3.6.1.23 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10567908&form=6&db=m Expression of deoxyuridine triphosphatase (dUTPase) in colorectal tumours. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,4 3.6.1.23 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10567908&form=6&db=m Expression of deoxyuridine triphosphatase (dUTPase) in colorectal tumours. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,4 3.6.1.23 African Swine Fever http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10515998&form=6&db=m African swine fever virus dUTPase is a highly specific enzyme required for efficient replication in swine macrophages. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,3,0 3.6.1.23 African Swine Fever http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11961258&form=6&db=m Orf virus encodes a functional dUTPase gene. therapeutic application,unassigned 1,0 3.6.1.23 African Swine Fever http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31662460&form=6&db=m Crystal Structure of African Swine Fever Virus dUTPase Reveals a Potential Drug Target. causal interaction,therapeutic application,unassigned 2,4,0 3.6.1.23 African Swine Fever http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31748385&form=6&db=m Structural Insight into African Swine Fever Virus dUTPase Reveals a Novel Folding Pattern in the dUTPase Family. unassigned - 3.6.1.23 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15468912&form=6&db=m [Molecular cloning and identification and biological activity of GIF-interacting protein(s)] causal interaction,unassigned 4,0 3.6.1.23 Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7542416&form=6&db=m Incorporation of uracil into viral DNA correlates with reduced replication of EIAV in macrophages. unassigned - 3.6.1.23 Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7663176&form=6&db=m dUTPase from the retrovirus equine infectious anemia virus: high-level expression in Escherichia coli and purification. ongoing research,therapeutic application,unassigned 2,1,0 3.6.1.23 Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7707512&form=6&db=m Replication in vitro and in vivo of an equine infectious anemia virus mutant deficient in dUTPase activity. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 3.6.1.23 Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8386267&form=6&db=m Characterization of equine infectious anemia virus dUTPase: growth properties of a dUTPase-deficient mutant. ongoing research,therapeutic application,unassigned 4,1,0 3.6.1.23 Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8604980&form=6&db=m Specific derivatization of the active site tyrosine in dUTPase perturbs ligand binding to the active site. therapeutic application,unassigned 1,0 3.6.1.23 Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9187238&form=6&db=m Characterization and mutational studies of equine infectious anemia virus dUTPase. diagnostic usage,ongoing research,unassigned 3,4,0 3.6.1.23 Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9315700&form=6&db=m dUTPase from the retrovirus equine infectious anemia virus: specificity, turnover and inhibition. causal interaction,ongoing research,therapeutic application,unassigned 2,4,2,0 3.6.1.23 Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9847382&form=6&db=m "Hidden" dUTPase sequence in human immunodeficiency virus type 1 gp120. unassigned - 3.6.1.23 Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9878436&form=6&db=m Crystal structure of dUTPase from equine infectious anaemia virus; active site metal binding in a substrate analogue complex. ongoing research,therapeutic application,unassigned 2,1,0 3.6.1.23 Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10788633&form=6&db=m Transient kinetics of ligand binding and role of the C-terminus in the dUTPase from equine infectious anemia virus. ongoing research,unassigned 2,0 3.6.1.23 Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12374097&form=6&db=m The role of retroviral dUTPases in replication and virulence. therapeutic application,unassigned 2,0 3.6.1.23 Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25117862&form=6&db=m The dUTPase-related gene of bovine immunodeficiency virus is critical for viral replication, despite the lack of dUTPase activity of the encoded protein. ongoing research,unassigned 3,0 3.6.1.23 Anemia, Megaloblastic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8923782&form=6&db=m Elevated deoxyuridine triphosphate nucleotidohydrolase (dUTPase) activity in the cobalamin-deficient megaloblastic bone marrow cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 3.6.1.23 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16325515&form=6&db=m Immunohistochemical detection of dUTPase in intracranial tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.6.1.23 Bone Marrow Failure Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28073829&form=6&db=m dUTPase (DUT) Is Mutated in a Novel Monogenic Syndrome With Diabetes and Bone Marrow Failure. causal interaction,unassigned 1,0 3.6.1.23 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18790783&form=6&db=m Novel opportunities for thymidylate metabolism as a therapeutic target. causal interaction,therapeutic application,unassigned 3,4,0 3.6.1.23 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27452458&form=6&db=m The Impact of dUTPase on Ribonucleotide Reductase-Induced Genome Instability in Cancer Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 3.6.1.23 Burkitt Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12376965&form=6&db=m Expression of viral and human dUTPase in Epstein-Barr virus-associated diseases. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.6.1.23 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23894549&form=6&db=m Epstein-Barr virus encoded dUTPase containing exosomes modulate innate and adaptive immune responses in human dendritic cells and peripheral blood mononuclear cells. causal interaction,ongoing research,unassigned 1,3,0 3.6.1.23 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10567908&form=6&db=m Expression of deoxyuridine triphosphatase (dUTPase) in colorectal tumours. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,4 3.6.1.23 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16325515&form=6&db=m Immunohistochemical detection of dUTPase in intracranial tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.6.1.23 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24760895&form=6&db=m Phosphorylation of herpes simplex virus 1 dUTPase upregulated viral dUTPase activity to compensate for low cellular dUTPase activity for efficient viral replication. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,4,0 3.6.1.23 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25145669&form=6&db=m Synergy between the NAMPT inhibitor GMX1777(8) and pemetrexed in non-small cell lung cancer cells is mediated by PARP activation and enhanced NAD consumption. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 3.6.1.23 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33107644&form=6&db=m CKS2 modulates cell-cycle progression of tongue squamous cell carcinoma cells partly via modulating the cellular distribution of DUTPase. causal interaction,ongoing research,unassigned 2,1,0 3.6.1.23 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=192467&form=6&db=m The reduction of uridine 5'-diphosphate and uridine 5'-triphosphate in some transplantable rat hepatomas. unassigned - 3.6.1.23 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1312954&form=6&db=m dUTP pyrophosphatase and uracil-DNA glycosylase in rat liver and hepatomas. causal interaction,ongoing research,unassigned 2,3,0 3.6.1.23 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8013732&form=6&db=m Deoxyuridine triphosphatase in human hepatoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 3.6.1.23 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19968781&form=6&db=m dUTP pyrophosphatase expression correlates with a poor prognosis in hepatocellular carcinoma. causal interaction,diagnostic usage,unassigned 3,3,0 3.6.1.23 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27498408&form=6&db=m Characterization and functional studies of fowl adenovirus 9 dUTPase. ongoing research,unassigned 1,0 3.6.1.23 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22172489&form=6&db=m Inhibition of dUTPase Induces Synthetic Lethality with Thymidylate Synthase-Targeted Therapies in Non-Small Cell Lung Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,2 3.6.1.23 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25145669&form=6&db=m Synergy between the NAMPT inhibitor GMX1777(8) and pemetrexed in non-small cell lung cancer cells is mediated by PARP activation and enhanced NAD consumption. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 3.6.1.23 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33107644&form=6&db=m CKS2 modulates cell-cycle progression of tongue squamous cell carcinoma cells partly via modulating the cellular distribution of DUTPase. causal interaction,ongoing research,unassigned 2,1,0 3.6.1.23 Chagas Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14725764&form=6&db=m The crystal structure of Trypanosoma cruzi dUTPase reveals a novel dUTP/dUDP binding fold. causal interaction,therapeutic application,unassigned 4,4,0 3.6.1.23 Chickenpox http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19200445&form=6&db=m The simian varicella virus uracil DNA glycosylase and dUTPase genes are expressed in vivo, but are non-essential for replication in cell culture. diagnostic usage,therapeutic application,unassigned 3,1,0 3.6.1.23 Chickenpox http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27717328&form=6&db=m Nationwide distribution of varicella-zoster virus clades in China. diagnostic usage,ongoing research,unassigned 3,3,0 3.6.1.23 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7652165&form=6&db=m Lack of dependence of 5-fluorodeoxyuridine-mediated radiosensitization on cytotoxicity. therapeutic application,unassigned 2,0 3.6.1.23 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10910061&form=6&db=m dUTP nucleotidohydrolase isoform expression in normal and neoplastic tissues: association with survival and response to 5-fluorouracil in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3 3.6.1.23 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12374095&form=6&db=m The role of dUTPase and uracil-DNA repair in cancer chemotherapy. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,3,0 3.6.1.23 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12697854&form=6&db=m Macrophages from cancer patients: analysis of TRAIL, TRAIL receptors, and colon tumor cell apoptosis. diagnostic usage,ongoing research,unassigned 3,3,0 3.6.1.23 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8162567&form=6&db=m Induction of resistance to fluorodeoxyuridine cytotoxicity and DNA damage in human tumor cells by expression of Escherichia coli deoxyuridinetriphosphatase. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 3.6.1.23 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10567908&form=6&db=m Expression of deoxyuridine triphosphatase (dUTPase) in colorectal tumours. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,4 3.6.1.23 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10910061&form=6&db=m dUTP nucleotidohydrolase isoform expression in normal and neoplastic tissues: association with survival and response to 5-fluorouracil in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3 3.6.1.23 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19052026&form=6&db=m Higher expression of deoxyuridine triphosphatase (dUTPase) may predict the metastasis potential of colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 3.6.1.23 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26208523&form=6&db=m The 1,2-Diaminocyclohexane Carrier Ligand in Oxaliplatin Induces p53-Dependent Transcriptional Repression of Factors Involved in Thymidylate Biosynthesis. ongoing research,unassigned 1,0 3.6.1.23 Communicable Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18837522&form=6&db=m Keeping Uracil Out of DNA: Physiological Role, Structure and Catalytic Mechanism of dUTPases. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.6.1.23 Cysticercosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17368551&form=6&db=m Taenia solium dUTPase: A potential target for anti-human cysticercosis. therapeutic application,unassigned 3,0 3.6.1.23 dutp diphosphatase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9230126&form=6&db=m Description of a novel eukaryotic deoxyuridine 5'-triphosphate nucleotidohydrolase in Leishmania major. ongoing research,therapeutic application,unassigned 2,1,0 3.6.1.23 dutp diphosphatase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23201394&form=6&db=m Pyrimidine requirements in deoxyuridine triphosphate nucleotidohydrolase deficient Trypanosoma brucei mutants. unassigned - 3.6.1.23 Ectromelia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11752168&form=6&db=m The genome of swinepox virus. therapeutic application,unassigned 1,0 3.6.1.23 Encephalitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9847382&form=6&db=m "Hidden" dUTPase sequence in human immunodeficiency virus type 1 gp120. unassigned - 3.6.1.23 Enteritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18646465&form=6&db=m Identification and characterization of duck enteritis virus dUTPase gene. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.6.1.23 Ependymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16325515&form=6&db=m Immunohistochemical detection of dUTPase in intracranial tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.6.1.23 Epstein-Barr Virus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12376965&form=6&db=m Expression of viral and human dUTPase in Epstein-Barr virus-associated diseases. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.6.1.23 Epstein-Barr Virus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19124728&form=6&db=m The EBV-encoded dUTPase activates NF-kappa B through the TLR2 and MyD88-dependent signaling pathway. causal interaction,therapeutic application,unassigned 3,4,0 3.6.1.23 Equine Infectious Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7542416&form=6&db=m Incorporation of uracil into viral DNA correlates with reduced replication of EIAV in macrophages. unassigned - 3.6.1.23 Equine Infectious Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7663176&form=6&db=m dUTPase from the retrovirus equine infectious anemia virus: high-level expression in Escherichia coli and purification. ongoing research,therapeutic application,unassigned 2,1,0 3.6.1.23 Equine Infectious Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7707512&form=6&db=m Replication in vitro and in vivo of an equine infectious anemia virus mutant deficient in dUTPase activity. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 3.6.1.23 Equine Infectious Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8386267&form=6&db=m Characterization of equine infectious anemia virus dUTPase: growth properties of a dUTPase-deficient mutant. ongoing research,therapeutic application,unassigned 4,1,0 3.6.1.23 Equine Infectious Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8604980&form=6&db=m Specific derivatization of the active site tyrosine in dUTPase perturbs ligand binding to the active site. therapeutic application,unassigned 1,0 3.6.1.23 Equine Infectious Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9187238&form=6&db=m Characterization and mutational studies of equine infectious anemia virus dUTPase. diagnostic usage,ongoing research,unassigned 3,4,0 3.6.1.23 Equine Infectious Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9315700&form=6&db=m dUTPase from the retrovirus equine infectious anemia virus: specificity, turnover and inhibition. causal interaction,ongoing research,therapeutic application,unassigned 2,4,2,0 3.6.1.23 Equine Infectious Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9847382&form=6&db=m "Hidden" dUTPase sequence in human immunodeficiency virus type 1 gp120. unassigned - 3.6.1.23 Equine Infectious Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9878436&form=6&db=m Crystal structure of dUTPase from equine infectious anaemia virus; active site metal binding in a substrate analogue complex. ongoing research,therapeutic application,unassigned 2,1,0 3.6.1.23 Equine Infectious Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10788633&form=6&db=m Transient kinetics of ligand binding and role of the C-terminus in the dUTPase from equine infectious anemia virus. ongoing research,unassigned 2,0 3.6.1.23 Equine Infectious Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12374097&form=6&db=m The role of retroviral dUTPases in replication and virulence. therapeutic application,unassigned 2,0 3.6.1.23 Equine Infectious Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25117862&form=6&db=m The dUTPase-related gene of bovine immunodeficiency virus is critical for viral replication, despite the lack of dUTPase activity of the encoded protein. ongoing research,unassigned 3,0 3.6.1.23 Fatigue Syndrome, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23155374&form=6&db=m Antibody to Epstein-Barr virus deoxyuridine triphosphate nucleotidohydrolase and deoxyribonucleotide polymerase in a chronic fatigue syndrome subset. diagnostic usage,ongoing research,unassigned 1,4,0 3.6.1.23 Fragile X Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2992271&form=6&db=m Antifolate-induced misincorporation of deoxyuridine monophosphate into DNA by cells from patients with the fragile X syndrome. unassigned - 3.6.1.23 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1328686&form=6&db=m Herpes simplex virus type 1 dUTPase mutants are attenuated for neurovirulence, neuroinvasiveness, and reactivation from latency. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 3.6.1.23 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2168898&form=6&db=m Inhibition of phosphorylation of cellular dUTP nucleotidohydrolase as a consequence of herpes simplex virus infection. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,1,3 3.6.1.23 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2842952&form=6&db=m Herpes simplex virus-induced dUTPase: target site for antiviral chemotherapy. causal interaction,therapeutic application,unassigned 2,4,0 3.6.1.23 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3002029&form=6&db=m Isolation and characterisation of herpes simplex virus type 1 mutants which fail to induce dUTPase activity. diagnostic usage,ongoing research,unassigned 1,3,0 3.6.1.23 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3005836&form=6&db=m Effects of mercury (II) compounds on the activity of dUTPases from various sources. ongoing research,therapeutic application,unassigned 4,1,0 3.6.1.23 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3027979&form=6&db=m Characterization of a herpes simplex virus type 2 deoxyuridine triphosphate nucleotidohydrolase and mapping of a gene conferring type specificity for the enzyme. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 3.6.1.23 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6115860&form=6&db=m Induction of uracil-DNA glycosylase and dUTP nucleotidohydrolase activity in herpes simplex virus-infected human cells. ongoing research,unassigned 4,0 3.6.1.23 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6141216&form=6&db=m Demonstration of a herpes simplex virus type 2-induced deoxyuridine triphosphate nucleotidohydrolase in infected KB cells and in biochemically transformed HeLa cells. ongoing research,unassigned 4,0 3.6.1.23 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6143756&form=6&db=m Purification and properties of the deoxyuridine triphosphate nucleotidohydrolase enzyme derived from HeLa S3 cells. Comparison to a distinct dUTP nucleotidohydrolase induced in herpes simplex virus-infected HeLa S3 cells. ongoing research,therapeutic application,unassigned 4,1,0 3.6.1.23 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6147344&form=6&db=m Deoxyuridine triphosphate nucleotidohydrolase induced by herpes simplex virus type 1. Purification and characterization of induced enzyme. ongoing research,unassigned 3,0 3.6.1.23 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6149651&form=6&db=m Identification of the herpes simplex virus type 1 gene encoding the dUTPase. ongoing research,therapeutic application,unassigned 4,4,0 3.6.1.23 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8021596&form=6&db=m Nucleotide sequence of a 55 kbp region from the right end of the genome of a pathogenic African swine fever virus isolate (Malawi LIL20/1). unassigned - 3.6.1.23 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8207826&form=6&db=m Mutations in accessory DNA replicating functions alter the relative mutation frequency of herpes simplex virus type 1 strains in cultured murine cells. ongoing research,unassigned 4,0 3.6.1.23 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8386036&form=6&db=m dUTPase from herpes simplex virus type 1; purification from infected green monkey kidney (Vero) cells and from an overproducing Escherichia coli strain. ongoing research,therapeutic application,unassigned 4,1,0 3.6.1.23 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8391186&form=6&db=m Identification and deletion mutagenesis of the bovine herpesvirus 1 dUTPase gene and a gene homologous to herpes simplex virus UL49.5. ongoing research,therapeutic application,unassigned 2,1,0 3.6.1.23 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9400986&form=6&db=m Analysis of cyclin-dependent kinase activity after herpes simplex virus type 2 infection. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0 3.6.1.23 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9883909&form=6&db=m Kinetic properties and stereospecificity of the monomeric dUTPase from herpes simplex virus type 1. diagnostic usage,ongoing research,unassigned 3,4,0 3.6.1.23 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10774198&form=6&db=m [The relationship between gene function and virulence in alpha-herpesviruses] unassigned - 3.6.1.23 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24173231&form=6&db=m Herpes simplex virus 1 protein kinase Us3 phosphorylates viral dUTPase and regulates its catalytic activity in infected cells. ongoing research,unassigned 3,0 3.6.1.23 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24352467&form=6&db=m Phosphorylation of a herpes simplex virus 1 dUTPase by a viral protein kinase, Us3, dictates viral pathogenicity in the central nervous system but not at the periphery. unassigned - 3.6.1.23 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24760895&form=6&db=m Phosphorylation of herpes simplex virus 1 dUTPase upregulated viral dUTPase activity to compensate for low cellular dUTPase activity for efficient viral replication. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,4,0 3.6.1.23 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25320299&form=6&db=m Phosphorylation of herpes simplex virus 1 dUTPase regulates viral virulence and genome integrity by compensating for low cellular dUTPase activity in the central nervous system. causal interaction,therapeutic application,unassigned 4,1,0 3.6.1.23 HIV Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10329142&form=6&db=m Structure/function analysis of a dUTPase: catalytic mechanism of a potential chemotherapeutic target. causal interaction,therapeutic application,unassigned 3,3,0 3.6.1.23 HIV Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10752557&form=6&db=m Expression and cytoplasmic localisation of deoxyuridine triphosphate pyrophosphatase encoded by a human endogenous retrovirus. causal interaction,ongoing research,unassigned 1,1,0 3.6.1.23 Hodgkin Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12376965&form=6&db=m Expression of viral and human dUTPase in Epstein-Barr virus-associated diseases. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.6.1.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34185707&form=6&db=m Monocyte-released HERV-K dUTPase engages TLR4 and MCAM causing endothelial mesenchymal transition. causal interaction,ongoing research,unassigned 3,2,0 3.6.1.23 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28935667&form=6&db=m Upregulation of HERV-K is Linked to Immunity and Inflammation in Pulmonary Arterial Hypertension. causal interaction,unassigned 2,0 3.6.1.23 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34185707&form=6&db=m Monocyte-released HERV-K dUTPase engages TLR4 and MCAM causing endothelial mesenchymal transition. causal interaction,ongoing research,unassigned 3,2,0 3.6.1.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=381286&form=6&db=m The properties of a bacteriophage T5 mutant unable to induce deoxyuridine 5'-triphosphate nucleotidohydrolase. Synthesis of uracil-containing T5 deoxyribonucleic acid. ongoing research,therapeutic application,unassigned 2,1,0 3.6.1.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=810487&form=6&db=m Bacillus subtilis deoxyuridinetriphosphatase and its bacteriophage PBS2-induced inhibitor. causal interaction,therapeutic application,unassigned 2,1,0 3.6.1.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2168898&form=6&db=m Inhibition of phosphorylation of cellular dUTP nucleotidohydrolase as a consequence of herpes simplex virus infection. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,1,3 3.6.1.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4291202&form=6&db=m New dUTPase and dUDPase activites after infection of Escherichia coli by T2 bacteriophage. therapeutic application,unassigned 3,0 3.6.1.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6143756&form=6&db=m Purification and properties of the deoxyuridine triphosphate nucleotidohydrolase enzyme derived from HeLa S3 cells. Comparison to a distinct dUTP nucleotidohydrolase induced in herpes simplex virus-infected HeLa S3 cells. ongoing research,therapeutic application,unassigned 4,1,0 3.6.1.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9188569&form=6&db=m Identification and characterization of a baculovirus structural protein, VP1054, required for nucleocapsid formation. unassigned - 3.6.1.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9400986&form=6&db=m Analysis of cyclin-dependent kinase activity after herpes simplex virus type 2 infection. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0 3.6.1.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10515998&form=6&db=m African swine fever virus dUTPase is a highly specific enzyme required for efficient replication in swine macrophages. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,3,0 3.6.1.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15276840&form=6&db=m Crystal structure of the Mycobacterium tuberculosis dUTPase: insights into the catalytic mechanism. causal interaction,therapeutic application,unassigned 3,4,0 3.6.1.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18646465&form=6&db=m Identification and characterization of duck enteritis virus dUTPase gene. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.6.1.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19124728&form=6&db=m The EBV-encoded dUTPase activates NF-kappa B through the TLR2 and MyD88-dependent signaling pathway. causal interaction,therapeutic application,unassigned 3,4,0 3.6.1.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20461535&form=6&db=m Nuclear-export-signal-dependent protein translocation of dUTPase encoded by Singapore grouper iridovirus. causal interaction,unassigned 4,0 3.6.1.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21122927&form=6&db=m Immunological parameters in goats experimentally infected with SRLV genotype E, strain Roccaverano. causal interaction,unassigned 4,0 3.6.1.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21998588&form=6&db=m The anti-interferon activity of conserved viral dUTPase ORF54 is essential for an effective MHV-68 infection. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0 3.6.1.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25309527&form=6&db=m Human herpesviruses-encoded dUTPases: a family of proteins that modulate dendritic cell function and innate immunity. causal interaction,therapeutic application,unassigned 3,4,0 3.6.1.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28342388&form=6&db=m Insights into the molecular and biological features of the dUTPase-related gene of bovine immunodeficiency virus. therapeutic application,unassigned 1,0 3.6.1.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30029015&form=6&db=m Murine cytomegalovirus M72 promotes acute virus replication in vivo and is a substrate of the TRiC/CCT complex. causal interaction,unassigned 1,0 3.6.1.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31748385&form=6&db=m Structural Insight into African Swine Fever Virus dUTPase Reveals a Novel Folding Pattern in the dUTPase Family. unassigned - 3.6.1.23 Infectious Mononucleosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12376965&form=6&db=m Expression of viral and human dUTPase in Epstein-Barr virus-associated diseases. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.6.1.23 Influenza in Birds http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19573638&form=6&db=m Live vaccination with an H5-hemagglutinin-expressing infectious laryngotracheitis virus recombinant protects chickens against different highly pathogenic avian influenza viruses of the H5 subtype. ongoing research,therapeutic application,unassigned 1,1,0 3.6.1.23 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=285077&form=6&db=m Human deoxyuridine triphosphate nucleotidohydrolase. Purification and characterization of the deoxyuridine triphosphate nucleotidohydrolase from acute lymphocytic leukemia. diagnostic usage,ongoing research,unassigned 1,4,0 3.6.1.23 Leukemia, Lymphoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=285077&form=6&db=m Human deoxyuridine triphosphate nucleotidohydrolase. Purification and characterization of the deoxyuridine triphosphate nucleotidohydrolase from acute lymphocytic leukemia. diagnostic usage,ongoing research,unassigned 1,4,0 3.6.1.23 Leukoplakia, Hairy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12376965&form=6&db=m Expression of viral and human dUTPase in Epstein-Barr virus-associated diseases. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.6.1.23 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18078828&form=6&db=m A tyrosine kinase inhibitor, beta-hydroxyisovalerylshikonin, induced apoptosis in human lung cancer DMS114 cells through reduction of dUTP nucleotidohydrolase activity. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 3.6.1.23 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22172489&form=6&db=m Inhibition of dUTPase Induces Synthetic Lethality with Thymidylate Synthase-Targeted Therapies in Non-Small Cell Lung Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,2 3.6.1.23 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32246224&form=6&db=m A randomized, phase 2 study of deoxyuridine triphosphatase inhibitor, TAS-114, in combination with S-1 versus S-1 alone in patients with advanced non-small-cell lung cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,4,0 3.6.1.23 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15698576&form=6&db=m dUTPase as a platform for antimalarial drug design: structural basis for the selectivity of a class of nucleoside inhibitors. ongoing research,therapeutic application,unassigned 4,2,0 3.6.1.23 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18586121&form=6&db=m Kinetic and thermodynamic characterization of dUTP hydrolysis by Plasmodium falciparum dUTPase. therapeutic application,unassigned 4,0 3.6.1.23 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18837522&form=6&db=m Keeping Uracil Out of DNA: Physiological Role, Structure and Catalytic Mechanism of dUTPases. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.6.1.23 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22049550&form=6&db=m Design, synthesis, and evaluation of 5'-diphenyl nucleoside analogues as inhibitors of the Plasmodium falciparum dUTPase. causal interaction,therapeutic application,unassigned 4,4,0 3.6.1.23 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30700216&form=6&db=m Functional genetic evaluation of DNA house-cleaning enzymes in the malaria parasite: dUTPase and Ap4AH are essential in Plasmodium berghei but ITPase and NDH are dispensable. causal interaction,ongoing research,therapeutic application,unassigned 2,1,4,0 3.6.1.23 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34185707&form=6&db=m Monocyte-released HERV-K dUTPase engages TLR4 and MCAM causing endothelial mesenchymal transition. causal interaction,ongoing research,unassigned 3,2,0 3.6.1.23 Meningioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16325515&form=6&db=m Immunohistochemical detection of dUTPase in intracranial tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.6.1.23 Myxoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11752168&form=6&db=m The genome of swinepox virus. therapeutic application,unassigned 1,0 3.6.1.23 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9714190&form=6&db=m A new lytic antibody, 7D6, detects Epstein-Barr virus dUTPase in nonkeratinizing undifferentiated nasopharyngeal carcinomas. ongoing research,therapeutic application,unassigned 1,1,0 3.6.1.23 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12376965&form=6&db=m Expression of viral and human dUTPase in Epstein-Barr virus-associated diseases. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.6.1.23 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10567908&form=6&db=m Expression of deoxyuridine triphosphatase (dUTPase) in colorectal tumours. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,4 3.6.1.23 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19052026&form=6&db=m Higher expression of deoxyuridine triphosphatase (dUTPase) may predict the metastasis potential of colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 3.6.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6110169&form=6&db=m The role of deoxyuridine triphosphate nucleotidohydrolase, uracil-DNA glycosylase, and DNA polymerase alpha in the metabolism of FUdR in human tumor cells. causal interaction,ongoing research,unassigned 1,4,0 3.6.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7660876&form=6&db=m Inhibition of the proliferation of human cancer cells in-vitro by substrate-analogous inhibitors of dUTPase. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 3.6.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8091672&form=6&db=m The protein p30, encoded at the gag-pro junction of mouse mammary tumor virus, is a dUTPase fused with a nucleocapsid protein. therapeutic application,unassigned 1,0 3.6.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8139016&form=6&db=m Expression and purification of the mouse mammary tumor virus gag-pro transframe protein p30 and characterization of its dUTPase activity. ongoing research,unassigned 3,0 3.6.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8162567&form=6&db=m Induction of resistance to fluorodeoxyuridine cytotoxicity and DNA damage in human tumor cells by expression of Escherichia coli deoxyuridinetriphosphatase. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 3.6.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10567908&form=6&db=m Expression of deoxyuridine triphosphatase (dUTPase) in colorectal tumours. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,4 3.6.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10910061&form=6&db=m dUTP nucleotidohydrolase isoform expression in normal and neoplastic tissues: association with survival and response to 5-fluorouracil in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3 3.6.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10952785&form=6&db=m Deoxyuridine triphosphatase (dUTPase) expression and sensitivity to the thymidylate synthase (TS) inhibitor ZD9331. causal interaction,ongoing research,unassigned 1,4,0 3.6.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11487279&form=6&db=m The ability to accumulate deoxyuridine triphosphate and cellular response to thymidylate synthase (TS) inhibition. ongoing research,therapeutic application,unassigned 4,1,0 3.6.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12096336&form=6&db=m Novel gain of function activity of p53 mutants: activation of the dUTPase gene expression leading to resistance to 5-fluorouracil. ongoing research,therapeutic application,unassigned 3,1,0 3.6.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12374095&form=6&db=m The role of dUTPase and uracil-DNA repair in cancer chemotherapy. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,3,0 3.6.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12376965&form=6&db=m Expression of viral and human dUTPase in Epstein-Barr virus-associated diseases. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.6.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12799180&form=6&db=m Identification of sequence determinants of human nuclear dUTPase isoform localization. causal interaction,therapeutic application,unassigned 4,4,0 3.6.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15138564&form=6&db=m Differentially expressed genes in multidrug resistant variants of U-2 OS human osteosarcoma cells. unassigned - 3.6.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15322254&form=6&db=m Small interfering RNA-mediated suppression of dUTPase sensitizes cancer cell lines to thymidylate synthase inhibition. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,2,4,3 3.6.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15740738&form=6&db=m Dimeric dUTPases, HisE, and MazG belong to a new superfamily of all-alpha NTP pyrophosphohydrolases with potential "house-cleaning" functions. diagnostic usage,unassigned 3,0 3.6.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16325515&form=6&db=m Immunohistochemical detection of dUTPase in intracranial tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.6.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17880943&form=6&db=m Active site closure facilitates juxtaposition of reactant atoms for initiation of catalysis by human dUTPase. causal interaction,unassigned 3,0 3.6.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17955371&form=6&db=m The action of Pdcd4 may be cell type specific: evidence that reduction of dUTPase levels might contribute to its tumor suppressor activity in Bon-1 cells. causal interaction,unassigned 4,0 3.6.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18790783&form=6&db=m Novel opportunities for thymidylate metabolism as a therapeutic target. causal interaction,therapeutic application,unassigned 3,4,0 3.6.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18837522&form=6&db=m Keeping Uracil Out of DNA: Physiological Role, Structure and Catalytic Mechanism of dUTPases. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.6.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19015155&form=6&db=m Regulation of human dUTPase gene expression and p53-mediated transcriptional repression in response to oxaliplatin-induced DNA damage. causal interaction,unassigned 1,0 3.6.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19052026&form=6&db=m Higher expression of deoxyuridine triphosphatase (dUTPase) may predict the metastasis potential of colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 3.6.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19645683&form=6&db=m The contribution of DNA base damage to human cancer is modulated by the base excision repair interaction network. unassigned - 3.6.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20560137&form=6&db=m Identification of potential pharmacogenomic markers of clinical efficacy of 5-fluorouracil in colorectal cancer. diagnostic usage,unassigned 1,0 3.6.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21776007&form=6&db=m A Human Endogenous Retrovirus K dUTPase Triggers a T(H)1, T(H)17 Cytokine Response: Does It Have a Role in Psoriasis? causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 3.6.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22172489&form=6&db=m Inhibition of dUTPase Induces Synthetic Lethality with Thymidylate Synthase-Targeted Therapies in Non-Small Cell Lung Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,2 3.6.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23307478&form=6&db=m Backbone nuclear magnetic resonance assignment of human deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase). causal interaction,therapeutic application,unassigned 4,1,0 3.6.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24014883&form=6&db=m New Challenges and Inspired Answers for Anticancer Drug Discovery and Development. therapeutic application,unassigned 4,0 3.6.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26666293&form=6&db=m Structural insights into the mechanism defining substrate affinity in Arabidopsis thaliana dUTPase: the role of tryptophan 93 in ligand orientation. therapeutic application,unassigned 2,0 3.6.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27452458&form=6&db=m The Impact of dUTPase on Ribonucleotide Reductase-Induced Genome Instability in Cancer Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 3.6.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28108422&form=6&db=m Role of Microglia Autophagy in Microglia Activation After Traumatic Brain Injury. unassigned - 3.6.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29531348&form=6&db=m Structural model of human dUTPase in complex with a novel proteinaceous inhibitor. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,2,0 3.6.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29578692&form=6&db=m ATP-Linked Chimeric Nucleotide as a Specific Luminescence Reporter of Deoxyuridine Triphosphatase. diagnostic usage,therapeutic application,unassigned 4,4,0 3.6.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29748212&form=6&db=m TAS-114, a First-in-Class Dual dUTPase/DPD Inhibitor, Demonstrates Potential to Improve Therapeutic Efficacy of Fluoropyrimidine-Based Chemotherapy. causal interaction,therapeutic application,unassigned 2,4,0 3.6.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30511200&form=6&db=m First-in-human phase 1 study of novel dUTPase inhibitor TAS-114 in combination with S-1 in Japanese patients with advanced solid tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4 3.6.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31404669&form=6&db=m Characterization of an integrated, endogenous mouse mammary tumor virus-like (MMTV) betaretrovirus genome in a black Syrian hamster (Mesocricetus auratus). unassigned - 3.6.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32700159&form=6&db=m A multicenter phase II study of TAS-114 in combination with S-1 in patients with pretreated advanced gastric cancer (EPOC1604). diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,4,0 3.6.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33140501&form=6&db=m dUTPase inhibition confers susceptibility to a thymidylate synthase inhibitor in DNA-repair-defective human cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3 3.6.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33824328&form=6&db=m Targeting nucleotide metabolism enhances the efficacy of anthracyclines and anti-metabolites in triple-negative breast cancer. therapeutic application,unassigned 2,0 3.6.1.23 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24760895&form=6&db=m Phosphorylation of herpes simplex virus 1 dUTPase upregulated viral dUTPase activity to compensate for low cellular dUTPase activity for efficient viral replication. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,4,0 3.6.1.23 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31040055&form=6&db=m Epstein-Barr Virus dUTPase Induces Neuroinflammatory Mediators: Implications for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,3,0 3.6.1.23 Oligodendroglioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16325515&form=6&db=m Immunohistochemical detection of dUTPase in intracranial tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.6.1.23 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31107447&form=6&db=m Combining Non-reducing SDS-PAGE Analysis and Chemical Crosslinking to Detect Multimeric Complexes Stabilized by Disulfide Linkages in Mammalian Cells in Culture. diagnostic usage,ongoing research,unassigned 3,4,0 3.6.1.23 Persistent Infection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21998588&form=6&db=m The anti-interferon activity of conserved viral dUTPase ORF54 is essential for an effective MHV-68 infection. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0 3.6.1.23 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=285077&form=6&db=m Human deoxyuridine triphosphate nucleotidohydrolase. Purification and characterization of the deoxyuridine triphosphate nucleotidohydrolase from acute lymphocytic leukemia. diagnostic usage,ongoing research,unassigned 1,4,0 3.6.1.23 Pseudorabies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8551587&form=6&db=m The UL49.5 gene of pseudorabies virus codes for an O-glycosylated structural protein of the viral envelope. ongoing research,unassigned 1,0 3.6.1.23 Pseudorabies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8551588&form=6&db=m Identification and characterization of pseudorabies virus dUTPase. diagnostic usage,ongoing research,unassigned 2,4,0 3.6.1.23 Pseudorabies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28794045&form=6&db=m Pseudorabies Virus dUTPase UL50 Induces Lysosomal Degradation of Type I Interferon Receptor 1 and Antagonizes the Alpha Interferon Response. causal interaction,therapeutic application,unassigned 4,1,0 3.6.1.23 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15654959&form=6&db=m Haplotype sharing analysis identifies a retroviral dUTPase as candidate susceptibility gene for psoriasis. diagnostic usage,unassigned 3,0 3.6.1.23 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21776007&form=6&db=m A Human Endogenous Retrovirus K dUTPase Triggers a T(H)1, T(H)17 Cytokine Response: Does It Have a Role in Psoriasis? causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 3.6.1.23 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22437317&form=6&db=m Protective effect of human endogenous retrovirus K dUTPase variants on psoriasis susceptibility. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,4,1 3.6.1.23 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11121581&form=6&db=m Identification of candidate growth-regulating genes that are overexpressed in late gestation fetal liver in the rat. causal interaction,therapeutic application,unassigned 1,1,0 3.6.1.23 Sarcoma, Kaposi http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10355777&form=6&db=m Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) ORF54 encodes a functional dUTPase expressed in the lytic replication cycle. ongoing research,unassigned 2,0 3.6.1.23 Sarcoma, Yoshida http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=858139&form=6&db=m A new deoxyuridine-5'-triphosphatase in Yoshida sarcoma cells involved in deoxyuridine 5'-triphosphate metabolism. unassigned - 3.6.1.23 Smallpox http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11752168&form=6&db=m The genome of swinepox virus. therapeutic application,unassigned 1,0 3.6.1.23 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19290488&form=6&db=m Loss of RUNX3 expression correlates with differentiation, nodal metastasis, and poor prognosis of gastric cancer. diagnostic usage,ongoing research,unassigned 3,4,0 3.6.1.23 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32700159&form=6&db=m A multicenter phase II study of TAS-114 in combination with S-1 in patients with pretreated advanced gastric cancer (EPOC1604). diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,4,0 3.6.1.23 Superinfection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2997989&form=6&db=m Induction of a deoxyuridine triphosphate nucleotidohydrolase activity in Epstein-Barr virus-infected cells. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 3.6.1.23 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15276840&form=6&db=m Crystal structure of the Mycobacterium tuberculosis dUTPase: insights into the catalytic mechanism. causal interaction,therapeutic application,unassigned 3,4,0 3.6.1.23 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18519027&form=6&db=m Active site of mycobacterial dUTPase: structural characteristics and a built-in sensor. therapeutic application,unassigned 1,0 3.6.1.23 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18837522&form=6&db=m Keeping Uracil Out of DNA: Physiological Role, Structure and Catalytic Mechanism of dUTPases. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.6.1.23 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21469751&form=6&db=m Molecular Modeling of Mycobacterium Tuberculosis dUTpase: Docking and Catalytic Mechanism Studies. unassigned - 3.6.1.23 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22515329&form=6&db=m Enhanced Cellular Uptake of a New, in Silico Identified Antitubercular Candidate by Peptide Conjugation. therapeutic application,unassigned 3,0 3.6.1.23 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22655049&form=6&db=m The dUTPase enzyme is essential in Mycobacterium smegmatis. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,1,2 3.6.1.23 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25728610&form=6&db=m Antimycobacterial activity of peptide conjugate of pyridopyrimidine derivative against Mycobacterium tuberculosis in a series of in vitro and in vivo models. unassigned - 3.6.1.23 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25841100&form=6&db=m Cross-species inhibition of dUTPase via the Staphylococcal Stl protein perturbs dNTP pool and colony formation in Mycobacterium. ongoing research,therapeutic application,unassigned 1,1,0 3.6.1.23 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26666293&form=6&db=m Structural insights into the mechanism defining substrate affinity in Arabidopsis thaliana dUTPase: the role of tryptophan 93 in ligand orientation. therapeutic application,unassigned 2,0 3.6.1.23 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27815500&form=6&db=m A Hidden Active Site in the Potential Drug Target Mycobacterium tuberculosis dUTPase Is Accessible through Small Amplitude Protein Conformational Changes. causal interaction,ongoing research,therapeutic application,unassigned 2,4,3,0 3.6.1.23 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31662460&form=6&db=m Crystal Structure of African Swine Fever Virus dUTPase Reveals a Potential Drug Target. causal interaction,therapeutic application,unassigned 2,4,0 3.6.1.23 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30127996&form=6&db=m Genetic variations in the SULF1 gene alter the risk of cervical cancer and precancerous lesions. diagnostic usage,ongoing research,unassigned 3,3,0 3.6.1.23 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8393252&form=6&db=m Vaccinia virus encodes a functional dUTPase. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 3.6.1.23 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8798559&form=6&db=m Purification and characterization of the vaccinia virus deoxyuridine triphosphatase expressed in Escherichia coli. ongoing research,therapeutic application,unassigned 4,3,0 3.6.1.23 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8847502&form=6&db=m Genomic analysis of a transposition-deletion variant of orf virus reveals a 3.3 kbp region of non-essential DNA. ongoing research,therapeutic application,unassigned 2,1,0 3.6.1.23 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11752168&form=6&db=m The genome of swinepox virus. therapeutic application,unassigned 1,0 3.6.1.23 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11961258&form=6&db=m Orf virus encodes a functional dUTPase gene. therapeutic application,unassigned 1,0 3.6.1.23 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17452782&form=6&db=m Structures of vaccinia virus dUTPase and its nucleotide complexes. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 3.6.1.23 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18321387&form=6&db=m Vaccinia virus lacking the deoxyuridine triphosphatase gene (F2L) replicates well in vitro and in vivo, but is hypersensitive to the antiviral drug (N)-methanocarbathymidine. therapeutic application,unassigned 1,0 3.6.1.23 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19055736&form=6&db=m Effects of vaccinia virus uracil DNA glycosylase catalytic site and deoxyuridine triphosphatase deletion mutations individually and together on replication in active and quiescent cells and pathogenesis in mice. ongoing research,unassigned 4,0 3.6.1.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2168898&form=6&db=m Inhibition of phosphorylation of cellular dUTP nucleotidohydrolase as a consequence of herpes simplex virus infection. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,1,3 3.6.1.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8393252&form=6&db=m Vaccinia virus encodes a functional dUTPase. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 3.6.1.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8922474&form=6&db=m Cloning and expression of the Epstein-Barr virus-encoded dUTPase: patients with acute, reactivated or chronic virus infection develop antibodies against the enzyme. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,1 3.6.1.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27498408&form=6&db=m Characterization and functional studies of fowl adenovirus 9 dUTPase. ongoing research,unassigned 1,0 3.6.1.23 Visna http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8551582&form=6&db=m Replication properties of dUTPase-deficient mutants of caprine and ovine lentiviruses. diagnostic usage,ongoing research,unassigned 1,3,0 3.6.1.23 Visna http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9445073&form=6&db=m Visna virus dUTPase is dispensable for neuropathogenicity. therapeutic application,unassigned 1,0 3.6.1.23 Visna http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9847382&form=6&db=m "Hidden" dUTPase sequence in human immunodeficiency virus type 1 gp120. unassigned - 3.6.1.23 Visna http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12374097&form=6&db=m The role of retroviral dUTPases in replication and virulence. therapeutic application,unassigned 2,0