3.1.11.2 Acquired Immunodeficiency Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12367650&form=6&db=m Novel mutations in the thymidine kinase and DNA polymerase genes of acyclovir and foscarnet resistant herpes simplex viruses infecting an immunocompromised patient. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 3.1.11.2 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28943952&form=6&db=m miRNA biogenesis-associated RNase III nucleases Drosha and Dicer are upregulated in colorectal adenocarcinoma. causal interaction,unassigned 4,0 3.1.11.2 African Swine Fever http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8623526&form=6&db=m Evolutionary relationships among large double-stranded DNA viruses that infect microalgae and other organisms as inferred from DNA polymerase genes. ongoing research,unassigned 2,0 3.1.11.2 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34528746&form=6&db=m p38 MAPK-mediated loss of nuclear RNase III enzyme Drosha underlies amyloid beta-induced neuronal stress in Alzheimer's disease. causal interaction,unassigned 4,0 3.1.11.2 Blindness http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22869729&form=6&db=m ERK1/2 activation is a therapeutic target in age-related macular degeneration. causal interaction,therapeutic application,unassigned 4,4,0 3.1.11.2 Bloom Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28279982&form=6&db=m A prosurvival DNA damage-induced cytoplasmic interferon response is mediated by end resection factors and is limited by Trex1. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0 3.1.11.2 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20551246&form=6&db=m Genomic analysis of the 55 kDa subunit of DNA polymerase epsilon in human intracranial neoplasms. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0 3.1.11.2 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12713808&form=6&db=m The expression of Exonuclease III from E. coli in mitochondria of breast cancer cells diminishes mitochondrial DNA repair capacity and cell survival after oxidative stress. causal interaction,ongoing research,unassigned 1,3,0 3.1.11.2 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19129559&form=6&db=m Genomic changes of the 55 kDa subunit of DNA polymerase epsilon in human breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0 3.1.11.2 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8819107&form=6&db=m Potential role of DNA polymerase beta in gene therapy against cancer: a case for colorectal cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 3.1.11.2 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11133819&form=6&db=m Candidate mutator genes in mismatch repair-deficient thymic lymphomas: no evidence of mutations in the DNA polymerase delta gene. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0 3.1.11.2 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19145245&form=6&db=m DNA polymerase delta is required for early mammalian embryogenesis. causal interaction,therapeutic application,unassigned 3,1,0 3.1.11.2 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27498873&form=6&db=m Dis3l2-Mediated Decay Is a Quality Control Pathway for Noncoding RNAs. unassigned - 3.1.11.2 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28943952&form=6&db=m miRNA biogenesis-associated RNase III nucleases Drosha and Dicer are upregulated in colorectal adenocarcinoma. causal interaction,unassigned 4,0 3.1.11.2 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3678823&form=6&db=m Factors that interact with the rat albumin promoter are present both in hepatocytes and other cell types. ongoing research,unassigned 2,0 3.1.11.2 Chickenpox http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2852411&form=6&db=m Computer-assisted primary and secondary structure analyses of DNA polymerases of herpes simplex, Epstein-Barr and varicella zoster viruses reveal conserved domains with some homology to DNA-binding domain in E. coli DNA pol I. unassigned - 3.1.11.2 Clostridium Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31221610&form=6&db=m Discovery and development of DNA polymerase IIIC inhibitors to treat Gram-positive infections. therapeutic application,unassigned 4,0 3.1.11.2 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9159160&form=6&db=m Positionally cloned human disease genes: patterns of evolutionary conservation and functional motifs. unassigned - 3.1.11.2 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8819107&form=6&db=m Potential role of DNA polymerase beta in gene therapy against cancer: a case for colorectal cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 3.1.11.2 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15075389&form=6&db=m A DNA polymerase beta mutant from colon cancer cells induces mutations. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 3.1.11.2 Colorectal Neoplasms, Hereditary Nonpolyposis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9159160&form=6&db=m Positionally cloned human disease genes: patterns of evolutionary conservation and functional motifs. unassigned - 3.1.11.2 Communicable Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32810705&form=6&db=m Grafting homogenous electrochemical biosensing strategy based on reverse proximity ligation and Exo III assisted target circulation for multiplexed communicable disease DNA assay. therapeutic application,unassigned 1,0 3.1.11.2 Coronary Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22915169&form=6&db=m Age-dependent down-regulation of DNA polymerase ?1 in human lymphocytes. diagnostic usage,ongoing research,unassigned 4,4,0 3.1.11.2 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33410447&form=6&db=m Dual recognition element-controlled logic DNA circuit for COVID-19 detection based on exonuclease III and DNAzyme. diagnostic usage,therapeutic application,unassigned 3,1,0 3.1.11.2 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18657606&form=6&db=m Single-tube genotyping using a solid-phase method that combines alpha-phosphorothioate-mediated primer extension and ExoIII: Proof of concept with the F508del cystic fibrosis diagnosis. diagnostic usage,therapeutic application,unassigned 2,1,0 3.1.11.2 Dehydration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26040115&form=6&db=m Detection of DNA polymerase ? activity during seed germination and enhancement after salinity stress and dehydration in the plumules of indica rice (Oryza sativa L. diagnostic usage,ongoing research,unassigned 3,2,0 3.1.11.2 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22915169&form=6&db=m Age-dependent down-regulation of DNA polymerase ?1 in human lymphocytes. diagnostic usage,ongoing research,unassigned 4,4,0 3.1.11.2 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30098371&form=6&db=m Potential effects of metformin in DNA BER system based on oxidative status in type 2 diabetes. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 3.1.11.2 DiGeorge Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24420069&form=6&db=m Expression of DGCR8-Dependent MicroRNAs Is Indispensable for Osteoclastic Development and Bone-Resorbing Activity. unassigned - 3.1.11.2 DNA Repair-Deficiency Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12949090&form=6&db=m YqfS from Bacillus subtilis is a spore protein and a new functional member of the type IV apurinic/apyrimidinic-endonuclease family. ongoing research,therapeutic application,unassigned 1,2,0 3.1.11.2 Encephalitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20419814&form=6&db=m Neurovirulence and latency of drug-resistant clinical herpes simplex viruses in animal models. diagnostic usage,ongoing research,unassigned 3,3,0 3.1.11.2 exodeoxyribonuclease (lambda-induced) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9657948&form=6&db=m Mutations in the Exo III motif of the herpes simplex virus DNA polymerase gene can confer altered drug sensitivities. causal interaction,therapeutic application,unassigned 3,1,0 3.1.11.2 exodeoxyribonuclease iii deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=98520&form=6&db=m Altered mRNA metabolism in ribonuclease III-deficient strains of Escherichia coli. unassigned - 3.1.11.2 exodeoxyribonuclease iii deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1100605&form=6&db=m Genetic mapping of a mutation that causes ribonucleases III deficiency in Escherichia coli. causal interaction,unassigned 3,0 3.1.11.2 exodeoxyribonuclease iii deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10498729&form=6&db=m A Streptomyces coelicolor antibiotic regulatory gene, absB, encodes an RNase III homolog. unassigned - 3.1.11.2 exodeoxyribonuclease iii deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30425296&form=6&db=m AP endonuclease EXO-3 deficiency causes developmental delay and abnormal vulval organogenesis, Pvl, through DNA glycosylase-initiated checkpoint activation in Caenorhabditis elegans. causal interaction,unassigned 2,0 3.1.11.2 Geographic Atrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22869729&form=6&db=m ERK1/2 activation is a therapeutic target in age-related macular degeneration. causal interaction,therapeutic application,unassigned 4,4,0 3.1.11.2 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32810705&form=6&db=m Grafting homogenous electrochemical biosensing strategy based on reverse proximity ligation and Exo III assisted target circulation for multiplexed communicable disease DNA assay. therapeutic application,unassigned 1,0 3.1.11.2 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16170153&form=6&db=m RNase III cleavage demonstrates a long range RNA: RNA duplex element flanking the hepatitis C virus internal ribosome entry site. causal interaction,therapeutic application,unassigned 4,2,0 3.1.11.2 Herpes Genitalis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12367650&form=6&db=m Novel mutations in the thymidine kinase and DNA polymerase genes of acyclovir and foscarnet resistant herpes simplex viruses infecting an immunocompromised patient. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 3.1.11.2 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=217168&form=6&db=m Exonuclease III digestion of herpes simplex virus DNA. unassigned - 3.1.11.2 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1652064&form=6&db=m Polymerization activity of an alpha-like DNA polymerase requires a conserved 3'-5' exonuclease active site. ongoing research,therapeutic application,unassigned 3,1,0 3.1.11.2 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2852411&form=6&db=m Computer-assisted primary and secondary structure analyses of DNA polymerases of herpes simplex, Epstein-Barr and varicella zoster viruses reveal conserved domains with some homology to DNA-binding domain in E. coli DNA pol I. unassigned - 3.1.11.2 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6167579&form=6&db=m Herpes simplex virus type I DNA polymerase. Kinetic properties of the associated 3'-5' exonuclease activity and its role in araAMP incorporation. ongoing research,unassigned 2,0 3.1.11.2 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7653104&form=6&db=m Identification and characterization of a Marek's disease virus gene encoding DNA polymerase. ongoing research,therapeutic application,unassigned 4,2,0 3.1.11.2 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8676514&form=6&db=m Evidence that the nuclease activities associated with the herpes simplex type 1 DNA polymerase are due to the 3'-5' exonuclease. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 3.1.11.2 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8847505&form=6&db=m Mutations within conserved motifs in the 3'-5' exonuclease domain of herpes simplex virus DNA polymerase. ongoing research,unassigned 4,0 3.1.11.2 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9311864&form=6&db=m Effects of mutations in the Exo III motif of the herpes simplex virus DNA polymerase gene on enzyme activities, viral replication, and replication fidelity. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,2,0 3.1.11.2 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9657948&form=6&db=m Mutations in the Exo III motif of the herpes simplex virus DNA polymerase gene can confer altered drug sensitivities. causal interaction,therapeutic application,unassigned 3,1,0 3.1.11.2 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15135733&form=6&db=m On the role of proofreading exonuclease in bypass of a 1,2 d(GpG) cisplatin adduct by the herpes simplex virus-1 DNA polymerase. unassigned - 3.1.11.2 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27136098&form=6&db=m Methods for Efficient Elimination of Mitochondrial DNA from Cultured Cells. unassigned - 3.1.11.2 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2852411&form=6&db=m Computer-assisted primary and secondary structure analyses of DNA polymerases of herpes simplex, Epstein-Barr and varicella zoster viruses reveal conserved domains with some homology to DNA-binding domain in E. coli DNA pol I. unassigned - 3.1.11.2 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6311255&form=6&db=m Structure of chromatin at deoxyribonucleic acid replication forks: nuclease hypersensitivity results from both prenucleosomal deoxyribonucleic acid and an immature chromatin structure. diagnostic usage,unassigned 3,0 3.1.11.2 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=353304&form=6&db=m Effect of RNase III on efficiency of translation of bacteriophage T7 lysozyme mRNA. diagnostic usage,ongoing research,unassigned 3,3,0 3.1.11.2 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2421253&form=6&db=m Nuclear activity from F9 embryonal carcinoma cells binding specifically to the enhancers of wild-type polyoma virus and PyEC mutant DNAs. diagnostic usage,ongoing research,unassigned 1,1,0 3.1.11.2 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6406499&form=6&db=m RNase III is positively regulated by T7 protein kinase. therapeutic application,unassigned 2,0 3.1.11.2 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12367650&form=6&db=m Novel mutations in the thymidine kinase and DNA polymerase genes of acyclovir and foscarnet resistant herpes simplex viruses infecting an immunocompromised patient. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 3.1.11.2 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12665598&form=6&db=m CDP/Cux stimulates transcription from the DNA polymerase alpha gene promoter. ongoing research,unassigned 1,0 3.1.11.2 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12829822&form=6&db=m Drug resistance patterns of recombinant herpes simplex virus DNA polymerase mutants generated with a set of overlapping cosmids and plasmids. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 3.1.11.2 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20071573&form=6&db=m An Ascovirus-encoded RNase III autoregulates its expression and suppresses RNA interference-mediated gene silencing. ongoing research,therapeutic application,unassigned 1,1,0 3.1.11.2 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20419814&form=6&db=m Neurovirulence and latency of drug-resistant clinical herpes simplex viruses in animal models. diagnostic usage,ongoing research,unassigned 3,3,0 3.1.11.2 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23480773&form=6&db=m Impaired antioxidant enzyme activity and increased DNA repair enzyme expression in hamster liver tissues related to cholangiocarcinoma development. causal interaction,ongoing research,unassigned 3,2,0 3.1.11.2 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27150669&form=6&db=m Mechanism of Ribonuclease III Catalytic Regulation by Serine Phosphorylation. therapeutic application,unassigned 1,0 3.1.11.2 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31221610&form=6&db=m Discovery and development of DNA polymerase IIIC inhibitors to treat Gram-positive infections. therapeutic application,unassigned 4,0 3.1.11.2 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34026825&form=6&db=m A Glimpse of "Dicer Biology" Through the Structural and Functional Perspective. causal interaction,therapeutic application,unassigned 1,1,0 3.1.11.2 Infertility http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11719970&form=6&db=m The RNase III family: a conserved structure and expanding functions in eukaryotic dsRNA metabolism. unassigned - 3.1.11.2 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7683082&form=6&db=m DNA damage induced by photosensitizers in cellular and cell-free systems. ongoing research,unassigned 2,0 3.1.11.2 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10833512&form=6&db=m A 3'-5' exonuclease in human leukemia cells: implications for resistance to 1-beta -D-arabinofuranosylcytosine and 9-beta -D-arabinofuranosyl-2-fluoroadenine 5'-monophosphate. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 3.1.11.2 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14521941&form=6&db=m Human AP endonuclease possesses a significant activity as major 3'-5' exonuclease in human leukemia cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 3.1.11.2 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2548146&form=6&db=m In situ and in vitro evidence for intragenic binding of nuclear factors at the murine c-myc locus. ongoing research,unassigned 3,0 3.1.11.2 Leukemia, Lymphocytic, Chronic, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10833512&form=6&db=m A 3'-5' exonuclease in human leukemia cells: implications for resistance to 1-beta -D-arabinofuranosylcytosine and 9-beta -D-arabinofuranosyl-2-fluoroadenine 5'-monophosphate. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 3.1.11.2 Leukemia, Lymphoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9067421&form=6&db=m A DNA polymerase alpha accessory protein exhibits structural and functional similarities to SV40 large tumor antigen. diagnostic usage,ongoing research,unassigned 3,3,0 3.1.11.2 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10833512&form=6&db=m A 3'-5' exonuclease in human leukemia cells: implications for resistance to 1-beta -D-arabinofuranosylcytosine and 9-beta -D-arabinofuranosyl-2-fluoroadenine 5'-monophosphate. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 3.1.11.2 Lyme Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29632096&form=6&db=m RNase III Processing of rRNA in the Lyme Disease Spirochete Borrelia burgdorferi. therapeutic application,unassigned 1,0 3.1.11.2 Lyme Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32703440&form=6&db=m Transcript decay mediated by RNase III in Borrelia burgdorferi. unassigned - 3.1.11.2 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11133819&form=6&db=m Candidate mutator genes in mismatch repair-deficient thymic lymphomas: no evidence of mutations in the DNA polymerase delta gene. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0 3.1.11.2 Macular Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22869729&form=6&db=m ERK1/2 activation is a therapeutic target in age-related macular degeneration. causal interaction,therapeutic application,unassigned 4,4,0 3.1.11.2 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17039395&form=6&db=m Potential roles of 3'-5' exonuclease activity of NM23-H1 in DNA repair and malignant progression. causal interaction,diagnostic usage,unassigned 2,1,0 3.1.11.2 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22028668&form=6&db=m Feed-forward microprocessing and splicing activities at a microRNA-containing intron. causal interaction,unassigned 1,0 3.1.11.2 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23370771&form=6&db=m Expression of the RNase III enzyme DROSHA is reduced during progression of human cutaneous melanoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1 3.1.11.2 Mitochondrial Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17762861&form=6&db=m The EM structure of human DNA polymerase gamma reveals a localized contact between the catalytic and accessory subunits. diagnostic usage,ongoing research,unassigned 3,3,0 3.1.11.2 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10402247&form=6&db=m Lack of mutations in DNA polymerase beta of estradiol-induced hamster kidney tumors: sequence of hamster DNA polymerase beta cDNA. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1 3.1.11.2 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14960567&form=6&db=m The metastasis suppressor NM23-H1 possesses 3'-5' exonuclease activity. causal interaction,unassigned 4,0 3.1.11.2 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17039395&form=6&db=m Potential roles of 3'-5' exonuclease activity of NM23-H1 in DNA repair and malignant progression. causal interaction,diagnostic usage,unassigned 2,1,0 3.1.11.2 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19381784&form=6&db=m Potential contributions of antimutator activity to the metastasis suppressor function of NM23-H1. causal interaction,therapeutic application,unassigned 1,4,0 3.1.11.2 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20209495&form=6&db=m Metastasis suppressor function of NM23-H1 requires its 3';-5' exonuclease activity. causal interaction,ongoing research,unassigned 1,4,0 3.1.11.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3028054&form=6&db=m The enzymatic basis of cyclophosphamide specificity. unassigned - 3.1.11.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3036207&form=6&db=m Characterization and sequence-specific binding to mouse mammary tumor virus DNA of purified activated human glucocorticoid receptor. ongoing research,therapeutic application,unassigned 3,1,0 3.1.11.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8653081&form=6&db=m Mutations in DNA polymerase beta mRNA of stilbene estrogen-induced kidney tumors in Syrian hamster. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 3.1.11.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10402247&form=6&db=m Lack of mutations in DNA polymerase beta of estradiol-induced hamster kidney tumors: sequence of hamster DNA polymerase beta cDNA. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1 3.1.11.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12756620&form=6&db=m RT-PCR detection of the expression of the polymerase gene of a novel reptilian herpesvirus in tumor tissues of green turtles with fibropapilloma. ongoing research,unassigned 3,0 3.1.11.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15075389&form=6&db=m A DNA polymerase beta mutant from colon cancer cells induces mutations. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 3.1.11.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18421256&form=6&db=m Interactions between the double-stranded RNA-binding proteins TRBP and PACT define the Medipal domain that mediates protein-protein interactions. ongoing research,unassigned 1,0 3.1.11.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19074842&form=6&db=m MicroRNAs and cancer: past, present, and potential future. unassigned - 3.1.11.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19336415&form=6&db=m Human DNA polymerase {beta} polymorphism, Arg137Gln, impairs its polymerase activity and interaction with PCNA and the cellular base excision repair capacity. diagnostic usage,unassigned 3,0 3.1.11.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20551246&form=6&db=m Genomic analysis of the 55 kDa subunit of DNA polymerase epsilon in human intracranial neoplasms. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0 3.1.11.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21205968&form=6&db=m DICER1 mutations in familial multinodular goiter with and without ovarian Sertoli-Leydig cell tumors. causal interaction,unassigned 4,0 3.1.11.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22122464&form=6&db=m Biological Relevance of DNA Polymerase Beta and Translesion Synthesis Polymerases to Cancer and its Treatment. diagnostic usage,unassigned 3,0 3.1.11.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22187960&form=6&db=m Recurrent somatic DICER1 mutations in nonepithelial ovarian cancers. causal interaction,unassigned 4,0 3.1.11.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22546613&form=6&db=m In vivo structure-function analysis of human Dicer reveals directional processing of precursor miRNAs. causal interaction,unassigned 3,0 3.1.11.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23118481&form=6&db=m Silencing of human DNA polymerase ? causes replication stress and is synthetically lethal with an impaired S phase checkpoint. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0 3.1.11.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23480773&form=6&db=m Impaired antioxidant enzyme activity and increased DNA repair enzyme expression in hamster liver tissues related to cholangiocarcinoma development. causal interaction,ongoing research,unassigned 3,2,0 3.1.11.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23547758&form=6&db=m Germ-line DICER1 mutations do not make a major contribution to the etiology of familial testicular germ cell tumours. causal interaction,diagnostic usage,unassigned 2,3,0 3.1.11.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24154628&form=6&db=m Base excision repair AP endonucleases and mismatch repair act together to induce checkpoint-mediated autophagy. therapeutic application,unassigned 4,0 3.1.11.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24325353&form=6&db=m A low dicer expression is associated with resistance to 5-FU-based chemoradiotherapy and a shorter overall survival in patients with oral squamous cell carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,2,0 3.1.11.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24730476&form=6&db=m Detection of microRNA in Tumor Cells using Exonuclease III and Graphene Oxide-Regulated Signal Amplification. diagnostic usage,ongoing research,unassigned 3,3,0 3.1.11.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24839956&form=6&db=m Pituitary blastoma: a pathognomonic feature of germ-line DICER1 mutations. causal interaction,unassigned 4,0 3.1.11.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25018051&form=6&db=m The development of Wilms tumor: from WT1 and microRNA to animal models. causal interaction,unassigned 4,0 3.1.11.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26519729&form=6&db=m New function of exonuclease and highly sensitive label-free colorimetric DNA detection. ongoing research,unassigned 1,0 3.1.11.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27108253&form=6&db=m Fluorescence detection of telomerase activity in cancer cell extracts based on autonomous exonuclease III-assisted isothermal cycling signal amplification. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,2,0 3.1.11.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28230864&form=6&db=m Dicer promotes tumorigenesis by translocating to nucleus to promote SFRP1 promoter methylation in cholangiocarcinoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.1.11.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28916654&form=6&db=m Biallelic Dicer1 loss mediated by aP2-Cre drives angiosarcoma. causal interaction,therapeutic application,unassigned 3,3,0 3.1.11.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29301327&form=6&db=m Family A and B DNA Polymerases in Cancer: Opportunities for Therapeutic Interventions. unassigned - 3.1.11.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32859993&form=6&db=m Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 3.1.11.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33085544&form=6&db=m Analysis of CNOT Family Gene Expression, Clinicopathological Features, and Prognosis Value in Hepatocellular Carcinoma. therapeutic application,unassigned 1,0 3.1.11.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33208384&form=6&db=m A complex DICER1 syndrome phenotype associated with a germline pathogenic variant affecting the RNase IIIa domain of DICER1. causal interaction,diagnostic usage,unassigned 3,3,0 3.1.11.2 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33608117&form=6&db=m Underappreciated Roles of DNA Polymerase ? in Replication Stress Survival. causal interaction,unassigned 2,0 3.1.11.2 Neoplasms, Germ Cell and Embryonal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23547758&form=6&db=m Germ-line DICER1 mutations do not make a major contribution to the etiology of familial testicular germ cell tumours. causal interaction,diagnostic usage,unassigned 2,3,0 3.1.11.2 Peste-des-Petits-Ruminants http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20099465&form=6&db=m Quantitative PCR: a quality control assay for estimation of viable virus content in live attenuated goat pox vaccine. diagnostic usage,ongoing research,unassigned 2,1,0 3.1.11.2 Photosensitivity Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7690977&form=6&db=m Roles of uracil-DNA glycosylase and apyrimidinic endonucleases in the molecular 5-bromo-2'-deoxyuridine photosensitization in Escherichia coli K-12. ongoing research,therapeutic application,unassigned 2,1,0 3.1.11.2 Photosensitivity Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31165808&form=6&db=m Universal and label-free photosensitization colorimetric assays enabled by target-induced termini transformation of dsDNA resistant to Exo III digestion. unassigned - 3.1.11.2 Photosensitivity Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31460466&form=6&db=m Systematic Probing of the Sequence Selectivity of Exonuclease III with a Photosensitization Colorimetric Assay. unassigned - 3.1.11.2 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2167848&form=6&db=m Characterisation of tissue-specific trans-acting factor binding to a proximal element in the rat growth hormone gene promoter. ongoing research,unassigned 3,0 3.1.11.2 Precursor B-Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24939216&form=6&db=m Rapamycin inhibits pre-B acute lymphoblastic leukemia cells by downregulating DNA and RNA polymerases. causal interaction,therapeutic application,unassigned 3,2,0 3.1.11.2 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33389538&form=6&db=m Evaluation of the clinical significance of RNase III enzyme DROSHA in pediatrics acute lymphocytic leukemia. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,1,0 3.1.11.2 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28524158&form=6&db=m Sequencing of DICER1 in sarcomas identifies biallelic somatic DICER1 mutations in an adult-onset embryonal rhabdomyosarcoma. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,2,0 3.1.11.2 Sarcoma, Avian http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=74124&form=6&db=m Rous sarcoma virus p19 binds to specific double-stranded regions of viral RNA: effect of p19 on cleavage of viral RNA by RNase III. ongoing research,therapeutic application,unassigned 2,1,0 3.1.11.2 Seminoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23547758&form=6&db=m Germ-line DICER1 mutations do not make a major contribution to the etiology of familial testicular germ cell tumours. causal interaction,diagnostic usage,unassigned 2,3,0 3.1.11.2 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=775291&form=6&db=m Consequences of losing ribonuclease III on the Escherichia coli cell. unassigned - 3.1.11.2 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16309817&form=6&db=m Adaptation to carbon starvation: RNase III ensures normal expression levels of bolA1p mRNA and sigma(S). causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,2 3.1.11.2 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24939216&form=6&db=m Rapamycin inhibits pre-B acute lymphoblastic leukemia cells by downregulating DNA and RNA polymerases. causal interaction,therapeutic application,unassigned 3,2,0 3.1.11.2 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28061446&form=6&db=m ?40p53 is involved in the inactivation of autophagy and contributes to inhibition of cell death in HCT116-?40p53 cells. ongoing research,unassigned 2,0 3.1.11.2 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7512868&form=6&db=m Nucleotide sequence and secondary structures of precursor 16S rRNA of slow-growing mycobacteria. diagnostic usage,unassigned 1,0 3.1.11.2 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15032606&form=6&db=m Using property based sequence motifs and 3D modeling to determine structure and functional regions of proteins. ongoing research,unassigned 1,0 3.1.11.2 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16155207&form=6&db=m Structure of the nuclease domain of ribonuclease III from M. tuberculosis at 2.1 A. ongoing research,unassigned 4,0 3.1.11.2 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25748880&form=6&db=m Critical determinants for substrate recognition and catalysis in the M. tuberculosis class II AP-endonuclease/3'-5' exonuclease III. therapeutic application,unassigned 1,0 3.1.11.2 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26043425&form=6&db=m Characterization of DNA substrate specificities of apurinic/apyrimidinic endonucleases from Mycobacterium tuberculosis. therapeutic application,unassigned 1,0 3.1.11.2 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26103519&form=6&db=m Mycobacterium tuberculosis class II apurinic/apyrimidinic-endonuclease/3'-5' exonuclease III exhibits DNA regulated modes of interaction with the sliding DNA ?-clamp. unassigned - 3.1.11.2 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33871439&form=6&db=m [Characterization of Recombinant Endonuclease IV from Mycobacterium tuberculosis]. ongoing research,unassigned 2,0 3.1.11.2 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2581949&form=6&db=m DNA primase-DNA polymerase alpha from simian cells. Modulation of RNA primer synthesis by ribonucleoside triphosphates. diagnostic usage,ongoing research,unassigned 3,1,0 3.1.11.2 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8389930&form=6&db=m Genetic characterization of the vaccinia virus DNA polymerase: cytosine arabinoside resistance requires a variable lesion conferring phosphonoacetate resistance in conjunction with an invariant mutation localized to the 3'-5' exonuclease domain. therapeutic application,unassigned 1,0 3.1.11.2 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9007060&form=6&db=m Complementation of deletion of the vaccinia virus E3L gene by the Escherichia coli RNase III gene. ongoing research,therapeutic application,unassigned 3,2,0 3.1.11.2 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16768460&form=6&db=m Intercalating polycyclic aromatic hydrocarbon-DNA adducts poison DNA religation by Vaccinia topoisomerase and act as roadblocks to digestion by exonuclease III. ongoing research,unassigned 2,0 3.1.11.2 Vesicular Stomatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=225509&form=6&db=m RNase III cleaves vesicular stomatitis virus genome-length RNAs but fails to cleave viral mRNA's. diagnostic usage,therapeutic application,unassigned 3,2,0 3.1.11.2 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=200942&form=6&db=m Sequence arrangement of the 5' ends of simian virus 40 16S and 19S mRNAs. unassigned - 3.1.11.2 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11252379&form=6&db=m Accumulation of barley stripe mosaic virus is significantly reduced in transgenic wheat plants expressing a bacterial ribonuclease. diagnostic usage,unassigned 3,0 3.1.11.2 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24778219&form=6&db=m Drosha as an interferon-independent antiviral factor. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 3.1.11.2 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31754801&form=6&db=m Study of the role of Mg2+ in dsRNA processing mechanism by bacterial RNase III through QM/MM simulations. causal interaction,unassigned 2,0 3.1.11.2 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9159160&form=6&db=m Positionally cloned human disease genes: patterns of evolutionary conservation and functional motifs. unassigned - 3.1.11.2 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15385537&form=6&db=m Regulation of WRN helicase activity in human base excision repair. causal interaction,therapeutic application,unassigned 2,1,0 3.1.11.2 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17224176&form=6&db=m WRN exonuclease activity is blocked by DNA termini harboring 3' obstructive groups. diagnostic usage,therapeutic application,unassigned 3,1,0 3.1.11.2 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17229737&form=6&db=m Probing the roles of active site residues in the 3'-5' exonuclease of the Werner syndrome protein. therapeutic application,unassigned 1,0 3.1.11.2 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18346216&form=6&db=m Identification and characterization of a Drosophila ortholog of WRN exonuclease that is required to maintain genome integrity. causal interaction,unassigned 3,0 3.1.11.2 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30137433&form=6&db=m Mutations induced by 8-oxo-7,8-dihydroguanine in WRN- and DNA polymerase ?-double knockdown cells. unassigned - 3.1.11.2 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33646120&form=6&db=m C. elegans orthologs MUT-7/CeWRN-1 of Werner syndrome protein regulate neuronal plasticity. therapeutic application,unassigned 1,0 3.1.11.2 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34406853&form=6&db=m RNase III and RNase E Influence Posttranscriptional Regulatory Networks Involved in Virulence Factor Production, Metabolism, and Regulatory RNA Processing in Bordetella pertussis. causal interaction,therapeutic application,unassigned 1,1,0 3.1.11.2 Wilms Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25018051&form=6&db=m The development of Wilms tumor: from WT1 and microRNA to animal models. causal interaction,unassigned 4,0