3.6.1.15 Adenomyosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31123897&form=6&db=m The ectonucleoside triphosphate diphosphohydrolase-2 (NTPDase2) in human endometrium: a novel marker of basal stroma and mesenchymal stem cells. diagnostic usage,ongoing research,unassigned 3,4,0 3.6.1.15 Adenomyosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33922226&form=6&db=m Characterization of the Endometrial MSC Marker Ectonucleoside Triphosphate Diphosphohydrolase-2 (NTPDase2/CD39L1) in Low- and High-Grade Endometrial Carcinomas: Loss of Stromal Expression in the Invasive Phenotypes. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.6.1.15 African Horse Sickness http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10588005&form=6&db=m [Use of the immunoenzyme test ELISA-NS3 to distinguish horses infected by African horsesickness virus from vaccinated horses] ongoing research,therapeutic application,unassigned 2,2,0 3.6.1.15 African Horse Sickness http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19153641&form=6&db=m Genome segment reassortment identifies non-structural protein NS3 as a key protein in African horsesickness virus release and alteration of membrane permeability. ongoing research,therapeutic application,unassigned 4,1,0 3.6.1.15 African Swine Fever http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6271106&form=6&db=m Nucleoside triphosphate phosphohydrolase activities in African swine fever virus. ongoing research,unassigned 3,0 3.6.1.15 African Swine Fever http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8266720&form=6&db=m Nucleotide sequence of a nucleoside triphosphate phosphohydrolase gene from African swine fever virus. ongoing research,unassigned 3,0 3.6.1.15 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23118350&form=6&db=m Kidins220 accumulates with tau in human Alzheimer's disease and related models: modulation of its calpain-processing by GSK3?/PP1 imbalance. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.6.1.15 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1851409&form=6&db=m Synovial fluid pyrophosphate and nucleoside triphosphate pyrophosphatase: comparison between normal and diseased and between inflamed and non-inflamed joints. diagnostic usage,ongoing research,unassigned 1,3,0 3.6.1.15 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20599872&form=6&db=m Activities of enzymes that hydrolyze adenine nucleotides in platelets from patients with rheumatoid arthritis. diagnostic usage,ongoing research,unassigned 2,3,0 3.6.1.15 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24649008&form=6&db=m Blockade of ankyrin repeat-rich membrane spanning protein modulates extracellular signal-regulated kinase expression and inhibits allergic inflammation in ovalbumin-sensitized mice. causal interaction,unassigned 4,0 3.6.1.15 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6116538&form=6&db=m Isolation and characterization of plasma membranes from transplantable human astrocytoma, oat cell carcinoma, and melanomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,1,1 3.6.1.15 Azoospermia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16931801&form=6&db=m Mutations in the testis-specific NALP14 gene in men suffering from spermatogenic failure. causal interaction,ongoing research,unassigned 2,3,0 3.6.1.15 Bluetongue http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1645903&form=6&db=m High level expression of the major core protein VP7 and the non-structural protein NS3 of bluetongue virus in yeast: use of expressed VP7 as a diagnostic, group-reactive antigen in a blocking ELISA. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 3.6.1.15 Bluetongue http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1654377&form=6&db=m Localization of the non-structural protein NS3 in bluetongue virus-infected cells. ongoing research,unassigned 2,0 3.6.1.15 Bluetongue http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9780054&form=6&db=m Bluetongue virus core protein VP4 has nucleoside triphosphate phosphohydrolase activity. therapeutic application,unassigned 3,0 3.6.1.15 Bluetongue http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12235365&form=6&db=m The membrane trafficking protein calpactin forms a complex with bluetongue virus protein NS3 and mediates virus release. ongoing research,therapeutic application,unassigned 2,2,0 3.6.1.15 Bluetongue http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14557620&form=6&db=m Defining the structure-function relationships of bluetongue virus helicase protein VP6. diagnostic usage,therapeutic application,unassigned 1,1,0 3.6.1.15 Bluetongue http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19553329&form=6&db=m Bluetongue virus VP6 acts early in the replication cycle and can form the basis of chimeric virus formation. unassigned - 3.6.1.15 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15464860&form=6&db=m Biochemical brain markers and purinergic parameters in rat CSF after seizure induced by pentylenetetrazol. causal interaction,diagnostic usage,unassigned 1,2,0 3.6.1.15 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7755206&form=6&db=m Nuclear-envelope nucleoside triphosphatase kinetics and mRNA transport following brain ischemia and reperfusion. diagnostic usage,unassigned 1,0 3.6.1.15 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15949710&form=6&db=m Enzymes that hydrolyze adenine nucleotides in platelets from breast cancer patients. diagnostic usage,ongoing research,unassigned 1,3,0 3.6.1.15 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17291528&form=6&db=m NMR structure and functional characterization of a human cancer-related nucleoside triphosphatase. diagnostic usage,unassigned 3,0 3.6.1.15 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28283039&form=6&db=m Hepatitis C virus NS3 protein enhances hepatocellular carcinoma cell invasion by promoting PPM1A ubiquitination and degradation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,2 3.6.1.15 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28849114&form=6&db=m Kidins220 and tumour development: Insights into a complexity of cross-talk among signalling pathways (Review). causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0 3.6.1.15 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33955519&form=6&db=m Reduced kinase D?interacting substrate of 220 kDa (Kidins220) in pancreatic cancer promotes EGFR/ERK signalling and disease progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.6.1.15 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2425954&form=6&db=m Arabinosyl-5-azacytosine: mechanisms of native and acquired resistance. diagnostic usage,ongoing research,unassigned 3,4,0 3.6.1.15 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6116538&form=6&db=m Isolation and characterization of plasma membranes from transplantable human astrocytoma, oat cell carcinoma, and melanomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,1,1 3.6.1.15 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12392715&form=6&db=m Cell-type specificity of ectonucleotidase expression and upregulation by 2,3,7,8-tetrachlorodibenzo-p-dioxin. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 3.6.1.15 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28283039&form=6&db=m Hepatitis C virus NS3 protein enhances hepatocellular carcinoma cell invasion by promoting PPM1A ubiquitination and degradation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,2 3.6.1.15 Carcinoma, Small Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6116538&form=6&db=m Isolation and characterization of plasma membranes from transplantable human astrocytoma, oat cell carcinoma, and melanomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,1,1 3.6.1.15 Cardiovascular Abnormalities http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22048155&form=6&db=m Kidins220/ARMS mediates the integration of the neurotrophin and VEGF pathways in the vascular and nervous systems. causal interaction,ongoing research,unassigned 3,2,0 3.6.1.15 Cardiovascular Abnormalities http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28849114&form=6&db=m Kidins220 and tumour development: Insights into a complexity of cross-talk among signalling pathways (Review). causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0 3.6.1.15 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16028070&form=6&db=m Expression of NTPDase1 and caveolins in human cardiovascular disease. causal interaction,ongoing research,unassigned 3,4,0 3.6.1.15 Cholestasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15799977&form=6&db=m Portal fibroblasts regulate the proliferation of bile duct epithelia via expression of NTPDase2. causal interaction,unassigned 4,0 3.6.1.15 Classical Swine Fever http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17447110&form=6&db=m Identification and characterization of the NTPase activity of classical swine fever virus (CSFV) nonstructural protein 3 (NS3) expressed in bacteria. diagnostic usage,ongoing research,unassigned 1,2,0 3.6.1.15 Classical Swine Fever http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18204288&form=6&db=m Cytopathic effect of classical swine fever virus NS3 protein on PK-15 cells. ongoing research,unassigned 4,0 3.6.1.15 Classical Swine Fever http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19185595&form=6&db=m Characterization of classical swine fever virus (CSFV) nonstructural protein 3 (NS3) helicase activity and its modulation by CSFV RNA-dependent RNA polymerase. diagnostic usage,ongoing research,unassigned 1,3,0 3.6.1.15 Classical Swine Fever http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21236462&form=6&db=m Identification of an NTPase motif in classical swine fever virus NS4B protein. unassigned - 3.6.1.15 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28472257&form=6&db=m Expression of Ecto-nucleoside Triphosphate Diphosphohydrolases-2 and -3 in the Enteric Nervous System Affects Inflammation in Experimental Colitis and Crohn's Disease. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.6.1.15 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31188623&form=6&db=m NTPDase1 and -2 are expressed by distinct cellular compartments in the mouse colon and differentially impact colonic physiology and function after DSS colitis. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 3.6.1.15 Contracture http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28934391&form=6&db=m Homozygous KIDINS220 loss-of-function variants in fetuses with cerebral ventriculomegaly and limb contractures. causal interaction,unassigned 4,0 3.6.1.15 Contracture http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32909676&form=6&db=m Prenatal delineation of a distinct lethal fetal syndrome caused by a homozygous truncating KIDINS220 variant. causal interaction,unassigned 3,0 3.6.1.15 Contracture http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33205811&form=6&db=m TrkA mediates effect of novel KIDINS220 mutation in human brain ventriculomegaly. unassigned - 3.6.1.15 Coronavirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21918226&form=6&db=m Coronavirus infection induces DNA replication stress partly through interaction of its nonstructural protein 13 with the p125 subunit of DNA polymerase ?. therapeutic application,unassigned 1,0 3.6.1.15 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32536457&form=6&db=m Should We Try SARS-CoV-2 Helicase Inhibitors for COVID-19 Therapy? causal interaction,therapeutic application,unassigned 2,4,0 3.6.1.15 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32606248&form=6&db=m Genomic discovery of an evolutionarily programmed modality for small-molecule targeting of an intractable protein surface. causal interaction,therapeutic application,unassigned 1,2,0 3.6.1.15 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32668444&form=6&db=m SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls. ongoing research,unassigned 3,0 3.6.1.15 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32676607&form=6&db=m Structural basis for helicase-polymerase coupling in the SARS-CoV-2 replication-transcription complex. causal interaction,therapeutic application,unassigned 4,1,0 3.6.1.15 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32783916&form=6&db=m Structural Basis for Helicase-Polymerase Coupling in the SARS-CoV-2 Replication-Transcription Complex. causal interaction,therapeutic application,unassigned 4,1,0 3.6.1.15 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32817950&form=6&db=m Discovery of COVID-19 Inhibitors Targeting the SARS-CoV2 Nsp13 Helicase. causal interaction,therapeutic application,unassigned 1,4,0 3.6.1.15 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33052685&form=6&db=m Discovery of COVID-19 Inhibitors Targeting the SARS-CoV-2 Nsp13 Helicase. causal interaction,therapeutic application,unassigned 2,4,0 3.6.1.15 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33681535&form=6&db=m Analysis and comparison of genetic variants and mutations of the novel coronavirus SARS-CoV-2. causal interaction,therapeutic application,unassigned 3,3,0 3.6.1.15 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34455933&form=6&db=m Discovering potential inhibitors against SARS-CoV-2 by targeting Nsp13 Helicase. therapeutic application,unassigned 4,0 3.6.1.15 Crohn Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28472257&form=6&db=m Expression of Ecto-nucleoside Triphosphate Diphosphohydrolases-2 and -3 in the Enteric Nervous System Affects Inflammation in Experimental Colitis and Crohn's Disease. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.6.1.15 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20190036&form=6&db=m CYSTIC FIBROSIS REMODELS THE REGULATION OF PURINERGIC SIGNALING BY NTPDASE1 (CD39) AND NTPDASE3. causal interaction,ongoing research,unassigned 1,2,0 3.6.1.15 Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3032798&form=6&db=m Detection of nucleoside triphosphate hydrolase as a circulating antigen in sera of mice infected with Toxoplasma gondii. ongoing research,unassigned 3,0 3.6.1.15 Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11989532&form=6&db=m Kinetics of the nucleoside triphosphate hydrolase of Toxoplasma gondii in mice with acute and chronic toxoplasmosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 3.6.1.15 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23118350&form=6&db=m Kidins220 accumulates with tau in human Alzheimer's disease and related models: modulation of its calpain-processing by GSK3?/PP1 imbalance. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.6.1.15 Demyelinating Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17239402&form=6&db=m Activities of enzymes that hydrolyze adenine nucleotides in platelets from rats experimentally demyelinated with ethidium bromide and treated with interferon-beta. ongoing research,unassigned 1,0 3.6.1.15 Demyelinating Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19463911&form=6&db=m Effect of vitamin E on ectonucleotidase activities in synaptosomes and platelets and parameters of oxidative stress in rats experimentally demyelinated. ongoing research,unassigned 1,0 3.6.1.15 Dengue http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2138211&form=6&db=m Passive protection studies in mice with monoclonal antibodies directed against the non-structural protein NS3 of dengue 1 virus. ongoing research,therapeutic application,unassigned 4,3,0 3.6.1.15 Dengue http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9657959&form=6&db=m Recombinant dengue virus type 1 NS3 protein exhibits specific viral RNA binding and NTPase activity regulated by the NS5 protein. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,2,0 3.6.1.15 Dengue http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10074162&form=6&db=m The serine protease and RNA-stimulated nucleoside triphosphatase and RNA helicase functional domains of dengue virus type 2 NS3 converge within a region of 20 amino acids. ongoing research,therapeutic application,unassigned 2,1,0 3.6.1.15 Dengue http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11559795&form=6&db=m Mutagenesis of the Dengue virus type 2 NS3 protein within and outside helicase motifs: effects on enzyme activity and virus replication. ongoing research,therapeutic application,unassigned 4,1,0 3.6.1.15 Dengue http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15074713&form=6&db=m Synthesis and evaluation of ATP-binding site directed potential inhibitors of nucleoside triphosphatases/helicases and polymerases of hepatitis C and other selected Flaviviridae viruses. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0 3.6.1.15 Dengue http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15464841&form=6&db=m The RNA helicase, nucleotide 5'-triphosphatase, and RNA 5'-triphosphatase activities of Dengue virus protein NS3 are Mg2+-dependent and require a functional Walker B motif in the helicase catalytic core. ongoing research,unassigned 1,0 3.6.1.15 Dengue http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16051821&form=6&db=m Structure of the Dengue virus helicase/nucleoside triphosphatase catalytic domain at a resolution of 2.4 A. ongoing research,unassigned 4,0 3.6.1.15 Dengue http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18442976&form=6&db=m The two-component NS2B-NS3 proteinase represses DNA unwinding activity of the West Nile virus NS3 helicase. unassigned - 3.6.1.15 Dengue http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18644250&form=6&db=m Structural proteomics of dengue virus. ongoing research,therapeutic application,unassigned 3,1,0 3.6.1.15 Dengue http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19166847&form=6&db=m Analysis of the nucleoside triphosphatase, RNA triphosphatase, and unwinding activities of the helicase domain of dengue virus NS3 protein. unassigned - 3.6.1.15 Dengue http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22031819&form=6&db=m Induction of a protective response in mice by the dengue virus NS3 protein using DNA vaccines. causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0 3.6.1.15 Dengue http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23526990&form=6&db=m Steady-State NTPase Activity of Dengue Virus NS3: Number of Catalytic Sites, Nucleotide Specificity and Activation by ssRNA. ongoing research,therapeutic application,unassigned 3,1,0 3.6.1.15 Dengue http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24228882&form=6&db=m Modulation of enzymatic activity of dengue virus nonstructural protein NS3 nucleoside triphosphatase/helicase by poly(U). ongoing research,unassigned 2,0 3.6.1.15 Dengue http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27903271&form=6&db=m Differential humoral and cellular immunity induced by vaccination using plasmid DNA and protein recombinant expressing the NS3 protein of dengue virus type 3. ongoing research,therapeutic application,unassigned 1,1,0 3.6.1.15 Dengue http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29659571&form=6&db=m Allostery in the dengue virus NS3 helicase: Insights into the NTPase cycle from molecular simulations. ongoing research,unassigned 2,0 3.6.1.15 Dermatitis, Contact http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21605671&form=6&db=m Improved efficacy in the treatment of contact dermatitis in rats by a dermatological nanomedicine containing clobetasol propionate. unassigned - 3.6.1.15 Dermatitis, Contact http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26328452&form=6&db=m Nanoencapsulation of Clobetasol Propionate Decreases Its Penetration to Skin Layers Without Changing Its Relative Skin Distribution. therapeutic application,unassigned 4,0 3.6.1.15 Dermatitis, Contact http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27610146&form=6&db=m Enhancement of Anti-Dermatitis Potential of Clobetasol Propionate by DHA [Docosahexaenoic Acid] Rich Algal Oil Nanoemulsion Gel. therapeutic application,unassigned 3,0 3.6.1.15 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17119848&form=6&db=m Enhanced NTPDase and 5'-nucleotidase activities in diabetes mellitus and iron-overload model. diagnostic usage,ongoing research,unassigned 3,3,0 3.6.1.15 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12757773&form=6&db=m Enzymes that hydrolyze adenine nucleotides in diabetes and associated pathologies. causal interaction,therapeutic application,unassigned 4,1,0 3.6.1.15 Encephalitis, Japanese http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7732656&form=6&db=m Japanese encephalitis virus nonstructural protein NS3 has RNA binding and ATPase activities. ongoing research,therapeutic application,unassigned 3,1,0 3.6.1.15 Encephalitis, Japanese http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8811006&form=6&db=m Characterization of the NTPase activity of Japanese encephalitis virus NS3 protein. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 3.6.1.15 Encephalitis, Japanese http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12694177&form=6&db=m Halogenated benzimidazoles and benzotriazoles as inhibitors of the NTPase/helicase activities of hepatitis C and related viruses. causal interaction,therapeutic application,unassigned 2,4,0 3.6.1.15 Encephalitis, Japanese http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15074713&form=6&db=m Synthesis and evaluation of ATP-binding site directed potential inhibitors of nucleoside triphosphatases/helicases and polymerases of hepatitis C and other selected Flaviviridae viruses. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0 3.6.1.15 Encephalitis, Japanese http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15909930&form=6&db=m Inhibitors of the NTPase/helicases of hepatitis C and related Flaviviridae viruses. therapeutic application,unassigned 3,0 3.6.1.15 Encephalitis, Japanese http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18479669&form=6&db=m Viral NS3 helicase activity is inhibited by peptides reproducing the Arg-rich conserved motif of the enzyme (motif VI). ongoing research,unassigned 1,0 3.6.1.15 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29163045&form=6&db=m Down-regulation of NTPDase2 and ADP-sensitive P2 Purinoceptors Correlate with Severity of Symptoms during Experimental Autoimmune Encephalomyelitis. ongoing research,unassigned 4,0 3.6.1.15 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29163045&form=6&db=m Down-regulation of NTPDase2 and ADP-sensitive P2 Purinoceptors Correlate with Severity of Symptoms during Experimental Autoimmune Encephalomyelitis. ongoing research,unassigned 4,0 3.6.1.15 Encephalomyelitis, Western Equine http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6115512&form=6&db=m Nucleoside triphosphate phosphohydrolase produced in BHK cells infected with western equine encephalitis virus is probably associated with the 82K dalton nonstructural polypeptide. ongoing research,unassigned 2,0 3.6.1.15 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33922226&form=6&db=m Characterization of the Endometrial MSC Marker Ectonucleoside Triphosphate Diphosphohydrolase-2 (NTPDase2/CD39L1) in Low- and High-Grade Endometrial Carcinomas: Loss of Stromal Expression in the Invasive Phenotypes. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.6.1.15 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22945235&form=6&db=m A ketogenic diet did not prevent effects on the ectonucleotidases pathway promoted by lithium-pilocarpine-induced status epilepticus in rat hippocampus. ongoing research,unassigned 2,0 3.6.1.15 Foot-and-Mouth Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16644283&form=6&db=m Expression of tuberculosis antigen ESAT-6 in Nicotiana tabacum using a potato virus X-based vector. therapeutic application,unassigned 1,0 3.6.1.15 Foot-and-Mouth Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24243237&form=6&db=m Genetic engineering and chemical conjugation of potato virus X. unassigned - 3.6.1.15 Fowlpox http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8266720&form=6&db=m Nucleotide sequence of a nucleoside triphosphate phosphohydrolase gene from African swine fever virus. ongoing research,unassigned 3,0 3.6.1.15 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16995949&form=6&db=m In vivo glioblastoma growth is reduced by apyrase activity in a rat glioma model. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1 3.6.1.15 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19558578&form=6&db=m Selective NTPDase2 expression modulates in vivo rat glioma growth. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 3.6.1.15 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22038661&form=6&db=m Overexpression of NTPDase2 in gliomas promotes systemic inflammation and pulmonary injury. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,2 3.6.1.15 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18815297&form=6&db=m Murine coronaviruses encoding nsp2 at different genomic loci have altered replication, protein expression, and localization. ongoing research,unassigned 2,0 3.6.1.15 Hepatitis A http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9645199&form=6&db=m Membrane association and RNA binding of recombinant hepatitis A virus protein 2C. unassigned - 3.6.1.15 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7489969&form=6&db=m Proteolytic activity of NS3 serine proteinase of hepatitis C virus efficiently expressed in Escherichia coli. causal interaction,therapeutic application,unassigned 3,4,0 3.6.1.15 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8396675&form=6&db=m Hepatitis C virus NS3 protein polynucleotide-stimulated nucleoside triphosphatase and comparison with the related pestivirus and flavivirus enzymes. ongoing research,therapeutic application,unassigned 1,1,0 3.6.1.15 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8647104&form=6&db=m Non-structural protein 3 of hepatitis C virus inhibits phosphorylation mediated by cAMP-dependent protein kinase. causal interaction,ongoing research,unassigned 1,2,0 3.6.1.15 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8676447&form=6&db=m Enzymatic characterization of hepatitis C virus NS3/4A complexes expressed in mammalian cells by using the herpes simplex virus amplicon system. ongoing research,unassigned 3,0 3.6.1.15 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8753814&form=6&db=m Characterization of RNA binding activity and RNA helicase activity of the hepatitis C virus NS3 protein. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 3.6.1.15 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8794305&form=6&db=m Activity of purified hepatitis C virus protease NS3 on peptide substrates. ongoing research,unassigned 2,0 3.6.1.15 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8798703&form=6&db=m A steady-state and pre-steady-state kinetic analysis of the NTPase activity associated with the hepatitis C virus NS3 helicase domain. diagnostic usage,ongoing research,unassigned 3,1,0 3.6.1.15 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9049378&form=6&db=m In vitro cleavage of hepatitis C virus polyprotein substrates by purified recombinant NS3 protease. ongoing research,therapeutic application,unassigned 4,2,0 3.6.1.15 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9094652&form=6&db=m Polynucleotide modulation of the protease, nucleoside triphosphatase, and helicase activities of a hepatitis C virus NS3-NS4A complex isolated from transfected COS cells. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 3.6.1.15 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9178493&form=6&db=m Towards defining a minimal functional domain for NTPase and RNA helicase activities of the hepatitis C virus NS3 protein. diagnostic usage,therapeutic application,unassigned 2,3,0 3.6.1.15 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9187654&form=6&db=m Structure of the hepatitis C virus RNA helicase domain. ongoing research,therapeutic application,unassigned 2,2,0 3.6.1.15 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9223530&form=6&db=m A point mutation abolishes the helicase but not the nucleoside triphosphatase activity of hepatitis C virus NS3 protein. causal interaction,unassigned 1,0 3.6.1.15 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9658124&form=6&db=m Multiple enzymatic activities associated with recombinant NS3 protein of hepatitis C virus. causal interaction,unassigned 1,0 3.6.1.15 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10092010&form=6&db=m Characterization and mutational analysis of the helicase and NTPase activities of hepatitis C virus full-length NS3 protein. diagnostic usage,ongoing research,unassigned 2,2,0 3.6.1.15 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10220351&form=6&db=m Modulation of hepatitis C virus NS3 protease and helicase activities through the interaction with NS4A. therapeutic application,unassigned 2,0 3.6.1.15 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10404596&form=6&db=m Crystal structure of the ATPase domain of translation initiation factor 4A from Saccharomyces cerevisiae--the prototype of the DEAD box protein family. causal interaction,unassigned 1,0 3.6.1.15 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10499448&form=6&db=m Functional interactions between conserved motifs of the hepatitis C virus RNA helicase protein NS3. diagnostic usage,ongoing research,unassigned 2,2,0 3.6.1.15 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10583365&form=6&db=m Biochemical properties of a minimal functional domain with ATP-binding activity of the NTPase/helicase of hepatitis C virus. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,1,0 3.6.1.15 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10618278&form=6&db=m Characterization of a monoclonal antibody and its single-chain antibody fragment recognizing the nucleoside Triphosphatase/Helicase domain of the hepatitis C virus nonstructural 3 protein. ongoing research,unassigned 4,0 3.6.1.15 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10683335&form=6&db=m Internal cleavage of hepatitis C virus NS3 protein is dependent on the activity of NS34A protease. causal interaction,therapeutic application,unassigned 1,3,0 3.6.1.15 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10769077&form=6&db=m Enzymatic properties of hepatitis C virus NS3-associated helicase. ongoing research,unassigned 1,0 3.6.1.15 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10961691&form=6&db=m ATP-binding domain of NTPase/helicase as a target for hepatitis C antiviral therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 3.6.1.15 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11000246&form=6&db=m Roles of the AX(4)GKS and arginine-rich motifs of hepatitis C virus RNA helicase in ATP- and viral RNA-binding activity. unassigned - 3.6.1.15 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11330818&form=6&db=m Backbone 1H, 15N and 13C resonance assignments of the NTPase subdomain of the hepatitis C virus NS3 RNA helicase. therapeutic application,unassigned 1,0 3.6.1.15 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11369873&form=6&db=m Humoral and CD4(+) T helper (Th) cell responses to the hepatitis C virus non-structural 3 (NS3) protein: NS3 primes Th1-like responses more effectively as a DNA-based immunogen than as a recombinant protein. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,2,0 3.6.1.15 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11472230&form=6&db=m Of minibody, camel and bacteriophage. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0 3.6.1.15 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11579226&form=6&db=m Design, high-level expression, purification and characterization of soluble fragments of the hepatitis C virus NS3 RNA helicase suitable for NMR-based drug discovery methods and mechanistic studies. ongoing research,therapeutic application,unassigned 4,2,0 3.6.1.15 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11697897&form=6&db=m Hepatitis C virus NS3 NTPase/helicase: different stereoselectivity in nucleoside triphosphate utilisation suggests that NTPase and helicase activities are coupled by a nucleotide-dependent rate limiting step. causal interaction,therapeutic application,unassigned 2,2,0 3.6.1.15 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11833782&form=6&db=m Inhibition of the helicase activity of HCV NTPase/helicase by 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide-5 '-triphosphate (ribavirin-TP). ongoing research,therapeutic application,unassigned 1,3,0 3.6.1.15 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11959550&form=6&db=m Characterization of imidazo[4,5-d]pyridazine nucleosides as modulators of unwinding reaction mediated by West Nile virus nucleoside triphosphatase/helicase: evidence for activity on the level of substrate and/or enzyme. ongoing research,therapeutic application,unassigned 2,1,0 3.6.1.15 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12206878&form=6&db=m Nucleotide triphosphatase/helicase of hepatitis C virus as a target for antiviral therapy. causal interaction,unassigned 4,0 3.6.1.15 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12694177&form=6&db=m Halogenated benzimidazoles and benzotriazoles as inhibitors of the NTPase/helicase activities of hepatitis C and related viruses. causal interaction,therapeutic application,unassigned 2,4,0 3.6.1.15 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14565459&form=6&db=m 5'-O-fluorosulfonylbenzoyl esters of purine nucleosides as potential inhibitors of NTPase/helicase and polymerase of Flaviviridae viruses. therapeutic application,unassigned 1,0 3.6.1.15 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15074713&form=6&db=m Synthesis and evaluation of ATP-binding site directed potential inhibitors of nucleoside triphosphatases/helicases and polymerases of hepatitis C and other selected Flaviviridae viruses. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0 3.6.1.15 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15178332&form=6&db=m Direct fluorometric measurement of hepatitis C virus helicase activity. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,2,2,3 3.6.1.15 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15247433&form=6&db=m Isolation of specific and high-affinity RNA aptamers against NS3 helicase domain of hepatitis C virus. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 3.6.1.15 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15303969&form=6&db=m Hepatitis C virus non-structural protein NS3 interacts with LMP7, a component of the immunoproteasome, and affects its proteasome activity. causal interaction,unassigned 1,0 3.6.1.15 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15466383&form=6&db=m Inhibition of hepatitis C virus nonstructural protein, helicase activity, and viral replication by a recombinant human antibody clone. causal interaction,ongoing research,therapeutic application,unassigned 2,4,3,0 3.6.1.15 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15651265&form=6&db=m Ectonucleotidase NTPDase2 is selectively down-regulated in biliary cirrhosis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.6.1.15 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15909930&form=6&db=m Inhibitors of the NTPase/helicases of hepatitis C and related Flaviviridae viruses. therapeutic application,unassigned 3,0 3.6.1.15 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16515039&form=6&db=m [Impact of the heterogenicity of amino acid sequence on the immunoreactivity of an antigenic epitopic complex localized within amino acids 1192-1456 of protein NS3 protein of hepatitis C virus] causal interaction,ongoing research,unassigned 1,4,0 3.6.1.15 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17447110&form=6&db=m Identification and characterization of the NTPase activity of classical swine fever virus (CSFV) nonstructural protein 3 (NS3) expressed in bacteria. diagnostic usage,ongoing research,unassigned 1,2,0 3.6.1.15 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18479669&form=6&db=m Viral NS3 helicase activity is inhibited by peptides reproducing the Arg-rich conserved motif of the enzyme (motif VI). ongoing research,unassigned 1,0 3.6.1.15 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18620531&form=6&db=m Hepatitis C virus helicase/NTPase: an efficient expression system and new inhibitors. diagnostic usage,therapeutic application,unassigned 1,3,0 3.6.1.15 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18723512&form=6&db=m Hepatitis C viral NS3-4A protease activity is enhanced by the NS3 helicase. causal interaction,therapeutic application,unassigned 4,1,0 3.6.1.15 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18774154&form=6&db=m In vivo attenuation of recombinant murine gammaherpesvirus 68 (MHV-68) is due to the expression and immunogenicity but not to the insertion of foreign sequences. ongoing research,therapeutic application,unassigned 4,2,0 3.6.1.15 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22578462&form=6&db=m Identification of myricetin and scutellarein as novel chemical inhibitors of the SARS coronavirus helicase, nsP13. ongoing research,therapeutic application,unassigned 3,1,0 3.6.1.15 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22888642&form=6&db=m [The combined application of nucleotide and amino acid sequences of NS3 hepatitis C virus protein, DNA encoding granulocyte macrophage colony-stimulating factor and inhibitor of regulatory T cells induces effective immune response against hepatitis C virus]. causal interaction,unassigned 1,0 3.6.1.15 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23893289&form=6&db=m The NTPase/helicase domain of hepatitis C virus nonstructural protein 3 inhibits protein kinase C independently of its NTPase activity. diagnostic usage,ongoing research,unassigned 1,2,0 3.6.1.15 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23894620&form=6&db=m Significance of monoclonal antibodies against the conserved epitopes within non-structural protein 3 helicase of hepatitis C virus. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,4 3.6.1.15 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26577923&form=6&db=m The hepatitis C virus protein NS3 suppresses TNF-?-stimulated activation of NF-?B by targeting LUBAC. causal interaction,therapeutic application,unassigned 1,1,0 3.6.1.15 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26776200&form=6&db=m BIOFILTER AS A FUNCTIONAL ANNOTATION PIPELINE FOR COMMON AND RARE COPY NUMBER BURDEN. causal interaction,therapeutic application,unassigned 3,1,0 3.6.1.15 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33080173&form=6&db=m Zika virus NS4A N-Terminal region (1-48) acts as a cofactor for inducing NTPase activity of NS3 helicase but not NS3 protease. therapeutic application,unassigned 1,0 3.6.1.15 Hepatitis E http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20071563&form=6&db=m NTPase and 5' to 3' RNA duplex-unwinding activities of the hepatitis E virus helicase domain. ongoing research,unassigned 2,0 3.6.1.15 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8380407&form=6&db=m The herpes simplex virus type I origin binding protein. DNA-dependent nucleoside triphosphatase activity. diagnostic usage,ongoing research,unassigned 1,3,0 3.6.1.15 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8612599&form=6&db=m The herpes simplex virus type 1 origin-binding protein carries out origin specific DNA unwinding and forms stem-loop structures. therapeutic application,unassigned 1,0 3.6.1.15 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9013584&form=6&db=m Interactions of a subassembly of the herpes simplex virus type 1 helicase-primase with DNA. unassigned - 3.6.1.15 HIV Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16344116&form=6&db=m HIV infection is associated with increased NTPDase activity that correlates with CD39-positive lymphocytes. causal interaction,unassigned 3,0 3.6.1.15 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31264746&form=6&db=m Differential regulation of Kidins220 isoforms in Huntington's disease. unassigned - 3.6.1.15 Hydrocephalus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28934391&form=6&db=m Homozygous KIDINS220 loss-of-function variants in fetuses with cerebral ventriculomegaly and limb contractures. causal interaction,unassigned 4,0 3.6.1.15 Hydrocephalus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34002021&form=6&db=m Kidins220 deficiency causes ventriculomegaly via SNX27-retromer-dependent AQP4 degradation. causal interaction,unassigned 3,0 3.6.1.15 Hydrocephalus, Normal Pressure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34002021&form=6&db=m Kidins220 deficiency causes ventriculomegaly via SNX27-retromer-dependent AQP4 degradation. causal interaction,unassigned 3,0 3.6.1.15 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17401661&form=6&db=m NTPDase and 5'-nucleotidase activities of synaptosomes from hippocampus of rats subjected to hyperargininemia. ongoing research,unassigned 3,0 3.6.1.15 Hypercholesterolemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8913886&form=6&db=m Nuclear cholesterol content and nucleoside triphosphatase activity are altered in the JCR:LA-cp corpulent rat. ongoing research,unassigned 3,0 3.6.1.15 Hypercholesterolemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28432556&form=6&db=m Enzymes that hydrolyze adenine nucleotides in a model of hypercholesterolemia induced by Triton WR-1339: protective effects of ?-caryophyllene. ongoing research,unassigned 3,0 3.6.1.15 Hyperlipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8913886&form=6&db=m Nuclear cholesterol content and nucleoside triphosphatase activity are altered in the JCR:LA-cp corpulent rat. ongoing research,unassigned 3,0 3.6.1.15 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12757773&form=6&db=m Enzymes that hydrolyze adenine nucleotides in diabetes and associated pathologies. causal interaction,therapeutic application,unassigned 4,1,0 3.6.1.15 Hyperthyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15811553&form=6&db=m Hypo-and hyperthyroidism affect the ATP, ADP and AMP hydrolysis in rat hippocampal and cortical slices. causal interaction,unassigned 1,0 3.6.1.15 Hypertriglyceridemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8913886&form=6&db=m Nuclear cholesterol content and nucleoside triphosphatase activity are altered in the JCR:LA-cp corpulent rat. ongoing research,unassigned 3,0 3.6.1.15 Hypothyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15811553&form=6&db=m Hypo-and hyperthyroidism affect the ATP, ADP and AMP hydrolysis in rat hippocampal and cortical slices. causal interaction,unassigned 1,0 3.6.1.15 Hypothyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16978660&form=6&db=m Genomic-independent action of thyroid hormones on NTPDase activities in Sertoli cell cultures from congenital hypothyroid rats. unassigned - 3.6.1.15 Hypothyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26879755&form=6&db=m Hypothyroidism Enhanced Ectonucleotidases and Acetylcholinesterase Activities in Rat Synaptosomes can be Prevented by the Naturally Occurring Polyphenol Quercetin. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,4,0 3.6.1.15 Hypothyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27832996&form=6&db=m Quercetin changes purinergic enzyme activities and oxidative profile in platelets of rats with hypothyroidism. ongoing research,unassigned 4,0 3.6.1.15 hypoxanthine phosphoribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15935074&form=6&db=m Altered membrane NTPase activity in Lesch-Nyhan disease fibroblasts: comparison with HPRT knockout mice and HPRT-deficient cell lines. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 3.6.1.15 hypoxanthine phosphoribosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17459584&form=6&db=m Complex changes in ecto-nucleoside 5'-triphosphate diphosphohydrolase expression in hypoxanthine phosphoribosyl transferase deficiency. causal interaction,ongoing research,unassigned 4,3,0 3.6.1.15 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9548978&form=6&db=m Cell-to-cell and phloem-mediated transport of potato virus X. The role of virions causal interaction,unassigned 3,0 3.6.1.15 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10733939&form=6&db=m CD39 modulates IL-1 release from activated endothelial cells. ongoing research,therapeutic application,unassigned 1,1,0 3.6.1.15 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12297660&form=6&db=m Expression of Amino-Terminal Portions or Full-Length Viral Replicase Genes in Transgenic Plants Confers Resistance to Potato Virus X Infection. diagnostic usage,ongoing research,unassigned 3,2,0 3.6.1.15 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16453840&form=6&db=m Analysis of the mechanism of protection in transgenic plants expressing the potato virus X coat protein or its antisense RNA. causal interaction,therapeutic application,unassigned 3,4,0 3.6.1.15 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16528051&form=6&db=m Tobacco mosaic virus (TMV) and potato virus X (PVX) coat proteins confer heterologous interference to PVX and TMV infection, respectively. unassigned - 3.6.1.15 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18337253&form=6&db=m Enzymatic properties of an ecto-nucleoside triphosphate diphosphohydrolase from Legionella pneumophila: substrate specificity and requirement for virulence. ongoing research,therapeutic application,unassigned 3,1,0 3.6.1.15 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19153641&form=6&db=m Genome segment reassortment identifies non-structural protein NS3 as a key protein in African horsesickness virus release and alteration of membrane permeability. ongoing research,therapeutic application,unassigned 4,1,0 3.6.1.15 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22216925&form=6&db=m NTPDase activity in lymphocytes of rats infected by Trypanosoma evansi. causal interaction,unassigned 3,0 3.6.1.15 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24407286&form=6&db=m Functional cross-talk between distant domains of chikungunya virus non-structural protein 2 is decisive for its RNA-modulating activity. therapeutic application,unassigned 3,0 3.6.1.15 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26577923&form=6&db=m The hepatitis C virus protein NS3 suppresses TNF-?-stimulated activation of NF-?B by targeting LUBAC. causal interaction,therapeutic application,unassigned 1,1,0 3.6.1.15 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26911648&form=6&db=m Ectonucleotidases and adenosine deaminase activity in laying hens naturally infected by Salmonella Gallinarum and their effects on the pathogenesis of the disease. causal interaction,unassigned 4,0 3.6.1.15 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26928238&form=6&db=m Seric and hepatic NTPDase and 5' nucleotidase activities of rats experimentally infected by Fasciola hepatica. causal interaction,ongoing research,unassigned 1,1,0 3.6.1.15 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26945560&form=6&db=m Influence of experimental Anaplasma marginale infection and splenectomy on NTPDase and 5'nucleotidase activities in platelets of cattle. ongoing research,unassigned 1,0 3.6.1.15 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28070446&form=6&db=m Immobilization of NTPDase-1 from Trypanosoma cruzi and Development of an Online Label-Free Assay. causal interaction,therapeutic application,unassigned 3,3,0 3.6.1.15 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28466032&form=6&db=m Identification of new potent inhibitors of dengue virus NS3 protease from traditional Chinese medicine database. causal interaction,therapeutic application,unassigned 3,4,0 3.6.1.15 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28546114&form=6&db=m Melaleuca alternifolia essential oil prevents alterations to purinergic enzymes and ameliorates the innate immune response in silver catfish infected with Aeromonas hydrophila. causal interaction,ongoing research,unassigned 1,2,0 3.6.1.15 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28710007&form=6&db=m Toxoplasmosis treatment with diphenyl diselenide in infected mice modulates the activity of purinergic enzymes and reduces inflammation in spleen. diagnostic usage,unassigned 3,0 3.6.1.15 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30567986&form=6&db=m Koala and wombat gammaherpesviruses encode the first known viral nucleoside triphosphate diphosphohydrolase (NTPDase) homologs and are phylogenetically divergent from all known gammaherpesviruses. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 3.6.1.15 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30578035&form=6&db=m N-Naphthoyl-substituted indole thio-barbituric acid analogs inhibit the helicase activity of the hepatitis C virus NS3. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 3.6.1.15 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31247308&form=6&db=m Curcumin pre-treatment modulate the activities of adenine nucleotide and nucleoside degradation enzymes in lymphocyte of rats infected with Trypanosoma evansi. ongoing research,unassigned 4,0 3.6.1.15 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31604153&form=6&db=m Impacts of Escherichia coli infection in young breeder chicks on the animal behavior and cerebral activity of purinergic and cholinergic enzymes involved in the regulation of molecules with neurotransmitter and neuromodulator function. diagnostic usage,ongoing research,unassigned 4,2,0 3.6.1.15 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32677001&form=6&db=m Neuroprotective role of resveratrol mediated by purinergic signalling in cerebral cortex of mice infected by Toxoplasma gondii. ongoing research,unassigned 4,0 3.6.1.15 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33351712&form=6&db=m Generation and Characterization of Monoclonal Antibody Against Porcine Epidemic Diarrhea Virus Nonstructural Protein 13. ongoing research,unassigned 3,0 3.6.1.15 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33658345&form=6&db=m The reovirus ?2 C-terminal loop inversely regulates NTPase and transcription functions versus binding to factory-forming ?NS and promotes replication in tumorigenic cells. therapeutic application,unassigned 4,0 3.6.1.15 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=100009410&form=6&db=m NTPDase Specific Inhibitors Suppress Rice Infection by Magnaporthe oryzae causal interaction,therapeutic application,unassigned 2,3,0 3.6.1.15 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=100202013&form=6&db=m Expression of the PVY(O) coat protein (CP) under the control of the PVX CP gene leader sequence: protection under greenhouse and field conditions against PVT(O) and PVY(N) infection in three potato cultivars. ongoing research,therapeutic application,unassigned 1,1,0 3.6.1.15 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22049093&form=6&db=m Immunogenic compositions assembled from tobacco mosaic virus-generated spherical particle platforms and foreign antigens. ongoing research,therapeutic application,unassigned 3,2,0 3.6.1.15 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26038410&form=6&db=m Adaptive mutation in influenza A virus non-structural gene is linked to host switching and induces a novel protein by alternative splicing. ongoing research,therapeutic application,unassigned 1,1,0 3.6.1.15 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28934391&form=6&db=m Homozygous KIDINS220 loss-of-function variants in fetuses with cerebral ventriculomegaly and limb contractures. causal interaction,unassigned 4,0 3.6.1.15 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31577543&form=6&db=m Atypical, milder presentation in a child with CC2D2A and KIDINS220 variants. causal interaction,diagnostic usage,unassigned 3,1,0 3.6.1.15 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31630374&form=6&db=m Genetic and Clinical Profile of Chinese Patients with Autosomal Dominant Spastic Paraplegia. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 3.6.1.15 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32909676&form=6&db=m Prenatal delineation of a distinct lethal fetal syndrome caused by a homozygous truncating KIDINS220 variant. causal interaction,unassigned 3,0 3.6.1.15 Joint Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1851409&form=6&db=m Synovial fluid pyrophosphate and nucleoside triphosphate pyrophosphatase: comparison between normal and diseased and between inflamed and non-inflamed joints. diagnostic usage,ongoing research,unassigned 1,3,0 3.6.1.15 Kidney Failure, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16019192&form=6&db=m Enzymes that hydrolyze adenine nucleotides in chronic renal failure: relationship between hemostatic defects and renal failure severity. diagnostic usage,unassigned 1,0 3.6.1.15 Leishmaniasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26638034&form=6&db=m Label-free assay based on immobilized capillary enzyme reactor of Leishmania infantum nucleoside triphosphate diphosphohydrolase (LicNTPDase-2-ICER-LC/UV). therapeutic application,unassigned 4,0 3.6.1.15 Leishmaniasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29384228&form=6&db=m NTPDase activities: possible roles on Leishmania spp infectivity and virulence. unassigned - 3.6.1.15 Leishmaniasis, Visceral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22995148&form=6&db=m An antigenic domain within a catalytically active Leishmania infantum nucleoside triphosphate diphosphohydrolase (NTPDase 1) is a target of inhibitory antibodies. ongoing research,unassigned 3,0 3.6.1.15 Leishmaniasis, Visceral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31303201&form=6&db=m Leishmania infantum nucleoside triphosphate diphosphohydrolase 1 (NTPDase 1) B-domain: Antibody antiproliferative effect on the promastigotes and IgG subclass responses in canine visceral leishmaniasis. ongoing research,therapeutic application,unassigned 3,1,0 3.6.1.15 Lesch-Nyhan Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15935074&form=6&db=m Altered membrane NTPase activity in Lesch-Nyhan disease fibroblasts: comparison with HPRT knockout mice and HPRT-deficient cell lines. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 3.6.1.15 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32825435&form=6&db=m Ecto-Nucleotide Triphosphate Diphosphohydrolase-2 (NTPDase2) Deletion Increases Acetaminophen-Induced Hepatotoxicity. causal interaction,therapeutic application,unassigned 3,2,0 3.6.1.15 Liver Cirrhosis, Biliary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15651265&form=6&db=m Ectonucleotidase NTPDase2 is selectively down-regulated in biliary cirrhosis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.6.1.15 Liver Cirrhosis, Biliary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18202114&form=6&db=m IL-6 downregulates transcription of NTPDase2 via specific promoter elements. unassigned - 3.6.1.15 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15651265&form=6&db=m Ectonucleotidase NTPDase2 is selectively down-regulated in biliary cirrhosis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.6.1.15 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22038661&form=6&db=m Overexpression of NTPDase2 in gliomas promotes systemic inflammation and pulmonary injury. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,2 3.6.1.15 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22244962&form=6&db=m Lung cancer alters the hydrolysis of nucleotides and nucleosides in platelets. diagnostic usage,ongoing research,unassigned 2,4,0 3.6.1.15 Lupus Erythematosus, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30803848&form=6&db=m ATP signaling and NTPDase in Systemic Lupus Erythematosus (SLE). unassigned - 3.6.1.15 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2565812&form=6&db=m Energy requirement and kinetics of transport of poly(A)-free histone mRNA compared to poly(A)-rich mRNA from isolated L-cell nuclei. unassigned - 3.6.1.15 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30700216&form=6&db=m Functional genetic evaluation of DNA house-cleaning enzymes in the malaria parasite: dUTPase and Ap4AH are essential in Plasmodium berghei but ITPase and NDH are dispensable. causal interaction,ongoing research,therapeutic application,unassigned 2,1,4,0 3.6.1.15 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6098441&form=6&db=m Purification and properties of a nucleoside triphosphatase from Sinclair swine. ongoing research,unassigned 3,0 3.6.1.15 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6116538&form=6&db=m Isolation and characterization of plasma membranes from transplantable human astrocytoma, oat cell carcinoma, and melanomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,1,1 3.6.1.15 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6330211&form=6&db=m Effect of dexamethasone on nuclear envelope nucleoside triphosphatase in fibroblasts 3T3 and melanoma cells MMLI. ongoing research,unassigned 4,0 3.6.1.15 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21343931&form=6&db=m Upregulated ankyrin repeat-rich membrane spanning protein contributes to tumour progression in cutaneous melanoma. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0 3.6.1.15 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30548323&form=6&db=m 1?, 25-Dihydroxyvitamin D3 alters ectonucleotidase expression and activity in human cutaneous melanoma cells. ongoing research,unassigned 4,0 3.6.1.15 Memory Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27400424&form=6&db=m Memory deficit, toxic effects and activity of Na(+), K(+)-ATPase and NTPDase in brain of Wistar rats submitted to orally treatment with alpha-terpinene. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0 3.6.1.15 Mouth Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16644283&form=6&db=m Expression of tuberculosis antigen ESAT-6 in Nicotiana tabacum using a potato virus X-based vector. therapeutic application,unassigned 1,0 3.6.1.15 Mouth Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24243237&form=6&db=m Genetic engineering and chemical conjugation of potato virus X. unassigned - 3.6.1.15 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19914228&form=6&db=m The activity and expression of NTPDase is altered in lymphocytes of multiple sclerosis patients. causal interaction,diagnostic usage,unassigned 3,3,0 3.6.1.15 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12649347&form=6&db=m Metabolic control of excessive extracellular nucleotide accumulation by CD39/ecto-nucleotidase-1: implications for ischemic vascular diseases. causal interaction,therapeutic application,unassigned 1,3,0 3.6.1.15 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31069159&form=6&db=m The role of NK cells and CD39 in the immunological control of tumor metastases. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,3,0 3.6.1.15 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33955519&form=6&db=m Reduced kinase D?interacting substrate of 220 kDa (Kidins220) in pancreatic cancer promotes EGFR/ERK signalling and disease progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.6.1.15 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=192642&form=6&db=m Hydrolysis of nucleoside triphosphate in plasma membranes of the hepatocytes of normal, regenerating and foetal livers and in cancer cells of hepatomas. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 3.6.1.15 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2413344&form=6&db=m Nucleocytoplasmic RNA transport. causal interaction,unassigned 3,0 3.6.1.15 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2895607&form=6&db=m Functional dissection of nuclear envelope mRNA translocation system: effects of phorbol ester and a monoclonal antibody recognizing cytoskeletal structures. diagnostic usage,unassigned 3,0 3.6.1.15 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4345987&form=6&db=m Nucleoside triphosphatase activity in induced mammary tumours in rats. causal interaction,unassigned 1,0 3.6.1.15 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6098441&form=6&db=m Purification and properties of a nucleoside triphosphatase from Sinclair swine. ongoing research,unassigned 3,0 3.6.1.15 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6291940&form=6&db=m An RNA-dependent nucleoside triphosphate hydrolase from Krebs-II ascites tumor cells. Detection and preliminary characterization. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 3.6.1.15 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6301157&form=6&db=m [Effect of antiestrogen and antiandrogen derivatives of acylhydrazines on properties of nucleoside triphosphatases and adenyl nucleotide content of nuclei of normal and tumor cells] causal interaction,therapeutic application,unassigned 1,1,0 3.6.1.15 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11897808&form=6&db=m Localization of NTPDase1/CD39 in normal and transformed human pancreas. causal interaction,unassigned 4,0 3.6.1.15 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16691503&form=6&db=m Increased expression of peripheral benzodiazepine receptor (PBR) in dimethylbenz[a]anthracene-induced mammary tumors in rats. causal interaction,unassigned 4,0 3.6.1.15 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17574764&form=6&db=m NTPDase and 5' ecto-nucleotidase expression profiles and the pattern of extracellular ATP metabolism in the Walker 256 tumor. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 3.6.1.15 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18630897&form=6&db=m Selective nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) inhibitors: nucleotide mimetics derived from uridine-5'-carboxamide. causal interaction,therapeutic application,unassigned 4,4,0 3.6.1.15 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19519914&form=6&db=m On the cytotoxicity of HCR-NTPase in the neuroblastoma cell line SH-SY5Y. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 3.6.1.15 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19558578&form=6&db=m Selective NTPDase2 expression modulates in vivo rat glioma growth. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 3.6.1.15 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20347573&form=6&db=m Nucleotide degrading enzymes in platelets from uterine cervical neoplasia patients treated with conization or radiotherapy. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,2,0 3.6.1.15 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20546740&form=6&db=m CD39/ENTPD1 expression by CD4+Foxp3+ regulatory T cells promotes hepatic metastatic tumor growth in mice. causal interaction,therapeutic application,unassigned 2,1,0 3.6.1.15 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21343931&form=6&db=m Upregulated ankyrin repeat-rich membrane spanning protein contributes to tumour progression in cutaneous melanoma. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0 3.6.1.15 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21390184&form=6&db=m Vascular CD39/ENTPD1 Directly Promotes Tumor Cell Growth by Scavenging Extracellular Adenosine Triphosphate. ongoing research,unassigned 4,0 3.6.1.15 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22038661&form=6&db=m Overexpression of NTPDase2 in gliomas promotes systemic inflammation and pulmonary injury. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,2 3.6.1.15 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23333500&form=6&db=m Kidins220/ARMS depletion is associated with the neural-to Schwann-like transition in a human neuroblastoma cell line model. causal interaction,ongoing research,unassigned 3,2,0 3.6.1.15 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23425137&form=6&db=m 8-BuS-ATP derivatives as specific NTPDase1 inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 3.6.1.15 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24972256&form=6&db=m 2-hexylthio-?,?-CH2-ATP is an effective and selective NTPDase2 inhibitor. causal interaction,therapeutic application,unassigned 4,3,0 3.6.1.15 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26577923&form=6&db=m The hepatitis C virus protein NS3 suppresses TNF-?-stimulated activation of NF-?B by targeting LUBAC. causal interaction,therapeutic application,unassigned 1,1,0 3.6.1.15 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28849114&form=6&db=m Kidins220 and tumour development: Insights into a complexity of cross-talk among signalling pathways (Review). causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0 3.6.1.15 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29181864&form=6&db=m Functions of the multi-interacting protein KIDINS220/ARMS in cancer and other pathologies. causal interaction,unassigned 3,0 3.6.1.15 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30452268&form=6&db=m Co-delivery of miR-4638-5p and docetaxel based on redox-sensitive polypeptide micelles as an improved strategy for the treatment of castration-resistant prostate cancer. ongoing research,therapeutic application,unassigned 2,1,0 3.6.1.15 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31069159&form=6&db=m The role of NK cells and CD39 in the immunological control of tumor metastases. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,3,0 3.6.1.15 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31511648&form=6&db=m The Epstein-Barr virus nuclear antigen-1 upregulates the cellular antioxidant defense to enable B-cell growth transformation and immortalization. causal interaction,unassigned 1,0 3.6.1.15 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31955347&form=6&db=m Imatinib mesylate affects extracellular ATP catabolism and expression of NTPDases in a chronic myeloid leukemia cell line. ongoing research,unassigned 3,0 3.6.1.15 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32973513&form=6&db=m Development of Anthraquinone Derivatives as Ectonucleoside Triphosphate Diphosphohydrolase (NTPDase) Inhibitors With Selectivity for NTPDase2 and NTPDase3. causal interaction,therapeutic application,unassigned 4,4,0 3.6.1.15 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33238630&form=6&db=m Radiolabeled 6-(2, 3-Dichlorophenyl)-N4-methylpyrimidine-2, 4-diamine (TH287): A Potential Radiotracer for Measuring and Imaging MTH1. therapeutic application,unassigned 2,0 3.6.1.15 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33658345&form=6&db=m The reovirus ?2 C-terminal loop inversely regulates NTPase and transcription functions versus binding to factory-forming ?NS and promotes replication in tumorigenic cells. therapeutic application,unassigned 4,0 3.6.1.15 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33922226&form=6&db=m Characterization of the Endometrial MSC Marker Ectonucleoside Triphosphate Diphosphohydrolase-2 (NTPDase2/CD39L1) in Low- and High-Grade Endometrial Carcinomas: Loss of Stromal Expression in the Invasive Phenotypes. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.6.1.15 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33955519&form=6&db=m Reduced kinase D?interacting substrate of 220 kDa (Kidins220) in pancreatic cancer promotes EGFR/ERK signalling and disease progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.6.1.15 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4279724&form=6&db=m Nucleoside triphosphatase activity at the external surface of neuroblastoma cells. ongoing research,unassigned 3,0 3.6.1.15 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17459584&form=6&db=m Complex changes in ecto-nucleoside 5'-triphosphate diphosphohydrolase expression in hypoxanthine phosphoribosyl transferase deficiency. causal interaction,ongoing research,unassigned 4,3,0 3.6.1.15 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19519914&form=6&db=m On the cytotoxicity of HCR-NTPase in the neuroblastoma cell line SH-SY5Y. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 3.6.1.15 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23118350&form=6&db=m Kidins220 accumulates with tau in human Alzheimer's disease and related models: modulation of its calpain-processing by GSK3?/PP1 imbalance. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.6.1.15 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27013979&form=6&db=m Stepping Out of the Shade: Control of Neuronal Activity by the Scaffold Protein Kidins220/ARMS. causal interaction,unassigned 2,0 3.6.1.15 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32973513&form=6&db=m Development of Anthraquinone Derivatives as Ectonucleoside Triphosphate Diphosphohydrolase (NTPDase) Inhibitors With Selectivity for NTPDase2 and NTPDase3. causal interaction,therapeutic application,unassigned 4,4,0 3.6.1.15 Neurofibroma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1280127&form=6&db=m The neurofibromatosis 1 gene transcripts expressed in peripheral nerve and neurofibromas bear the additional exon located in the GAP domain. causal interaction,unassigned 4,0 3.6.1.15 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23990338&form=6&db=m Expression of Ecto-Nucleoside Triphosphate Diphosphohydrolase1-3 (NTPDase1-3) by Cortical Astrocytes After Exposure to Pro-inflammatory Factors In Vitro. causal interaction,unassigned 3,0 3.6.1.15 nucleoside-triphosphate phosphatase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34002021&form=6&db=m Kidins220 deficiency causes ventriculomegaly via SNX27-retromer-dependent AQP4 degradation. causal interaction,unassigned 3,0 3.6.1.15 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28934391&form=6&db=m Homozygous KIDINS220 loss-of-function variants in fetuses with cerebral ventriculomegaly and limb contractures. causal interaction,unassigned 4,0 3.6.1.15 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29667355&form=6&db=m Heterozygous KIDINS220 mutation leads to spastic paraplegia and obesity in an Asian girl. causal interaction,unassigned 2,0 3.6.1.15 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30192062&form=6&db=m Heterozygous KIDINS220 mutation leads to spastic paraplegia and obesity in an Asian girl. causal interaction,unassigned 2,0 3.6.1.15 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31577543&form=6&db=m Atypical, milder presentation in a child with CC2D2A and KIDINS220 variants. causal interaction,diagnostic usage,unassigned 3,1,0 3.6.1.15 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31630374&form=6&db=m Genetic and Clinical Profile of Chinese Patients with Autosomal Dominant Spastic Paraplegia. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 3.6.1.15 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32909676&form=6&db=m Prenatal delineation of a distinct lethal fetal syndrome caused by a homozygous truncating KIDINS220 variant. causal interaction,unassigned 3,0 3.6.1.15 Oligospermia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16931801&form=6&db=m Mutations in the testis-specific NALP14 gene in men suffering from spermatogenic failure. causal interaction,ongoing research,unassigned 2,3,0 3.6.1.15 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1851409&form=6&db=m Synovial fluid pyrophosphate and nucleoside triphosphate pyrophosphatase: comparison between normal and diseased and between inflamed and non-inflamed joints. diagnostic usage,ongoing research,unassigned 1,3,0 3.6.1.15 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33955519&form=6&db=m Reduced kinase D?interacting substrate of 220 kDa (Kidins220) in pancreatic cancer promotes EGFR/ERK signalling and disease progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.6.1.15 Paraplegia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28934391&form=6&db=m Homozygous KIDINS220 loss-of-function variants in fetuses with cerebral ventriculomegaly and limb contractures. causal interaction,unassigned 4,0 3.6.1.15 Paraplegia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29667355&form=6&db=m Heterozygous KIDINS220 mutation leads to spastic paraplegia and obesity in an Asian girl. causal interaction,unassigned 2,0 3.6.1.15 Paraplegia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30192062&form=6&db=m Heterozygous KIDINS220 mutation leads to spastic paraplegia and obesity in an Asian girl. causal interaction,unassigned 2,0 3.6.1.15 Paraplegia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31577543&form=6&db=m Atypical, milder presentation in a child with CC2D2A and KIDINS220 variants. causal interaction,diagnostic usage,unassigned 3,1,0 3.6.1.15 Paraplegia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31630374&form=6&db=m Genetic and Clinical Profile of Chinese Patients with Autosomal Dominant Spastic Paraplegia. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 3.6.1.15 Paraplegia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32909676&form=6&db=m Prenatal delineation of a distinct lethal fetal syndrome caused by a homozygous truncating KIDINS220 variant. causal interaction,unassigned 3,0 3.6.1.15 Parasitemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21426906&form=6&db=m Trypanosoma evansi: Activities of adenine nucleotide degradation enzymes in cerebral cortex of infected rats. causal interaction,unassigned 3,0 3.6.1.15 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16273081&form=6&db=m MTH1, an oxidized purine nucleoside triphosphatase, protects the dopamine neurons from oxidative damage in nucleic acids caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. causal interaction,unassigned 3,0 3.6.1.15 Periodontal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24863659&form=6&db=m Periodontal disease and high doses of inhaled corticosteroids alter NTPDase activity in the blood serum of rats. diagnostic usage,unassigned 1,0 3.6.1.15 Polycystic Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15381417&form=6&db=m STAND, a class of P-loop NTPases including animal and plant regulators of programmed cell death: multiple, complex domain architectures, unusual phyletic patterns, and evolution by horizontal gene transfer. unassigned - 3.6.1.15 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27329728&form=6&db=m MiR-4638-5p inhibits castration resistance of prostate cancer through repressing Kidins220 expression and PI3K/AKT pathway activity. diagnostic usage,therapeutic application,unassigned 1,1,0 3.6.1.15 Pythiosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20970953&form=6&db=m Immunotherapy for pythiosis: Effect on NTPDase activity in lymphocytes of an experimental model. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,3,0 3.6.1.15 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11014639&form=6&db=m Recombinant adenoviral mediated CD39 gene transfer prolongs cardiac xenograft survival. unassigned - 3.6.1.15 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21656186&form=6&db=m Liver damage and systemic inflammatory responses are exacerbated by the genetic deletion of CD39 in total hepatic ischemia. ongoing research,therapeutic application,unassigned 4,2,0 3.6.1.15 Retinal Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23964074&form=6&db=m Lysosomal alkalinization, lipid oxidation, and reduced phagosome clearance triggered by activation of the P2X7 receptor. ongoing research,unassigned 3,0 3.6.1.15 Rubella http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8599224&form=6&db=m Identification of an RNA-stimulated NTPase in the predicted helicase sequence of the Rubella virus nonstructural polyprotein. ongoing research,unassigned 1,0 3.6.1.15 Rubella http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22049093&form=6&db=m Immunogenic compositions assembled from tobacco mosaic virus-generated spherical particle platforms and foreign antigens. ongoing research,therapeutic application,unassigned 3,2,0 3.6.1.15 Salmonella Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26911648&form=6&db=m Ectonucleotidases and adenosine deaminase activity in laying hens naturally infected by Salmonella Gallinarum and their effects on the pathogenesis of the disease. causal interaction,unassigned 4,0 3.6.1.15 Schistosomiasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28857186&form=6&db=m Anti-schistosome antibodies change NTPDase 1 activity from macrophages. therapeutic application,unassigned 3,0 3.6.1.15 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15464860&form=6&db=m Biochemical brain markers and purinergic parameters in rat CSF after seizure induced by pentylenetetrazol. causal interaction,diagnostic usage,unassigned 1,2,0 3.6.1.15 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26907925&form=6&db=m A genetic context for the study of audiogenic seizures. unassigned - 3.6.1.15 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22645477&form=6&db=m Increased NTPDase activity in lymphocytes during experimental sepsis. ongoing research,unassigned 4,0 3.6.1.15 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30730441&form=6&db=m Targeting CD39 Toward Activated Platelets Reduces Systemic Inflammation and Improves Survival in Sepsis: A Preclinical Pilot Study. therapeutic application,unassigned 4,0 3.6.1.15 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12917423&form=6&db=m The severe acute respiratory syndrome (SARS) coronavirus NTPase/helicase belongs to a distinct class of 5' to 3' viral helicases. causal interaction,unassigned 3,0 3.6.1.15 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18082623&form=6&db=m Isolation of inhibitory RNA aptamers against severe acute respiratory syndrome (SARS) coronavirus NTPase/Helicase. therapeutic application,unassigned 1,0 3.6.1.15 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19031435&form=6&db=m Differential inhibitory activities and stabilisation of DNA aptamers against the SARS coronavirus helicase. causal interaction,unassigned 2,0 3.6.1.15 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19625187&form=6&db=m Investigation of the pharmacophore space of Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) NTPase/helicase by dihydroxychromone derivatives. unassigned - 3.6.1.15 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27631026&form=6&db=m Biochemical Characterization of Middle East Respiratory Syndrome Coronavirus Helicase. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0 3.6.1.15 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31131400&form=6&db=m Delicate structural coordination of the Severe Acute Respiratory Syndrome coronavirus Nsp13 upon ATP hydrolysis. unassigned - 3.6.1.15 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31883088&form=6&db=m Deducing the Crystal Structure of MERS-CoV Helicase. ongoing research,unassigned 2,0 3.6.1.15 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32161317&form=6&db=m A high ATP concentration enhances the cooperative translocation of the SARS coronavirus helicase nsP13 in the unwinding of duplex RNA. causal interaction,unassigned 1,0 3.6.1.15 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33984520&form=6&db=m Plant-derived exosomal microRNAs inhibit lung inflammation induced by exosomes SARS-CoV-2 Nsp12. ongoing research,unassigned 4,0 3.6.1.15 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34092840&form=6&db=m Chemical constituents from coconut waste and their in silico evaluation as potential antiviral agents against SARS-CoV-2. ongoing research,therapeutic application,unassigned 2,1,0 3.6.1.15 Spasm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27005418&form=6&db=m Heterozygous KIDINS220/ARMS nonsense variants cause spastic paraplegia, intellectual disability, nystagmus, and obesity. unassigned - 3.6.1.15 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18353782&form=6&db=m Crystal structure of Escherichia coli MazG, the regulator of nutritional stress response. therapeutic application,unassigned 1,0 3.6.1.15 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18630897&form=6&db=m Selective nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) inhibitors: nucleotide mimetics derived from uridine-5'-carboxamide. causal interaction,therapeutic application,unassigned 4,4,0 3.6.1.15 Subacute Sclerosing Panencephalitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32251370&form=6&db=m SspABCD-SspE is a phosphorothioation-sensing bacterial defence system with broad anti-phage activities. therapeutic application,unassigned 1,0 3.6.1.15 Subacute Sclerosing Panencephalitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33906925&form=6&db=m SspABCD-SspFGH Constitutes a New Type of DNA Phosphorothioate-Based Bacterial Defense System. therapeutic application,unassigned 1,0 3.6.1.15 Thrombocytopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21273003&form=6&db=m Activities of adenine nucleotide and nucleoside degradation enzymes in platelets of rats infected by Trypanosoma evansi. unassigned - 3.6.1.15 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17557193&form=6&db=m NTPDase and 5'-nucleotidase activities in platelets of human pregnants with a normal or high risk for thrombosis. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,2,0 3.6.1.15 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21586363&form=6&db=m Ectonucleotidases as regulators of purinergic signaling in thrombosis, inflammation, and immunity. unassigned - 3.6.1.15 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23425137&form=6&db=m 8-BuS-ATP derivatives as specific NTPDase1 inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 3.6.1.15 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24972256&form=6&db=m 2-hexylthio-?,?-CH2-ATP is an effective and selective NTPDase2 inhibitor. causal interaction,therapeutic application,unassigned 4,3,0 3.6.1.15 Toxoplasmosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11227761&form=6&db=m Evaluation of serodiagnosis of toxoplasmosis by using the recombinant nucleoside triphosphate hydrolase isoforms expressed in Escherichia coli. diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,2,0 3.6.1.15 Toxoplasmosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11989532&form=6&db=m Kinetics of the nucleoside triphosphate hydrolase of Toxoplasma gondii in mice with acute and chronic toxoplasmosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 3.6.1.15 Toxoplasmosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12850206&form=6&db=m The relationship between nucleoside triphosphate hydrolase (NTPase) isoform and Toxoplasma strain virulence in rat and human toxoplasmosis. ongoing research,unassigned 3,0 3.6.1.15 Trichomonas Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25946243&form=6&db=m Iron from haemoglobin and haemin modulates nucleotide hydrolysis in Trichomonas vaginalis. unassigned - 3.6.1.15 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25229539&form=6&db=m Mycobacterium tuberculosis Rho is an NTPase with distinct kinetic properties and a novel RNA-binding subdomain. therapeutic application,unassigned 1,0 3.6.1.15 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1321883&form=6&db=m Vaccinia virus encodes four putative DNA and/or RNA helicases distantly related to each other. ongoing research,unassigned 1,0 3.6.1.15 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1850911&form=6&db=m DNA sequence of the nucleoside triphosphate phosphohydrolase I (NPH I) of the Choristoneura biennis entomopoxvirus. unassigned - 3.6.1.15 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2144016&form=6&db=m Protection of mice against yellow fever virus encephalitis by immunization with a vaccinia virus recombinant encoding the yellow fever virus non-structural proteins, NS1, NS2a and NS2b. ongoing research,unassigned 2,0 3.6.1.15 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2154883&form=6&db=m Identification of the point mutations in two vaccinia virus nucleoside triphosphate phosphohydrolase I temperature-sensitive mutants and role of this DNA-dependent ATPase enzyme in virus gene expression. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 3.6.1.15 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2437324&form=6&db=m Identification of the vaccinia virus gene encoding nucleoside triphosphate phosphohydrolase I, a DNA-dependent ATPase. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 3.6.1.15 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3025846&form=6&db=m Molecular cloning, encoding sequence, and expression of vaccinia virus nucleic acid-dependent nucleoside triphosphatase gene. ongoing research,unassigned 3,0 3.6.1.15 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3031483&form=6&db=m Sedimentation of an RNA polymerase complex from vaccinia virus that specifically initiates and terminates transcription. therapeutic application,unassigned 1,0 3.6.1.15 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7609038&form=6&db=m Mutational analysis of vaccinia virus nucleoside triphosphate phosphohydrolase II, a DExH box RNA helicase. ongoing research,unassigned 2,0 3.6.1.15 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7636979&form=6&db=m The vaccinia virus D5 protein, which is required for DNA replication, is a nucleic acid-independent nucleoside triphosphatase. causal interaction,unassigned 3,0 3.6.1.15 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8212591&form=6&db=m A mutation of the nucleoside triphosphate phosphohydrolase I (NPH-I) gene confers sensitivity of vaccinia virus to interferon. ongoing research,therapeutic application,unassigned 3,1,0 3.6.1.15 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8230476&form=6&db=m Vaccinia virus nucleoside triphosphate phosphohydrolase I controls early and late gene expression by regulating the rate of transcription. ongoing research,unassigned 4,0 3.6.1.15 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8266720&form=6&db=m Nucleotide sequence of a nucleoside triphosphate phosphohydrolase gene from African swine fever virus. ongoing research,unassigned 3,0 3.6.1.15 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8662635&form=6&db=m Domain structure of the vaccinia virus mRNA capping enzyme. Expression in Escherichia coli of a subdomain possessing the RNA 5'-triphosphatase and guanylyltransferase activities and a kinetic comparison to the full-size enzyme. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,2,0 3.6.1.15 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8970979&form=6&db=m Vaccinia virions lacking the RNA helicase nucleoside triphosphate phosphohydrolase II are defective in early transcription. unassigned - 3.6.1.15 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9573237&form=6&db=m The nucleoside triphosphatase and helicase activities of vaccinia virus NPH-II are essential for virus replication. diagnostic usage,therapeutic application,unassigned 3,1,0 3.6.1.15 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9636376&form=6&db=m Vaccinia virus nucleoside triphosphate phosphohydrolase I is an essential viral early gene transcription termination factor. ongoing research,therapeutic application,unassigned 2,1,0 3.6.1.15 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9811740&form=6&db=m RNA 5'-triphosphatase, nucleoside triphosphatase, and guanylyltransferase activities of baculovirus LEF-4 protein. diagnostic usage,unassigned 3,0 3.6.1.15 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9852075&form=6&db=m Yeast and viral RNA 5' triphosphatases comprise a new nucleoside triphosphatase family. causal interaction,unassigned 1,0 3.6.1.15 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9882335&form=6&db=m Mutational analysis of vaccinia virus nucleoside triphosphate phosphohydrolase I, a DNA-dependent ATPase of the DExH box family. diagnostic usage,unassigned 3,0 3.6.1.15 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10366585&form=6&db=m Histidine codons appended to the gene encoding the RPO22 subunit of vaccinia virus RNA polymerase facilitate the isolation and purification of functional enzyme and associated proteins from virus-infected cells. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,3,0 3.6.1.15 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10387052&form=6&db=m Interaction of the vaccinia virus nucleoside triphosphate phosphohydrolase I with linear oligonucleotides. therapeutic application,unassigned 2,0 3.6.1.15 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10833518&form=6&db=m Interaction between nucleoside triphosphate phosphohydrolase I and the H4L subunit of the viral RNA polymerase is required for vaccinia virus early gene transcript release. ongoing research,therapeutic application,unassigned 3,2,0 3.6.1.15 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11279216&form=6&db=m The viral RNA polymerase H4L subunit is required for Vaccinia virus early gene transcription termination. therapeutic application,unassigned 1,0 3.6.1.15 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12556520&form=6&db=m UUUUUNU oligonucleotide stimulation of vaccinia virus early gene transcription termination, in trans. unassigned - 3.6.1.15 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12788635&form=6&db=m Effect of selected mutations in the C-terminal region of the vaccinia virus nucleoside triphosphate phosphohydrolase I on binding to the H4L subunit of the viral RNA polymerase and early gene transcription termination in vitro. causal interaction,ongoing research,unassigned 1,2,0 3.6.1.15 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18433825&form=6&db=m Determinants of vaccinia virus early gene transcription termination. causal interaction,unassigned 1,0 3.6.1.15 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18455214&form=6&db=m Vaccinia virus early gene transcription termination factors VTF and Rap94 interact with the U9 termination motif in the nascent RNA in a transcription ternary complex. diagnostic usage,ongoing research,unassigned 3,1,0 3.6.1.15 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19007959&form=6&db=m Products and substrate/template usage of vaccinia virus DNA primase. therapeutic application,unassigned 1,0 3.6.1.15 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22069335&form=6&db=m Role of forward translocation in nucleoside triphosphate phosphohydrolase I (NPH I)-mediated transcription termination of vaccinia virus early genes. unassigned - 3.6.1.15 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26168720&form=6&db=m A carboxy terminal domain of the L protein of rinderpest virus possesses RNA triphosphatase activity - The first enzyme in the viral mRNA capping pathway. diagnostic usage,ongoing research,unassigned 3,2,0 3.6.1.15 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26280468&form=6&db=m The role of vaccinia termination factor and cis-acting elements in vaccinia virus early gene transcription termination. unassigned - 3.6.1.15 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27189950&form=6&db=m Nucleoside Triphosphate Phosphohydrolase I (NPH I) Functions as a 5' to 3' Translocase in Transcription Termination of Vaccinia Early Genes. diagnostic usage,unassigned 1,0 3.6.1.15 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12953115&form=6&db=m Phosphorylation of the potyvirus capsid protein by protein kinase CK2 and its relevance for virus infection. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0 3.6.1.15 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16038398&form=6&db=m Heterogeneity in extracellular nucleotide hydrolysis among clinical isolates of Trichomonas vaginalis. diagnostic usage,unassigned 1,0 3.6.1.15 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27516903&form=6&db=m Inhibition of RNA Helicases of ssRNA(+) Virus Belonging to Flaviviridae, Coronaviridae and Picornaviridae Families. therapeutic application,unassigned 4,0 3.6.1.15 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29800592&form=6&db=m Development of an infectious clone and replicon system of norovirus GII.4. ongoing research,unassigned 2,0 3.6.1.15 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30567986&form=6&db=m Koala and wombat gammaherpesviruses encode the first known viral nucleoside triphosphate diphosphohydrolase (NTPDase) homologs and are phylogenetically divergent from all known gammaherpesviruses. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 3.6.1.15 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34254564&form=6&db=m Emetine, a potent alkaloid for the treatment of SARS-CoV-2 targeting papain-like protease and non-structural proteins: pharmacokinetics, molecular docking and dynamic studies. unassigned - 3.6.1.15 Yellow Fever http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2144016&form=6&db=m Protection of mice against yellow fever virus encephalitis by immunization with a vaccinia virus recombinant encoding the yellow fever virus non-structural proteins, NS1, NS2a and NS2b. ongoing research,unassigned 2,0 3.6.1.15 Yellow Fever http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8380474&form=6&db=m RNA-stimulated NTPase activity associated with yellow fever virus NS3 protein expressed in bacteria. diagnostic usage,ongoing research,unassigned 1,3,0 3.6.1.15 Yellow Fever http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18442976&form=6&db=m The two-component NS2B-NS3 proteinase represses DNA unwinding activity of the West Nile virus NS3 helicase. unassigned -