2.7.1.3 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31750240&form=6&db=m Prognostic Impact of Metabolism Reprogramming Markers Acetyl-CoA Synthetase 2 Phosphorylation and Ketohexokinase-A Expression in Non-Small-Cell Lung Carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,2,0 2.7.1.3 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16372272&form=6&db=m The expression of ketohexokinase is diminished in human clear cell type of renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0 2.7.1.3 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32928708&form=6&db=m KHK-A promotes the proliferation of oesophageal squamous cell carcinoma through the up-regulation of PRPS1. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,2,0 2.7.1.3 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27088854&form=6&db=m A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation. ongoing research,unassigned 1,0 2.7.1.3 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16372272&form=6&db=m The expression of ketohexokinase is diminished in human clear cell type of renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0 2.7.1.3 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26083752&form=6&db=m HIF-driven SF3B1 induces KHK-C to enforce fructolysis and heart disease. therapeutic application,unassigned 1,0 2.7.1.3 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34487756&form=6&db=m Endogenous fructose is correlated with urinary albumin creatinine ratios and uric acid in type 2 diabetes mellitus. diagnostic usage,unassigned 4,0 2.7.1.3 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34487756&form=6&db=m Endogenous fructose is correlated with urinary albumin creatinine ratios and uric acid in type 2 diabetes mellitus. diagnostic usage,unassigned 4,0 2.7.1.3 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32928708&form=6&db=m KHK-A promotes the proliferation of oesophageal squamous cell carcinoma through the up-regulation of PRPS1. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,2,0 2.7.1.3 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28972537&form=6&db=m Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling. ongoing research,therapeutic application,unassigned 2,1,0 2.7.1.3 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33490936&form=6&db=m Ketohexokinase inhibition improves NASH by reducing fructose-induced steatosis and fibrogenesis. unassigned - 2.7.1.3 Fructose Intolerance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8471037&form=6&db=m Expression of rat liver ketohexokinase in yeast results in fructose intolerance. ongoing research,unassigned 2,0 2.7.1.3 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30031605&form=6&db=m Ketohexokinase is involved in fructose utilization and promotes tumor progression in glioma. causal interaction,unassigned 4,0 2.7.1.3 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26083752&form=6&db=m HIF-driven SF3B1 induces KHK-C to enforce fructolysis and heart disease. therapeutic application,unassigned 1,0 2.7.1.3 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20205309&form=6&db=m Science letters: Proteomic analysis of differentially expressed proteins in mice with concanavalin A-induced hepatitis. unassigned - 2.7.1.3 Hyperoxaluria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19300989&form=6&db=m Calciuria, oxaluria and phosphaturia after ingestion of glucose, xylitol and sorbitol in two population groups with different stone-risk profiles. causal interaction,therapeutic application,unassigned 3,2,0 2.7.1.3 Hypoglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29533924&form=6&db=m Ketohexokinase C blockade ameliorates fructose-induced metabolic dysfunction in fructose-sensitive mice. causal interaction,therapeutic application,unassigned 4,4,0 2.7.1.3 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31935149&form=6&db=m Fructose and hepatic insulin resistance. unassigned - 2.7.1.3 ketohexokinase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12941785&form=6&db=m Properties of normal and mutant recombinant human ketohexokinases and implications for the pathogenesis of essential fructosuria. causal interaction,unassigned 4,0 2.7.1.3 ketohexokinase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33057854&form=6&db=m Tissue-Specific Fructose Metabolism in Obesity and Diabetes. unassigned - 2.7.1.3 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33490936&form=6&db=m Ketohexokinase inhibition improves NASH by reducing fructose-induced steatosis and fibrogenesis. unassigned - 2.7.1.3 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34326012&form=6&db=m Fructose and fructose kinase in cancer and other pathologies. ongoing research,unassigned 3,0 2.7.1.3 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29017895&form=6&db=m Short-term fructose ingestion affects the brain independently from establishment of metabolic syndrome. unassigned - 2.7.1.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16372272&form=6&db=m The expression of ketohexokinase is diminished in human clear cell type of renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0 2.7.1.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30031605&form=6&db=m Ketohexokinase is involved in fructose utilization and promotes tumor progression in glioma. causal interaction,unassigned 4,0 2.7.1.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31750240&form=6&db=m Prognostic Impact of Metabolism Reprogramming Markers Acetyl-CoA Synthetase 2 Phosphorylation and Ketohexokinase-A Expression in Non-Small-Cell Lung Carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,2,0 2.7.1.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32928708&form=6&db=m KHK-A promotes the proliferation of oesophageal squamous cell carcinoma through the up-regulation of PRPS1. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,2,0 2.7.1.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34326012&form=6&db=m Fructose and fructose kinase in cancer and other pathologies. ongoing research,unassigned 3,0 2.7.1.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34408323&form=6&db=m Dietary fructose improves intestinal cell survival and nutrient absorption. therapeutic application,unassigned 2,0 2.7.1.3 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33490936&form=6&db=m Ketohexokinase inhibition improves NASH by reducing fructose-induced steatosis and fibrogenesis. unassigned - 2.7.1.3 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22795331&form=6&db=m Pyrimidinopyrimidine inhibitors of ketohexokinase: Exploring the ring C2 group that interacts with Asp-27B in the ligand binding pocket. causal interaction,therapeutic application,unassigned 4,4,0 2.7.1.3 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24900346&form=6&db=m Inhibitors of Ketohexokinase: Discovery of Pyrimidinopyrimidines with Specific Substitution that Complements the ATP-Binding Site. therapeutic application,unassigned 4,0 2.7.1.3 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34252535&form=6&db=m IL-6/STAT3 signaling activation exacerbates high fructose-induced podocyte hypertrophy by ketohexokinase-A-mediated tristetraprolin down-regulation. causal interaction,unassigned 3,0