3.2.2.23 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32364878&form=6&db=m Overexpression of NEIL3 associated with altered genome and poor survival in selected types of human cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 3.2.2.23 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32175161&form=6&db=m Evaluation of gene expression levels in the diagnosis of lung adenocarcinoma and malignant pleural mesothelioma. unassigned - 3.2.2.23 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32364878&form=6&db=m Overexpression of NEIL3 associated with altered genome and poor survival in selected types of human cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 3.2.2.23 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33879165&form=6&db=m NEIL3 may act as a potential prognostic biomarker for lung adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.2.2.23 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16010685&form=6&db=m Rapid recognition of aberrant dHPLC elution profiles using the Transgenomic Navigator software. diagnostic usage,ongoing research,unassigned 2,2,0 3.2.2.23 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18515411&form=6&db=m Inherited predisposition to colorectal adenomas caused by multiple rare alleles of MUTYH but not OGG1, NUDT1, NTH1 or NEIL 1, 2 or 3. diagnostic usage,unassigned 3,0 3.2.2.23 Agammaglobulinemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27760045&form=6&db=m Deficiency of base excision repair enzyme NEIL3 drives increased predisposition to autoimmunity. causal interaction,unassigned 2,0 3.2.2.23 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15370876&form=6&db=m Detection of oxidative DNA damage in lymphocytes of patients with Alzheimer's disease. diagnostic usage,ongoing research,unassigned 2,1,0 3.2.2.23 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25448603&form=6&db=m Loss of NEIL1 causes defects in olfactory function in mice. causal interaction,unassigned 4,0 3.2.2.23 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19840299&form=6&db=m DNA damage and glutathione level in children with asthma bronchiale: Effect of antiasthmatic therapy. unassigned - 3.2.2.23 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28378638&form=6&db=m Expression signatures of DNA repair genes correlate with survival prognosis of astrocytoma patients. causal interaction,therapeutic application,unassigned 3,4,0 3.2.2.23 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27328939&form=6&db=m Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice. causal interaction,therapeutic application,unassigned 4,2,0 3.2.2.23 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33714552&form=6&db=m DNA glycosylase Neil3 regulates vascular smooth muscle cell biology during atherosclerosis development. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 3.2.2.23 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15319300&form=6&db=m Inactivating mutations of the human base excision repair gene NEIL1 in gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.2.2.23 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18594018&form=6&db=m Functional variants of the NEIL1 and NEIL2 genes and risk and progression of squamous cell carcinoma of the oral cavity and oropharynx. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 3.2.2.23 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32198476&form=6&db=m Cervical carcinoma risk associate with genetic polymorphisms of NEIL2 gene in Chinese population and its significance as predictive biomarker. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,1,0 3.2.2.23 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34434267&form=6&db=m NEIL3 contributes toward the carcinogenesis of liver cancer and regulates PI3K/Akt/mTOR signaling. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,1 3.2.2.23 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16118226&form=6&db=m Induction of the human oxidized base-specific DNA glycosylase NEIL1 by reactive oxygen species. therapeutic application,unassigned 1,0 3.2.2.23 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18594018&form=6&db=m Functional variants of the NEIL1 and NEIL2 genes and risk and progression of squamous cell carcinoma of the oral cavity and oropharynx. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 3.2.2.23 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22286769&form=6&db=m Epigenetic screen of human DNA repair genes identifies aberrant promoter methylation of NEIL1 in head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 3.2.2.23 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26095805&form=6&db=m NEIL1 p.Gln282Stop variant is predominantly localized in the cytoplasm and exhibits reduced activity in suppressing mutations. causal interaction,therapeutic application,unassigned 4,1,0 3.2.2.23 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32364878&form=6&db=m Overexpression of NEIL3 associated with altered genome and poor survival in selected types of human cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 3.2.2.23 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7955043&form=6&db=m The Fpg protein, a DNA repair enzyme, is inhibited by the biomediator nitric oxide in vitro and in vivo. ongoing research,unassigned 4,0 3.2.2.23 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20074151&form=6&db=m Hepatitis C virus induces oxidative stress, DNA damage and modulates the DNA repair enzyme NEIL1. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,4,2 3.2.2.23 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28373545&form=6&db=m NEIL1 protects against aflatoxin-induced hepatocellular carcinoma in mice. ongoing research,therapeutic application,unassigned 2,3,0 3.2.2.23 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30448017&form=6&db=m Processing of N5-substituted formamidopyrimidine DNA adducts by DNA glycosylases NEIL1 and NEIL3. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 3.2.2.23 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33525928&form=6&db=m Phase I studies of peptide vaccine cocktails derived from GPC3, WDRPUH and NEIL3 for advanced hepatocellular carcinoma. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 3.2.2.23 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34045188&form=6&db=m NEIL3 Prevents Senescence in Hepatocellular Carcinoma by Repairing Oxidative Lesions at Telomeres during Mitosis. therapeutic application,unassigned 1,0 3.2.2.23 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24569633&form=6&db=m A critical re-assessment of DNA repair gene promoter methylation in non-small cell lung carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0 3.2.2.23 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18594018&form=6&db=m Functional variants of the NEIL1 and NEIL2 genes and risk and progression of squamous cell carcinoma of the oral cavity and oropharynx. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 3.2.2.23 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22286769&form=6&db=m Epigenetic screen of human DNA repair genes identifies aberrant promoter methylation of NEIL1 in head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 3.2.2.23 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19443904&form=6&db=m Catalytically impaired hMYH and NEIL1 mutant proteins identified in patients with primary sclerosing cholangitis and cholangiocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,1,0 3.2.2.23 Cholangitis, Sclerosing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19443904&form=6&db=m Catalytically impaired hMYH and NEIL1 mutant proteins identified in patients with primary sclerosing cholangitis and cholangiocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,1,0 3.2.2.23 Cockayne Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17512460&form=6&db=m Complementation of the oxidatively damaged DNA repair defect in Cockayne syndrome A and B cells by Escherichia coli formamidopyrimidine DNA glycosylase. therapeutic application,unassigned 2,0 3.2.2.23 Cockayne Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18393852&form=6&db=m Oxidatively damaged DNA repair defect in cockayne syndrome and its complementation by heterologous repair proteins. therapeutic application,unassigned 3,0 3.2.2.23 Cockayne Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19179336&form=6&db=m Cockayne syndrome group B protein stimulates repair of formamidopyrimidines by NEIL1 DNA glycosylase. therapeutic application,unassigned 1,0 3.2.2.23 Cockayne Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20026203&form=6&db=m Defective repair of 5-hydroxy-2'-deoxycytidine in Cockayne syndrome cells and its complementation by Escherichia coli formamidopyrimidine DNA glycosylase and endonuclease III. therapeutic application,unassigned 1,0 3.2.2.23 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24912782&form=6&db=m The eucalyptus oil ingredient 1,8-cineol induces oxidative DNA damage. ongoing research,unassigned 1,0 3.2.2.23 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32685496&form=6&db=m Nei Endonuclease VIII-Like1 (NEIL1) Inhibits Apoptosis of Human Colorectal Cancer Cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 3.2.2.23 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17029639&form=6&db=m Evaluation of NTHL1, NEIL1, NEIL2, MPG, TDG, UNG and SMUG1 genes in familial colorectal cancer predisposition. diagnostic usage,unassigned 1,0 3.2.2.23 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32312920&form=6&db=m Sirt3 regulates the level of mitochondrial DNA repair activity through deacetylation of NEIL1, NEIL2, OGG1, MUTYH, APE1 and LIG3 in colorectal cancer. causal interaction,therapeutic application,unassigned 1,3,0 3.2.2.23 Common Variable Immunodeficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28093361&form=6&db=m NEIL1 is a candidate gene associated with common variable immunodeficiency in a patient with a chromosome 15q24 deletion. causal interaction,unassigned 4,0 3.2.2.23 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20942575&form=6&db=m Supplementation with a combination of antioxidants does not affect glycaemic control, oxidative stress or inflammation in type 2 diabetes subjects. diagnostic usage,ongoing research,unassigned 1,3,0 3.2.2.23 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21985917&form=6&db=m Prevalence of the DNA repair enzyme-NEIL1 - gene mutation in patients with type 2 diabetes in the Turkish population. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.2.2.23 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23392254&form=6&db=m Identification of a genetic locus on chromosome 4q34-35 for type 2 diabetes with overweight. therapeutic application,unassigned 1,0 3.2.2.23 dna-formamidopyrimidine glycosylase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21285402&form=6&db=m Variable penetrance of metabolic phenotypes and development of high-fat diet-induced adiposity in NEIL1-deficient mice. causal interaction,therapeutic application,unassigned 4,1,0 3.2.2.23 dna-formamidopyrimidine glycosylase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22927410&form=6&db=m Endonuclease VIII-like 1 (NEIL1) promotes short-term spatial memory retention and protects from ischemic stroke-induced brain dysfunction and death in mice. causal interaction,therapeutic application,unassigned 4,1,0 3.2.2.23 dna-formamidopyrimidine glycosylase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32437792&form=6&db=m Endonuclease VIII-like 1 deficiency impairs survival of newly generated hippocampal neurons and memory performance in young-adult male mice. causal interaction,unassigned 2,0 3.2.2.23 dna-formamidopyrimidine glycosylase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33714552&form=6&db=m DNA glycosylase Neil3 regulates vascular smooth muscle cell biology during atherosclerosis development. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 3.2.2.23 Dyslipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16446448&form=6&db=m The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 3.2.2.23 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24022861&form=6&db=m An NEIL1 single nucleotide polymorphism (rs4462560) predicts the risk of radiation-induced toxicities in esophageal cancer patients treated with definitive radiotherapy. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,2,0 3.2.2.23 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34105905&form=6&db=m Genetic variations in DNA repair gene NEIL1 associated with radiation pneumonitis risk in lung cancer patients. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0 3.2.2.23 Fanconi Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9838922&form=6&db=m Fanconi's anaemia cells have normal steady-state levels and repair of oxidative DNA base modifications sensitive to Fpg protein. ongoing research,unassigned 3,0 3.2.2.23 Fanconi Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30842657&form=6&db=m TRAIP is a master regulator of DNA interstrand crosslink repair. causal interaction,therapeutic application,unassigned 3,1,0 3.2.2.23 Fanconi Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31980815&form=6&db=m Cooperation of the NEIL3 and Fanconi anemia/BRCA pathways in interstrand crosslink repair. unassigned - 3.2.2.23 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16446448&form=6&db=m The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 3.2.2.23 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23508956&form=6&db=m NEIL1 responds and binds to psoralen-induced DNA interstrand crosslinks. therapeutic application,unassigned 1,0 3.2.2.23 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24005813&form=6&db=m Association of polymorphisms in FLT3, EGFR, ALOX5, and NEIL3 with glioblastoma in the Han Chinese population. unassigned - 3.2.2.23 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28378638&form=6&db=m Expression signatures of DNA repair genes correlate with survival prognosis of astrocytoma patients. causal interaction,therapeutic application,unassigned 3,4,0 3.2.2.23 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29348879&form=6&db=m Loss of NEIL3 DNA glycosylase markedly increases replication associated double strand breaks and enhances sensitivity to ATR inhibitor in glioblastoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 3.2.2.23 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32364878&form=6&db=m Overexpression of NEIL3 associated with altered genome and poor survival in selected types of human cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 3.2.2.23 glutathione synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16036337&form=6&db=m Oxidative DNA damage in cultured fibroblasts from patients with hereditary glutathione synthetase deficiency. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.2.2.23 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28052262&form=6&db=m NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture. causal interaction,ongoing research,unassigned 1,1,0 3.2.2.23 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20074151&form=6&db=m Hepatitis C virus induces oxidative stress, DNA damage and modulates the DNA repair enzyme NEIL1. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,4,2 3.2.2.23 HIV Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21448280&form=6&db=m The base excision repair pathway is required for efficient lentivirus integration. causal interaction,unassigned 1,0 3.2.2.23 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16446448&form=6&db=m The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 3.2.2.23 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20120016&form=6&db=m The Fanconi anemia pathway promotes DNA glycosylase-dependent excision of interstrand DNA crosslinks. causal interaction,ongoing research,unassigned 1,4,0 3.2.2.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27760045&form=6&db=m Deficiency of base excision repair enzyme NEIL3 drives increased predisposition to autoimmunity. causal interaction,unassigned 2,0 3.2.2.23 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27503022&form=6&db=m Ginsenoside Rd Attenuates DNA Damage by Increasing Expression of DNA Glycosylase Endonuclease VIII-like Proteins after Focal Cerebral Ischemia. causal interaction,therapeutic application,unassigned 2,3,0 3.2.2.23 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31175982&form=6&db=m NEIL1 stimulates neurogenesis and suppresses neuroinflammation after stress. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.2.2.23 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7683082&form=6&db=m DNA damage induced by photosensitizers in cellular and cell-free systems. ongoing research,unassigned 2,0 3.2.2.23 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7859366&form=6&db=m Oxidative DNA damage induced by potassium bromate under cell-free conditions and in mammalian cells. unassigned - 3.2.2.23 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16446448&form=6&db=m The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 3.2.2.23 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20074151&form=6&db=m Hepatitis C virus induces oxidative stress, DNA damage and modulates the DNA repair enzyme NEIL1. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,4,2 3.2.2.23 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34434267&form=6&db=m NEIL3 contributes toward the carcinogenesis of liver cancer and regulates PI3K/Akt/mTOR signaling. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,1 3.2.2.23 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28587419&form=6&db=m Regulation of the angiotensin II-p22phox-reactive oxygen species signaling pathway, apoptosis and 8-oxoguanine-DNA glycosylase 1 retrieval in hyperoxia-induced lung injury and fibrosis in rats. ongoing research,therapeutic application,unassigned 3,1,0 3.2.2.23 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15781210&form=6&db=m Green tea consumption, genetic susceptibility, PAH-rich smoky coal, and the risk of lung cancer. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 3.2.2.23 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18155253&form=6&db=m OGG1 expression and OGG1 Ser326Cys polymorphism and risk of lung cancer in a prospective study. ongoing research,unassigned 2,0 3.2.2.23 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24569633&form=6&db=m A critical re-assessment of DNA repair gene promoter methylation in non-small cell lung carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0 3.2.2.23 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34105905&form=6&db=m Genetic variations in DNA repair gene NEIL1 associated with radiation pneumonitis risk in lung cancer patients. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0 3.2.2.23 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33921035&form=6&db=m Deficiency of NEIL3 Enhances the Chemotherapy Resistance of Prostate Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4 3.2.2.23 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11080664&form=6&db=m Evaluation of mutagenic effects of hyperbaric oxygen (HBO) in vitro. II. Induction of oxidative DNA damage and mutations in the mouse lymphoma assay. therapeutic application,unassigned 1,0 3.2.2.23 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25813722&form=6&db=m Genotoxicity of tungsten carbide-cobalt (WC-Co) nanoparticles in vitro: mechanisms-of-action studies. ongoing research,unassigned 1,0 3.2.2.23 Mesothelioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32175161&form=6&db=m Evaluation of gene expression levels in the diagnosis of lung adenocarcinoma and malignant pleural mesothelioma. unassigned - 3.2.2.23 Mesothelioma, Malignant http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32175161&form=6&db=m Evaluation of gene expression levels in the diagnosis of lung adenocarcinoma and malignant pleural mesothelioma. unassigned - 3.2.2.23 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16446448&form=6&db=m The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 3.2.2.23 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17389588&form=6&db=m Human polymorphic variants of the NEIL1 DNA glycosylase. causal interaction,ongoing research,unassigned 4,2,0 3.2.2.23 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25703835&form=6&db=m Genetic variants in the DNA repair gene NEIL3 and the risk of myocardial infarction in a nested case-control study. The HUNT Study. ongoing research,therapeutic application,unassigned 2,1,0 3.2.2.23 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27328939&form=6&db=m Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice. causal interaction,therapeutic application,unassigned 4,2,0 3.2.2.23 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33921035&form=6&db=m Deficiency of NEIL3 Enhances the Chemotherapy Resistance of Prostate Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4 3.2.2.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11409938&form=6&db=m Requirement of glutathione and cysteine in guanine-specific oxidation of DNA by carcinogenic potassium bromate. unassigned - 3.2.2.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18594018&form=6&db=m Functional variants of the NEIL1 and NEIL2 genes and risk and progression of squamous cell carcinoma of the oral cavity and oropharynx. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 3.2.2.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19426544&form=6&db=m Expression patterns of Neil3 during embryonic brain development and neoplasia. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.2.2.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19443904&form=6&db=m Catalytically impaired hMYH and NEIL1 mutant proteins identified in patients with primary sclerosing cholangitis and cholangiocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,1,0 3.2.2.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22286769&form=6&db=m Epigenetic screen of human DNA repair genes identifies aberrant promoter methylation of NEIL1 in head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 3.2.2.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24382305&form=6&db=m Genome and cancer single nucleotide polymorphisms of the human NEIL1 DNA glycosylase: activity, structure, and the effect of editing. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1 3.2.2.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24569633&form=6&db=m A critical re-assessment of DNA repair gene promoter methylation in non-small cell lung carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0 3.2.2.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25971446&form=6&db=m Oxidative DNA damage induced by metabolites of chloramphenicol, an antibiotic drug. ongoing research,unassigned 4,0 3.2.2.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26095805&form=6&db=m NEIL1 p.Gln282Stop variant is predominantly localized in the cytoplasm and exhibits reduced activity in suppressing mutations. causal interaction,therapeutic application,unassigned 4,1,0 3.2.2.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27042257&form=6&db=m Abnormal Expressions of DNA Glycosylase Genes NEIL1, NEIL2, and NEIL3 Are Associated with Somatic Mutation Loads in Human Cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.2.2.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29348879&form=6&db=m Loss of NEIL3 DNA glycosylase markedly increases replication associated double strand breaks and enhances sensitivity to ATR inhibitor in glioblastoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 3.2.2.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31614656&form=6&db=m PARP1 Co-Regulates EP300-BRG1-Dependent Transcription of Genes Involved in Breast Cancer Cell Proliferation and DNA Repair. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,1,0 3.2.2.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32312920&form=6&db=m Sirt3 regulates the level of mitochondrial DNA repair activity through deacetylation of NEIL1, NEIL2, OGG1, MUTYH, APE1 and LIG3 in colorectal cancer. causal interaction,therapeutic application,unassigned 1,3,0 3.2.2.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32364878&form=6&db=m Overexpression of NEIL3 associated with altered genome and poor survival in selected types of human cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 3.2.2.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33300026&form=6&db=m Heritable pattern of oxidized DNA base repair coincides with pre-targeting of repair complexes to open chromatin. unassigned - 3.2.2.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33879165&form=6&db=m NEIL3 may act as a potential prognostic biomarker for lung adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.2.2.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34434267&form=6&db=m NEIL3 contributes toward the carcinogenesis of liver cancer and regulates PI3K/Akt/mTOR signaling. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,1 3.2.2.23 Nephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27760052&form=6&db=m Genetic cause of immune dysregulation - one gene or two? diagnostic usage,unassigned 3,0 3.2.2.23 Nephrotic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21697813&form=6&db=m Exome sequencing identified MYO1E and NEIL1 as candidate genes for human autosomal recessive steroid-resistant nephrotic syndrome. diagnostic usage,unassigned 1,0 3.2.2.23 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20622253&form=6&db=m Specific Inhibition of NEIL-initiated repair of oxidized base damage in human genome by copper and iron: potential etiological linkage to neurodegenerative diseases. unassigned - 3.2.2.23 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31175982&form=6&db=m NEIL1 stimulates neurogenesis and suppresses neuroinflammation after stress. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.2.2.23 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21285402&form=6&db=m Variable penetrance of metabolic phenotypes and development of high-fat diet-induced adiposity in NEIL1-deficient mice. causal interaction,therapeutic application,unassigned 4,1,0 3.2.2.23 Obesity, Morbid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16446448&form=6&db=m The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 3.2.2.23 Photosensitivity Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1731864&form=6&db=m Substrate specificity of the Escherichia coli Fpg protein (formamidopyrimidine-DNA glycosylase): excision of purine lesions in DNA produced by ionizing radiation or photosensitization. ongoing research,therapeutic application,unassigned 1,1,0 3.2.2.23 Photosensitivity Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25431849&form=6&db=m The Tryptophan-Derived Endogenous Aryl Hydrocarbon Receptor Ligand 6-Formylindolo[3,2-b]Carbazole Is a Nanomolar UVA Photosensitizer in Epidermal Keratinocytes. unassigned - 3.2.2.23 Polycystic Ovary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16509054&form=6&db=m DNA damage, DNA susceptibility to oxidation and glutathione level in women with polycystic ovary syndrome. unassigned - 3.2.2.23 Prion Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27886261&form=6&db=m Neil3 induced neurogenesis protects against prion disease during the clinical phase. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 3.2.2.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25873625&form=6&db=m Regulation of NEIL1 protein abundance by RAD9 is important for efficient base excision repair. ongoing research,unassigned 3,0 3.2.2.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33115829&form=6&db=m Distinct Genomic Alterations in Prostate Tumors Derived from African American Men. causal interaction,unassigned 4,0 3.2.2.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33921035&form=6&db=m Deficiency of NEIL3 Enhances the Chemotherapy Resistance of Prostate Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4 3.2.2.23 Radiation Pneumonitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34105905&form=6&db=m Genetic variations in DNA repair gene NEIL1 associated with radiation pneumonitis risk in lung cancer patients. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0 3.2.2.23 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22286769&form=6&db=m Epigenetic screen of human DNA repair genes identifies aberrant promoter methylation of NEIL1 in head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 3.2.2.23 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8676878&form=6&db=m Effect of mutY and mutM/fpg-1 mutations on starvation-associated mutation in Escherichia coli: implications for the role of 7,8-dihydro-8-oxoguanine. therapeutic application,unassigned 1,0 3.2.2.23 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9568583&form=6&db=m Mutation frequency decline in MMS-treated Escherichia coli K-12 mutS strains. diagnostic usage,therapeutic application,unassigned 3,1,0 3.2.2.23 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11506801&form=6&db=m Contribution of E. coli AlkA, TagA glycosylases and UvrABC-excinuclease in MMS mutagenesis. therapeutic application,unassigned 1,0 3.2.2.23 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15447793&form=6&db=m Prediction of DtxR regulon: identification of binding sites and operons controlled by Diphtheria toxin repressor in Corynebacterium diphtheriae. causal interaction,diagnostic usage,unassigned 3,3,0 3.2.2.23 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15319300&form=6&db=m Inactivating mutations of the human base excision repair gene NEIL1 in gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.2.2.23 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21160930&form=6&db=m Three novel NEIL1 promoter polymorphisms in gastric cancer patients. ongoing research,therapeutic application,unassigned 3,2,0 3.2.2.23 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22927410&form=6&db=m Endonuclease VIII-like 1 (NEIL1) promotes short-term spatial memory retention and protects from ischemic stroke-induced brain dysfunction and death in mice. causal interaction,therapeutic application,unassigned 4,1,0 3.2.2.23 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25971543&form=6&db=m Partial loss of the DNA repair scaffolding protein, Xrcc1, results in increased brain damage and reduced recovery from ischemic stroke in mice. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,1,0 3.2.2.23 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29128308&form=6&db=m Oxidative stress and DNA damage after cerebral ischemia: Potential therapeutic targets to repair the genome and improve stroke recovery. therapeutic application,unassigned 3,0 3.2.2.23 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19496823&form=6&db=m Characterization of the major formamidopyrimidine-DNA glycosylase homolog in Mycobacterium tuberculosis and its linkage to variable tandem repeats. diagnostic usage,ongoing research,unassigned 3,2,0 3.2.2.23 Vitiligo http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15491637&form=6&db=m Increased oxidative DNA damage in mononuclear leukocytes in vitiligo. diagnostic usage,ongoing research,unassigned 3,4,0 3.2.2.23 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17611195&form=6&db=m The human Werner syndrome protein stimulates repair of oxidative DNA base damage by the DNA glycosylase NEIL1. ongoing research,therapeutic application,unassigned 1,1,0 3.2.2.23 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20346739&form=6&db=m Substrate specific stimulation of NEIL1 by WRN but not the other human RecQ helicases. ongoing research,unassigned 1,0 3.2.2.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12426134&form=6&db=m Interference by toxic metal ions with DNA repair processes and cell cycle control: molecular mechanisms. therapeutic application,unassigned 1,0 3.2.2.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15265038&form=6&db=m Interaction of selenium compounds with zinc finger proteins involved in DNA repair. ongoing research,therapeutic application,unassigned 1,1,0 3.2.2.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19258314&form=6&db=m The human oxidative DNA glycosylase NEIL1 excises psoralen-induced interstrand DNA cross-links in a three-stranded DNA structure. unassigned - 3.2.2.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22434712&form=6&db=m Effect of the multifunctional proteins RPA, YB-1, and XPC repair factor on AP site cleavage by DNA glycosylase NEIL1. unassigned -