferation. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0 5.6.1.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22390762&form=6&db=m Tubulins as Therapeutic Targets in Cancer: from Bench to Bedside. causal interaction,therapeutic application,unassigned 1,1,0 5.6.1.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25976261&form=6&db=m Emerging microtubule targets in glioma therapy. causal interaction,unassigned 3,0 5.6.1.1 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24330498&form=6&db=m Expression of EPHRIN-A1, SCINDERIN and MHC class I molecules in head and neck cancers and relationship with the prognostic value of intratumoral CD8+ T cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0 5.6.1.1 Hematologic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33233768&form=6&db=m IL3RA-Targeting Antibody-Drug Conjugate BAY-943 with a Kinesin Spindle Protein Inhibitor Payload Shows Efficacy in Preclinical Models of Hematologic Malignancies. therapeutic application,unassigned 3,0 5.6.1.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31595676&form=6&db=m Klebsiella pneumoniae Redistributes Katanin Severing Proteins and Alters Astral Microtubules during Mitosis. causal interaction,ongoing research,unassigned 2,3,0 5.6.1.1 Infertility http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22654668&form=6&db=m KATNAL1 regulation of sertoli cell microtubule dynamics is essential for spermiogenesis and male fertility. causal interaction,therapeutic application,unassigned 2,1,0 5.6.1.1 Infertility http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24913027&form=6&db=m Lack of association of KATNAL1 gene sequence variants and azoospermia in humans. causal interaction,ongoing research,unassigned 2,2,0 5.6.1.1 Infertility http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28093975&form=6&db=m Molecular Modeling and Dynamics Simulation Analysis of KATNAL1 for Identification of Novel Inhibitor of Sperm Maturation. therapeutic application,unassigned 1,0 5.6.1.1 Infertility, Male http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22654669&form=6&db=m An essential role for katanin p80 and microtubule severing in male gamete production. therapeutic application,unassigned 1,0 5.6.1.1 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24664804&form=6&db=m A newly recognized 13q12.3 microdeletion syndrome characterized by intellectual disability, microcephaly, and eczema/atopic dermatitis encompassing the HMGB1 and KATNAL1 genes. unassigned - 5.6.1.1 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28373692&form=6&db=m A missense mutation in Katnal1 underlies behavioural, neurological and ciliary anomalies. causal interaction,unassigned 4,0 5.6.1.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11568009&form=6&db=m Expression of scinderin in megakaryoblastic leukemia cells induces differentiation, maturation, and apoptosis with release of plateletlike particles and inhibits proliferation and tumorigenesis. causal interaction,ongoing research,unassigned 1,4,0 5.6.1.1 Leukemia, Myelogenous, Chronic, BCR-ABL Positive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25146433&form=6&db=m Kinesin spindle protein inhibitor SB743921 induces mitotic arrest and apoptosis and overcomes imatinib resistance of chronic myeloid leukemia cells. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,3,0 5.6.1.1 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22139909&form=6&db=m A phase 1 dose-escalation study of ARRY-520, a kinesin spindle protein inhibitor, in patients with advanced myeloid leukemias. therapeutic application,unassigned 4,0 5.6.1.1 Lissencephaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16203747&form=6&db=m Recruitment of katanin p60 by phosphorylated NDEL1, an LIS1 interacting protein, is essential for mitotic cell division and neuronal migration. causal interaction,diagnostic usage,unassigned 1,3,0 5.6.1.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23394180&form=6&db=m Optimized S-Trityl-l-cysteine-Based Inhibitors of Kinesin Spindle Protein with Potent in Vivo Antitumor Activity in Lung Cancer Xenograft Models. therapeutic application,unassigned 4,0 5.6.1.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27536893&form=6&db=m Purine-Type Compounds Induce Microtubule Fragmentation and Lung Cancer Cell Death through Interaction with Katanin. therapeutic application,unassigned 2,0 5.6.1.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31944409&form=6&db=m Katanin P80 correlates with larger tumor size, lymph node metastasis, and advanced TNM stage and predicts poor prognosis in non-small-cell lung cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 5.6.1.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32631334&form=6&db=m Katanin P60: a potential biomarker for lymph node metastasis and prognosis for non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 5.6.1.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29103029&form=6&db=m Tumor tissue katanin P60 expression correlates with lymph node metastasis and worse prognosis in patients with breast cancer: A cohort study. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 5.6.1.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30223388&form=6&db=m Katanin P80 expression correlates with lymph node metastasis and worse overall survival in patients with breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 5.6.1.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31944409&form=6&db=m Katanin P80 correlates with larger tumor size, lymph node metastasis, and advanced TNM stage and predicts poor prognosis in non-small-cell lung cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 5.6.1.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32631334&form=6&db=m Katanin P60: a potential biomarker for lymph node metastasis and prognosis for non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 5.6.1.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32636728&form=6&db=m Differential expression of Scinderin and Gelsolin in gastric cancer and comparison with clinical and morphological characteristics. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1 5.6.1.1 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22615058&form=6&db=m A Phase I trial of the kinesin spindle protein (Eg5) inhibitor AZD4877 in patients with solid and lymphoid malignancies. causal interaction,ongoing research,therapeutic application,unassigned 2,3,4,0 5.6.1.1 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25665464&form=6&db=m The Addition of G-CSF Shifts the Dose Limiting Toxicity (DLT) and Markedly Increases the Maximum Tolerated Dose (MTD) and Activity of the Kinesin Spindle Protein Inhibitor SB-743921in Patients with Relapsed or Refractory Lymphoma: Results of an International, Multicenter Phase I/II Study. therapeutic application,unassigned 3,0 5.6.1.1 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25860245&form=6&db=m The novel kinesin spindle protein (KSP) inhibitor SB-743921 exhibits marked activity in in vivo and in vitro models of aggressive large B-cell lymphoma. ongoing research,unassigned 2,0 5.6.1.1 Malformations of Cortical Development http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25521378&form=6&db=m Mutations in KATNB1 cause complex cerebral malformations by disrupting asymmetrically dividing neural progenitors. unassigned - 5.6.1.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17962907&form=6&db=m A phase II study of ispinesib (SB-715992) in patients with metastatic or recurrent malignant melanoma: a National Cancer Institute of Canada Clinical Trials Group trial. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,2 5.6.1.1 Memory Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32866173&form=6&db=m Spastin depletion increases tubulin polyglutamylation and impairs kinesin-mediated neuronal transport, leading to working and associative memory deficits. ongoing research,therapeutic application,unassigned 4,2,0 5.6.1.1 Microcephaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24664804&form=6&db=m A newly recognized 13q12.3 microdeletion syndrome characterized by intellectual disability, microcephaly, and eczema/atopic dermatitis encompassing the HMGB1 and KATNAL1 genes. unassigned - 5.6.1.1 Microcephaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25521379&form=6&db=m Katanin p80 regulates human cortical development by limiting centriole and cilia number. causal interaction,unassigned 2,0 5.6.1.1 Microcephaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28373692&form=6&db=m A missense mutation in Katnal1 underlies behavioural, neurological and ciliary anomalies. causal interaction,unassigned 4,0 5.6.1.1 Microcephaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28436967&form=6&db=m Microtubule minus-end regulation at spindle poles by an ASPM-katanin complex. ongoing research,therapeutic application,unassigned 2,1,0 5.6.1.1 microtubule-severing atpase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17846175&form=6&db=m Katanin regulates dynamics of microtubules and biogenesis of motile cilia. unassigned - 5.6.1.1 microtubule-severing atpase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26875866&form=6&db=m Graded Control of Microtubule Severing by Tubulin Glutamylation. causal interaction,unassigned 1,0 5.6.1.1 microtubule-severing atpase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33013303&form=6&db=m Suppression of spastin Mutant Phenotypes by Pak3 Loss Implicates a Role for Reactive Glia in AD-HSP. causal interaction,unassigned 4,0 5.6.1.1 Motor Neuron Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15079007&form=6&db=m Large-scale disruption of microtubule pathways in morphologically normal human spastin muscle. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 5.6.1.1 Motor Neuron Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16240363&form=6&db=m Spastin mutations in sporadic adult-onset upper motor neuron syndromes. causal interaction,ongoing research,unassigned 4,2,0 5.6.1.1 Motor Neuron Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27773584&form=6&db=m Branch-Specific Microtubule Destabilization Mediates Axon Branch Loss during Neuromuscular Synapse Elimination. unassigned - 5.6.1.1 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20571074&form=6&db=m Mcl-1 stability determines mitotic cell fate of human multiple myeloma tumor cells treated with the kinesin spindle protein inhibitor ARRY-520. ongoing research,therapeutic application,unassigned 3,2,0 5.6.1.1 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27433944&form=6&db=m A phase 1 dose-escalation study of filanesib plus bortezomib and dexamethasone in patients with recurrent/refractory multiple myeloma. causal interaction,unassigned 1,0 5.6.1.1 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28860344&form=6&db=m The kinesin spindle protein inhibitor filanesib enhances the activity of pomalidomide and dexamethasone in multiple myeloma. causal interaction,therapeutic application,unassigned 4,4,0 5.6.1.1 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29188449&form=6&db=m Current and New Therapeutic Strategies for Relapsed and Refractory Multiple Myeloma: An Update. causal interaction,therapeutic application,unassigned 3,4,0 5.6.1.1 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32501528&form=6&db=m Filanesib in combination with pomalidomide and dexamethasone in refractory MM patients: safety and efficacy, and association with alpha 1-acid glycoprotein (AAG) levels. Phase Ib/II Pomdefil clinical trial conducted by the Spanish MM group. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,4,0 5.6.1.1 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11723204&form=6&db=m A large family with hereditary spastic paraparesis due to a frame shift mutation of the spastin (SPG4) gene: association with multiple sclerosis in two affected siblings and epilepsy in other affected family members. causal interaction,unassigned 1,0 5.6.1.1 Muscle Spasticity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17122756&form=6&db=m Identification of a novel mutation in the spastin gene (SPG4) in an Italian family with hereditary spastic paresis. unassigned - 5.6.1.1 Muscle Spasticity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19289482&form=6&db=m Posterior fossa abnormalities in hereditary spastic paraparesis with spastin mutations. causal interaction,unassigned 3,0 5.6.1.1 Muscular Atrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30804259&form=6&db=m Effect of exogenous spastin combined with polyethylene glycol on sciatic nerve injury. therapeutic application,unassigned 1,0 5.6.1.1 Muscular Dystrophies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25511172&form=6&db=m A new double-trouble phenotype: fascioscapulohumeral muscular dystrophy ameliorates hereditary spastic paraparesis due to spastin mutation. unassigned - 5.6.1.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18303116&form=6&db=m SPAS-1 (stimulator of prostatic adenocarcinoma-specific T cells)/SH3GLB2: A prostate tumor antigen identified by CTLA-4 blockade. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1 5.6.1.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21681775&form=6&db=m Aberrant expression of katanin p60 in prostate cancer bone metastasis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 5.6.1.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27033455&form=6&db=m Scinderin promotes the invasion and metastasis of gastric cancer cells and predicts the outcome of patients. causal interaction,diagnostic usage,unassigned 3,3,0 5.6.1.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29103029&form=6&db=m Tumor tissue katanin P60 expression correlates with lymph node metastasis and worse prognosis in patients with breast cancer: A cohort study. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 5.6.1.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29552132&form=6&db=m The role of katanin p60 in breast cancer bone metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 5.6.1.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30223388&form=6&db=m Katanin P80 expression correlates with lymph node metastasis and worse overall survival in patients with breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 5.6.1.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31736743&form=6&db=m Aberrant Scinderin Expression Correlates With Liver Metastasis and Poor Prognosis in Colorectal Cancer. causal interaction,diagnostic usage,unassigned 3,1,0 5.6.1.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31944409&form=6&db=m Katanin P80 correlates with larger tumor size, lymph node metastasis, and advanced TNM stage and predicts poor prognosis in non-small-cell lung cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 5.6.1.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32631334&form=6&db=m Katanin P60: a potential biomarker for lymph node metastasis and prognosis for non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 5.6.1.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32636728&form=6&db=m Differential expression of Scinderin and Gelsolin in gastric cancer and comparison with clinical and morphological characteristics. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1 5.6.1.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11568009&form=6&db=m Expression of scinderin in megakaryoblastic leukemia cells induces differentiation, maturation, and apoptosis with release of plateletlike particles and inhibits proliferation and tumorigenesis. causal interaction,ongoing research,unassigned 1,4,0 5.6.1.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17040200&form=6&db=m Development of new cancer therapeutic agents targeting mitosis. causal interaction,therapeutic application,unassigned 3,4,0 5.6.1.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17210704&form=6&db=m Potentiation of kinesin spindle protein inhibitor-induced cell death by modulation of mitochondrial and death receptor apoptotic pathways. causal interaction,therapeutic application,unassigned 3,4,0 5.6.1.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17351128&form=6&db=m LAPSER1 is a putative cytokinetic tumor suppressor that shows the same centrosome and midbody subcellular localization pattern as p80 katanin. causal interaction,therapeutic application,unassigned 4,2,0 5.6.1.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18303116&form=6&db=m SPAS-1 (stimulator of prostatic adenocarcinoma-specific T cells)/SH3GLB2: A prostate tumor antigen identified by CTLA-4 blockade. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1 5.6.1.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18319713&form=6&db=m A phase I trial of ispinesib, a kinesin spindle protein inhibitor, with docetaxel in patients with advanced solid tumours. ongoing research,therapeutic application,unassigned 2,4,0 5.6.1.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18578472&form=6&db=m Kinesin spindle protein (KSP) inhibitors. 9. Discovery of (2S)-4-(2,5-difluorophenyl)-n-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide (MK-0731) for the treatment of taxane-refractory cancer. causal interaction,therapeutic application,unassigned 4,4,0 5.6.1.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18824433&form=6&db=m Southwest Oncology Group Phase II Study of Ispinesib in Androgen-Independent Prostate Cancer Previously Treated with Taxanes. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,2,0 5.6.1.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19229107&form=6&db=m Confirming the RNAi-mediated mechanism of action of siRNA-based cancer therapeutics in mice. ongoing research,unassigned 2,0 5.6.1.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19270519&form=6&db=m Preferential killing of tetraploid tumor cells by targeting the mitotic kinesin Eg5. ongoing research,therapeutic application,unassigned 2,1,0 5.6.1.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19458629&form=6&db=m Inhibition of KSP by ARRY-520 induces cell cycle block and cell death via the mitochondrial pathway in AML cells. causal interaction,therapeutic application,unassigned 4,1,0 5.6.1.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20032381&form=6&db=m ARRY-520, a novel KSP inhibitor with potent activity in hematological and taxane-resistant tumor models. ongoing research,therapeutic application,unassigned 1,1,0 5.6.1.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20069338&form=6&db=m A phase I study of ispinesib, a kinesin spindle protein inhibitor, administered weekly for three consecutive weeks of a 28-day cycle in patients with solid tumors. ongoing research,therapeutic application,unassigned 2,4,0 5.6.1.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20571074&form=6&db=m Mcl-1 stability determines mitotic cell fate of human multiple myeloma tumor cells treated with the kinesin spindle protein inhibitor ARRY-520. ongoing research,therapeutic application,unassigned 3,2,0 5.6.1.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20712019&form=6&db=m A pediatric phase I trial and pharmacokinetic study of ispinesib: a Children's Oncology Group phase I consortium study. ongoing research,therapeutic application,unassigned 2,2,0 5.6.1.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21235439&form=6&db=m Discovery of allosteric inhibitors of kinesin spindle protein (KSP) for the treatment of taxane-refractory cancer: MK-0731 and analogs. therapeutic application,unassigned 4,0 5.6.1.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21424701&form=6&db=m A phase I trial of MK-0731, a Kinesin Spindle Protein (KSP) inhibitor, in patients with solid tumors. ongoing research,therapeutic application,unassigned 3,4,0 5.6.1.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21681775&form=6&db=m Aberrant expression of katanin p60 in prostate cancer bone metastasis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 5.6.1.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21865889&form=6&db=m Microtubule-Severing ATPase Spastin in Glioblastoma: Increased Expression in Human Glioblastoma Cell Lines and Inverse Roles in Cell Motility and Proliferation. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0 5.6.1.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22552964&form=6&db=m Intratumoral electro-transfer of small interfering RNA against kinesin spindle protein (KSP) slows down tumor progression. causal interaction,therapeutic application,unassigned 2,1,0 5.6.1.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22615058&form=6&db=m A Phase I trial of the kinesin spindle protein (Eg5) inhibitor AZD4877 in patients with solid and lymphoid malignancies. causal interaction,ongoing research,therapeutic application,unassigned 2,3,4,0 5.6.1.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22754781&form=6&db=m CTLA-4 blockade synergizes with cryoablation to mediate tumor rejection. diagnostic usage,ongoing research,unassigned 3,3,0 5.6.1.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23358650&form=6&db=m First-in-Humans Trial of an RNA Interference Therapeutic Targeting VEGF and KSP in Cancer Patients with Liver Involvement. ongoing research,therapeutic application,unassigned 2,2,0 5.6.1.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23964020&form=6&db=m Kinesin Spindle Protein (KSP) Inhibitors in Combination with Chemotherapeutic Agents for Cancer Therapy. causal interaction,therapeutic application,unassigned 4,4,0 5.6.1.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23978071&form=6&db=m Kinesin spindle protein inhibitors in cancer: a patent review (2008 - present). causal interaction,therapeutic application,unassigned 3,4,0 5.6.1.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24133978&form=6&db=m [Antitumor activity of novel tetrahydro-beta-carboline derivatives as KSP inhibitors]. causal interaction,therapeutic application,unassigned 4,4,0 5.6.1.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24330498&form=6&db=m Expression of EPHRIN-A1, SCINDERIN and MHC class I molecules in head and neck cancers and relationship with the prognostic value of intratumoral CD8+ T cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0 5.6.1.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24410085&form=6&db=m Bioengineered bacterial outer membrane vesicles as cell-specific drug-delivery vehicles for cancer therapy. therapeutic application,unassigned 2,0 5.6.1.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24607899&form=6&db=m Delivery of kinesin spindle protein targeting siRNA in solid lipid nanoparticles to cellular models of tumor vasculature. causal interaction,ongoing research,unassigned 2,2,0 5.6.1.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25174406&form=6&db=m Suppression of scinderin modulates epithelial?mesenchymal transition markers in highly metastatic gastric cancer cell line SGC?7901. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 5.6.1.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25684345&form=6&db=m First-in-human phase 1 study of filanesib (ARRY-520), a kinesin spindle protein inhibitor, in patients with advanced solid tumors. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 5.6.1.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25723613&form=6&db=m Simultaneous silencing of VEGF and KSP by siRNA cocktail inhibits proliferation and induces apoptosis of hepatocellular carcinoma Hep3B cells. causal interaction,unassigned 1,0 5.6.1.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25976261&form=6&db=m Emerging microtubule targets in glioma therapy. causal interaction,unassigned 3,0 5.6.1.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26078295&form=6&db=m Patient Mutation Directed shRNA Screen Uncovers Novel Bladder Tumor Growth Suppressors. unassigned - 5.6.1.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26877778&form=6&db=m Mono-arginine Cholesterol-based Small Lipid Nanoparticles as a Systemic siRNA Delivery Platform for Effective Cancer Therapy. diagnostic usage,ongoing research,unassigned 1,3,0 5.6.1.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27033455&form=6&db=m Scinderin promotes the invasion and metastasis of gastric cancer cells and predicts the outcome of patients. causal interaction,diagnostic usage,unassigned 3,3,0 5.6.1.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28489567&form=6&db=m Eg5 inhibitor YL001 induces mitotic arrest and inhibits tumor proliferation. causal interaction,therapeutic application,unassigned 4,3,0 5.6.1.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28860344&form=6&db=m The kinesin spindle protein inhibitor filanesib enhances the activity of pomalidomide and dexamethasone in multiple myeloma. causal interaction,therapeutic application,unassigned 4,4,0 5.6.1.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29103029&form=6&db=m Tumor tissue katanin P60 expression correlates with lymph node metastasis and worse prognosis in patients with breast cancer: A cohort study. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 5.6.1.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29454915&form=6&db=m Synthesis of N-(1-(6-acetamido-5-phenylpyrimidin-4-yl) piperidin-3-yl) amide derivatives as potential inhibitors for mitotic kinesin spindle protein. causal interaction,unassigned 1,0 5.6.1.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29552132&form=6&db=m The role of katanin p60 in breast cancer bone metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 5.6.1.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29744289&form=6&db=m Loss of scinderin decreased expression of epidermal growth factor receptor and promoted apoptosis of castration-resistant prostate cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 5.6.1.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30049442&form=6&db=m PEGylated DC-Chol/DOPE cationic liposomes containing KSP siRNA as a systemic siRNA delivery Carrier for ovarian cancer therapy. ongoing research,therapeutic application,unassigned 1,1,0 5.6.1.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30127916&form=6&db=m Scinderin-knockdown inhibits proliferation and promotes apoptosis in human breast carcinoma cells. causal interaction,unassigned 4,0 5.6.1.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31944409&form=6&db=m Katanin P80 correlates with larger tumor size, lymph node metastasis, and advanced TNM stage and predicts poor prognosis in non-small-cell lung cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 5.6.1.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32035195&form=6&db=m KSP siRNA/paclitaxel-loaded PEGylated cationic liposomes for overcoming resistance to KSP inhibitors: Synergistic antitumor effects in drug-resistant ovarian cancer. causal interaction,therapeutic application,unassigned 3,4,0 5.6.1.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32462403&form=6&db=m Updating dual-specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2): molecular basis, functions and role in diseases. diagnostic usage,ongoing research,unassigned 1,3,0 5.6.1.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32631334&form=6&db=m Katanin P60: a potential biomarker for lymph node metastasis and prognosis for non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 5.6.1.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32636728&form=6&db=m Differential expression of Scinderin and Gelsolin in gastric cancer and comparison with clinical and morphological characteristics. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1 5.6.1.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33171265&form=6&db=m Non-mitotic functions of polo-like kinases in cancer cells. causal interaction,therapeutic application,unassigned 2,1,0 5.6.1.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33274499&form=6&db=m Katanin P60 and P80 in papillary thyroid carcinoma patients: Indicators for exacerbated tumor features and worse disease-free survival. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1 5.6.1.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33640763&form=6&db=m Design, synthesis, and evaluation of a novel prodrug, a S-trityl-l-cysteine derivative targeting kinesin spindle protein. causal interaction,therapeutic application,unassigned 1,4,0 5.6.1.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33836291&form=6&db=m Systemic delivery of CRISPR/Cas9 to hepatic tumors for cancer treatment using altered tropism of lentiviral vector. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 5.6.1.1 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15242610&form=6&db=m The hereditary spastic paraplegia gene, spastin, regulates microtubule stability to modulate synaptic structure and function. causal interaction,therapeutic application,unassigned 4,4,0 5.6.1.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12908108&form=6&db=m Identification of the Drosophila melanogaster homolog of the human spastin gene. causal interaction,unassigned 4,0 5.6.1.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15147984&form=6&db=m Identification of nuclear localisation sequences in spastin (SPG4) using a novel Tetra-GFP reporter system. causal interaction,unassigned 3,0 5.6.1.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15823537&form=6&db=m The Drosophila homologue of the hereditary spastic paraplegia protein, spastin, severs and disassembles microtubules. causal interaction,unassigned 3,0 5.6.1.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16276409&form=6&db=m All neuropathies great and small. causal interaction,diagnostic usage,unassigned 2,3,0 5.6.1.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17389232&form=6&db=m Recognition of C-terminal amino acids in tubulin by pore loops in Spastin is important for microtubule severing. unassigned - 5.6.1.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18305248&form=6&db=m Quantitative and functional analyses of spastin in the nervous system: implications for hereditary spastic paraplegia. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,2,0 5.6.1.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20154342&form=6&db=m Functional conservation of human Spastin in a Drosophila model of autosomal dominant-hereditary spastic paraplegia. causal interaction,ongoing research,unassigned 3,4,0 5.6.1.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20209135&form=6&db=m Role of spastin in apical domain control along the rhabdomere elongation in Drosophila photoreceptor. causal interaction,unassigned 4,0 5.6.1.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33106322&form=6&db=m Spastin recovery in hereditary spastic paraplegia by preventing neddylation-dependent degradation. unassigned - 5.6.1.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25998394&form=6&db=m Potential new chemotherapy strategy for human ovarian carcinoma with a novel KSP inhibitor. diagnostic usage,ongoing research,unassigned 3,3,0 5.6.1.1 Paralysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32486213&form=6&db=m ?he Nematicidal Potential of Bioactive Streptomyces Strains Isolated from Greek Rhizosphere Soils Tested on Arabidopsis Plants of Varying Susceptibility to Meloidogyne spp. therapeutic application,unassigned 1,0 5.6.1.1 Paraparesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19289482&form=6&db=m Posterior fossa abnormalities in hereditary spastic paraparesis with spastin mutations. causal interaction,unassigned 3,0 5.6.1.1 Paraparesis, Spastic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10891911&form=6&db=m Clinical and pathologic findings in hereditary spastic paraparesis with spastin mutation. causal interaction,unassigned 4,0 5.6.1.1 Paraparesis, Spastic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11015453&form=6&db=m Mutation analysis of the spastin gene (SPG4) in patients with hereditary spastic paraparesis. ongoing research,unassigned 1,0 5.6.1.1 Paraparesis, Spastic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11148263&form=6&db=m Clinical and pathologic findings in hereditary spastic paraparesis with spastin mutation. causal interaction,unassigned 4,0 5.6.1.1 Paraparesis, Spastic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11723204&form=6&db=m A large family with hereditary spastic paraparesis due to a frame shift mutation of the spastin (SPG4) gene: association with multiple sclerosis in two affected siblings and epilepsy in other affected family members. causal interaction,unassigned 1,0 5.6.1.1 Paraparesis, Spastic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12876245&form=6&db=m Motor system abnormalities in hereditary spastic paraparesis type 4 (SPG4) depend on the type of mutation in the spastin gene. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 5.6.1.1 Paraparesis, Spastic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12939659&form=6&db=m Novel spastin mutations and their expression analysis in two Italian families. unassigned - 5.6.1.1 Paraparesis, Spastic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14506940&form=6&db=m Spastin and paraplegin gene analysis in selected cases of motor neurone disease (MND). causal interaction,unassigned 3,0 5.6.1.1 Paraparesis, Spastic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14656074&form=6&db=m The cellular and molecular pathology of the motor system in hereditary spastic paraparesis due to mutation of the spastin gene. causal interaction,ongoing research,unassigned 4,3,0 5.6.1.1 Paraparesis, Spastic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14681884&form=6&db=m Hereditary spastic paraparesis: disrupted intracellular transport associated with spastin mutation. causal interaction,unassigned 4,0 5.6.1.1 Paraparesis, Spastic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14974310&form=6&db=m [From gene to disease; spastin and hereditary spastic paraparesis] ongoing research,unassigned 4,0 5.6.1.1 Paraparesis, Spastic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15197701&form=6&db=m Clinical signs and symptoms in a large hereditary spastic paraparesis pedigree with a novel spastin mutation. causal interaction,unassigned 4,0 5.6.1.1 Paraparesis, Spastic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15326248&form=6&db=m Infantile hereditary spastic paraparesis due to codominant mutations in the spastin gene. unassigned - 5.6.1.1 Paraparesis, Spastic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16055926&form=6&db=m Spastin mutations are frequent in sporadic spastic paraparesis and their spectrum is different from that observed in familial cases. causal interaction,unassigned 3,0 5.6.1.1 Paraparesis, Spastic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16240363&form=6&db=m Spastin mutations in sporadic adult-onset upper motor neuron syndromes. causal interaction,ongoing research,unassigned 4,2,0 5.6.1.1 Paraparesis, Spastic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16832076&form=6&db=m Clinical features of hereditary spastic paraplegia due to spastin mutation. causal interaction,diagnostic usage,unassigned 3,2,0 5.6.1.1 Paraparesis, Spastic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19289482&form=6&db=m Posterior fossa abnormalities in hereditary spastic paraparesis with spastin mutations. causal interaction,unassigned 3,0 5.6.1.1 Paraparesis, Spastic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25511172&form=6&db=m A new double-trouble phenotype: fascioscapulohumeral muscular dystrophy ameliorates hereditary spastic paraparesis due to spastin mutation. unassigned - 5.6.1.1 Paraplegia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10610178&form=6&db=m Spastin, a new AAA protein, is altered in the most frequent form of autosomal dominant spastic paraplegia. unassigned - 5.6.1.1 Paraplegia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11359470&form=6&db=m Novel mutation of the Spastin gene in familial spastic paraplegia. causal interaction,ongoing research,unassigned 2,2,0 5.6.1.1 Paraplegia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12023066&form=6&db=m A novel mutation in the spastin gene in a family with spastic paraplegia. causal interaction,ongoing research,unassigned 3,1,0 5.6.1.1 Paraplegia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12736085&form=6&db=m A novel insertion mutation in spastin gene is the cause of spastic paraplegia in a Chinese family. causal interaction,unassigned 3,0 5.6.1.1 Paraplegia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15079007&form=6&db=m Large-scale disruption of microtubule pathways in morphologically normal human spastin muscle. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 5.6.1.1 Paraplegia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15517445&form=6&db=m Early onset autosomal dominant spastic paraplegia caused by novel mutations in SPG3A. diagnostic usage,unassigned 1,0 5.6.1.1 Paraplegia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15667412&form=6&db=m Hereditary spastic paraplegia with cerebellar ataxia: a complex phenotype associated with a new SPG4 gene mutation. causal interaction,unassigned 4,0 5.6.1.1 Paraplegia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16055926&form=6&db=m Spastin mutations are frequent in sporadic spastic paraparesis and their spectrum is different from that observed in familial cases. causal interaction,unassigned 3,0 5.6.1.1 Paraplegia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16684598&form=6&db=m Novel spastin (SPG4) mutations in Italian patients with hereditary spastic paraplegia. causal interaction,unassigned 3,0 5.6.1.1 Paraplegia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16788734&form=6&db=m Four mutations of the spastin gene in Japanese families with spastic paraplegia. unassigned - 5.6.1.1 Paraplegia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17101632&form=6&db=m A mutation of spastin is responsible for swellings and impairment of transport in a region of axon characterized by changes in microtubule composition. causal interaction,unassigned 1,0 5.6.1.1 Paraplegia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17285536&form=6&db=m [SPG3A-hereditary spastin paraplegia with genetic anticipation and incomplete penetrance] diagnostic usage,ongoing research,unassigned 3,1,0 5.6.1.1 Paraplegia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17531954&form=6&db=m The C. elegans homologue of the spastic paraplegia protein, spastin, disassembles microtubules. unassigned - 5.6.1.1 Paraplegia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18306668&form=6&db=m [Spastic paraplegia caused by a novel mutation in the spastin gene (1207C-->G, P361R)--clinical features of a patient without family history] causal interaction,unassigned 1,0 5.6.1.1 Paraplegia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20154342&form=6&db=m Functional conservation of human Spastin in a Drosophila model of autosomal dominant-hereditary spastic paraplegia. causal interaction,ongoing research,unassigned 3,4,0 5.6.1.1 Paraplegia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20209135&form=6&db=m Role of spastin in apical domain control along the rhabdomere elongation in Drosophila photoreceptor. causal interaction,unassigned 4,0 5.6.1.1 Paraplegia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22192498&form=6&db=m Peripheral neuropathy in hereditary spastic paraplegia due to spastin (SPG4) mutation - A neurophysiological study using excitability techniques. diagnostic usage,ongoing research,unassigned 1,1,0 5.6.1.1 Paraplegia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22960362&form=6&db=m Novel and recurrent spastin mutations in a large series of SPG4 Italian families. unassigned - 5.6.1.1 Paraplegia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25143843&form=6&db=m Valproate Treatment in an ALS Patient Carrying a c.194G>A Spastin Mutation and SMN2 Homozygous Deletion. causal interaction,unassigned 4,0 5.6.1.1 Paraplegia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30476002&form=6&db=m Spastic paraplegia due to SPAST mutations is modified by the underlying mutation and sex. causal interaction,unassigned 4,0 5.6.1.1 Paraplegia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32866173&form=6&db=m Spastin depletion increases tubulin polyglutamylation and impairs kinesin-mediated neuronal transport, leading to working and associative memory deficits. ongoing research,therapeutic application,unassigned 4,2,0 5.6.1.1 Paraplegia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33708099&form=6&db=m Coexistence of Hereditary Spastic Paraplegia Type 4 and Narcolepsy: A Case Report. causal interaction,unassigned 1,0 5.6.1.1 Paresis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17122756&form=6&db=m Identification of a novel mutation in the spastin gene (SPG4) in an Italian family with hereditary spastic paresis. unassigned - 5.6.1.1 Peripheral Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22192498&form=6&db=m Peripheral neuropathy in hereditary spastic paraplegia due to spastin (SPG4) mutation - A neurophysiological study using excitability techniques. diagnostic usage,ongoing research,unassigned 1,1,0 5.6.1.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18303116&form=6&db=m SPAS-1 (stimulator of prostatic adenocarcinoma-specific T cells)/SH3GLB2: A prostate tumor antigen identified by CTLA-4 blockade. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1 5.6.1.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18824433&form=6&db=m Southwest Oncology Group Phase II Study of Ispinesib in Androgen-Independent Prostate Cancer Previously Treated with Taxanes. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,2,0 5.6.1.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21681775&form=6&db=m Aberrant expression of katanin p60 in prostate cancer bone metastasis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 5.6.1.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29552132&form=6&db=m The role of katanin p60 in breast cancer bone metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 5.6.1.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29744289&form=6&db=m Loss of scinderin decreased expression of epidermal growth factor receptor and promoted apoptosis of castration-resistant prostate cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11087788&form=6&db=m Novel mutations in spastin gene and absence of correlation with age at onset of symptoms. causal interaction,diagnostic usage,unassigned 3,1,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11309678&form=6&db=m Identification and expression analysis of spastin gene mutations in hereditary spastic paraplegia. causal interaction,unassigned 1,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11377972&form=6&db=m Molecular basis of inherited spastic paraplegias. unassigned - 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11809724&form=6&db=m Spastin, the protein mutated in autosomal dominant hereditary spastic paraplegia, is involved in microtubule dynamics. unassigned - 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12023066&form=6&db=m A novel mutation in the spastin gene in a family with spastic paraplegia. causal interaction,ongoing research,unassigned 3,1,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12124993&form=6&db=m Mutation analysis of the spastin gene (SPG4) in patients in Germany with autosomal dominant hereditary spastic paraplegia. causal interaction,unassigned 2,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12161613&form=6&db=m Spastin gene mutation in Japanese with hereditary spastic paraplegia. causal interaction,ongoing research,unassigned 1,2,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12163196&form=6&db=m Three novel spastin (SPG4) mutations in families with autosomal dominant hereditary spastic paraplegia. causal interaction,unassigned 3,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12490534&form=6&db=m Mutations of SPG4 are responsible for a loss of function of spastin, an abundant neuronal protein localized in the nucleus. causal interaction,unassigned 2,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12676568&form=6&db=m The identification of a conserved domain in both spartin and spastin, mutated in hereditary spastic paraplegia. unassigned - 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12736085&form=6&db=m A novel insertion mutation in spastin gene is the cause of spastic paraplegia in a Chinese family. causal interaction,unassigned 3,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12778437&form=6&db=m [Spastin gene mutation in Chinese patients with hereditary spastic paraplegia] diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,1,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12908108&form=6&db=m Identification of the Drosophila melanogaster homolog of the human spastin gene. causal interaction,unassigned 4,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14681884&form=6&db=m Hereditary spastic paraparesis: disrupted intracellular transport associated with spastin mutation. causal interaction,unassigned 4,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14732620&form=6&db=m Three novel mutations of the spastin gene in Chinese patients with hereditary spastic paraplegia. causal interaction,unassigned 4,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15147984&form=6&db=m Identification of nuclear localisation sequences in spastin (SPG4) using a novel Tetra-GFP reporter system. causal interaction,unassigned 3,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15210518&form=6&db=m Hereditary spastic paraplegia: spastin phenotype and function. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15242610&form=6&db=m The hereditary spastic paraplegia gene, spastin, regulates microtubule stability to modulate synaptic structure and function. causal interaction,therapeutic application,unassigned 4,4,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15248095&form=6&db=m Intragenic modifiers of hereditary spastic paraplegia due to spastin gene mutations. causal interaction,unassigned 2,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15482961&form=6&db=m Two novel mutations in the spastin gene (SPG4) found by DHPLC mutation analysis. causal interaction,unassigned 4,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15537668&form=6&db=m The hereditary spastic paraplegia protein spastin interacts with the ESCRT-III complex-associated endosomal protein CHMP1B. unassigned - 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15562320&form=6&db=m Drosophila spastin regulates synaptic microtubule networks and is required for normal motor function. causal interaction,ongoing research,unassigned 1,1,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15637712&form=6&db=m Large deletion involving the 5'-UTR in the spastin gene caused mild phenotype of autosomal dominant hereditary spastic paraplegia. unassigned - 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15716377&form=6&db=m Linking axonal degeneration to microtubule remodeling by Spastin-mediated microtubule severing. unassigned - 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15823537&form=6&db=m The Drosophila homologue of the hereditary spastic paraplegia protein, spastin, severs and disassembles microtubules. causal interaction,unassigned 3,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15891913&form=6&db=m Subcellular localization of spastin: implications for the pathogenesis of hereditary spastic paraplegia. ongoing research,unassigned 2,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16009377&form=6&db=m Spastin related hereditary spastic paraplegia with dysplastic corpus callosum. therapeutic application,unassigned 1,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16026783&form=6&db=m Spastin subcellular localization is regulated through usage of different translation start sites and active export from the nucleus. diagnostic usage,therapeutic application,unassigned 3,4,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16339213&form=6&db=m Spastin and atlastin, two proteins mutated in autosomal-dominant hereditary spastic paraplegia, are binding partners. unassigned - 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16476820&form=6&db=m A missense mutation in the coiled-coil domain of the KIF5A gene and late-onset hereditary spastic paraplegia. diagnostic usage,therapeutic application,unassigned 1,1,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16602018&form=6&db=m Spastin, the most commonly mutated protein in hereditary spastic paraplegia interacts with Reticulon 1 an endoplasmic reticulum protein. unassigned - 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16684598&form=6&db=m Novel spastin (SPG4) mutations in Italian patients with hereditary spastic paraplegia. causal interaction,unassigned 3,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16815977&form=6&db=m Interaction of two hereditary spastic paraplegia gene products, spastin and atlastin, suggests a common pathway for axonal maintenance. therapeutic application,unassigned 1,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16826525&form=6&db=m ZFYVE27 (SPG33), a novel spastin-binding protein, is mutated in hereditary spastic paraplegia. unassigned - 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16832076&form=6&db=m Clinical features of hereditary spastic paraplegia due to spastin mutation. causal interaction,diagnostic usage,unassigned 3,2,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17098887&form=6&db=m Exon deletions of SPG4 are a frequent cause of hereditary spastic paraplegia. causal interaction,unassigned 3,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17100993&form=6&db=m Spastin gene mutations in Bulgarian patients with hereditary spastic paraplegia. causal interaction,unassigned 1,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17348041&form=6&db=m Spastin and microtubules: Functions in health and disease. unassigned - 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17389232&form=6&db=m Recognition of C-terminal amino acids in tubulin by pore loops in Spastin is important for microtubule severing. unassigned - 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17407089&form=6&db=m [Clinical characteristics and spastin gene mutation analysis on an autosomal dominant kindred with hereditary spastic paraplegia] diagnostic usage,ongoing research,unassigned 2,4,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17425157&form=6&db=m Systematic isolation and characterization of cDNAs encoding AAA proteins from human brain. causal interaction,therapeutic application,unassigned 3,1,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17531954&form=6&db=m The C. elegans homologue of the spastic paraplegia protein, spastin, disassembles microtubules. unassigned - 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17560499&form=6&db=m Infantile onset of hereditary spastic paraplegia poorly predicts the genotype. causal interaction,unassigned 3,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17597328&form=6&db=m A de novo SPAST mutation leading to somatic mosaicism is associated with a later age at onset in HSP. causal interaction,unassigned 2,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17690846&form=6&db=m Autosomal dominant hereditary spastic paraplegia: report of a large Italian family with R581X spastin mutation. causal interaction,unassigned 4,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17916079&form=6&db=m Isoform-specific increase of spastin stability by N-terminal missense variants including intragenic modifiers of SPG4 hereditary spastic paraplegia. unassigned - 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18093520&form=6&db=m Knot/Collier and cut control different aspects of dendrite cytoskeleton and synergize to define final arbor shape. unassigned - 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18202664&form=6&db=m Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin. causal interaction,unassigned 4,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18305248&form=6&db=m Quantitative and functional analyses of spastin in the nervous system: implications for hereditary spastic paraplegia. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,2,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18410514&form=6&db=m Spastin oligomerizes into a hexamer and the mutant spastin (E442Q) redistribute the wild-type spastin into filamentous microtubule. causal interaction,unassigned 2,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18613979&form=6&db=m A cryptic promoter in the first exon of the SPG4 gene directs the synthesis of the 60-kDa spastin isoform. causal interaction,therapeutic application,unassigned 3,4,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18701882&form=6&db=m Expansion of mutation spectrum, determination of mutation cluster regions and predictive structural classification of SPAST mutations in hereditary spastic paraplegia. therapeutic application,unassigned 1,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19000169&form=6&db=m Spastin couples microtubule severing to membrane traffic in completion of cytokinesis and secretion. causal interaction,unassigned 2,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19141076&form=6&db=m Pleiotropic effects of spastin on neurite growth depending on expression levels. causal interaction,diagnostic usage,unassigned 3,1,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19453301&form=6&db=m Direct evidence for axonal transport defects in a novel mouse model of mutant spastin-induced hereditary spastic paraplegia (HSP) and human HSP patients. causal interaction,unassigned 3,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19494379&form=6&db=m Hereditary spastic paraplegias. causal interaction,unassigned 1,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19619244&form=6&db=m Conserved aromatic and basic amino acid residues in the pore region of Caenorhabditis elegans spastin play critical roles in microtubule severing. causal interaction,unassigned 1,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19620182&form=6&db=m The hereditary spastic paraplegia proteins NIPA1, spastin and spartin are inhibitors of mammalian BMP signalling. therapeutic application,unassigned 3,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20200447&form=6&db=m Hereditary spastic paraplegia proteins REEP1, spastin, and atlastin-1 coordinate microtubule interactions with the tubular ER network. unassigned - 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20559269&form=6&db=m [Hereditary spastic paraplegia type 4 (SPG4): clinical and molecular-genetic characteristics] unassigned - 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20718791&form=6&db=m Mutation screening of spastin, atlastin, and REEP1 in hereditary spastic paraplegia. causal interaction,unassigned 2,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20829563&form=6&db=m Genetic and chemical modulation of spastin-dependent axon outgrowth in zebrafish embryos indicates a role for impaired microtubule dynamics in hereditary spastic paraplegia. causal interaction,unassigned 3,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20935173&form=6&db=m Drosophila FMRP regulates microtubule network formation and axonal transport of mitochondria. causal interaction,unassigned 2,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21395583&form=6&db=m SPG4 gene promoter regulation via Elk1 transcription factor. causal interaction,unassigned 4,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21546041&form=6&db=m Detection of novel mutations and review of published data suggests that hereditary spastic paraplegia caused by spastin (SPAST) mutations is found more often in males. causal interaction,unassigned 4,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21834905&form=6&db=m Two novel mutations in the Spastin gene of Chinese patients with hereditary spastic paraplegia. therapeutic application,unassigned 1,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21888932&form=6&db=m The AAA ATPase spastin links microtubule severing to membrane modelling. unassigned - 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22192498&form=6&db=m Peripheral neuropathy in hereditary spastic paraplegia due to spastin (SPG4) mutation - A neurophysiological study using excitability techniques. diagnostic usage,ongoing research,unassigned 1,1,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22216323&form=6&db=m Oligomerization of ZFYVE27 (Protrudin) is necessary to promote neurite extension. causal interaction,unassigned 2,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22773755&form=6&db=m Microtubule-targeting drugs rescue axonal swellings in cortical neurons from spastin knock-out mice. causal interaction,unassigned 1,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23279441&form=6&db=m First mutation in the nuclear localization signal sequence of spastin protein identified in a patient with hereditary spastic paraplegia. causal interaction,unassigned 1,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23897888&form=6&db=m An ESCRT-spastin interaction promotes fission of recycling tubules from the endosome. unassigned - 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23969831&form=6&db=m Protrudin binds atlastins and endoplasmic reticulum-shaping proteins and regulates network formation. unassigned - 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24123785&form=6&db=m Loss of spastin function results in disease-specific axonal defects in human pluripotent stem cell-based models of hereditary spastic paraplegia. unassigned - 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24478365&form=6&db=m Pathogenic mutation of spastin has gain-of-function effects on microtubule dynamics. causal interaction,unassigned 1,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24824479&form=6&db=m Spastin mutation screening in Chinese patients with pure hereditary spastic paraplegia. diagnostic usage,unassigned 2,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25577683&form=6&db=m [Genetic testing of hereditary spastic paraplegia]. causal interaction,diagnostic usage,unassigned 4,3,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25875445&form=6&db=m Spastin binds to lipid droplets and affects lipid metabolism. causal interaction,unassigned 4,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26691836&form=6&db=m Tau missorting and spastin-induced microtubule disruption in neurodegeneration: Alzheimer Disease and Hereditary Spastic Paraplegia. causal interaction,unassigned 1,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26875866&form=6&db=m Graded Control of Microtubule Severing by Tubulin Glutamylation. causal interaction,unassigned 1,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27605706&form=6&db=m Spastin, atlastin and ER relocalization are involved in axon, but not dendrite, regeneration. causal interaction,unassigned 2,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27638887&form=6&db=m Reep1 null mice reveal a converging role for hereditary spastic paraplegia proteins in lipid droplet regulation. causal interaction,unassigned 2,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28006827&form=6&db=m An Automated Image Analysis System to Quantify Endosomal Tubulation. causal interaction,unassigned 4,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28389476&form=6&db=m Defects in ER-endosome contacts impact lysosome function in hereditary spastic paraplegia. causal interaction,unassigned 1,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28495799&form=6&db=m Truncating mutations of SPAST associated with hereditary spastic paraplegia indicate greater accumulation and toxicity of the M1 isoform of spastin. causal interaction,unassigned 3,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30082270&form=6&db=m BMP- and neuropilin 1-mediated motor axon navigation relies on spastin alternative translation. causal interaction,unassigned 3,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30213879&form=6&db=m Functional differences of short and long isoforms of spastin harboring missense mutation. unassigned - 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30520996&form=6&db=m Hereditary Spastic Paraplegia: gain-of-function mechanisms revealed by new transgenic mouse. causal interaction,diagnostic usage,unassigned 3,1,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31227594&form=6&db=m Spastin tethers lipid droplets to peroxisomes and directs fatty acid trafficking through ESCRT-III. ongoing research,therapeutic application,unassigned 2,1,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31285604&form=6&db=m An allosteric network in spastin couples multiple activities required for microtubule severing. causal interaction,unassigned 3,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31587092&form=6&db=m ESCRT-III-associated proteins and spastin inhibit protrudin-dependent polarised membrane traffic. unassigned - 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32315314&form=6&db=m Spastin mutations impair coordination between lipid droplet dispersion and reticulum. therapeutic application,unassigned 1,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32321733&form=6&db=m Microtubule-dependent and independent roles of spastin in lipid droplet dispersion and biogenesis. causal interaction,therapeutic application,unassigned 2,1,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32866173&form=6&db=m Spastin depletion increases tubulin polyglutamylation and impairs kinesin-mediated neuronal transport, leading to working and associative memory deficits. ongoing research,therapeutic application,unassigned 4,2,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33106322&form=6&db=m Spastin recovery in hereditary spastic paraplegia by preventing neddylation-dependent degradation. unassigned - 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33708099&form=6&db=m Coexistence of Hereditary Spastic Paraplegia Type 4 and Narcolepsy: A Case Report. causal interaction,unassigned 1,0 5.6.1.1 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34439700&form=6&db=m Therapeutic Strategies for Mutant SPAST-Based Hereditary Spastic Paraplegia. causal interaction,unassigned 3,0 5.6.1.1 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33907047&form=6&db=m Spastin interacts with collapsin response mediator protein 3 to regulate neurite growth and branching. diagnostic usage,therapeutic application,unassigned 3,1,0 5.6.1.1 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32321733&form=6&db=m Microtubule-dependent and independent roles of spastin in lipid droplet dispersion and biogenesis. causal interaction,therapeutic application,unassigned 2,1,0 5.6.1.1 Status Epilepticus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16828199&form=6&db=m Spastin in the human and mouse central nervous system with special reference to its expression in the hippocampus of mouse pilocarpine model of status epilepticus and temporal lobe epilepsy. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 5.6.1.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25174406&form=6&db=m Suppression of scinderin modulates epithelial?mesenchymal transition markers in highly metastatic gastric cancer cell line SGC?7901. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 5.6.1.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27033455&form=6&db=m Scinderin promotes the invasion and metastasis of gastric cancer cells and predicts the outcome of patients. causal interaction,diagnostic usage,unassigned 3,3,0 5.6.1.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32636728&form=6&db=m Differential expression of Scinderin and Gelsolin in gastric cancer and comparison with clinical and morphological characteristics. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1 5.6.1.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28783150&form=6&db=m Katanin spiral and ring structures shed light on power stroke for microtubule severing. unassigned - 5.6.1.1 Tauopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21118899&form=6&db=m Strategies for diminishing katanin-based loss of microtubules in tauopathic neurodegenerative diseases. diagnostic usage,unassigned 1,0 5.6.1.1 Tauopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26691836&form=6&db=m Tau missorting and spastin-induced microtubule disruption in neurodegeneration: Alzheimer Disease and Hereditary Spastic Paraplegia. causal interaction,unassigned 1,0 5.6.1.1 Thyroid Cancer, Papillary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33274499&form=6&db=m Katanin P60 and P80 in papillary thyroid carcinoma patients: Indicators for exacerbated tumor features and worse disease-free survival. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1 5.6.1.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22265592&form=6&db=m Adseverin: A novel cisplatin-resistant marker in the human bladder cancer cell line HT1376 identified by quantitative proteomic analysis. diagnostic usage,ongoing research,unassigned 3,2,0 5.6.1.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31369818&form=6&db=m Adseverin modulates morphology and invasive function of MCF7 cells. causal interaction,unassigned 3,0