3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10213160&form=6&db=m Insulin-degrading enzyme in the Alzheimer's disease brain: prominent localization in neurons and senile plaques. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10786709&form=6&db=m Degradation of soluble amyloid beta-peptides 1-40, 1-42, and the Dutch variant 1-40Q by insulin degrading enzyme from Alzheimer disease and control brains. unassigned - 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10833395&form=6&db=m Functional human insulin-degrading enzyme can be expressed in bacteria. causal interaction,unassigned 3,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11102481&form=6&db=m Insulysin hydrolyzes amyloid beta peptides to products that are neither neurotoxic nor deposit on amyloid plaques. therapeutic application,unassigned 4,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11125142&form=6&db=m Evidence for genetic linkage of Alzheimer's disease to chromosome 10q. causal interaction,unassigned 3,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11810277&form=6&db=m Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease. causal interaction,unassigned 4,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12161276&form=6&db=m Polymorphisms of insulin degrading enzyme gene are not associated with Alzheimer's disease. causal interaction,unassigned 4,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12507914&form=6&db=m Reduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's disease is associated with the apolipoprotein E-epsilon4 allele. causal interaction,unassigned 2,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12634421&form=6&db=m Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo. causal interaction,unassigned 4,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12732730&form=6&db=m Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo. causal interaction,unassigned 3,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12809979&form=6&db=m Insulin degrading enzyme (IDE) genetic variants and risk of Alzheimer's disease: evidence of effect modification by apolipoprotein E (APOE). causal interaction,diagnostic usage,unassigned 2,1,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12850277&form=6&db=m Non-covalent interaction of ubiquitin with insulin-degrading enzyme. causal interaction,unassigned 3,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14755451&form=6&db=m No association between the insulin degrading enzyme gene and Alzheimer's disease in a Japanese population. causal interaction,ongoing research,unassigned 1,2,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15088150&form=6&db=m Sequence variation in the proximity of IDE may impact age at onset of both Parkinson disease and Alzheimer disease. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15181249&form=6&db=m Insulin-degrading enzyme, apolipoprotein E, and Alzheimer's disease. causal interaction,unassigned 3,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15277615&form=6&db=m Insulin-degrading enzyme and Alzheimer disease: a genetic association study in the Han Chinese. causal interaction,unassigned 1,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15590928&form=6&db=m Insulin-degrading enzyme as a downstream target of insulin receptor signaling cascade: implications for Alzheimer's disease intervention. therapeutic application,unassigned 3,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15718037&form=6&db=m Sequence variants of IDE are associated with the extent of beta-amyloid deposition in the Alzheimer's disease brain. causal interaction,unassigned 3,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15800373&form=6&db=m Insulysin: an allosteric enzyme as a target for Alzheimer's disease. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15858813&form=6&db=m Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme. causal interaction,diagnostic usage,unassigned 1,2,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15858821&form=6&db=m Mutation screening of a haplotype block around the insulin degrading enzyme gene and association with Alzheimer's disease. causal interaction,unassigned 4,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16327352&form=6&db=m Insulin degrading enzyme and alpha-3 catenin polymorphisms in Italian patients with Alzheimer disease. diagnostic usage,unassigned 3,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16399206&form=6&db=m Insulin, insulin-degrading enzyme and amyloid-beta peptide in Alzheimer's disease: review and hypothesis. unassigned - 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16444902&form=6&db=m The role of insulin, insulin growth factor, and insulin-degrading enzyme in brain aging and Alzheimer's disease. causal interaction,ongoing research,unassigned 3,2,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16722821&form=6&db=m A common genetic system for functional studies of pitrilysin and related M16A proteases. causal interaction,unassigned 4,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16769157&form=6&db=m Insulin degrading enzyme activity selectively decreases in the hippocampal formation of cases at high risk to develop Alzheimer's disease. causal interaction,diagnostic usage,unassigned 4,4,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16876916&form=6&db=m Positive association between risk for late-onset Alzheimer disease and genetic variation in IDE. causal interaction,unassigned 4,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16894402&form=6&db=m Links between Alzheimer's disease and diabetes. causal interaction,unassigned 4,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16914266&form=6&db=m Lack of association of 5 SNPs in the vicinity of the insulin-degrading enzyme (IDE) gene with late-onset Alzheimer's disease. causal interaction,unassigned 3,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17021402&form=6&db=m Plaque-associated overexpression of insulin-degrading enzyme in the cerebral cortex of aged transgenic tg2576 mice with Alzheimer pathology. causal interaction,diagnostic usage,unassigned 1,1,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17066144&form=6&db=m Links between Alzheimer's disease and diabetes. causal interaction,unassigned 4,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17244626&form=6&db=m Decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease families. causal interaction,diagnostic usage,unassigned 3,1,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17496198&form=6&db=m Insulin-degrading enzyme is genetically associated with Alzheimer's disease in the Finnish population. causal interaction,unassigned 4,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17613531&form=6&db=m Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE. causal interaction,unassigned 3,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18411275&form=6&db=m The catalytic domain of insulin-degrading enzyme forms a denaturant-resistant complex with amyloid beta peptide: implications for Alzheimer disease pathogenesis. diagnostic usage,unassigned 3,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18996360&form=6&db=m Promoter polymorphisms which modulate insulin degrading enzyme expression may increase susceptibility to Alzheimer's disease. causal interaction,unassigned 4,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19073193&form=6&db=m Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity. causal interaction,unassigned 3,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19098445&form=6&db=m The irreversible binding of amyloid peptide substrates to insulin-degrading enzyme: a biological perspective. causal interaction,unassigned 2,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19117523&form=6&db=m Detergent resistant membrane-associated IDE in brain tissue and cultured cells: Relevance to Abeta and insulin degradation. causal interaction,unassigned 4,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19144176&form=6&db=m Insulin-degrading enzyme is exported via an unconventional protein secretion pathway. causal interaction,unassigned 4,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19383491&form=6&db=m PPARgamma transcriptionally regulates the expression of insulin-degrading enzyme in primary neurons. causal interaction,unassigned 4,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19384407&form=6&db=m Small-molecule activators of insulin-degrading enzyme discovered through high-throughput compound screening. causal interaction,unassigned 3,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19606063&form=6&db=m Neprilysin and insulin-degrading enzyme levels are increased in Alzheimer disease in relation to disease severity. causal interaction,diagnostic usage,unassigned 4,2,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19770104&form=6&db=m [Cerebral proteolysis of amiloid-b peptide: relevance of insulin-degrading enzyme in Alzheimer's disease] unassigned - 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19835587&form=6&db=m Development of monoclonal antibodies and quantitative ELISAs targeting insulin-degrading enzyme. unassigned - 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19864659&form=6&db=m Combined risk effects of IDE and NEP gene variants on Alzheimer disease. unassigned - 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19877269&form=6&db=m The metalloendopeptidase gene Pitrm1 is regulated by hedgehog signaling in the developing mouse limb and is expressed in muscle progenitors. causal interaction,unassigned 4,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19896952&form=6&db=m Molecular basis for the recognition and cleavages of IGF-II, TGF-alpha, and amylin by human insulin-degrading enzyme. causal interaction,unassigned 1,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20098734&form=6&db=m Concordant association of insulin degrading enzyme gene (IDE) variants with IDE mRNA, Abeta, and Alzheimer's disease. causal interaction,ongoing research,unassigned 4,2,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20493190&form=6&db=m Insulin-degrading enzyme antagonizes insulin-dependent tissue growth and Abeta-induced neurotoxicity in Drosophila. causal interaction,unassigned 4,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21185309&form=6&db=m Ubiquitin is a novel substrate for human insulin-degrading enzyme. causal interaction,unassigned 1,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21212741&form=6&db=m Physiological effects of manipulating the level of insulin-degrading enzyme in insulin-producing cells of Drosophila. unassigned - 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21274957&form=6&db=m Copper(I) and copper(II) inhibit A? peptides proteolysis by insulin-degrading enzyme differently: implications for metallostasis alteration in Alzheimer's disease. unassigned - 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21448434&form=6&db=m Redox regulation of insulin degradation by insulin-degrading enzyme. causal interaction,unassigned 1,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21731629&form=6&db=m Identification of the allosteric regulatory site of insulysin. causal interaction,unassigned 4,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21731745&form=6&db=m Multiple insulin degrading enzyme variants alter in vitro reporter gene expression. causal interaction,unassigned 4,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22355395&form=6&db=m Structure based discovery of small molecules to regulate the activity of human insulin degrading enzyme. causal interaction,unassigned 3,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22502914&form=6&db=m The association between two single nucleotide polymorphisms within the insulin-degrading enzyme gene and Alzheimer's disease in a Chinese Han population. ongoing research,unassigned 1,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23076436&form=6&db=m The Association Between Small Vessel Infarcts and the Activities of Amyloid-? Peptide Degrading Proteases in Apolipoprotein E4 AlleleCarriers. diagnostic usage,therapeutic application,unassigned 1,1,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23257117&form=6&db=m Insulin-degrading enzyme deficiency accelerates cerebrovascular amyloidosis in an animal model. causal interaction,unassigned 2,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23416320&form=6&db=m Meta-analysis of the insulin degrading enzyme polymorphisms and susceptibility to Alzheimer's disease. causal interaction,diagnostic usage,unassigned 4,4,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23437776&form=6&db=m Optimization of Peptide hydroxamate inhibitors of insulin-degrading enzyme reveals marked substrate-selectivity. causal interaction,unassigned 4,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23520555&form=6&db=m Ginsenoside Rg1 Decreases A?1-42 Level by Upregulating PPAR? and IDE Expression in the Hippocampus of a Rat Model of Alzheimer's Disease. ongoing research,unassigned 4,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23826334&form=6&db=m Deletion of the fission yeast homologue of human insulinase reveals a TORC1-dependent pathway mediating resistance to proteotoxic stress. causal interaction,unassigned 4,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24059320&form=6&db=m Insulin-Degrading Enzyme: A Link between Alzheimer's and Type 2 Diabetes Mellitus. causal interaction,ongoing research,unassigned 3,2,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24355596&form=6&db=m C allele of the rs2209972 single nucleotide polymorphism of the insulin degrading enzyme gene and Alzheimer's disease in type 2 diabetes, a case control study. ongoing research,unassigned 2,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24380312&form=6&db=m [Effect of tongluo xingnao effervescent tablet on learning and memory of AD rats and expression of insulin-degrading enzyme in hippocampus]. ongoing research,unassigned 2,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25100059&form=6&db=m Insulin-degrading enzyme inhibition, a novel therapy for type 2 diabetes? unassigned - 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25105907&form=6&db=m Association of insulin degrading enzyme gene polymorphisms with Alzheimer's disease: a meta-analysis. causal interaction,ongoing research,unassigned 4,1,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25120481&form=6&db=m Amylin and its analogs: a friend or foe for the treatment of Alzheimer's disease? unassigned - 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25414272&form=6&db=m Association Between Polymorphisms of the Insulin-Degrading Enzyme Gene and Late-Onset Alzheimer Disease. causal interaction,unassigned 4,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25539133&form=6&db=m QM/MM Simulations of Amyloid-? 42 Degradation by IDE in the Presence and Absence of ATP. therapeutic application,unassigned 3,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25597881&form=6&db=m Accumulation of BRI2-BRICHOS ectodomain correlates with a decreased clearance of A? by insulin degrading enzyme (IDE) in Alzheimer's disease. causal interaction,unassigned 3,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25714973&form=6&db=m Protective effect of Notoginsenoside R1 on an APP/PS1 mouse model of Alzheimer's disease by up-regulating insulin degrading enzyme and inhibiting A? accumulation. ongoing research,therapeutic application,unassigned 2,1,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26025789&form=6&db=m A neglected modulator of insulin-degrading enzyme activity and conformation: The pH. causal interaction,unassigned 2,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26228656&form=6&db=m Insulin-degrading enzyme prevents ?-synuclein fibril formation in a nonproteolytical manner. causal interaction,therapeutic application,unassigned 2,1,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26305888&form=6&db=m Cognitive and Disease-Modifying Effects of 11?-Hydroxysteroid Dehydrogenase Type 1 Inhibition in Male Tg2576 Mice, a Model of Alzheimer's Disease. causal interaction,therapeutic application,unassigned 1,3,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26444774&form=6&db=m Impact of Insulin Degrading Enzyme and Neprilysin in Alzheimer's Disease Biology: Characterization of Putative Cognates for Therapeutic Applications. therapeutic application,unassigned 1,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26520569&form=6&db=m Statins induce insulin-degrading enzyme secretion from astrocytes via an autophagy-based unconventional secretory pathway. causal interaction,unassigned 4,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26637123&form=6&db=m Enhanced Phospholipase A2 Group 3 Expression by Oxidative Stress Decreases the Insulin-Degrading Enzyme. ongoing research,unassigned 2,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26963025&form=6&db=m Insulin-degrading enzyme secretion from astrocytes is mediated by an autophagy-based unconventional secretory pathway in Alzheimer disease. unassigned - 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26968463&form=6&db=m Characterization of insulin-degrading enzyme-mediated cleavage of A? in distinct aggregation states. ongoing research,unassigned 1,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27320287&form=6&db=m Insulin-degrading enzyme: new therapeutic target for diabetes and Alzheimer's disease? causal interaction,unassigned 3,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27443962&form=6&db=m Identification and functional characterization of a putative IDE, C28F5.4 (ceIDE-1), in Caenorhabditis elegans: Implications for Alzheimer's disease. causal interaction,unassigned 2,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27982586&form=6&db=m Toward Allosterically Increased Catalytic Activity of Insulin-Degrading Enzyme against Amyloid Peptides. causal interaction,unassigned 1,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29132916&form=6&db=m Insulin-Degrading Enzyme in the Fight against Alzheimer's Disease. causal interaction,unassigned 3,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29222348&form=6&db=m Insulin degrading enzyme contributes to the pathology in a mixed model of Type 2 diabetes and Alzheimer's disease: possible mechanisms of IDE in T2D and AD. ongoing research,therapeutic application,unassigned 4,1,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29263141&form=6&db=m GLP-1 receptor regulates cell growth through regulating IDE expression level in A?1-42-treated PC12 cells. ongoing research,unassigned 3,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29357797&form=6&db=m Characteristics of Insulin-degrading Enzyme in Alzheimer's Disease: A Meta-analysis. causal interaction,ongoing research,unassigned 4,2,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29888573&form=6&db=m [Kidney-reinforcing and Governor Vessel-regulating EA Intervention May Improve Learningmemory Possibly by Suppressing Formation of Senile Plaques in Hippocampus in APP/PS 1 Double Transgenic Alzheimer's Disease Mice]. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30110883&form=6&db=m Chia Seed Does Not Improve Cognitive Impairment in SAMP8 Mice Fed with High Fat Diet. unassigned - 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30133282&form=6&db=m Catalytic Mechanism of Amyloid-? Peptide Degradation by Insulin Degrading Enzyme: Insights from Quantum Mechanics and Molecular Mechanics Style Møller-Plesset Second Order Perturbation Theory Calculation. causal interaction,unassigned 3,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30305381&form=6&db=m Enzyme kinetics from circular dichroism of insulin reveals mechanistic insights into the regulation of insulin-degrading enzyme. causal interaction,unassigned 3,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30338033&form=6&db=m The core sequence of PIF competes for insulin/amyloid ? in insulin degrading enzyme: potential treatment for Alzheimer's disease. causal interaction,therapeutic application,unassigned 1,4,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31151136&form=6&db=m The extracellular matrix enriched with membrane metalloendopeptidase and insulin-degrading enzyme suppresses the deposition of amyloid-beta peptide in Alzheimer's disease cell models. ongoing research,unassigned 1,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31193223&form=6&db=m Altered expression of insulin-degrading enzyme and regulator of calcineurin in the rat intracerebral streptozotocin model and human apolipoprotein E-?4-associated Alzheimer's disease. ongoing research,unassigned 4,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31403945&form=6&db=m CDK5 Participates in Amyloid-? Production by Regulating PPAR? Phosphorylation in Primary Rat Hippocampal Neurons. unassigned - 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31885312&form=6&db=m Drug Target Engagement Using Coupled Cellular Thermal Shift Assay-Acoustic Reverse-Phase Protein Array. causal interaction,ongoing research,unassigned 3,2,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32377293&form=6&db=m Metformin Ameliorates A? Pathology by Insulin-Degrading Enzyme in a Transgenic Mouse Model of Alzheimer's Disease. ongoing research,unassigned 2,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33128835&form=6&db=m Regulatory feedback cycle of the insulin-degrading enzyme and the amyloid precursor protein intracellular domain: Implications for Alzheimer's disease. causal interaction,unassigned 1,0 3.4.24.56 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33951271&form=6&db=m Gain of PITRM1 peptidase in cortical neurons affords protection of mitochondrial and synaptic function in an advanced age mouse model of Alzheimer's disease. unassigned - 3.4.24.56 Amyloidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23257117&form=6&db=m Insulin-degrading enzyme deficiency accelerates cerebrovascular amyloidosis in an animal model. causal interaction,unassigned 2,0 3.4.24.56 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23684818&form=6&db=m Insulin-degrading enzyme deficiency in bone marrow cells increases atherosclerosis in LDL receptor-deficient mice. causal interaction,ongoing research,unassigned 4,2,0 3.4.24.56 Brain Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23076436&form=6&db=m The Association Between Small Vessel Infarcts and the Activities of Amyloid-? Peptide Degrading Proteases in Apolipoprotein E4 AlleleCarriers. diagnostic usage,therapeutic application,unassigned 1,1,0 3.4.24.56 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21983158&form=6&db=m Pyrrolidine dithiocarbamate attenuates brain A? increase and improves long-term neurological outcome in rats after transient focal brain ischemia. causal interaction,unassigned 4,0 3.4.24.56 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19825794&form=6&db=m Complex formation between metabolic enzymes in tumor cells: Unfolding the MDR1-IDE paradigm. therapeutic application,unassigned 2,0 3.4.24.56 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3026782&form=6&db=m In vivo association of [125I]-insulin with a cytosolic insulin-degrading enzyme: detection by covalent cross-linking and immunoprecipitation with a monoclonal antibody. unassigned - 3.4.24.56 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6749484&form=6&db=m Identification of insulin-degrading enzyme on the surface of cultured human lymphocytes, rat hepatoma cells, and primary cultures of rat hepatocytes. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.24.56 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8504733&form=6&db=m Inhibition of insulin-degrading enzyme increases translocation of insulin to the nucleus in H35 rat hepatoma cells: evidence of a cytosolic pathway. ongoing research,unassigned 3,0 3.4.24.56 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8573122&form=6&db=m Dexamethasone inhibits insulin binding to insulin-degrading enzyme and cytosolic insulin-binding protein p82. ongoing research,therapeutic application,unassigned 3,1,0 3.4.24.56 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8870662&form=6&db=m Association of insulin-degrading enzyme with a 70 kDa cytosolic protein in hepatoma cells. causal interaction,ongoing research,unassigned 1,3,0 3.4.24.56 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27806189&form=6&db=m Effect of the Interplay Between Genetic and Behavioral Risks on Survival After Age 75. unassigned - 3.4.24.56 Cerebellar Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32632204&form=6&db=m Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer's disease-like pathology in human cerebral organoids. causal interaction,unassigned 4,0 3.4.24.56 Cerebral Amyloid Angiopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15489232&form=6&db=m Insulin-degrading enzyme in brain microvessels: proteolysis of amyloid {beta} vasculotropic variants and reduced activity in cerebral amyloid angiopathy. unassigned - 3.4.24.56 Cerebral Amyloid Angiopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31280448&form=6&db=m Memantine, a Noncompetitive N-Methyl-D-Aspartate Receptor Antagonist, Attenuates Cerebral Amyloid Angiopathy by Increasing Insulin-Degrading Enzyme Expression. causal interaction,unassigned 2,0 3.4.24.56 Cerebral Amyloid Angiopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34311050&form=6&db=m Metformin attenuates vascular pathology by increasing expression of insulin-degrading enzyme in a mixed model of cerebral amyloid angiopathy and type 2 diabetes mellitus. causal interaction,therapeutic application,unassigned 2,1,0 3.4.24.56 Chickenpox http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19835587&form=6&db=m Development of monoclonal antibodies and quantitative ELISAs targeting insulin-degrading enzyme. unassigned - 3.4.24.56 Chickenpox http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19864391&form=6&db=m Insulin degrading enzyme binds to the nonglycosylated precursor of varicella zoster virus gE protein found in the endoplasmic reticulum. unassigned - 3.4.24.56 Chickenpox http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30806771&form=6&db=m Binding varicella zoster virus: an underestimated facet of insulin-degrading enzyme´s implication for Alzheimer´s disease pathology? diagnostic usage,ongoing research,unassigned 3,2,0 3.4.24.56 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7596985&form=6&db=m Insulin-degrading enzyme in a human colon adenocarcinoma cell line (Caco-2). ongoing research,unassigned 4,0 3.4.24.56 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9002470&form=6&db=m Immunohistochemical localization of insulin-degrading enzyme along the rat intestine, in the human colon adenocarcinoma cell line (Caco-2), and in human ileum. ongoing research,unassigned 4,0 3.4.24.56 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12695513&form=6&db=m Differential degradation of amyloid beta genetic variants associated with hereditary dementia or stroke by insulin-degrading enzyme. unassigned - 3.4.24.56 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15913558&form=6&db=m Insulin-degrading enzyme degrades amyloid peptides associated with British and Danish familial dementia. causal interaction,unassigned 1,0 3.4.24.56 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17192720&form=6&db=m Insulin-degrading enzyme haplotypes affect insulin levels but not dementia risk. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.56 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18644361&form=6&db=m Transducible P11-CNTF rescues the learning and memory impairments induced by amyloid-beta peptide in mice. ongoing research,unassigned 2,0 3.4.24.56 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19415148&form=6&db=m IDE Gene Polymorphism Influences on BPSD in Mild Dementia of Alzheimer's Type. causal interaction,unassigned 3,0 3.4.24.56 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24380312&form=6&db=m [Effect of tongluo xingnao effervescent tablet on learning and memory of AD rats and expression of insulin-degrading enzyme in hippocampus]. ongoing research,unassigned 2,0 3.4.24.56 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25597881&form=6&db=m Accumulation of BRI2-BRICHOS ectodomain correlates with a decreased clearance of A? by insulin degrading enzyme (IDE) in Alzheimer's disease. causal interaction,unassigned 3,0 3.4.24.56 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28137222&form=6&db=m Machine Learning and Molecular Dynamics Based Insights into Mode of Actions of Insulin Degrading Enzyme Modulators. causal interaction,unassigned 4,0 3.4.24.56 Dementia, Vascular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24316935&form=6&db=m [Effect of rehabilitation training on insulin-resistance and hippocampus amyloid-beta peptide in rats with vascular dementia]. ongoing research,unassigned 3,0 3.4.24.56 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12634421&form=6&db=m Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo. causal interaction,unassigned 4,0 3.4.24.56 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19144176&form=6&db=m Insulin-degrading enzyme is exported via an unconventional protein secretion pathway. causal interaction,unassigned 4,0 3.4.24.56 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19383491&form=6&db=m PPARgamma transcriptionally regulates the expression of insulin-degrading enzyme in primary neurons. causal interaction,unassigned 4,0 3.4.24.56 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19835587&form=6&db=m Development of monoclonal antibodies and quantitative ELISAs targeting insulin-degrading enzyme. unassigned - 3.4.24.56 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20493190&form=6&db=m Insulin-degrading enzyme antagonizes insulin-dependent tissue growth and Abeta-induced neurotoxicity in Drosophila. causal interaction,unassigned 4,0 3.4.24.56 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21448434&form=6&db=m Redox regulation of insulin degradation by insulin-degrading enzyme. causal interaction,unassigned 1,0 3.4.24.56 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22355395&form=6&db=m Structure based discovery of small molecules to regulate the activity of human insulin degrading enzyme. causal interaction,unassigned 3,0 3.4.24.56 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23146021&form=6&db=m Han ethnicity-specific type 2 diabetic treatment from traditional Chinese medicine? therapeutic application,unassigned 1,0 3.4.24.56 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24059320&form=6&db=m Insulin-Degrading Enzyme: A Link between Alzheimer's and Type 2 Diabetes Mellitus. causal interaction,ongoing research,unassigned 3,2,0 3.4.24.56 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26651592&form=6&db=m Targeting Insulin-Degrading Enzyme to Treat Type 2 Diabetes Mellitus. ongoing research,therapeutic application,unassigned 2,2,0 3.4.24.56 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28429777&form=6&db=m Interleukin-6 increases the expression and activity of insulin-degrading enzyme. causal interaction,unassigned 4,0 3.4.24.56 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34311050&form=6&db=m Metformin attenuates vascular pathology by increasing expression of insulin-degrading enzyme in a mixed model of cerebral amyloid angiopathy and type 2 diabetes mellitus. causal interaction,therapeutic application,unassigned 2,1,0 3.4.24.56 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12634421&form=6&db=m Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo. causal interaction,unassigned 4,0 3.4.24.56 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12716770&form=6&db=m Association and haplotype analysis of the insulin-degrading enzyme (IDE) gene, a strong positional and biological candidate for type 2 diabetes susceptibility. causal interaction,therapeutic application,unassigned 1,1,0 3.4.24.56 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12765971&form=6&db=m Polymorphisms in the insulin-degrading enzyme gene are associated with type 2 diabetes in men from the NHLBI Framingham Heart Study. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 3.4.24.56 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15277398&form=6&db=m Quantitative trait loci near the insulin-degrading enzyme (IDE) gene contribute to variation in plasma insulin levels. causal interaction,unassigned 4,0 3.4.24.56 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16380485&form=6&db=m High-Density Haplotype Structure and Association Testing of the Insulin-Degrading Enzyme (IDE) Gene With Type 2 Diabetes in 4,206 People. causal interaction,ongoing research,unassigned 1,1,0 3.4.24.56 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17913278&form=6&db=m Association of polymorphisms in the insulin-degrading enzyme gene with type 2 diabetes in the Korean population. causal interaction,ongoing research,unassigned 3,1,0 3.4.24.56 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19144176&form=6&db=m Insulin-degrading enzyme is exported via an unconventional protein secretion pathway. causal interaction,unassigned 4,0 3.4.24.56 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19383491&form=6&db=m PPARgamma transcriptionally regulates the expression of insulin-degrading enzyme in primary neurons. causal interaction,unassigned 4,0 3.4.24.56 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19809796&form=6&db=m Polymorphisms within insulin-degrading enzyme (IDE) gene determine insulin metabolism and risk of type 2 diabetes. ongoing research,therapeutic application,unassigned 2,1,0 3.4.24.56 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19835587&form=6&db=m Development of monoclonal antibodies and quantitative ELISAs targeting insulin-degrading enzyme. unassigned - 3.4.24.56 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20493190&form=6&db=m Insulin-degrading enzyme antagonizes insulin-dependent tissue growth and Abeta-induced neurotoxicity in Drosophila. causal interaction,unassigned 4,0 3.4.24.56 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21448434&form=6&db=m Redox regulation of insulin degradation by insulin-degrading enzyme. causal interaction,unassigned 1,0 3.4.24.56 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22355395&form=6&db=m Structure based discovery of small molecules to regulate the activity of human insulin degrading enzyme. causal interaction,unassigned 3,0 3.4.24.56 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23146021&form=6&db=m Han ethnicity-specific type 2 diabetic treatment from traditional Chinese medicine? therapeutic application,unassigned 1,0 3.4.24.56 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23597493&form=6&db=m IDE (rs6583817) polymorphism and type 2 diabetes differentially modify executive function in older adults. ongoing research,therapeutic application,unassigned 3,1,0 3.4.24.56 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24059320&form=6&db=m Insulin-Degrading Enzyme: A Link between Alzheimer's and Type 2 Diabetes Mellitus. causal interaction,ongoing research,unassigned 3,2,0 3.4.24.56 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24355596&form=6&db=m C allele of the rs2209972 single nucleotide polymorphism of the insulin degrading enzyme gene and Alzheimer's disease in type 2 diabetes, a case control study. ongoing research,unassigned 2,0 3.4.24.56 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24740421&form=6&db=m Regulation of insulin degrading enzyme activity by obesity-associated factors and pioglitazone in liver of diet-induced obese mice. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.56 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25100059&form=6&db=m Insulin-degrading enzyme inhibition, a novel therapy for type 2 diabetes? unassigned - 3.4.24.56 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26025789&form=6&db=m A neglected modulator of insulin-degrading enzyme activity and conformation: The pH. causal interaction,unassigned 2,0 3.4.24.56 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26228656&form=6&db=m Insulin-degrading enzyme prevents ?-synuclein fibril formation in a nonproteolytical manner. causal interaction,therapeutic application,unassigned 2,1,0 3.4.24.56 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26651592&form=6&db=m Targeting Insulin-Degrading Enzyme to Treat Type 2 Diabetes Mellitus. ongoing research,therapeutic application,unassigned 2,2,0 3.4.24.56 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27320287&form=6&db=m Insulin-degrading enzyme: new therapeutic target for diabetes and Alzheimer's disease? causal interaction,unassigned 3,0 3.4.24.56 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28429777&form=6&db=m Interleukin-6 increases the expression and activity of insulin-degrading enzyme. causal interaction,unassigned 4,0 3.4.24.56 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29222348&form=6&db=m Insulin degrading enzyme contributes to the pathology in a mixed model of Type 2 diabetes and Alzheimer's disease: possible mechanisms of IDE in T2D and AD. ongoing research,therapeutic application,unassigned 4,1,0 3.4.24.56 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29263141&form=6&db=m GLP-1 receptor regulates cell growth through regulating IDE expression level in A?1-42-treated PC12 cells. ongoing research,unassigned 3,0 3.4.24.56 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29596046&form=6&db=m Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme. causal interaction,unassigned 2,0 3.4.24.56 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30305381&form=6&db=m Enzyme kinetics from circular dichroism of insulin reveals mechanistic insights into the regulation of insulin-degrading enzyme. causal interaction,unassigned 3,0 3.4.24.56 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31479304&form=6&db=m Pancreatic beta-cell-specific deletion of insulin-degrading enzyme leads to dysregulated insulin secretion and beta-cell functional immaturity. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.56 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32191993&form=6&db=m FADD Phosphorylation Modulates Blood Glucose Levels by Decreasing the Expression of Insulin-Degrading Enzyme. causal interaction,unassigned 3,0 3.4.24.56 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34311050&form=6&db=m Metformin attenuates vascular pathology by increasing expression of insulin-degrading enzyme in a mixed model of cerebral amyloid angiopathy and type 2 diabetes mellitus. causal interaction,therapeutic application,unassigned 2,1,0 3.4.24.56 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33835239&form=6&db=m In-frame deletion in canine PITRM1 is associated with a severe early-onset epilepsy, mitochondrial dysfunction and neurodegeneration. causal interaction,unassigned 3,0 3.4.24.56 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32857715&form=6&db=m Expression of IDE and PITRM1 genes in ERN1 knockdown U87 glioma cells: effect of hypoxia and glucose deprivation. diagnostic usage,ongoing research,unassigned 4,3,0 3.4.24.56 Glucose Intolerance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15850385&form=6&db=m Alternative splicing of human insulin-degrading enzyme yields a novel isoform with a decreased ability to degrade insulin and amyloid beta-protein. causal interaction,unassigned 2,0 3.4.24.56 Glucose Intolerance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26394692&form=6&db=m Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice. causal interaction,ongoing research,therapeutic application,unassigned 1,4,3,0 3.4.24.56 Glucose Intolerance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30098324&form=6&db=m Liver-specific ablation of insulin-degrading enzyme causes hepatic insulin resistance and glucose intolerance, without affecting insulin clearance in mice. causal interaction,ongoing research,therapeutic application,unassigned 2,2,2,0 3.4.24.56 Granuloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16930758&form=6&db=m Severe insulin resistance associated with subcutaneous amyloid deposition. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.56 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29344085&form=6&db=m Synthesis, secretion, function, metabolism and application of natriuretic peptides in heart failure. unassigned - 3.4.24.56 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19835587&form=6&db=m Development of monoclonal antibodies and quantitative ELISAs targeting insulin-degrading enzyme. unassigned - 3.4.24.56 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19864391&form=6&db=m Insulin degrading enzyme binds to the nonglycosylated precursor of varicella zoster virus gE protein found in the endoplasmic reticulum. unassigned - 3.4.24.56 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30806771&form=6&db=m Binding varicella zoster virus: an underestimated facet of insulin-degrading enzyme´s implication for Alzheimer´s disease pathology? diagnostic usage,ongoing research,unassigned 3,2,0 3.4.24.56 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2206136&form=6&db=m Rat brain insulin degrading enzyme in insulin and thyroid hormones imbalances. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.24.56 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23868462&form=6&db=m Type 2 Diabetes Mellitus and Alzheimer's Disease: from physiopathology to treatment implications. causal interaction,unassigned 3,0 3.4.24.56 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2206136&form=6&db=m Rat brain insulin degrading enzyme in insulin and thyroid hormones imbalances. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.24.56 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15850385&form=6&db=m Alternative splicing of human insulin-degrading enzyme yields a novel isoform with a decreased ability to degrade insulin and amyloid beta-protein. causal interaction,unassigned 2,0 3.4.24.56 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24629693&form=6&db=m [Dementia and diabetes: Casual or causal relationship?] causal interaction,unassigned 1,0 3.4.24.56 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26386462&form=6&db=m Hyperinsulinemia caused by dexamethasone treatment is associated with reduced insulin clearance and lower hepatic activity of insulin-degrading enzyme. causal interaction,therapeutic application,unassigned 3,2,0 3.4.24.56 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28975521&form=6&db=m Nigella sativa Oil and Chromium Picolinate Ameliorate Fructose-Induced Hyperinsulinemia by Enhancing Insulin Signaling and Suppressing Insulin-Degrading Enzyme in Male Rats. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,2,0 3.4.24.56 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32052016&form=6&db=m Reduced Insulin Clearance and Insulin-Degrading Enzyme Activity Contribute to Hyperinsulinemia in African Americans. causal interaction,unassigned 2,0 3.4.24.56 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19145983&form=6&db=m Angiotensin-converting enzyme as a potential target for treatment of Alzheimer's disease: inhibition or activation? causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.56 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26836178&form=6&db=m Effects of Hypertension and Anti-Hypertensive Treatment on Amyloid-? (A?) Plaque Load and A?-Synthesizing and A?-Degrading Enzymes in Frontal Cortex. unassigned - 3.4.24.56 Hyperthyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2206136&form=6&db=m Rat brain insulin degrading enzyme in insulin and thyroid hormones imbalances. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.24.56 Hypothyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2206136&form=6&db=m Rat brain insulin degrading enzyme in insulin and thyroid hormones imbalances. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.24.56 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17553876&form=6&db=m The amino terminus of varicella-zoster virus (VZV) glycoprotein E is required for binding to insulin-degrading enzyme, a VZV receptor. causal interaction,unassigned 1,0 3.4.24.56 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19233447&form=6&db=m The insulin degrading enzyme binding domain of varicella-zoster virus (VZV) glycoprotein E is important for cell-to-cell spread and VZV infectivity, while a glycoprotein I binding domain is essential for infection. unassigned - 3.4.24.56 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20962081&form=6&db=m Varicella-zoster virus glycoprotein E is a critical determinant of virulence in the SCID mouse-human model of neuropathogenesis. unassigned - 3.4.24.56 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12390813&form=6&db=m Relationship between insulin-degrading enzyme activity and insulin sensitivity in cell model of insulin-resistance. diagnostic usage,ongoing research,unassigned 2,4,0 3.4.24.56 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15033922&form=6&db=m Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease. diagnostic usage,therapeutic application,unassigned 3,1,0 3.4.24.56 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16894402&form=6&db=m Links between Alzheimer's disease and diabetes. causal interaction,unassigned 4,0 3.4.24.56 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17066144&form=6&db=m Links between Alzheimer's disease and diabetes. causal interaction,unassigned 4,0 3.4.24.56 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21549699&form=6&db=m Effect of pioglitazone on altered expression of A? metabolism-associated molecules in the brain of fructose-drinking rats, a rodent model of insulin resistance. causal interaction,unassigned 1,0 3.4.24.56 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24629693&form=6&db=m [Dementia and diabetes: Casual or causal relationship?] causal interaction,unassigned 1,0 3.4.24.56 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25036874&form=6&db=m Reduced insulin clearance and lower insulin-degrading enzyme expression in the liver might contribute to the thrifty phenotype of protein-restricted mice. causal interaction,unassigned 1,0 3.4.24.56 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30098324&form=6&db=m Liver-specific ablation of insulin-degrading enzyme causes hepatic insulin resistance and glucose intolerance, without affecting insulin clearance in mice. causal interaction,ongoing research,therapeutic application,unassigned 2,2,2,0 3.4.24.56 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31062332&form=6&db=m Therapeutic Strategies for Alzheimer's Disease in the View of Diabetes Mellitus. causal interaction,therapeutic application,unassigned 2,4,0 3.4.24.56 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33477364&form=6&db=m Modulation of Insulin Sensitivity by Insulin-Degrading Enzyme. causal interaction,unassigned 3,0 3.4.24.56 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33865877&form=6&db=m Reduced insulin sensitivity and increased ?/? cell mass is associated with reduced hepatic insulin-degrading enzyme activity in pregnant rats. ongoing research,unassigned 4,0 3.4.24.56 Insulinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12941771&form=6&db=m An insulin-degrading enzyme inhibitor decreases amylin degradation, increases amylin-induced cytotoxicity, and increases amyloid formation in insulinoma cell cultures. causal interaction,ongoing research,unassigned 1,3,0 3.4.24.56 insulysin deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23257117&form=6&db=m Insulin-degrading enzyme deficiency accelerates cerebrovascular amyloidosis in an animal model. causal interaction,unassigned 2,0 3.4.24.56 insulysin deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23684818&form=6&db=m Insulin-degrading enzyme deficiency in bone marrow cells increases atherosclerosis in LDL receptor-deficient mice. causal interaction,ongoing research,unassigned 4,2,0 3.4.24.56 insulysin deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32632204&form=6&db=m Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer's disease-like pathology in human cerebral organoids. causal interaction,unassigned 4,0 3.4.24.56 insulysin deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34356897&form=6&db=m Role of PITRM1 in Mitochondrial Dysfunction and Neurodegeneration. causal interaction,diagnostic usage,unassigned 4,1,0 3.4.24.56 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26697887&form=6&db=m Defective PITRM1 mitochondrial peptidase is associated with A? amyloidotic neurodegeneration. unassigned - 3.4.24.56 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8821707&form=6&db=m Insulin-degrading activity in experimental liver cirrhosis of the rat. ongoing research,unassigned 3,0 3.4.24.56 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19592050&form=6&db=m Variants in the insulin-degrading enzyme gene are associated with metabolic syndrome in Chinese elders. unassigned - 3.4.24.56 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33398768&form=6&db=m Insulin-degrading enzyme higher in subjects with metabolic syndrome. causal interaction,diagnostic usage,unassigned 3,1,0 3.4.24.56 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15911128&form=6&db=m Lack of association between IDE genetic variability and Down's syndrome. causal interaction,unassigned 3,0 3.4.24.56 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17475416&form=6&db=m One for all and all for one: RB defends the cell while IDE, PTEN and IGFBP-7 antagonize insulin and IGFs to protect RB. causal interaction,unassigned 3,0 3.4.24.56 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18783335&form=6&db=m Immunohistochemical evidence of ubiquitous distribution of the metalloendoprotease insulin-degrading enzyme (IDE; insulysin) in human non-malignant tissues and tumor cell lines. causal interaction,ongoing research,unassigned 1,4,0 3.4.24.56 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20364150&form=6&db=m Production of an antigenic peptide by insulin-degrading enzyme. ongoing research,therapeutic application,unassigned 2,1,0 3.4.24.56 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21457557&form=6&db=m Intracellular insulin in human tumors: examples and implications. causal interaction,unassigned 3,0 3.4.24.56 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24516642&form=6&db=m No major role for insulin-degrading enzyme in antigen presentation by MHC molecules. unassigned - 3.4.24.56 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28515362&form=6&db=m Insulin supplementation attenuates cancer-induced cardiomyopathy and slows tumor disease progression. unassigned - 3.4.24.56 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29687202&form=6&db=m Attenuation of Aluminum Chloride-Induced Neuroinflammation and Caspase Activation Through the AKT/GSK-3? Pathway by Hesperidin in Wistar Rats. causal interaction,ongoing research,unassigned 1,1,0 3.4.24.56 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30253123&form=6&db=m Dendrobiumpolysaccharides attenuate cognitive impairment in senescence-accelerated mouse prone 8 mice via modulation of microglial activation. unassigned - 3.4.24.56 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30894055&form=6&db=m Autophagy-dependent secretion: mechanism, factors secreted, and disease implications. diagnostic usage,unassigned 3,0 3.4.24.56 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31476414&form=6&db=m Isorhynchophylline ameliorates cognitive impairment via modulating amyloid pathology, tau hyperphosphorylation and neuroinflammation: Studies in a transgenic mouse model of Alzheimer's disease. diagnostic usage,therapeutic application,unassigned 1,1,0 3.4.24.56 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34414399&form=6&db=m Adiponectin receptor fragmentation in mouse models of type 1 and type 2 diabetes. ongoing research,therapeutic application,unassigned 3,3,0 3.4.24.56 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8780892&form=6&db=m Regulation by retinoic acid of insulin-degrading enzyme and of a related endoprotease in human neuroblastoma cell lines. ongoing research,unassigned 4,0 3.4.24.56 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25450414&form=6&db=m Novel Platinum(II) compounds modulate insulin-degrading enzyme activity and induce cell death in neuroblastoma cells. ongoing research,unassigned 3,0 3.4.24.56 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22020115&form=6&db=m Age-associated neurodegeneration and oxidative damage to lipids, proteins and DNA. therapeutic application,unassigned 1,0 3.4.24.56 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34396529&form=6&db=m Insulin-degrading enzyme: an ally against metabolic and neurodegenerative diseases. therapeutic application,unassigned 1,0 3.4.24.56 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30796737&form=6&db=m Intranasal Losartan Decreases Perivascular Beta Amyloid, Inflammation, and the Decline of Neurogenesis in Hypertensive Rats. therapeutic application,unassigned 1,0 3.4.24.56 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32784004&form=6&db=m Sodium orthovanadate improves learning and memory in intracerebroventricular-streptozotocin rat model of Alzheimer's disease through modulation of brain insulin resistance induced tau pathology. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0 3.4.24.56 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12746301&form=6&db=m In vitro inhibition of insulin-degrading enzyme by long-chain fatty acids and their coenzyme A thioesters. ongoing research,unassigned 4,0 3.4.24.56 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18710364&form=6&db=m Dissecting the nutrigenomics, diabetes, and gastrointestinal disease interface: from risk assessment to health intervention. causal interaction,unassigned 1,0 3.4.24.56 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28429777&form=6&db=m Interleukin-6 increases the expression and activity of insulin-degrading enzyme. causal interaction,unassigned 4,0 3.4.24.56 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33681678&form=6&db=m High-Fat Diet Modulates Hepatic Amyloid ? and Cerebrosterol Metabolism in the Triple Transgenic Mouse Model of Alzheimer's Disease. unassigned - 3.4.24.56 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18813847&form=6&db=m Expression of metalloprotease insulin-degrading enzyme insulysin in normal and malignant human tissues. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 3.4.24.56 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30112966&form=6&db=m 6-Hydroxydopamine induces secretion of PARK7/DJ-1 via autophagy-based unconventional secretory pathway. causal interaction,ongoing research,unassigned 1,3,0 3.4.24.56 Parkinsonian Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30112966&form=6&db=m 6-Hydroxydopamine induces secretion of PARK7/DJ-1 via autophagy-based unconventional secretory pathway. causal interaction,ongoing research,unassigned 1,3,0 3.4.24.56 Polycystic Ovary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17953957&form=6&db=m Association of genetic variants of insulin degrading enzyme with metabolic features in women with polycystic ovary syndrome. diagnostic usage,ongoing research,unassigned 3,3,0 3.4.24.56 Prediabetic State http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32889954&form=6&db=m Relationship Between Cognitive Functions and Insulin-degrading Enzyme in Individuals With Prediabetes. causal interaction,unassigned 1,0 3.4.24.56 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20362553&form=6&db=m Retinoblastoma protein co-purifies with proteasomal insulin-degrading enzyme: implications for cell proliferation control. causal interaction,ongoing research,unassigned 3,1,0 3.4.24.56 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21457557&form=6&db=m Intracellular insulin in human tumors: examples and implications. causal interaction,unassigned 3,0 3.4.24.56 Spinocerebellar Ataxias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26697887&form=6&db=m Defective PITRM1 mitochondrial peptidase is associated with A? amyloidotic neurodegeneration. unassigned - 3.4.24.56 Spinocerebellar Ataxias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33835239&form=6&db=m In-frame deletion in canine PITRM1 is associated with a severe early-onset epilepsy, mitochondrial dysfunction and neurodegeneration. causal interaction,unassigned 3,0 3.4.24.56 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12695513&form=6&db=m Differential degradation of amyloid beta genetic variants associated with hereditary dementia or stroke by insulin-degrading enzyme. unassigned - 3.4.24.56 Varicella Zoster Virus Infection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19835587&form=6&db=m Development of monoclonal antibodies and quantitative ELISAs targeting insulin-degrading enzyme. unassigned - 3.4.24.56 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17055432&form=6&db=m Insulin degrading enzyme is a cellular receptor mediating varicella-zoster virus infection and cell-to-cell spread. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.56 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19835587&form=6&db=m Development of monoclonal antibodies and quantitative ELISAs targeting insulin-degrading enzyme. unassigned -