2.4.1.11 1,4-alpha-glucan branching enzyme deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23607684&form=6&db=m Polyglucosan neurotoxicity caused by glycogen branching enzyme deficiency can be reversed by inhibition of glycogen synthase. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,4 2.4.1.11 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32364678&form=6&db=m Protection of melatonin against acidosis-induced neuronal injuries. unassigned - 2.4.1.11 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22258319&form=6&db=m Inhibition of glycogen synthase kinase-3? prevents NSAID-induced acute kidney injury. causal interaction,therapeutic application,unassigned 2,3,0 2.4.1.11 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22785175&form=6&db=m Specific deletion of glycogen synthase kinase-3? in the renal proximal tubule protects against acute nephrotoxic injury in mice. causal interaction,unassigned 3,0 2.4.1.11 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25323773&form=6&db=m Inhibition of glycogen synthase kinase-3? attenuates acute kidney injury in sodium taurocholate?induced severe acute pancreatitis in rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 2.4.1.11 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26092126&form=6&db=m Glycogen synthase kinase-3 inhibition attenuates fibroblast activation and development of fibrosis following renal ischemia-reperfusion in mice. causal interaction,unassigned 4,0 2.4.1.11 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28962480&form=6&db=m Glycogen synthase kinase-3? inhibitor ameliorates imbalance of connexin 43 in an acute kidney injury model. therapeutic application,unassigned 3,0 2.4.1.11 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31315730&form=6&db=m [Experimental study on the mechanism of glycogen synthase kinase-3? inhibitor on acute kidney injury of acute necrotizing pancreatitis in rats]. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 2.4.1.11 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31685087&form=6&db=m Effect of acetazolamide on lithium reabsorption and lithium-induced GSK3? phosphorylation in rat kidney. unassigned - 2.4.1.11 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32813289&form=6&db=m Glycogen synthase kinase-3? inhibits tubular regeneration in acute kidney injury by a FoxM1-dependent mechanism. therapeutic application,unassigned 1,0 2.4.1.11 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34440091&form=6&db=m Pharmacologically Inhibiting Glycogen Synthase Kinase-3? Ameliorates Renal Inflammation and Nephrotoxicity in an Animal Model of Cisplatin-Induced Acute Kidney Injury. ongoing research,unassigned 3,0 2.4.1.11 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28901469&form=6&db=m Glycogen synthase kinase?3? inhibitor reduces LPS?induced acute lung injury in mice. causal interaction,ongoing research,therapeutic application,unassigned 2,1,4,0 2.4.1.11 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9464846&form=6&db=m Tamoxifen exerts oestrogen-agonistic effects on proliferation and plasminogen activation, but not on gelatinase activity, glycogen metabolism and p53 protein expression, in cultures of oestrogen-responsive human endometrial adenocarcinoma cells. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.1.11 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27236820&form=6&db=m Inhibition of p90 ribosomal S6 kinase attenuates cell migration and proliferation of the human lung adenocarcinoma through phospho-GSK-3? and osteopontin. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 2.4.1.11 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7927248&form=6&db=m Hepatic preneoplasia in hepatitis B virus transgenic mice. causal interaction,unassigned 4,0 2.4.1.11 Adenoma, Liver Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2569254&form=6&db=m Unusual histochemical pattern in preneoplastic hepatic foci characterized by hyperactivity of several enzymes. unassigned - 2.4.1.11 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16426922&form=6&db=m Expression of Wnt-signaling pathway proteins in intraductal papillary mucinous neoplasms of the pancreas: a tissue microarray analysis. unassigned - 2.4.1.11 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16670426&form=6&db=m Novel method for high throughput DNA methylation marker evaluation using PNA-probe library hybridization and MALDI-TOF detection. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.1.11 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21880954&form=6&db=m Whole blueberry powder modulates the growth and metastasis of MDA-MB-231 triple negative breast tumors in nude mice. causal interaction,ongoing research,unassigned 1,3,0 2.4.1.11 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26992223&form=6&db=m MicroRNA-1229 overexpression promotes cell proliferation and tumorigenicity and activates Wnt/?-catenin signaling in breast cancer. unassigned - 2.4.1.11 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28057765&form=6&db=m Insulin signaling regulates a functional interaction between adenomatous polyposis coli and cytoplasmic dynein. ongoing research,therapeutic application,unassigned 2,1,0 2.4.1.11 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29238040&form=6&db=m IL-3R-alpha blockade inhibits tumor endothelial cell-derived extracellular vesicle (EV)-mediated vessel formation by targeting the ?-catenin pathway. causal interaction,unassigned 1,0 2.4.1.11 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30033597&form=6&db=m LncNEN885 inhibits epithelial-mesenchymal transition by partially regulation of Wnt/?-catenin signalling in gastroenteropancreatic neuroendocrine neoplasms. causal interaction,therapeutic application,unassigned 2,1,0 2.4.1.11 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32096189&form=6&db=m Influence of miR-155 on behaviors of depression mice through regulating Wnt/?-catenin signaling pathway. unassigned - 2.4.1.11 Adrenal Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32199239&form=6&db=m Dexamethasone and prednisolone treatment in beef cattle: influence on glycogen deposition and gene expression in the liver. ongoing research,unassigned 1,0 2.4.1.11 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7566335&form=6&db=m Networking with proline-directed protein kinases implicated in tau phosphorylation. causal interaction,unassigned 3,0 2.4.1.11 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12410379&form=6&db=m Glycogen synthase kinase-3 is associated with neuronal and glial hyperphosphorylated tau deposits in Alzheimer's disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration. causal interaction,unassigned 3,0 2.4.1.11 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17010615&form=6&db=m Probing the physicochemical and structural requirements for glycogen synthase kinase-3alpha inhibition: 2D-QSAR for 3-anilino-4-phenylmaleimides. causal interaction,therapeutic application,unassigned 4,3,0 2.4.1.11 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20043814&form=6&db=m Up-regulation of Hypoxia-Inducible Factor (HIF) -1alpha and HIF-Target Genes in Cortical Neurons by the Novel Multifunctional Iron Chelator Anti-Alzheimer Drug, M30. unassigned - 2.4.1.11 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21171034&form=6&db=m Inhibition of glycogen synthase kinase-3? by Angelica sinensis extract decreases ?-amyloid-induced neurotoxicity and tau phosphorylation in cultured cortical neurons. causal interaction,unassigned 4,0 2.4.1.11 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21212533&form=6&db=m Glycogen synthase kinase-3?2 has lower phosphorylation activity to tau than glycogen synthase kinase-3?1. causal interaction,unassigned 1,0 2.4.1.11 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21259330&form=6&db=m Inhibition of glycogen synthase kinase-3? by Angelica sinensis extract decreases ?-amyloid-induced neurotoxicity and tau phosphorylation in cultured cortical neurons. causal interaction,unassigned 4,0 2.4.1.11 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21321394&form=6&db=m Long-Term Treatment with Lithium Alleviates Memory Deficits and Reduces Amyloid-? Production in an Aged Alzheimer's Disease Transgenic Mouse Model. causal interaction,unassigned 2,0 2.4.1.11 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21411544&form=6&db=m Insulin Suppresses the Expression of Amyloid Precursor Protein, Presenilins, and Glycogen Synthase Kinase-3{beta} in Peripheral Blood Mononuclear Cells. causal interaction,unassigned 4,0 2.4.1.11 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21561378&form=6&db=m Development of a Cellular Tau Enzyme-Linked Immunosorbent Assay Method for Screening GSK-3? Inhibitors. causal interaction,unassigned 3,0 2.4.1.11 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21629716&form=6&db=m Targeting Glycogen Synthase Kinase-3? for Therapeutic Benefit against Oxidative Stress in Alzheimer's Disease: Involvement of the Nrf2-ARE Pathway. causal interaction,therapeutic application,unassigned 2,4,0 2.4.1.11 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21629736&form=6&db=m Glycogen synthase kinase-3?: a mediator of inflammation in Alzheimer's disease? causal interaction,unassigned 1,0 2.4.1.11 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21689104&form=6&db=m Acetyl-L-Carnitine ameliorates spatial memory deficits induced by inhibition of phosphoinositol-3 kinase and protein kinase C. causal interaction,therapeutic application,unassigned 1,1,0 2.4.1.11 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21826701&form=6&db=m The new indirubin derivative inhibitors of glycogen synthase kinase-3, 6-BIDECO and 6-BIMYEO, prevent tau phosphorylation and apoptosis induced by the inhibition of protein phosphatase-2A by okadaic acid in cultured neurons. causal interaction,unassigned 3,0 2.4.1.11 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22184106&form=6&db=m Prolyl Isomerase Pin1 Promotes Amyloid Precursor Protein (APP) Turnover by Inhibiting Glycogen Synthase Kinase-3? (GSK3?) Activity: NOVEL MECHANISM FOR Pin1 TO PROTECT AGAINST ALZHEIMER DISEASE. therapeutic application,unassigned 1,0 2.4.1.11 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22489897&form=6&db=m Discovery of Novel Potent and Highly Selective Glycogen Synthase Kinase-3? (GSK3?) Inhibitors for Alzheimer's Disease: Design, Synthesis, and Characterization of Pyrazines. causal interaction,therapeutic application,unassigned 1,4,0 2.4.1.11 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22785398&form=6&db=m Association of a GSK-3? Polymorphism with Brain Resting-State Function in Amnestic-Type Mild Cognitive Impairment. causal interaction,unassigned 3,0 2.4.1.11 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22944069&form=6&db=m Lithium treatment induces proteasomal degradation of over-expressed acetylcholinesterase (AChE-S) and inhibit GSK3? causal interaction,unassigned 3,0 2.4.1.11 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23047001&form=6&db=m Design, synthesis and biological evaluation of benzothiazepinones (BTZs) as novel non-ATP competitive inhibitors of glycogen synthase kinase-3? (GSK-3?). causal interaction,therapeutic application,unassigned 3,3,0 2.4.1.11 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23279147&form=6&db=m The peripheral messenger RNA expression of glycogen synthase kinase-3? genes in Alzheimer's disease patients: a preliminary study. causal interaction,ongoing research,unassigned 1,4,0 2.4.1.11 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23390016&form=6&db=m Glycogen synthase kinase-3? (GSK3?) expression in a mouse model of Alzheimer's disease: A light and electron microscopy study. causal interaction,ongoing research,unassigned 4,4,0 2.4.1.11 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23410232&form=6&db=m AZD1080, a novel GSK3 inhibitor, rescues synaptic plasticity deficits in rodent brain and exhibits peripheral target engagement in humans. causal interaction,therapeutic application,unassigned 4,4,0 2.4.1.11 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24334212&form=6&db=m GSK3?, CREB, and BDNF in peripheral blood of patients with Alzheimer's disease and depression. causal interaction,unassigned 2,0 2.4.1.11 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24768148&form=6&db=m Synthesis and evaluation of [(11)C]PyrATP-1, a novel radiotracer for PET imaging of glycogen synthase kinase-3? (GSK-3?). causal interaction,unassigned 4,0 2.4.1.11 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25960981&form=6&db=m Treadmill exercise decreases incidence of Alzheimer's disease by suppressing glycogen synthase kinase-3? expression in streptozotocin-induced diabetic rats. unassigned - 2.4.1.11 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26328540&form=6&db=m Combination of PKC? Activation and PTP1B Inhibition Effectively Suppresses A?-Induced GSK-3? Activation and Tau Phosphorylation. causal interaction,unassigned 2,0 2.4.1.11 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26385876&form=6&db=m Valproic Acid Modifies Synaptic Structure and Accelerates Neurite Outgrowth Via the Glycogen Synthase Kinase-3? Signaling Pathway in an Alzheimer's Disease Model. causal interaction,unassigned 4,0 2.4.1.11 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27064095&form=6&db=m Exploring Structural and Physicochemical Profiles of Potential GSK-3? Inhibitors Using Structure- and Ligand-Based Modeling Studies. causal interaction,therapeutic application,unassigned 4,1,0 2.4.1.11 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27131827&form=6&db=m Subcutaneous administration of liraglutide ameliorates learning and memory impairment by modulating tau hyperphosphorylation via the glycogen synthase kinase-3? pathway in an amyloid ? protein induced alzheimer disease mouse model. causal interaction,unassigned 1,0 2.4.1.11 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27660034&form=6&db=m Schisantherin B ameliorates A?1-42-induced cognitive decline via restoration of GLT-1 in a mouse model of Alzheimer's disease. unassigned - 2.4.1.11 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27832289&form=6&db=m Glycogen synthase kinase-3? regulates fractalkine production by altering its trafficking from Golgi to plasma membrane: implications for Alzheimer's disease. ongoing research,unassigned 1,0 2.4.1.11 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29234273&form=6&db=m Indirubin Derivative 7-Bromoindirubin-3-Oxime (7Bio) Attenuates A? Oligomer-Induced Cognitive Impairments in Mice. ongoing research,unassigned 2,0 2.4.1.11 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29381861&form=6&db=m Discovery of Selective, Substrate-Competitive, and Passive Membrane Permeable Glycogen Synthase Kinase-3? Inhibitors: Synthesis, Biological Evaluation, and Molecular Modeling of New C-Glycosylflavones. causal interaction,unassigned 4,0 2.4.1.11 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29944335&form=6&db=m Stereoisomers of Schisandrin B Are Potent ATP Competitive GSK-3? Inhibitors with Neuroprotective Effects against Alzheimer's Disease: Stereochemistry and Biological Activity. causal interaction,unassigned 4,0 2.4.1.11 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30413117&form=6&db=m Rosmarinic Acid Derivatives' Inhibition of Glycogen Synthase Kinase-3? Is the Pharmacological Basis of Kangen-Karyu in Alzheimer's Disease. causal interaction,therapeutic application,unassigned 4,4,0 2.4.1.11 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30533546&form=6&db=m IL-33 suppresses GSK-3? activation through an ST2-independent MyD88/TRAF6/RIP/PI3K/Akt pathway. causal interaction,ongoing research,unassigned 1,2,0 2.4.1.11 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31242571&form=6&db=m Design, Synthesis and Biological Evaluation of 7-Chloro-9H-pyrimido[4,5-b]indole-based Glycogen Synthase Kinase-3? Inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 2.4.1.11 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31459768&form=6&db=m Arylbenzofurans from the Root Bark of Morus alba as Triple Inhibitors of Cholinesterase, ?-Site Amyloid Precursor Protein Cleaving Enzyme 1, and Glycogen Synthase Kinase-3?: Relevance to Alzheimer's Disease. causal interaction,diagnostic usage,unassigned 3,3,0 2.4.1.11 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32283762&form=6&db=m Dietary Supplementation with Curcumin Reduce Circulating Levels of Glycogen Synthase Kinase-3? and Islet Amyloid Polypeptide in Adults with High Risk of Type 2 Diabetes and Alzheimer's Disease. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,1,0 2.4.1.11 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32588759&form=6&db=m In silico screening of glycogen synthase kinase-3? targeted ligands against acetylcholinesterase and its probable relevance to Alzheimer's disease. causal interaction,unassigned 1,0 2.4.1.11 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32643890&form=6&db=m [Advances in the experimental mechanism of acupuncture in the treatment of Alzheimer's disease based on Wnt/?-catenin pathway]. therapeutic application,unassigned 1,0 2.4.1.11 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32960565&form=6&db=m Development of Bisindole-Substituted Aminopyrazoles as Novel GSK-3? Inhibitors with Suppressive Effects against Microglial Inflammation and Oxidative Neurotoxicity. causal interaction,therapeutic application,unassigned 2,3,0 2.4.1.11 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32968615&form=6&db=m Insight into glycogen synthase kinase-3? inhibitory activity of phyto-constituents from Melissa officinalis: in silico studies. causal interaction,therapeutic application,unassigned 1,1,0 2.4.1.11 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33105671&form=6&db=m Discovery and Evaluation of Enantiopure 9H-pyrimido[4,5-b]indoles as Nanomolar GSK-3? Inhibitors with Improved Metabolic Stability. causal interaction,unassigned 4,0 2.4.1.11 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33392916&form=6&db=m GSK-3? Disrupts Neuronal Oscillatory Function to Inhibit Learning and Memory in Male Rats. causal interaction,unassigned 4,0 2.4.1.11 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33492962&form=6&db=m Novel 18F-Labeled Isonicotinamide-Based Radioligands for Positron Emission Tomography Imaging of Glycogen Synthase Kinase-3?. causal interaction,unassigned 4,0 2.4.1.11 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33517657&form=6&db=m ((E)-N-(4-(((2-Amino-5-phenylpyridin-3-yl)imino)methyl)pyridin-2-yl)cyclopropanecarboxamide) Ameliorated A?1-42-Induced Alzheimer's Disease in SD Rats by Inhibiting Oxidative Stress and Apoptosis. ongoing research,unassigned 4,0 2.4.1.11 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33554064&form=6&db=m Isoform-selective decrease of glycogen synthase kinase-3-beta (GSK-3?) reduces synaptic tau phosphorylation, transcellular spreading, and aggregation. causal interaction,unassigned 3,0 2.4.1.11 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21603026&form=6&db=m Brief review of the role of glycogen synthase kinase-3? in amyotrophic lateral sclerosis. unassigned - 2.4.1.11 Arrhythmogenic Right Ventricular Dysplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31567019&form=6&db=m Severe Cardiac Dysfunction and Death Caused by Arrhythmogenic Right Ventricular Cardiomyopathy Type 5 Are Improved by Inhibition of Glycogen Synthase Kinase-3?. causal interaction,unassigned 4,0 2.4.1.11 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31994915&form=6&db=m Inhibition of glycogen synthase kinase-3? protects against collagen type II-induced arthritis associated with the inhibition of miR155/24 and inflammation and upregulation of apoptosis in rats. causal interaction,therapeutic application,unassigned 4,1,0 2.4.1.11 Arthritis, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24176738&form=6&db=m Inhibition of glycogen synthase kinase-3? suppresses inflammatory responses in rheumatoid arthritis fibroblast-like synoviocytes and collagen-induced arthritis. causal interaction,therapeutic application,unassigned 4,3,0 2.4.1.11 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24176738&form=6&db=m Inhibition of glycogen synthase kinase-3? suppresses inflammatory responses in rheumatoid arthritis fibroblast-like synoviocytes and collagen-induced arthritis. causal interaction,therapeutic application,unassigned 4,3,0 2.4.1.11 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30100905&form=6&db=m Glycogen Metabolism and Rheumatoid Arthritis: The Role of Glycogen Synthase 1 in Regulation of Synovial Inflammation via Blocking AMP-Activated Protein Kinase Activation. ongoing research,unassigned 1,0 2.4.1.11 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31994915&form=6&db=m Inhibition of glycogen synthase kinase-3? protects against collagen type II-induced arthritis associated with the inhibition of miR155/24 and inflammation and upregulation of apoptosis in rats. causal interaction,therapeutic application,unassigned 4,1,0 2.4.1.11 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19011050&form=6&db=m Airway smooth muscle hyperplasia and hypertrophy correlate with glycogen synthase kinase-3(beta) phosphorylation in a mouse model of asthma. therapeutic application,unassigned 1,0 2.4.1.11 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21668450&form=6&db=m R3F, a novel membrane-associated glycogen targeting subunit of protein phosphatase 1 regulates glycogen synthase in astrocytoma cells in response to glucose and extracellular signals. ongoing research,unassigned 2,0 2.4.1.11 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28042322&form=6&db=m Chromatin Remodeling Factor LSH is Upregulated by the LRP6-GSK3?-E2F1 Axis Linking Reversely with Survival in Gliomas. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,1,0 2.4.1.11 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22505033&form=6&db=m Expression pattern of ataxia telangiectasia mutated (ATM), p53, Akt, and glycogen synthase kinase-3? in the striatum of rats treated with 3-nitropropionic acid. ongoing research,unassigned 2,0 2.4.1.11 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20888430&form=6&db=m Atherosclerosis induced by a high-fat diet is alleviated by lithium chloride via reduction of VCAM expression in ApoE-deficient mice. ongoing research,therapeutic application,unassigned 4,2,0 2.4.1.11 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21998135&form=6&db=m Endoplasmic reticulum stress and glycogen synthase kinase-3? activation in apolipoprotein E-deficient mouse models of accelerated atherosclerosis. causal interaction,ongoing research,unassigned 3,3,0 2.4.1.11 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26820679&form=6&db=m Arachidonyl-2-Chloroethylamide Alleviates Cerebral Ischemia Injury Through Glycogen Synthase Kinase-3?-Mediated Mitochondrial Biogenesis and Functional Improvement. causal interaction,unassigned 2,0 2.4.1.11 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28553165&form=6&db=m GSK-3? as a target for protection against transient cerebral ischemia. causal interaction,therapeutic application,unassigned 4,4,0 2.4.1.11 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21757741&form=6&db=m Glycogen Synthase Kinase-3{beta} (GSK3{beta}) Negatively Regulates PTTG1/Human Securin Protein Stability, and GSK3{beta} Inactivation Correlates with Securin Accumulation in Breast Tumors. therapeutic application,unassigned 1,0 2.4.1.11 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26246283&form=6&db=m Enhancement of paclitaxel-induced breast cancer cell death via the glycogen synthase kinase-3?-mediated B-cell lymphoma 2 regulation. causal interaction,therapeutic application,unassigned 3,1,0 2.4.1.11 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26992223&form=6&db=m MicroRNA-1229 overexpression promotes cell proliferation and tumorigenicity and activates Wnt/?-catenin signaling in breast cancer. unassigned - 2.4.1.11 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27424289&form=6&db=m GSK-3 inhibition overcomes chemoresistance in human breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.1.11 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31325197&form=6&db=m Delphinidin suppresses breast carcinogenesis through the HOTAIR/microRNA-34a axis. causal interaction,therapeutic application,unassigned 2,1,0 2.4.1.11 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34403222&form=6&db=m PGK1-coupled HSP90 stabilizes GSK3? expression to regulate the stemness of breast cancer stem cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.1.11 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17145894&form=6&db=m Adiponectin modulates the glycogen synthase kinase-3beta/beta-catenin signaling pathway and attenuates mammary tumorigenesis of MDA-MB-231 cells in nude mice. causal interaction,ongoing research,therapeutic application,unassigned 2,2,2,0 2.4.1.11 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22534782&form=6&db=m Glycogen synthase kinase-3?, NF-?B signaling, and tumorigenesis of human osteosarcoma. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.1.11 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22561258&form=6&db=m PTEN regulates apoptotic cell death through PI3-K/Akt/GSK3? signaling pathway in DMH induced early colon carcinogenesis in rat. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4 2.4.1.11 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22844359&form=6&db=m Inhibitory effects of lupeal acetate of Cortex periplocae on N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis. diagnostic usage,ongoing research,unassigned 1,4,0 2.4.1.11 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26902162&form=6&db=m Nimbolide, a neem limonoid inhibits Phosphatidyl Inositol-3 Kinase to activate Glycogen Synthase Kinase-3? in a hamster model of oral oncogenesis. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.4.1.11 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27050373&form=6&db=m The role of glycogen synthase kinase-3? (GSK-3?) in endometrial carcinoma: A carcinogenesis, progression, prognosis, and target therapy marker. causal interaction,therapeutic application,unassigned 3,3,0 2.4.1.11 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27051274&form=6&db=m Role of glycogen synthase kinase-3? inhibitor AZD1080 in ovarian cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.4.1.11 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30556279&form=6&db=m FAM134B induces tumorigenesis and epithelial-to-mesenchymal transition via Akt signaling in hepatocellular carcinoma. causal interaction,unassigned 3,0 2.4.1.11 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31114749&form=6&db=m Clinicohistopathological implications of phosphoserine 9 glycogen synthase kinase-3?/ ?-catenin in urinary bladder cancer patients. causal interaction,therapeutic application,unassigned 2,1,0 2.4.1.11 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31147141&form=6&db=m A novel indirubin derivative that increases somatic cell plasticity and inhibits tumorigenicity. causal interaction,unassigned 3,0 2.4.1.11 Carcinoid Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31750236&form=6&db=m The Role of Lithium in Management of Endocrine Tumors-A Comprehensive Review. causal interaction,unassigned 1,0 2.4.1.11 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3137231&form=6&db=m Activity of glycogen synthase and phosphorylase and glucose 6-phosphate content in renal clear cell carcinomas. causal interaction,ongoing research,unassigned 1,4,0 2.4.1.11 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4374242&form=6&db=m Glycogen synthesis in mouse Ehrlich ascites carcinoma cells. The presence of an endogenous inhibitor for activation of glycogen synthase. diagnostic usage,unassigned 3,0 2.4.1.11 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22949937&form=6&db=m The inactive form of glycogen synthase kinase-3? is associated with the development of carcinomas in galectin-3 wild-type mice, but not in galectin-3-deficient mice. unassigned - 2.4.1.11 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25123268&form=6&db=m miR-203a regulates proliferation, migration, and apoptosis by targeting glycogen synthase kinase-3? in human renal cell carcinoma. ongoing research,unassigned 3,0 2.4.1.11 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25591548&form=6&db=m Overexpression of interleukin-18 protein reduces viability and induces apoptosis of tongue squamous cell carcinoma cells by activation of glycogen synthase kinase-3? signaling. causal interaction,ongoing research,unassigned 1,2,0 2.4.1.11 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26315788&form=6&db=m miRNA-99b-3p functions as a potential tumor suppressor by targeting glycogen synthase kinase-3? in oral squamous cell carcinoma Tca-8113 cells. causal interaction,therapeutic application,unassigned 2,3,0 2.4.1.11 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29134466&form=6&db=m Glycogen synthase kinase-3? mediated regulation of matrix metalloproteinase-9 and its involvement in oral squamous cell carcinoma progression and invasion. causal interaction,ongoing research,unassigned 4,3,0 2.4.1.11 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=205362&form=6&db=m Activities of key gluconeogenic enzymes and glycogen synthase in rat and human livers, hepatomas, and hepatoma cell cultures. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.4.1.11 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1910304&form=6&db=m Long-term effects of insulin on the enzyme activity and messenger RNA of glycogen synthase in rat hepatoma H4 cells: an effect of insulin on glycogen synthase mRNA stability. ongoing research,unassigned 4,0 2.4.1.11 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2158961&form=6&db=m Particulate-associated protein phosphatases of rat hepatomas as compared with the enzymes of rat liver. diagnostic usage,ongoing research,unassigned 1,3,0 2.4.1.11 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2510600&form=6&db=m Glycogen synthase turnover and phosphorylation in rat H4IIE hepatoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1 2.4.1.11 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3041200&form=6&db=m Long term regulation of glycogen metabolizing enzymes by insulin in H4 hepatoma cells. diagnostic usage,unassigned 4,0 2.4.1.11 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3124751&form=6&db=m Contrasting interactions between phorbol ester and insulin on the regulation of glycogen synthase activity and p33 mRNA accumulation in rat hepatoma cells. ongoing research,unassigned 3,0 2.4.1.11 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6086436&form=6&db=m Cytosolic protein phosphatases of rat ascites hepatoma AH-13 as compared with those of rat liver: isolation and characterization of a novel protein phosphatase. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.1.11 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6137358&form=6&db=m Analysis of insulin action using differentiated and dedifferentiated hepatoma cells. causal interaction,ongoing research,unassigned 2,2,0 2.4.1.11 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7927248&form=6&db=m Hepatic preneoplasia in hepatitis B virus transgenic mice. causal interaction,unassigned 4,0 2.4.1.11 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8886626&form=6&db=m Insulin stimulates protein synthesis of glycogen synthase in rat hepatoma H4 cells associated with acceleration of translation rate. causal interaction,ongoing research,unassigned 1,4,0 2.4.1.11 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11882651&form=6&db=m Liver glycogen synthase but not the muscle isoform differentiates between glucose 6-phosphate produced by glucokinase or hexokinase. ongoing research,unassigned 4,0 2.4.1.11 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17945190&form=6&db=m AICAR positively regulate glycogen synthase activity and LDL receptor expression through Raf-1/MEK/p42/44MAPK/p90RSK/GSK-3 signaling cascade. ongoing research,unassigned 1,0 2.4.1.11 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23899607&form=6&db=m Oral Porphyromonas gingivalis translocates to the liver and regulates hepatic glycogen synthesis through the Akt/GSK-3? signaling pathway. ongoing research,unassigned 4,0 2.4.1.11 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25157753&form=6&db=m Glycogen synthase kinase-3? is associated with the prognosis of hepatocellular carcinoma and may mediate the influence of type 2 diabetes mellitus on hepatocellular carcinoma. causal interaction,diagnostic usage,unassigned 4,1,0 2.4.1.11 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25876909&form=6&db=m A Novel Partial Agonist of Peroxisome Proliferator-Activated Receptor ? with Excellent Effect on Insulin Resistance and Type 2 Diabetes. causal interaction,ongoing research,unassigned 1,3,0 2.4.1.11 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25915842&form=6&db=m Sirtuin 3 inhibits hepatocellular carcinoma growth through the glycogen synthase kinase-3?/BCL2-associated X protein-dependent apoptotic pathway. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 2.4.1.11 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26788169&form=6&db=m Glycogen synthase kinase-3? regulates tumor necrosis factor-related apoptosis inducing ligand (TRAIL)-induced apoptosis via the NF-?B pathway in hepatocellular carcinoma. therapeutic application,unassigned 1,0 2.4.1.11 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27221474&form=6&db=m Glycogen synthase kinase-3? antagonizes ROS-induced hepatocellular carcinoma cell death through suppression of the apoptosis signal-regulating kinase 1. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.1.11 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31289467&form=6&db=m Expression levels of MRP1, GST-?, and GSK3? in ovarian cancer and the relationship with drug resistance and prognosis of patients. diagnostic usage,ongoing research,unassigned 4,4,0 2.4.1.11 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25123268&form=6&db=m miR-203a regulates proliferation, migration, and apoptosis by targeting glycogen synthase kinase-3? in human renal cell carcinoma. ongoing research,unassigned 3,0 2.4.1.11 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25591548&form=6&db=m Overexpression of interleukin-18 protein reduces viability and induces apoptosis of tongue squamous cell carcinoma cells by activation of glycogen synthase kinase-3? signaling. causal interaction,ongoing research,unassigned 1,2,0 2.4.1.11 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17597616&form=6&db=m Activation of peroxisome proliferator-activated receptor-alpha prevents glycogen synthase 3beta phosphorylation and inhibits cardiac hypertrophy. causal interaction,therapeutic application,unassigned 2,2,0 2.4.1.11 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17855351&form=6&db=m Glycogen synthase kinase-3alpha reduces cardiac growth and pressure overload-induced cardiac hypertrophy by inhibition of extracellular signal-regulated kinases. causal interaction,therapeutic application,unassigned 3,2,0 2.4.1.11 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27977752&form=6&db=m GSK-3?/NFAT Signaling Is Involved in Testosterone-Induced Cardiac Myocyte Hypertrophy. causal interaction,therapeutic application,unassigned 1,1,0 2.4.1.11 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30745182&form=6&db=m Glycogen Synthase Kinase-3? Promotes Fatty Acid Uptake and Lipotoxic Cardiomyopathy. unassigned - 2.4.1.11 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31567019&form=6&db=m Severe Cardiac Dysfunction and Death Caused by Arrhythmogenic Right Ventricular Cardiomyopathy Type 5 Are Improved by Inhibition of Glycogen Synthase Kinase-3?. causal interaction,unassigned 4,0 2.4.1.11 Central Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25453207&form=6&db=m Activation of AKT/GSK3? pathway by TDZD-8 attenuates kainic acid induced neurodegeneration but not seizures in mice. causal interaction,unassigned 3,0 2.4.1.11 Central Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30336136&form=6&db=m The neuroprotective effect of lithium chloride on cognitive impairment through glycogen synthase kinase-3? inhibition in intracerebral hemorrhage rats. causal interaction,therapeutic application,unassigned 4,4,0 2.4.1.11 Central Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31226691&form=6&db=m BIO alleviates inflammation through inhibition of GSK-3? in a rat model of intracerebral hemorrhage. causal interaction,unassigned 2,0 2.4.1.11 Central Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31325596&form=6&db=m Lithium chloride promoted hematoma resolution after intracerebral hemorrhage through GSK-3?-mediated pathways-dependent microglia phagocytosis and M2-phenotype differentiation, angiogenesis and neurogenesis in a rat model. causal interaction,therapeutic application,unassigned 1,3,0 2.4.1.11 Cerebral Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23538063&form=6&db=m [Gly14]-Humanin Offers Neuroprotection through Glycogen Synthase Kinase-3? Inhibition in a Mouse Model of Intracerebral Hemorrhage. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,2,0 2.4.1.11 Cerebral Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27739937&form=6&db=m Lithium posttreatment confers neuroprotection through glycogen synthase kinase-3? inhibition in intracerebral hemorrhage rats. therapeutic application,unassigned 2,0 2.4.1.11 Cerebral Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28195036&form=6&db=m GSK-3? Inhibition Induced Neuroprotection, Regeneration, and Functional Recovery After Intracerebral Hemorrhagic Stroke. ongoing research,therapeutic application,unassigned 3,3,0 2.4.1.11 Cerebral Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30336136&form=6&db=m The neuroprotective effect of lithium chloride on cognitive impairment through glycogen synthase kinase-3? inhibition in intracerebral hemorrhage rats. causal interaction,therapeutic application,unassigned 4,4,0 2.4.1.11 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24054014&form=6&db=m [Expression of pGSK-3?? Tyr279216 and XIAP proteins in cholangiocarcinoma and their clinical significance]. ongoing research,therapeutic application,unassigned 2,1,0 2.4.1.11 Choline Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8420980&form=6&db=m Accumulation of 1,2-sn-diradylglycerol with increased membrane-associated protein kinase C may be the mechanism for spontaneous hepatocarcinogenesis in choline-deficient rats. causal interaction,diagnostic usage,unassigned 3,3,0 2.4.1.11 Choriocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=221217&form=6&db=m Regulation of glycogen synthase activity in choriocarcinoma cells. Effect of glucose starvation on the conversion of synthase D to synthase I and the kinetic properties of the enzyme. ongoing research,unassigned 3,0 2.4.1.11 Choriocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=416032&form=6&db=m Glycogen synthesis by choriocarcinoma cells in vitro. Active synthesis in the presence of the glucose 6-phosphate-dependent form of glycogen synthase. ongoing research,unassigned 3,0 2.4.1.11 Chronic Traumatic Encephalopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26381255&form=6&db=m Endoplasmic reticulum stress implicated in chronic traumatic encephalopathy. unassigned - 2.4.1.11 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16670426&form=6&db=m Novel method for high throughput DNA methylation marker evaluation using PNA-probe library hybridization and MALDI-TOF detection. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.1.11 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23389968&form=6&db=m Nuclear expression of Glycogen synthase kinase-3? and lack of membranous ?-catenin is correlated with poor survival in colon cancer. causal interaction,ongoing research,unassigned 3,2,0 2.4.1.11 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24634935&form=6&db=m Octreotide stimulates somatostatin receptor-induced apoptosis of SW480 colon cancer cells by activation of glycogen synthase kinase-3?, A Wnt/?-catenin pathway modulator. therapeutic application,unassigned 1,0 2.4.1.11 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26352871&form=6&db=m Upregulation of C-C chemokine receptor type 7 expression by membrane-associated prostaglandin E synthase-1/prostaglandin E2 requires glycogen synthase kinase 3?-mediated signal transduction in colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.4.1.11 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27313176&form=6&db=m PAR2-dependent activation of GSK3? regulates the survival of colon stem/progenitor cells. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.4.1.11 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29104081&form=6&db=m Wnt pathway activator TWS119 enhances the proliferation and cytolytic activity of human ??T cells against colon cancer. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.4.1.11 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31236153&form=6&db=m Glucose Metabolic Reprogramming and Cell Proliferation Arrest in Colorectal Micropapillary Carcinoma. ongoing research,unassigned 3,0 2.4.1.11 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32309890&form=6&db=m Synthesis, cytotoxicity, and molecular docking of substituted 3-(2-methylbenzofuran-3-yl)-5-(phenoxymethyl)-1,2,4-oxadiazoles. ongoing research,therapeutic application,unassigned 3,1,0 2.4.1.11 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23509364&form=6&db=m Epithelial-Mesenchymal Transition Induces an Antitumor Immune Response Mediated by NKG2D Receptor. causal interaction,ongoing research,unassigned 4,3,0 2.4.1.11 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27055860&form=6&db=m An Association Study Between Genetic Polymorphisms in Functional Regions of Five Genes and the Risk of Schizophrenia. therapeutic application,unassigned 1,0 2.4.1.11 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29568361&form=6&db=m Colorectal cancer cells require glycogen synthase kinase-3? for sustaining mitosis via translocated promoter region (TPR)-dynein interaction. causal interaction,therapeutic application,unassigned 4,4,0 2.4.1.11 Corticobasal Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12410379&form=6&db=m Glycogen synthase kinase-3 is associated with neuronal and glial hyperphosphorylated tau deposits in Alzheimer's disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration. causal interaction,unassigned 3,0 2.4.1.11 Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25629553&form=6&db=m Glycogen synthase kinase-3? promotes cyst expansion in polycystic kidney disease. unassigned - 2.4.1.11 Dehydration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11534633&form=6&db=m Alterations in the levels of glycogen and glycogen synthase transcripts during desiccation in the insect-killing nematode Steinernema feltiae IS-6. unassigned - 2.4.1.11 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21689104&form=6&db=m Acetyl-L-Carnitine ameliorates spatial memory deficits induced by inhibition of phosphoinositol-3 kinase and protein kinase C. causal interaction,therapeutic application,unassigned 1,1,0 2.4.1.11 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22514792&form=6&db=m The pharmacology of neurotrophic treatment with Cerebrolysin: brain protection and repair to counteract pathologies of acute and chronic neurological disorders. causal interaction,ongoing research,therapeutic application,unassigned 1,3,3,0 2.4.1.11 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31453129&form=6&db=m Orengedokuto and san'oshashinto improve memory deficits by inhibiting aging-dependent activation of glycogen synthase kinase-3?. causal interaction,therapeutic application,unassigned 3,1,0 2.4.1.11 Demyelinating Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28469664&form=6&db=m The mechanism of Naringin-enhanced remyelination after spinal cord injury. unassigned - 2.4.1.11 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1511806&form=6&db=m In vivo insulin action and muscle glycogen synthase activity in type 2 (non-insulin-dependent) diabetes mellitus: effects of diet treatment. ongoing research,therapeutic application,unassigned 1,3,0 2.4.1.11 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1541385&form=6&db=m Hyperglycaemia compensates for the defects in insulin-mediated glucose metabolism and in the activation of glycogen synthase in the skeletal muscle of patients with type 2 (non-insulin-dependent) diabetes mellitus. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.4.1.11 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1899428&form=6&db=m Multiple defects in muscle glycogen synthase activity contribute to reduced glycogen synthesis in non-insulin dependent diabetes mellitus. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,1 2.4.1.11 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1900248&form=6&db=m Hypoxemic stimulation of heart glycogen synthase and synthesis. Effects of insulin and diabetes mellitus. ongoing research,therapeutic application,unassigned 4,1,0 2.4.1.11 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1906024&form=6&db=m Reduced glycogen synthase activity in skeletal muscle from obese patients with and without type 2 (non-insulin-dependent) diabetes mellitus. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.4.1.11 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6247232&form=6&db=m Impaired glycogen synthase activating system in human diabetic polymorphonuclear leukocytes. ongoing research,unassigned 4,0 2.4.1.11 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7796924&form=6&db=m [Microsatellite polymorphism of muscle glycogen synthase gene and non-insulin dependent diabetes mellitus] ongoing research,unassigned 2,0 2.4.1.11 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7983804&form=6&db=m [DNA polymorphism in the human glycogen synthase gene and non-insulin dependent diabetes mellitus in Japanese] causal interaction,ongoing research,unassigned 3,4,0 2.4.1.11 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8462768&form=6&db=m Adipose tissue glycogen synthase activation by in vivo insulin in spontaneously insulin-resistant and type 2 (non-insulin-dependent) diabetic rhesus monkeys. causal interaction,unassigned 3,0 2.4.1.11 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8891456&form=6&db=m Intracellular glucose and fat metabolism in identical twins discordant for non-insulin-dependent diabetes mellitus (NIDDM): acquired versus genetic metabolic defects? causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 2.4.1.11 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10027756&form=6&db=m Reduced glycogen phosphorylase activity in denervated hindlimb muscles of rat is related to muscle atrophy and fibre type. causal interaction,therapeutic application,unassigned 1,1,0 2.4.1.11 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10447527&form=6&db=m A paired-sibling analysis of the XbaI polymorphism in the muscle glycogen synthase gene. ongoing research,unassigned 3,0 2.4.1.11 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11357475&form=6&db=m Peroxisome proliferator-activated receptor (PPAR) gamma and retinoid X receptor (RXR) agonists have complementary effects on glucose and lipid metabolism in human skeletal muscle. ongoing research,therapeutic application,unassigned 4,1,0 2.4.1.11 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12411100&form=6&db=m Association of GYS1 and beta(3)-AR gene with postprandial hyperglycemia and serum uric acid in type 2 diabetes mellitus. ongoing research,therapeutic application,unassigned 3,1,0 2.4.1.11 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19837931&form=6&db=m Dysregulation of Glycogen Synthase COOH- and NH2-Terminal Phosphorylation by Insulin in Obesity and Type 2 Diabetes Mellitus. causal interaction,ongoing research,unassigned 3,1,0 2.4.1.11 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20017397&form=6&db=m [The regulation of glucose-6-phosphate dehydrogenase and glycogen synthase activities by insulin superfamily peptides in myometrium of pregnant women and its impairments under different types of diabetes mellitus] diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.1.11 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21988345&form=6&db=m (WO2011057959) indole and indazole derivatives as glycogen synthase activators: a patent evaluation. therapeutic application,unassigned 1,0 2.4.1.11 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22567972&form=6&db=m [Experimental models of diabetes mellitus of the 1st and 2nd types in rats: regulation of activity of glycogen synthase by peptides of the insulin superfamily and by epidermal growth factor in skeletal muscles]. diagnostic usage,ongoing research,unassigned 1,4,0 2.4.1.11 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22881281&form=6&db=m Diabetes mellitus abrogates the cardioprotection of sufentanil against ischaemia/reperfusion injury by altering glycogen synthase kinase-3? unassigned - 2.4.1.11 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23702482&form=6&db=m Chloroquine stimulates glucose uptake and glycogen synthase in muscle cells through activation of Akt. causal interaction,therapeutic application,unassigned 3,4,0 2.4.1.11 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25157753&form=6&db=m Glycogen synthase kinase-3? is associated with the prognosis of hepatocellular carcinoma and may mediate the influence of type 2 diabetes mellitus on hepatocellular carcinoma. causal interaction,diagnostic usage,unassigned 4,1,0 2.4.1.11 Diabetes Mellitus, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2561413&form=6&db=m [Deficiency in hepatic uptake of glucose in chronic diabetes mellitus] ongoing research,therapeutic application,unassigned 3,1,0 2.4.1.11 Diabetes Mellitus, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6807982&form=6&db=m Effects of alloxan diabetes on the turnover of rat liver glycogen synthase. Comparison with liver phosphorylase. causal interaction,ongoing research,unassigned 1,4,0 2.4.1.11 Diabetes Mellitus, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10322649&form=6&db=m Changes of activity of liver glycogen synthase in experimental diabetes mellitus rats. ongoing research,unassigned 4,0 2.4.1.11 Diabetes Mellitus, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22567972&form=6&db=m [Experimental models of diabetes mellitus of the 1st and 2nd types in rats: regulation of activity of glycogen synthase by peptides of the insulin superfamily and by epidermal growth factor in skeletal muscles]. diagnostic usage,ongoing research,unassigned 1,4,0 2.4.1.11 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2499587&form=6&db=m Insulin receptor function and glycogen synthase activity in skeletal muscle biopsies from patients with insulin-dependent diabetes mellitus: effects of physical training. ongoing research,therapeutic application,unassigned 4,1,0 2.4.1.11 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9113484&form=6&db=m Post-marathon paradox in IDDM: unchanged insulin sensitivity in spite of glycogen depletion. unassigned - 2.4.1.11 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9151794&form=6&db=m Mechanism of impaired insulin-stimulated muscle glucose metabolism in subjects with insulin-dependent diabetes mellitus. therapeutic application,unassigned 1,0 2.4.1.11 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9726968&form=6&db=m Expression of constitutively activated Gialpha2 in vivo ameliorates streptozotocin-induced diabetes. causal interaction,ongoing research,unassigned 1,3,0 2.4.1.11 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27025050&form=6&db=m [CARBOHYDRATE METABOLISM IN TYPE 1 DIABETIC RATS UNDER THE CONDITIONS OF THE KIDNEY BEAN PODS AQUEOUS EXTRACT APPLICATION]. ongoing research,unassigned 4,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1485943&form=6&db=m The etiology and pathogenesis of non-insulin-dependent diabetes. causal interaction,therapeutic application,unassigned 4,1,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1541385&form=6&db=m Hyperglycaemia compensates for the defects in insulin-mediated glucose metabolism and in the activation of glycogen synthase in the skeletal muscle of patients with type 2 (non-insulin-dependent) diabetes mellitus. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1541672&form=6&db=m Decreased insulin activation of glycogen synthase in skeletal muscles in young nonobese Caucasian first-degree relatives of patients with non-insulin-dependent diabetes mellitus. causal interaction,unassigned 4,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1559409&form=6&db=m Insulin resistance in skeletal muscles in patients with NIDDM. causal interaction,unassigned 4,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1568529&form=6&db=m Impaired activation of glycogen synthase in people at increased risk for developing NIDDM. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1756915&form=6&db=m Impaired expression of glycogen synthase mRNA in skeletal muscle of NIDDM patients. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,3,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1794267&form=6&db=m Gliclazide and insulin action in human muscle. causal interaction,therapeutic application,unassigned 4,4,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1899428&form=6&db=m Multiple defects in muscle glycogen synthase activity contribute to reduced glycogen synthesis in non-insulin dependent diabetes mellitus. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,1 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1900343&form=6&db=m Impaired activation of skeletal muscle glycogen synthase in non-insulin-dependent diabetes mellitus is unrelated to the degree of obesity. causal interaction,ongoing research,unassigned 1,3,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1906024&form=6&db=m Reduced glycogen synthase activity in skeletal muscle from obese patients with and without type 2 (non-insulin-dependent) diabetes mellitus. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1908182&form=6&db=m Effects of sulfonylureas on adipocyte and skeletal muscle insulin action in patients with non-insulin-dependent diabetes mellitus. causal interaction,therapeutic application,unassigned 1,4,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2105341&form=6&db=m Intracellular glucose oxidation and glycogen synthase activity are reduced in non-insulin-dependent (type II) diabetes independent of impaired glucose uptake. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,1,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2121778&form=6&db=m Fasting hyperglycemia normalizes oxidative and nonoxidative pathways of insulin-stimulated glucose metabolism in noninsulin-dependent diabetes mellitus. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,3,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2122177&form=6&db=m Skeletal muscle glycogen synthase activity in subjects with non-insulin-dependent diabetes mellitus after glyburide therapy. causal interaction,ongoing research,therapeutic application,unassigned 1,4,3,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2837418&form=6&db=m Decreased activation of skeletal muscle glycogen synthase by mixed-meal ingestion in NIDDM. causal interaction,unassigned 1,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3094377&form=6&db=m Adipocyte glycogen synthase and pyruvate dehydrogenase in obese and type II diabetic subjects. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,4,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3124871&form=6&db=m Glycogen synthase kinetics in isolated human adipocytes: an in vitro model for the effects of insulin on glycogen synthase. causal interaction,unassigned 3,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7476288&form=6&db=m Defects in liver and muscle glycogen metabolism in neonatal and adult New Zealand obese mice. ongoing research,unassigned 4,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7508874&form=6&db=m Search for a third susceptibility gene for maturity-onset diabetes of the young. Studies with eleven candidate genes. causal interaction,unassigned 4,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7631777&form=6&db=m Increased concentrations of glycogen synthase protein in skeletal muscle of patients with NIDDM. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,3,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7657035&form=6&db=m Isolation and characterization of the human muscle glycogen synthase gene. causal interaction,unassigned 1,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7758880&form=6&db=m Multiple defects of both hepatic and peripheral intracellular glucose processing contribute to the hyperglycaemia of NIDDM. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,2,1 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7796924&form=6&db=m [Microsatellite polymorphism of muscle glycogen synthase gene and non-insulin dependent diabetes mellitus] ongoing research,unassigned 2,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7913686&form=6&db=m Description of a second microsatellite marker and linkage analysis of the muscle glycogen synthase locus in familial NIDDM. diagnostic usage,unassigned 1,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7983805&form=6&db=m [Glycogen synthase gene-glycogen synthase gene in Japanese patients with NIDDM] causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8037748&form=6&db=m Molecular scanning of the glycogen synthase and insulin receptor substrate-1 genes in Japanese subjects with non-insulin-dependent diabetes mellitus. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8039605&form=6&db=m Genetic variants in promoters and coding regions of the muscle glycogen synthase and the insulin-responsive GLUT4 genes in NIDDM. diagnostic usage,ongoing research,unassigned 1,3,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8040269&form=6&db=m Glycogen synthase: a putative locus for diet-induced hyperglycemia. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8056194&form=6&db=m Simple tandem repeat DNA polymorphism in the human glycogen synthase gene is associated with NIDDM in Japanese subjects. unassigned - 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8200993&form=6&db=m Increased epinephrine and skeletal muscle responses to hypoglycemia in non-insulin-dependent diabetes mellitus. unassigned - 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8375246&form=6&db=m Metabolic pathways of glucose in skeletal muscle of lean NIDDM patients. diagnostic usage,ongoing research,unassigned 1,1,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8416266&form=6&db=m Association between polymorphism of the glycogen synthase gene and non-insulin-dependent diabetes mellitus. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8479502&form=6&db=m Polymorphism of the glycogen synthase gene and non-insulin-dependent diabetes mellitus. ongoing research,unassigned 4,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8479503&form=6&db=m Polymorphism of the glycogen synthase gene and non-insulin-dependent diabetes mellitus. ongoing research,unassigned 4,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8495815&form=6&db=m Identification of a simple tandem repeat DNA polymorphism in the human glycogen synthase gene and linkage to five markers on chromosome 19q. ongoing research,unassigned 3,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8514849&form=6&db=m Glycogen synthase and phosphofructokinase protein and mRNA levels in skeletal muscle from insulin-resistant patients with non-insulin-dependent diabetes mellitus. diagnostic usage,ongoing research,unassigned 2,3,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8591890&form=6&db=m Polymorphism of the glycogen synthase gene in hypertensive and normotensive subjects. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8593932&form=6&db=m An approach for identifying simple sequence repeat DNA polymorphisms near cloned cDNAs and genes. Linkage studies of the islet amyloid polypeptide/amylin and liver glycogen synthase genes and NIDDM. ongoing research,unassigned 2,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8675629&form=6&db=m Impaired activity and gene expression of hexokinase II in muscle from non-insulin-dependent diabetes mellitus patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8690177&form=6&db=m Unchanged gene expression of glycogen synthase in muscle from patients with NIDDM following sulphonylurea-induced improvement of glycaemic control. ongoing research,therapeutic application,unassigned 2,1,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8690180&form=6&db=m The glycogen synthase gene in NIDDM and hypertension. ongoing research,therapeutic application,unassigned 2,1,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8712800&form=6&db=m Genetics of non-insulin-dependent (type-II) diabetes mellitus. causal interaction,unassigned 2,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8721777&form=6&db=m Association of the glycogen synthase locus on 19q13 with NIDDM in Pima Indians. causal interaction,unassigned 2,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8750222&form=6&db=m The effect of acute (60 minute) insulin stimulation upon human skeletal muscle glycogen synthase and protein phosphatase-1 in non-insulin-dependent diabetic patients and control subjects. causal interaction,therapeutic application,unassigned 3,1,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8786726&form=6&db=m Long-term effects of fluoxetine on glycemic control in obese patients with non-insulin-dependent diabetes mellitus or glucose intolerance: influence on muscle glycogen synthase and insulin receptor kinase activity. ongoing research,unassigned 4,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8787686&form=6&db=m Glycogen synthase activity is reduced in cultured skeletal muscle cells of non-insulin-dependent diabetes mellitus subjects. Biochemical and molecular mechanisms. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8891456&form=6&db=m Intracellular glucose and fat metabolism in identical twins discordant for non-insulin-dependent diabetes mellitus (NIDDM): acquired versus genetic metabolic defects? causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8960833&form=6&db=m UKPDS 19: heterogeneity in NIDDM: separate contributions of IRS-1 and beta 3-adrenergic-receptor mutations to insulin resistance and obesity respectively with no evidence for glycogen synthase gene mutations. UK Prospective Diabetes Study. unassigned - 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9030814&form=6&db=m Polymorphism of the glycogen synthase gene and non-insulin-dependent diabetes mellitus in the Russian population. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9126490&form=6&db=m Genetic analysis of human type 1 protein phosphatase inhibitor 2 in insulin-resistant Pima Indians. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9267989&form=6&db=m Chromosomal mapping and mutational analysis of the coding region of the glycogen synthase kinase-3alpha and beta isoforms in patients with NIDDM. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,2,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9389424&form=6&db=m New variants in the glycogen synthase gene (Gln71His, Met416Val) in patients with NIDDM from eastern Finland. therapeutic application,unassigned 1,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9727896&form=6&db=m Irreversibility of the defect in glycogen synthase activity in skeletal muscle from obese patients with NIDDM treated with diet and metformin. diagnostic usage,ongoing research,unassigned 1,3,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9855864&form=6&db=m The genetic basis of diabetes mellitus. ongoing research,unassigned 3,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10322649&form=6&db=m Changes of activity of liver glycogen synthase in experimental diabetes mellitus rats. ongoing research,unassigned 4,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10421979&form=6&db=m On the pathophysiology of late onset non-insulin dependent diabetes mellitus. Current controversies and new insights. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10443322&form=6&db=m Membrane physiology as a basis for the cellular effects of metformin in insulin resistance and diabetes. causal interaction,unassigned 2,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10770201&form=6&db=m Impaired insulin-stimulated expression of the glycogen synthase gene in skeletal muscle of type 2 diabetic patients is acquired rather than inherited. diagnostic usage,ongoing research,unassigned 1,3,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10868943&form=6&db=m Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11092303&form=6&db=m The Met416-->Val variant in the glycogen synthase gene: the prevalence and the association with diabetes in a large number of Japanese individuals. Study Group for the Identification of Type 2 Diabetes Genes in Japanese. causal interaction,ongoing research,unassigned 1,3,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11147787&form=6&db=m The stimulation-induced increase in skeletal muscle glycogen synthase content is impaired in carriers of the glycogen synthase XbaI gene polymorphism. unassigned - 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11189236&form=6&db=m Polymorphism of the glycogen synthase gene and non-insulin-dependent diabetes mellitus in Chinese population. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,3,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11408400&form=6&db=m A defect in glycogen synthesis characterizes insulin resistance in hypertensive patients with type 2 diabetes. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11549666&form=6&db=m Impaired muscle glycogen synthase in type 2 diabetes is associated with diminished phosphatidylinositol 3-kinase activation. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12387679&form=6&db=m The role of glycogen synthase kinase-3 in insulin resistance and type 2 diabetes. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12411100&form=6&db=m Association of GYS1 and beta(3)-AR gene with postprandial hyperglycemia and serum uric acid in type 2 diabetes mellitus. ongoing research,therapeutic application,unassigned 3,1,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12765949&form=6&db=m Increased phosphorylation of skeletal muscle glycogen synthase at NH2-terminal sites during physiological hyperinsulinemia in type 2 diabetes. therapeutic application,unassigned 1,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12870167&form=6&db=m Association of muscle glycogen synthase polymorphism with insulin resistance in type 2 diabetic patients. causal interaction,ongoing research,unassigned 2,2,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12962696&form=6&db=m Metabolic and genetic influence on glucose metabolism in type 2 diabetic subjects--experiences from relatives and twin studies. causal interaction,unassigned 3,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15375789&form=6&db=m Development of glucose intolerance in male transgenic mice overexpressing human glycogen synthase kinase-3beta on a muscle-specific promoter. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15855312&form=6&db=m Impact of genetic versus environmental factors on the control of muscle glycogen synthase activation in twins. causal interaction,therapeutic application,unassigned 1,1,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16609880&form=6&db=m Reduced plasma adiponectin concentrations may contribute to impaired insulin activation of glycogen synthase in skeletal muscle of patients with type 2 diabetes. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17356695&form=6&db=m Variation in GYS1 interacts with exercise and gender to predict cardiovascular mortality. unassigned - 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18056794&form=6&db=m Palmitate action to inhibit glycogen synthase and stimulate protein phosphatase 2A increases with risk factors for type 2 diabetes. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,1 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18220643&form=6&db=m Impaired glycogen synthase activity and mitochondrial dysfunction in skeletal muscle: markers or mediators of insulin resistance in type 2 diabetes? causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19267278&form=6&db=m Regulation of muscle glycogen synthase phosphorylation and kinetic properties by insulin, exercise, adrenaline and role in insulin resistance. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19837931&form=6&db=m Dysregulation of Glycogen Synthase COOH- and NH2-Terminal Phosphorylation by Insulin in Obesity and Type 2 Diabetes Mellitus. causal interaction,ongoing research,unassigned 3,1,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20938636&form=6&db=m Impaired insulin-induced site-specific phosphorylation of TBC1 domain family, member 4 (TBC1D4) in skeletal muscle of type 2 diabetes patients is restored by endurance exercise-training. causal interaction,therapeutic application,unassigned 1,1,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21862498&form=6&db=m Mechanisms involved in the desflurane-induced post-conditioning of isolated human right atria from patients with type 2 diabetes. diagnostic usage,ongoing research,unassigned 1,4,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21988345&form=6&db=m (WO2011057959) indole and indazole derivatives as glycogen synthase activators: a patent evaluation. therapeutic application,unassigned 1,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22322917&form=6&db=m Hyperglycaemia normalises insulin action on glucose metabolism but not the impaired activation of AKT and glycogen synthase in the skeletal muscle of patients with type 2 diabetes. causal interaction,ongoing research,unassigned 1,2,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22926827&form=6&db=m The role of glycogen synthase in the development of hyperglycemia in type 2 diabetes: "To store or not to store glucose, that's the question" ongoing research,unassigned 1,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23702482&form=6&db=m Chloroquine stimulates glucose uptake and glycogen synthase in muscle cells through activation of Akt. causal interaction,therapeutic application,unassigned 3,4,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25157753&form=6&db=m Glycogen synthase kinase-3? is associated with the prognosis of hepatocellular carcinoma and may mediate the influence of type 2 diabetes mellitus on hepatocellular carcinoma. causal interaction,diagnostic usage,unassigned 4,1,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25802191&form=6&db=m Anti-diabetic efficacy of KICG1338, a novel glycogen synthase kinase-3? inhibitor, and its molecular characterization in animal models of type 2 diabetes and insulin resistance. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25870023&form=6&db=m Dysregulation of muscle glycogen synthase in recovery from exercise in type 2 diabetes. ongoing research,unassigned 2,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27717746&form=6&db=m Brain and muscle aryl hydrocarbon receptor nuclear translocator-like protein-1 cooperates with glycogen synthase kinase-3? to regulate osteogenesis of bone-marrow mesenchymal stem cells in type 2 diabetes. ongoing research,unassigned 2,0 2.4.1.11 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32283762&form=6&db=m Dietary Supplementation with Curcumin Reduce Circulating Levels of Glycogen Synthase Kinase-3? and Islet Amyloid Polypeptide in Adults with High Risk of Type 2 Diabetes and Alzheimer's Disease. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,1,0 2.4.1.11 Diabetic Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30237226&form=6&db=m Apoptosis of cardiomyocytes in diabetic cardiomyopathy involves overexpression of glycogen synthase kinase-3?. unassigned - 2.4.1.11 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25371328&form=6&db=m Over-expression of muscle glycogen synthase in human diabetic nephropathy. ongoing research,unassigned 2,0 2.4.1.11 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26888388&form=6&db=m [Impact of glycogen synthase kinase-3? (GSK-3?) inhibitor on Wnt and NF-?B signal pathways in a rat model of diabetic nephropathy]. ongoing research,unassigned 2,0 2.4.1.11 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27284338&form=6&db=m Effects of a GSK-3? inhibitor on the renal expression levels of RANK, RANKL and NF-?B in a rat model of diabetic nephropathy. ongoing research,unassigned 4,0 2.4.1.11 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12171564&form=6&db=m Prospects for kinase activity modulators in the treatment of diabetes and diabetic complications. therapeutic application,unassigned 4,0 2.4.1.11 Donohue Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3920504&form=6&db=m Mechanisms of insulin resistance in cultured fibroblasts from a patient with leprechaunism: resistance to proteolytic activation of glycogen synthase by trypsin. ongoing research,unassigned 4,0 2.4.1.11 Dyskinesias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26997328&form=6&db=m Inhibition of Glycogen Synthase Kinase-3? (GSK-3?) as potent therapeutic strategy to ameliorates L-dopa-induced dyskinesia in 6-OHDA parkinsonian rats. therapeutic application,unassigned 2,0 2.4.1.11 Dyslipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24120122&form=6&db=m Dietary Salba (Salvia hispanica L) seed rich in ?-linolenic acid improves adipose tissue dysfunction and the altered skeletal muscle glucose and lipid metabolism in dyslipidemic insulin-resistant rats. unassigned - 2.4.1.11 Encephalitis, Japanese http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25557483&form=6&db=m Extended stability of cyclin D1 contributes to limited cell cycle arrest at G1-phase in BHK-21 cells with Japanese encephalitis virus persistent infection. ongoing research,unassigned 1,0 2.4.1.11 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27050373&form=6&db=m The role of glycogen synthase kinase-3? (GSK-3?) in endometrial carcinoma: A carcinogenesis, progression, prognosis, and target therapy marker. causal interaction,therapeutic application,unassigned 3,3,0 2.4.1.11 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29107840&form=6&db=m The Wnt/?-catenin signaling in endometriosis, the expression of total and active forms of ?-catenin, total and inactive forms of glycogen synthase kinase-3?, WNT7a and DICKKOPF-1. ongoing research,unassigned 2,0 2.4.1.11 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=185914&form=6&db=m Response of mouse liver glycogen cycle enzymes to endotoxin treatment. unassigned - 2.4.1.11 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3087652&form=6&db=m Glycogen synthase and phosphorylase activities during glycogen repletion in endotoxemic rats. unassigned - 2.4.1.11 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24884462&form=6&db=m Valproate pretreatment protects pancreatic ?-cells from palmitate-induced ER stress and apoptosis by inhibiting glycogen synthase kinase-3?. causal interaction,therapeutic application,unassigned 1,3,0 2.4.1.11 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26578889&form=6&db=m Role of brain glycogen in the response to hypoxia and in susceptibility to epilepsy. ongoing research,unassigned 3,0 2.4.1.11 Fanconi Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10821216&form=6&db=m The molecular background of glycogen metabolism disorders. causal interaction,ongoing research,unassigned 4,3,0 2.4.1.11 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31133092&form=6&db=m [?-aminobutyric acid fortified rice alleviated oxidative stress and pancreatic injury in type 2 diabetic mice]. diagnostic usage,unassigned 1,0 2.4.1.11 Food Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23675783&form=6&db=m Identification of an Abundant 56 kDa Protein Implicated in Food Allergy as Granule-Bound Starch Synthase. unassigned - 2.4.1.11 Fragile X Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28352664&form=6&db=m Intranasal siRNA administration reveals IGF2 deficiency contributes to impaired cognition in Fragile X syndrome mice. therapeutic application,unassigned 1,0 2.4.1.11 Gastrointestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22041920&form=6&db=m Glycogen synthase kinase 3? inhibition sensitizes pancreatic cancer cells to gemcitabine. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,4,0 2.4.1.11 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22041920&form=6&db=m Glycogen synthase kinase 3? inhibition sensitizes pancreatic cancer cells to gemcitabine. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,4,0 2.4.1.11 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23768967&form=6&db=m Glycogen synthase kinase-3? (GSK-3?) and its dysregulation in glioblastoma multiforme. causal interaction,therapeutic application,unassigned 4,1,0 2.4.1.11 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28042322&form=6&db=m Chromatin Remodeling Factor LSH is Upregulated by the LRP6-GSK3?-E2F1 Axis Linking Reversely with Survival in Gliomas. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,1,0 2.4.1.11 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28423558&form=6&db=m Biological basis and clinical study of glycogen synthase kinase- 3?-targeted therapy by drug repositioning for glioblastoma. causal interaction,therapeutic application,unassigned 1,4,0 2.4.1.11 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16170333&form=6&db=m Glycolytic glioma cells with active glycogen synthase are sensitive to PTEN and inhibitors of PI3K and gluconeogenesis. therapeutic application,unassigned 2,0 2.4.1.11 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17426442&form=6&db=m A New Putative Target for Antisense Gene Therapy of Glioma: Glycogen Synthase. therapeutic application,unassigned 4,0 2.4.1.11 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19882709&form=6&db=m Glycogen synthase kinases-3beta controls differentiation of malignant glioma cells. causal interaction,ongoing research,unassigned 3,4,0 2.4.1.11 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24312592&form=6&db=m Polarized regulation of glycogen synthase kinase-3? is important for glioma cell invasion. causal interaction,ongoing research,unassigned 4,2,0 2.4.1.11 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27802437&form=6&db=m Valproic Acid Promotes Human Glioma U87 Cells Apoptosis and Inhibits Glycogen Synthase Kinase-3? Through ERK/Akt Signaling. ongoing research,therapeutic application,unassigned 3,1,0 2.4.1.11 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28575066&form=6&db=m Combined application of arsenic trioxide and lithium chloride augments viability reduction and apoptosis induction in human rhabdomyosarcoma cell lines. causal interaction,therapeutic application,unassigned 1,1,0 2.4.1.11 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34350475&form=6&db=m TNIK influence the effects of antipsychotics on Wnt/?-catenin signaling pathway. ongoing research,unassigned 2,0 2.4.1.11 Glucose Intolerance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6423666&form=6&db=m Correlation between muscle glycogen synthase activity and in vivo insulin action in man. ongoing research,unassigned 4,0 2.4.1.11 Glucose Intolerance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8307248&form=6&db=m Metabolic origin of insulin resistance in obesity with and without type 2 (non-insulin-dependent) diabetes mellitus. causal interaction,therapeutic application,unassigned 1,1,0 2.4.1.11 Glucose Intolerance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8786726&form=6&db=m Long-term effects of fluoxetine on glycemic control in obese patients with non-insulin-dependent diabetes mellitus or glucose intolerance: influence on muscle glycogen synthase and insulin receptor kinase activity. ongoing research,unassigned 4,0 2.4.1.11 Glucose Intolerance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15375789&form=6&db=m Development of glucose intolerance in male transgenic mice overexpressing human glycogen synthase kinase-3beta on a muscle-specific promoter. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.4.1.11 Glucose Intolerance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20178984&form=6&db=m Impaired glucose tolerance and predisposition to the fasted state in liver glycogen synthase knock-out mice. causal interaction,ongoing research,unassigned 1,3,0 2.4.1.11 Glucose Intolerance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22008454&form=6&db=m Exercise with calorie restriction improves insulin sensitivity and glycogen synthase activity in obese postmenopausal women with impaired glucose tolerance. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,2,0 2.4.1.11 Glycogen Storage Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6220706&form=6&db=m Studies of the residual glycogen branching enzyme activity present in human skin fibroblasts from patients with type IV glycogen storage disease. ongoing research,unassigned 4,0 2.4.1.11 Glycogen Storage Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9691087&form=6&db=m Mutations in the liver glycogen synthase gene in children with hypoglycemia due to glycogen storage disease type 0. ongoing research,unassigned 2,0 2.4.1.11 Glycogen Storage Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12006356&form=6&db=m Decreased insulin action in skeletal muscle from patients with McArdle's disease. causal interaction,unassigned 3,0 2.4.1.11 Glycogen Storage Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18358695&form=6&db=m Glycogen synthase (GYS1) mutation causes a novel skeletal muscle glycogenosis. causal interaction,unassigned 4,0 2.4.1.11 Glycogen Storage Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20051115&form=6&db=m A novel mutation in the glycogen synthase 2 gene in a child with glycogen storage disease type 0. ongoing research,therapeutic application,unassigned 2,1,0 2.4.1.11 Glycogen Storage Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20331987&form=6&db=m Low level of fasting plasma mannose in a child with glycogen storage disease type 0 (liver glycogen synthase deficiency). ongoing research,unassigned 1,0 2.4.1.11 Glycogen Storage Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21194031&form=6&db=m Lentiviral vector delivery of shRNA into cultured primary myogenic cells: a tool for therapeutic target validation. ongoing research,unassigned 4,0 2.4.1.11 Glycogen Storage Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21958591&form=6&db=m Muscle glycogen storage disease 0 presenting recurrent syncope with weakness and myalgia. causal interaction,unassigned 4,0 2.4.1.11 Glycogen Storage Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22248338&form=6&db=m Glycogen and its metabolism: some new developments and old themes. therapeutic application,unassigned 1,0 2.4.1.11 Glycogen Storage Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22860112&form=6&db=m Allele Copy Number and Underlying Pathology Are Associated with Subclinical Severity in Equine Type 1 Polysaccharide Storage Myopathy (PSSM1). unassigned - 2.4.1.11 Glycogen Storage Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25272951&form=6&db=m A new muscle glycogen storage disease associated with glycogenin-1 deficiency. causal interaction,therapeutic application,unassigned 4,1,0 2.4.1.11 Glycogen Storage Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27592162&form=6&db=m A highly prevalent equine glycogen storage disease is explained by constitutive activation of a mutant glycogen synthase. causal interaction,unassigned 1,0 2.4.1.11 Glycogen Storage Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28245189&form=6&db=m The variable clinical phenotype of three patients with hepatic glycogen synthase deficiency. causal interaction,diagnostic usage,unassigned 4,3,0 2.4.1.11 Glycogen Storage Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29784585&form=6&db=m Inhibition of Glycogen Synthase II with RNAi Prevents Liver Injury in Mouse Models of Glycogen Storage Diseases. ongoing research,therapeutic application,unassigned 3,1,0 2.4.1.11 Glycogen Storage Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30968641&form=6&db=m Glycogen storage disease type 0 due to a novel frameshift mutation in glycogen synthase 2 (GYS2) gene in a child presenting with fasting hypoglycemia and postprandial hyperglycemia. causal interaction,unassigned 3,0 2.4.1.11 Glycogen Storage Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32779500&form=6&db=m A patient with glycogen storage disease type 0 and a novel sequence variant in GYS2: a case report and literature review. causal interaction,unassigned 3,0 2.4.1.11 Glycogen Storage Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33473338&form=6&db=m Three successful pregnancies in a patient with glycogen storage disease type 0. causal interaction,unassigned 4,0 2.4.1.11 Glycogen Storage Disease Type II http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21194031&form=6&db=m Lentiviral vector delivery of shRNA into cultured primary myogenic cells: a tool for therapeutic target validation. ongoing research,unassigned 4,0 2.4.1.11 Glycogen Storage Disease Type II http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25350581&form=6&db=m Antisense Oligonucleotide-mediated Suppression of Muscle Glycogen Synthase 1 Synthesis as an Approach for Substrate Reduction Therapy of Pompe Disease. causal interaction,therapeutic application,unassigned 4,4,0 2.4.1.11 Glycogen Storage Disease Type IV http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23607684&form=6&db=m Polyglucosan neurotoxicity caused by glycogen branching enzyme deficiency can be reversed by inhibition of glycogen synthase. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,4 2.4.1.11 Glycogen Storage Disease Type V http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12068056&form=6&db=m Role of 5'AMP-activated protein kinase in glycogen synthase activity and glucose utilization: insights from patients with McArdle's disease. causal interaction,ongoing research,unassigned 1,2,0 2.4.1.11 glycogen(starch) synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8831078&form=6&db=m Liver glycogen synthase deficiency: a rarely diagnosed entity. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 2.4.1.11 glycogen(starch) synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9589989&form=6&db=m [Glycogen synthase deficiency] causal interaction,unassigned 4,0 2.4.1.11 glycogen(starch) synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10821216&form=6&db=m The molecular background of glycogen metabolism disorders. causal interaction,ongoing research,unassigned 4,3,0 2.4.1.11 glycogen(starch) synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11483824&form=6&db=m Case report: liver glycogen synthase deficiency--a cause of ketotic hypoglycemia. causal interaction,unassigned 3,0 2.4.1.11 glycogen(starch) synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12072888&form=6&db=m Glycogen synthase deficiency (glycogen storage disease type 0) presenting with hyperglycemia and glucosuria: report of three new mutations. causal interaction,unassigned 4,0 2.4.1.11 glycogen(starch) synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12794686&form=6&db=m Long-term follow-up of a new case of liver glycogen synthase deficiency. causal interaction,unassigned 4,0 2.4.1.11 glycogen(starch) synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16337419&form=6&db=m Hepatic glycogen synthase deficiency: an infrequently recognized cause of ketotic hypoglycemia. causal interaction,unassigned 3,0 2.4.1.11 glycogen(starch) synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17027861&form=6&db=m Glycogen storage disease: clinical, biochemical, and molecular heterogeneity. causal interaction,ongoing research,unassigned 4,2,0 2.4.1.11 glycogen(starch) synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18341095&form=6&db=m The variable clinical phenotype of liver glycogen synthase deficiency. causal interaction,therapeutic application,unassigned 4,1,0 2.4.1.11 glycogen(starch) synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19699667&form=6&db=m Identification of a novel mutation in GYS1 (muscle-specific glycogen synthase) resulting in sudden cardiac death, that is diagnosable from skin fibroblasts. causal interaction,unassigned 4,0 2.4.1.11 glycogen(starch) synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20178984&form=6&db=m Impaired glucose tolerance and predisposition to the fasted state in liver glycogen synthase knock-out mice. causal interaction,ongoing research,unassigned 1,3,0 2.4.1.11 glycogen(starch) synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26835382&form=6&db=m Investigation and management of the hepatic glycogen storage diseases. unassigned - 2.4.1.11 glycogen(starch) synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26937415&form=6&db=m Pediatric patient with hyperketotic hypoglycemia diagnosed with glycogen synthase deficiency due to the novel homozygous mutation in GYS2. causal interaction,unassigned 4,0 2.4.1.11 glycogen(starch) synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28245189&form=6&db=m The variable clinical phenotype of three patients with hepatic glycogen synthase deficiency. causal interaction,diagnostic usage,unassigned 4,3,0 2.4.1.11 Graft vs Host Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23769106&form=6&db=m Utilizing glycogen synthase kinase-3? as a marker for the diagnosis of graft-versus-host disease. diagnostic usage,unassigned 4,0 2.4.1.11 Gram-Negative Bacterial Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33601795&form=6&db=m GSK3? inhibition confers survival advantage in Burkholderia pseudomallei-infected hyperglycaemic mice by regulating inflammatory response. causal interaction,unassigned 2,0 2.4.1.11 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30405781&form=6&db=m Aberrant expression of glycogen synthase kinase-3? in human breast and head and neck cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.1.11 Heart Arrest http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27177932&form=6&db=m Early glycogen synthase kinase-3? and protein phosphatase 2A independent tau dephosphorylation during global brain ischaemia and reperfusion following cardiac arrest and the role of the adenosine monophosphate kinase pathway. therapeutic application,unassigned 1,0 2.4.1.11 Heart Rupture http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22086876&form=6&db=m Glycogen synthase kinase-3? limits ischemic injury, cardiac rupture, post-myocardial infarction remodeling and death. causal interaction,therapeutic application,unassigned 4,2,0 2.4.1.11 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27470624&form=6&db=m [Role of glycogen synthase kinase-3? in development of severe hepatitis liver failure caused by hepatitis B virus]. causal interaction,unassigned 4,0 2.4.1.11 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27470624&form=6&db=m [Role of glycogen synthase kinase-3? in development of severe hepatitis liver failure caused by hepatitis B virus]. causal interaction,unassigned 4,0 2.4.1.11 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30584071&form=6&db=m A GYS2/p53 Negative Feedback Loop Restricts Tumor Growth in HBV-Related Hepatocellular Carcinoma. causal interaction,unassigned 3,0 2.4.1.11 Hepatomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28245189&form=6&db=m The variable clinical phenotype of three patients with hepatic glycogen synthase deficiency. causal interaction,diagnostic usage,unassigned 4,3,0 2.4.1.11 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29422655&form=6&db=m Glycogen synthase protects neurons from cytotoxicity of mutant huntingtin by enhancing the autophagy flux. ongoing research,unassigned 2,0 2.4.1.11 Hydatidiform Mole http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8514882&form=6&db=m Pre-eclampsia is associated with an increase in trophoblast glycogen content and glycogen synthase activity, similar to that found in hydatidiform moles. unassigned - 2.4.1.11 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22490960&form=6&db=m [Changes of glycogen synthase kinase-3? and its phospholation in spinal cord neurons in rats with incisional pain-remifentanil-induced hyperalgesia]. ongoing research,unassigned 1,0 2.4.1.11 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23267003&form=6&db=m Glycogen synthase kinase-3? contributes to remifentanil-induced postoperative hyperalgesia via regulating N-methyl-D-aspartate receptor trafficking. ongoing research,unassigned 3,0 2.4.1.11 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24147079&form=6&db=m Inhibition of glycogen synthase kinase-3? prevents remifentanil-induced hyperalgesia via regulating the expression and function of spinal N-methyl-D-aspartate receptors in vivo and vitro. ongoing research,therapeutic application,unassigned 1,1,0 2.4.1.11 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25126703&form=6&db=m Glycogen synthase kinase-3? inhibition prevents remifentanil-induced postoperative hyperalgesia via regulating the expression and function of AMPA receptors. causal interaction,therapeutic application,unassigned 1,1,0 2.4.1.11 Hyperandrogenism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12893722&form=6&db=m Effect of testosterone and endurance training on glycogen metabolism in skeletal muscle of chronic hyperglycaemic female rats. causal interaction,therapeutic application,unassigned 3,1,0 2.4.1.11 Hypercholesterolemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24213808&form=6&db=m Hypercholesterolemia abrogates the cardioprotection of ischemic postconditioning in isolated rat heart: roles of glycogen synthase kinase-3? and the mitochondrial permeability transition pore. ongoing research,unassigned 1,0 2.4.1.11 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1397721&form=6&db=m Hyperglycemia markedly enhances skeletal muscle glycogen synthase activity in diabetic, but not in normal conscious rats. ongoing research,unassigned 3,0 2.4.1.11 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1559409&form=6&db=m Insulin resistance in skeletal muscles in patients with NIDDM. causal interaction,unassigned 4,0 2.4.1.11 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1672795&form=6&db=m Hyperglycemia induces accumulation of glucose in human skeletal muscle. causal interaction,unassigned 1,0 2.4.1.11 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1733806&form=6&db=m Effect of acute hyperglycemia on glucose metabolism in skeletal muscles in IDDM patients. unassigned - 2.4.1.11 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1907347&form=6&db=m Effects of hyperinsulinemia and hyperglycemia on insulin receptor function and glycogen synthase activation in skeletal muscle of normal man. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 2.4.1.11 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2105341&form=6&db=m Intracellular glucose oxidation and glycogen synthase activity are reduced in non-insulin-dependent (type II) diabetes independent of impaired glucose uptake. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,1,0 2.4.1.11 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2121778&form=6&db=m Fasting hyperglycemia normalizes oxidative and nonoxidative pathways of insulin-stimulated glucose metabolism in noninsulin-dependent diabetes mellitus. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,3,0 2.4.1.11 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2503545&form=6&db=m Correction of chronic hyperglycemia with vanadate, but not with phlorizin, normalizes in vivo glycogen repletion and in vitro glycogen synthase activity in diabetic skeletal muscle. ongoing research,therapeutic application,unassigned 1,1,0 2.4.1.11 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3086163&form=6&db=m In vivo regulation of liver and skeletal muscle glycogen synthase activity by glucose and insulin. unassigned - 2.4.1.11 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3110217&form=6&db=m Regulation of glycogen synthase and phosphorylase activities by glucose and insulin in human skeletal muscle. diagnostic usage,ongoing research,unassigned 1,3,0 2.4.1.11 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6766890&form=6&db=m Effects of acute variation of fetal glycemia on glycogen storage and on glycogen synthase and phosphorylase activities in the liver of the rat fetus. unassigned - 2.4.1.11 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7010073&form=6&db=m Autoregulation by glucose of hepatic glucose balance: permissive effect of insulin. causal interaction,unassigned 1,0 2.4.1.11 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7895681&form=6&db=m Role of prostaglandins in mediating alterations in glucose metabolism during acute endotoxemia in the rat. causal interaction,therapeutic application,unassigned 1,1,0 2.4.1.11 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8040269&form=6&db=m Glycogen synthase: a putative locus for diet-induced hyperglycemia. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.1.11 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8156907&form=6&db=m Mechanisms of insulin resistance during acute endotoxemia. unassigned - 2.4.1.11 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8350867&form=6&db=m Effects of high sucrose diet on insulin-like effects of vanadate in diabetic rats. causal interaction,unassigned 1,0 2.4.1.11 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8786734&form=6&db=m Effect of troglitazone (CS-045) and bezafibrate on glucose tolerance, liver glycogen synthase activity, and beta-oxidation in fructose-fed rats. unassigned - 2.4.1.11 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9166674&form=6&db=m Regulation of glycogen synthase activity in cultured skeletal muscle cells from subjects with type II diabetes: role of chronic hyperinsulinemia and hyperglycemia. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.4.1.11 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9502760&form=6&db=m Mechanism by which glucose and insulin inhibit net hepatic glycogenolysis in humans. therapeutic application,unassigned 1,0 2.4.1.11 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12072888&form=6&db=m Glycogen synthase deficiency (glycogen storage disease type 0) presenting with hyperglycemia and glucosuria: report of three new mutations. causal interaction,unassigned 4,0 2.4.1.11 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12381415&form=6&db=m Hyperglycemia reduces nitric oxide synthase and glycogen synthase activity in endothelial cells. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.1.11 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15014073&form=6&db=m Hyperglycemia and inhibition of glycogen synthase in streptozotocin-treated mice: role of O-linked N-acetylglucosamine. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.1.11 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15326559&form=6&db=m Glucose catabolic gene mRNA levels in skeletal muscle exhibit non-coordinate expression in hyperglycemic mice. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.1.11 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18274898&form=6&db=m Effect of diabetes on glycogen metabolism in rat retina. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.1.11 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20367521&form=6&db=m Novel therapeutics based on inhibiting the interaction of glycogen phosphorylase and G(L)-subunit of glycogen-associated protein phosphatase 1: WO2009127723. causal interaction,therapeutic application,unassigned 1,1,0 2.4.1.11 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21846719&form=6&db=m Liver-specific iNOS expression is sufficient to cause hepatic insulin resistance and mild hyperglycemia in mice. causal interaction,unassigned 4,0 2.4.1.11 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22926827&form=6&db=m The role of glycogen synthase in the development of hyperglycemia in type 2 diabetes: "To store or not to store glucose, that's the question" ongoing research,unassigned 1,0 2.4.1.11 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23028137&form=6&db=m Portal vein glucose entry triggers a coordinated cellular response that potentiates hepatic glucose uptake and storage in normal but not high-fat/high-fructose-fed dogs. unassigned - 2.4.1.11 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24865981&form=6&db=m Hepatic glucose uptake and disposition during short-term high-fat vs. high-fructose feeding. therapeutic application,unassigned 1,0 2.4.1.11 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29437243&form=6&db=m Melatonin attenuates smoking-induced hyperglycemia via preserving insulin secretion and hepatic glycogen synthesis in rats. unassigned - 2.4.1.11 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29790091&form=6&db=m Effects of acute hyperglycemia stress on plasma glucose, glycogen content, and expressions of glycogen synthase and phosphorylase in hybrid grouper (Epinephelus fuscoguttatus ? × E. lanceolatus ?). ongoing research,therapeutic application,unassigned 3,1,0 2.4.1.11 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30213826&form=6&db=m Effect of Chronic Hyperglycemia on Glucose Metabolism in Subjects with Normal Glucose Tolerance. causal interaction,ongoing research,unassigned 1,1,0 2.4.1.11 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30968641&form=6&db=m Glycogen storage disease type 0 due to a novel frameshift mutation in glycogen synthase 2 (GYS2) gene in a child presenting with fasting hypoglycemia and postprandial hyperglycemia. causal interaction,unassigned 3,0 2.4.1.11 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1907347&form=6&db=m Effects of hyperinsulinemia and hyperglycemia on insulin receptor function and glycogen synthase activation in skeletal muscle of normal man. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 2.4.1.11 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1951684&form=6&db=m Fasting inhibits insulin-mediated glycolysis and anaplerosis in human skeletal muscle. therapeutic application,unassigned 1,0 2.4.1.11 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2105341&form=6&db=m Intracellular glucose oxidation and glycogen synthase activity are reduced in non-insulin-dependent (type II) diabetes independent of impaired glucose uptake. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,1,0 2.4.1.11 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3086163&form=6&db=m In vivo regulation of liver and skeletal muscle glycogen synthase activity by glucose and insulin. unassigned - 2.4.1.11 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3523411&form=6&db=m Insulin stimulates amino acid and lipid metabolism in isolated fetal rat hepatocytes. ongoing research,unassigned 3,0 2.4.1.11 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7485484&form=6&db=m Regulation of hexokinase II and glycogen synthase mRNA, protein, and activity in human muscle. ongoing research,unassigned 4,0 2.4.1.11 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7895681&form=6&db=m Role of prostaglandins in mediating alterations in glucose metabolism during acute endotoxemia in the rat. causal interaction,therapeutic application,unassigned 1,1,0 2.4.1.11 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8326021&form=6&db=m Interaction between glucose and free fatty acid metabolism in human skeletal muscle. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.4.1.11 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8541012&form=6&db=m Glycogen synthase activity in two rat models of hypertension. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.1.11 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9166674&form=6&db=m Regulation of glycogen synthase activity in cultured skeletal muscle cells from subjects with type II diabetes: role of chronic hyperinsulinemia and hyperglycemia. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.4.1.11 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9243486&form=6&db=m Blood flow, lipid oxidation, and muscle glycogen synthesis after glycogen depletion by strenuous exercise. unassigned - 2.4.1.11 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9502760&form=6&db=m Mechanism by which glucose and insulin inhibit net hepatic glycogenolysis in humans. therapeutic application,unassigned 1,0 2.4.1.11 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9589675&form=6&db=m Defects of insulin action and skeletal muscle glucose metabolism in growth hormone-deficient adults persist after 24 months of recombinant human growth hormone therapy. causal interaction,ongoing research,unassigned 4,1,0 2.4.1.11 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10416561&form=6&db=m Effects of exercise and insulin on insulin signaling proteins in human skeletal muscle. causal interaction,therapeutic application,unassigned 3,1,0 2.4.1.11 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10868952&form=6&db=m Insulin signaling and insulin sensitivity after exercise in human skeletal muscle. ongoing research,unassigned 1,0 2.4.1.11 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11254467&form=6&db=m Flux control in the rat gastrocnemius glycogen synthesis pathway by in vivo 13C/31P NMR spectroscopy. ongoing research,unassigned 3,0 2.4.1.11 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11287353&form=6&db=m Physiological hyperinsulinemia impairs insulin-stimulated glycogen synthase activity and glycogen synthesis. diagnostic usage,ongoing research,unassigned 1,4,0 2.4.1.11 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11375325&form=6&db=m Stimulating effects of low-dose fructose on insulin-stimulated hepatic glycogen synthesis in humans. unassigned - 2.4.1.11 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12765949&form=6&db=m Increased phosphorylation of skeletal muscle glycogen synthase at NH2-terminal sites during physiological hyperinsulinemia in type 2 diabetes. therapeutic application,unassigned 1,0 2.4.1.11 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17513702&form=6&db=m Effects of endurance exercise training on insulin signaling in human skeletal muscle: interactions at the level of phosphatidylinositol 3-kinase, Akt, and AS160. causal interaction,therapeutic application,unassigned 3,1,0 2.4.1.11 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22934083&form=6&db=m Period2 gene mutant mice show compromised insulin-mediated endothelial nitric oxide release and altered glucose homeostasis. ongoing research,therapeutic application,unassigned 4,1,0 2.4.1.11 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23028137&form=6&db=m Portal vein glucose entry triggers a coordinated cellular response that potentiates hepatic glucose uptake and storage in normal but not high-fat/high-fructose-fed dogs. unassigned - 2.4.1.11 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24865981&form=6&db=m Hepatic glucose uptake and disposition during short-term high-fat vs. high-fructose feeding. therapeutic application,unassigned 1,0 2.4.1.11 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32070154&form=6&db=m Impact of insulin and glucocorticoid signalling on hepatic glucose homeostasis in the rat exposed to high-fructose diet and chronic stress. causal interaction,therapeutic application,unassigned 3,2,0 2.4.1.11 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33651899&form=6&db=m Vanillic acid mitigates the impairments in glucose metabolism in HepG2 cells through BAD-GK interaction during hyperinsulinemia. unassigned - 2.4.1.11 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=100192907&form=6&db=m Glycogen synthase activation in the epididymal adipose tissue from chronic hyperinsulinemic/obese rats. unassigned - 2.4.1.11 Hyperlipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12794686&form=6&db=m Long-term follow-up of a new case of liver glycogen synthase deficiency. causal interaction,unassigned 4,0 2.4.1.11 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8416266&form=6&db=m Association between polymorphism of the glycogen synthase gene and non-insulin-dependent diabetes mellitus. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.1.11 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8541012&form=6&db=m Glycogen synthase activity in two rat models of hypertension. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.1.11 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8591890&form=6&db=m Polymorphism of the glycogen synthase gene in hypertensive and normotensive subjects. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.4.1.11 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8690180&form=6&db=m The glycogen synthase gene in NIDDM and hypertension. ongoing research,therapeutic application,unassigned 2,1,0 2.4.1.11 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8860096&form=6&db=m Glycogen synthase polymorphism, insulin resistance and hypertension. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.1.11 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9030814&form=6&db=m Polymorphism of the glycogen synthase gene and non-insulin-dependent diabetes mellitus in the Russian population. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0 2.4.1.11 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9240761&form=6&db=m Analysis of candidate genes for insulin resistance in essential hypertension. unassigned - 2.4.1.11 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10447527&form=6&db=m A paired-sibling analysis of the XbaI polymorphism in the muscle glycogen synthase gene. ongoing research,unassigned 3,0 2.4.1.11 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11408400&form=6&db=m A defect in glycogen synthesis characterizes insulin resistance in hypertensive patients with type 2 diabetes. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0 2.4.1.11 Hyperthyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3131128&form=6&db=m The effect of the thyroid status on the activation of glycogen synthase in liver cells. ongoing research,unassigned 2,0 2.4.1.11 Hyperthyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3530675&form=6&db=m Regulation of neonatal heart glycogen metabolism by thyroxine. ongoing research,unassigned 3,0 2.4.1.11 Hyperthyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8487755&form=6&db=m Triiodo-L-thyronine stimulates glycogen synthesis in rat hepatocyte cultures. diagnostic usage,unassigned 2,0 2.4.1.11 Hyperthyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14169578&form=6&db=m UDPG-GLYCOGEN TRANSGLUCOSYLASE ACTIVITY IN HYPERTHYROID ANIMALS. unassigned - 2.4.1.11 Hypoglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1907743&form=6&db=m Decrease of liver glycogen content in golden hamsters infected with plerocercoids of Spirometra erinacei. causal interaction,unassigned 3,0 2.4.1.11 Hypoglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6777219&form=6&db=m The minimal amino acid sequence of the insulin-potentiating fragments of human growth hormone: its mechanism of action. causal interaction,therapeutic application,unassigned 1,1,0 2.4.1.11 Hypoglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7698511&form=6&db=m Counterregulation of hypoglycemia. Skeletal muscle glycogen metabolism during three hours of physiological hyperinsulinemia in humans. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0 2.4.1.11 Hypoglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8200993&form=6&db=m Increased epinephrine and skeletal muscle responses to hypoglycemia in non-insulin-dependent diabetes mellitus. unassigned - 2.4.1.11 Hypoglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9361698&form=6&db=m Exercise in transgenic mice overexpressing GLUT4 glucose transporters: effects on substrate metabolism and glycogen regulation. unassigned - 2.4.1.11 Hypoglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9691087&form=6&db=m Mutations in the liver glycogen synthase gene in children with hypoglycemia due to glycogen storage disease type 0. ongoing research,unassigned 2,0 2.4.1.11 Hypoglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11483824&form=6&db=m Case report: liver glycogen synthase deficiency--a cause of ketotic hypoglycemia. causal interaction,unassigned 3,0 2.4.1.11 Hypoglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11592574&form=6&db=m Effect of growth hormone treatment on hypoglycemia in a patient with both hepatic glycogen synthase and isolated growth hormone deficiencies. causal interaction,therapeutic application,unassigned 3,2,0 2.4.1.11 Hypoglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16087376&form=6&db=m Changes in muscle mRNAs for hexokinase, phosphofructokinase-1 and glycogen synthase in acute and persistent hypoglycemia induced by tolbutamide in chickens. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,1,0 2.4.1.11 Hypoglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16337419&form=6&db=m Hepatic glycogen synthase deficiency: an infrequently recognized cause of ketotic hypoglycemia. causal interaction,unassigned 3,0 2.4.1.11 Hypoglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20733003&form=6&db=m Loss of Par-1a/MARK3/C-TAK1 kinase leads to reduced adiposity, resistance to hepatic steatosis, and defective gluconeogenesis. unassigned - 2.4.1.11 Hypoglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22934083&form=6&db=m Period2 gene mutant mice show compromised insulin-mediated endothelial nitric oxide release and altered glucose homeostasis. ongoing research,therapeutic application,unassigned 4,1,0 2.4.1.11 Hypoglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25152463&form=6&db=m Sex-specific basal and hypoglycemic patterns of in vivo caudal dorsal vagal complex astrocyte glycogen metabolic enzyme protein expression. unassigned - 2.4.1.11 Hypoglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26937415&form=6&db=m Pediatric patient with hyperketotic hypoglycemia diagnosed with glycogen synthase deficiency due to the novel homozygous mutation in GYS2. causal interaction,unassigned 4,0 2.4.1.11 Hypoglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28596236&form=6&db=m Acute Hypoglycemia in Healthy Humans Impairs Insulin-Stimulated Glucose Uptake and Glycogen Synthase in Skeletal Muscle: A Randomized Clinical Study. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,3 2.4.1.11 Hypoglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30968641&form=6&db=m Glycogen storage disease type 0 due to a novel frameshift mutation in glycogen synthase 2 (GYS2) gene in a child presenting with fasting hypoglycemia and postprandial hyperglycemia. causal interaction,unassigned 3,0 2.4.1.11 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7895681&form=6&db=m Role of prostaglandins in mediating alterations in glucose metabolism during acute endotoxemia in the rat. causal interaction,therapeutic application,unassigned 1,1,0 2.4.1.11 Hypothyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3530675&form=6&db=m Regulation of neonatal heart glycogen metabolism by thyroxine. ongoing research,unassigned 3,0 2.4.1.11 Immune System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27029564&form=6&db=m Inhibition of GSK-3? Alleviates Collagen II-Induced Rheumatoid Arthritis in Rats. causal interaction,unassigned 3,0 2.4.1.11 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23219579&form=6&db=m Both PI3K/Akt and ERK1/2 pathways participate in the protection by dexmedetomidine against transient focal cerebral ischemia/reperfusion injury in rats. ongoing research,unassigned 3,0 2.4.1.11 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32693014&form=6&db=m Protective effect of Hydroxysaf?or Yellow A on cerebral ischemia reperfusion-injury by regulating GSK3?-mediated pathways. ongoing research,therapeutic application,unassigned 4,1,0 2.4.1.11 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12556131&form=6&db=m Expression of a glycogen synthase protein kinase homolog from Colletotrichum gloeosporioides f.sp. malvae during infection of Malva pusilla. causal interaction,ongoing research,unassigned 1,2,0 2.4.1.11 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12805359&form=6&db=m Protein targeting to glycogen overexpression results in the specific enhancement of glycogen storage in 3T3-L1 adipocytes. unassigned - 2.4.1.11 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12941762&form=6&db=m Molecular mechanisms of insulin resistance in IRS-2-deficient hepatocytes. ongoing research,unassigned 2,0 2.4.1.11 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21763505&form=6&db=m Human Immunodeficiency Virus Type 1 Induces Lytic Cycle Replication of Kaposi's-Sarcoma-Associated Herpesvirus: Role of Ras/c-Raf/MEK1/2, PI3K/AKT, and NF-?B Signaling Pathways. unassigned - 2.4.1.11 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30926881&form=6&db=m Streptolysin S induces mitochondrial damage and macrophage death through inhibiting degradation of glycogen synthase kinase-3? in Streptococcus pyogenes infection. causal interaction,therapeutic application,unassigned 2,1,0 2.4.1.11 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32321878&form=6&db=m Is GSK3? a molecular target of chloroquine treatment against COVID-19? causal interaction,unassigned 1,0 2.4.1.11 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32533831&form=6&db=m GlgA plays an important role in the induction of hydrosalpinx by Chlamydia muridarum. causal interaction,ongoing research,unassigned 4,3,0 2.4.1.11 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33597499&form=6&db=m Anti-malarial and cytokine-modulating effects of andrographolide in a murine model of malarial infection. unassigned - 2.4.1.11 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33612762&form=6&db=m GSK3?: A plausible molecular target in the cytokinemodulating effect of exogenous insulin in a murine model of malarial infection. causal interaction,therapeutic application,unassigned 2,1,0 2.4.1.11 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33612800&form=6&db=m Potential of repurposing chloroquine as an adjunct therapy for melioidosis based on a murine model of Burkholderia pseudomallei infection. causal interaction,therapeutic application,unassigned 3,4,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=112380&form=6&db=m Insulin sensitivity of liver glycogen synthase b into a conversion. ongoing research,unassigned 2,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1485943&form=6&db=m The etiology and pathogenesis of non-insulin-dependent diabetes. causal interaction,therapeutic application,unassigned 4,1,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1541385&form=6&db=m Hyperglycaemia compensates for the defects in insulin-mediated glucose metabolism and in the activation of glycogen synthase in the skeletal muscle of patients with type 2 (non-insulin-dependent) diabetes mellitus. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1541672&form=6&db=m Decreased insulin activation of glycogen synthase in skeletal muscles in young nonobese Caucasian first-degree relatives of patients with non-insulin-dependent diabetes mellitus. causal interaction,unassigned 4,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1568529&form=6&db=m Impaired activation of glycogen synthase in people at increased risk for developing NIDDM. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1601390&form=6&db=m The effects of fasting and refeeding on liver glycogen synthase and phosphorylase in obese and lean mice. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1756915&form=6&db=m Impaired expression of glycogen synthase mRNA in skeletal muscle of NIDDM patients. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,3,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1794267&form=6&db=m Gliclazide and insulin action in human muscle. causal interaction,therapeutic application,unassigned 4,4,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1906024&form=6&db=m Reduced glycogen synthase activity in skeletal muscle from obese patients with and without type 2 (non-insulin-dependent) diabetes mellitus. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2115296&form=6&db=m Impairment of glucose tolerance: mechanism of action and impact on the cardiovascular system. causal interaction,unassigned 3,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2153707&form=6&db=m Insulin resistance is associated with reduced fasting and insulin-stimulated glycogen synthase phosphatase activity in human skeletal muscle. causal interaction,therapeutic application,unassigned 1,1,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2498196&form=6&db=m Prevention of insulin resistance by environmental manipulation as young rats mature. diagnostic usage,ongoing research,unassigned 3,1,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2499587&form=6&db=m Insulin receptor function and glycogen synthase activity in skeletal muscle biopsies from patients with insulin-dependent diabetes mellitus: effects of physical training. ongoing research,therapeutic application,unassigned 4,1,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2555996&form=6&db=m Activity of insulin receptor kinase and glycogen synthase in skeletal muscle from patients with chronic renal failure. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2837468&form=6&db=m Properties of a human insulin receptor with a COOH-terminal truncation. II. Truncated receptors have normal kinase activity but are defective in signaling metabolic effects. unassigned - 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2846655&form=6&db=m Impaired insulin-stimulated muscle glycogen synthase activation in vivo in man is related to low fasting glycogen synthase phosphatase activity. unassigned - 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3121620&form=6&db=m Insulin resistance in denervated skeletal muscle. Inability of insulin to stimulate dephosphorylation of glycogen synthase in denervated rat epitrochlearis muscles. ongoing research,therapeutic application,unassigned 2,2,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3134799&form=6&db=m Insulin resistance in Pima Indians. A combined effect of genetic predisposition and obesity-related skeletal muscle cell hypertrophy. causal interaction,unassigned 4,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3135217&form=6&db=m Liver and muscle insulin sensitivity, glycogen concentration and glycogen synthase activity in a rat model of non-insulin-dependent diabetes. ongoing research,unassigned 4,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3920504&form=6&db=m Mechanisms of insulin resistance in cultured fibroblasts from a patient with leprechaunism: resistance to proteolytic activation of glycogen synthase by trypsin. ongoing research,unassigned 4,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6437249&form=6&db=m Insulin resistance of denervated rat muscle: a model for impaired receptor-function coupling. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6777220&form=6&db=m Insulin stimulation of glycogen synthase in cultured human diploid fibroblasts. ongoing research,unassigned 1,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7498245&form=6&db=m Determinants of insulin-stimulated skeletal muscle glycogen metabolism in man. ongoing research,unassigned 4,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7713477&form=6&db=m [Pathophysiology of insulin resistance] ongoing research,therapeutic application,unassigned 2,1,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7758880&form=6&db=m Multiple defects of both hepatic and peripheral intracellular glucose processing contribute to the hyperglycaemia of NIDDM. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,2,1 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7821730&form=6&db=m Modulation of insulin receptor signalling: significance of altered receptor isoform patterns and mechanism of hyperglycaemia-induced receptor modulation. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7883119&form=6&db=m Regulation of glycogen synthase by glucose, glucosamine, and glutamine:fructose-6-phosphate amidotransferase. unassigned - 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7895681&form=6&db=m Role of prostaglandins in mediating alterations in glucose metabolism during acute endotoxemia in the rat. causal interaction,therapeutic application,unassigned 1,1,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7926294&form=6&db=m Sequence of the human glycogen-associated regulatory subunit of type 1 protein phosphatase and analysis of its coding region and mRNA level in muscle from patients with NIDDM. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7983805&form=6&db=m [Glycogen synthase gene-glycogen synthase gene in Japanese patients with NIDDM] causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8088709&form=6&db=m Modulation of insulin signalling in non-insulin-dependent diabetes mellitus: significance of altered receptor isoform patterns and mechanisms of glucose-induced receptor modulation. causal interaction,therapeutic application,unassigned 4,1,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8156907&form=6&db=m Mechanisms of insulin resistance during acute endotoxemia. unassigned - 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8178978&form=6&db=m Trypsin-Mn(2+)-resistant form of type 1 protein phosphatase in human muscle. causal interaction,therapeutic application,unassigned 1,1,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8385036&form=6&db=m Pathogenesis of type 2 (non-insulin-dependent) diabetes mellitus: candidates for a signal transmitter defect causing insulin resistance of the skeletal muscle. ongoing research,therapeutic application,unassigned 2,1,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8408617&form=6&db=m Mechanism of enhanced insulin sensitivity in athletes. Increased blood flow, muscle glucose transport protein (GLUT-4) concentration, and glycogen synthase activity. unassigned - 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8416266&form=6&db=m Association between polymorphism of the glycogen synthase gene and non-insulin-dependent diabetes mellitus. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8462768&form=6&db=m Adipose tissue glycogen synthase activation by in vivo insulin in spontaneously insulin-resistant and type 2 (non-insulin-dependent) diabetic rhesus monkeys. causal interaction,unassigned 3,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8475632&form=6&db=m [Metabolic syndrome--bridge to type II diabetes] unassigned - 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8495815&form=6&db=m Identification of a simple tandem repeat DNA polymorphism in the human glycogen synthase gene and linkage to five markers on chromosome 19q. ongoing research,unassigned 3,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8529791&form=6&db=m Modulation of insulin receptor signaling. Potential mechanisms of a cross talk between bradykinin and the insulin receptor. causal interaction,ongoing research,unassigned 1,1,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8530392&form=6&db=m Insulin stimulation of mitogen-activated protein kinase, p90rsk, and p70 S6 kinase in skeletal muscle of normal and insulin-resistant mice. Implications for the regulation of glycogen synthase. ongoing research,unassigned 2,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8536147&form=6&db=m Influence of exercise on insulin sensitivity. causal interaction,unassigned 1,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8561892&form=6&db=m The genetics and pathophysiology of type II and gestational diabetes. causal interaction,unassigned 4,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8587610&form=6&db=m Insulin action impaired by deficiency of the G-protein subunit G ialpha2. therapeutic application,unassigned 1,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8591890&form=6&db=m Polymorphism of the glycogen synthase gene in hypertensive and normotensive subjects. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8623155&form=6&db=m The effect of (steroid) immunosuppression on skeletal muscle glycogen metabolism in patients after kidney transplantation. causal interaction,unassigned 4,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8636267&form=6&db=m Insulin resistance in growth hormone-deficient adults: defects in glucose utilization and glycogen synthase activity. causal interaction,unassigned 4,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8680461&form=6&db=m Changes in glucose and lipid metabolism following weight loss produced by a very low calorie diet in obese subjects. ongoing research,unassigned 4,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8769349&form=6&db=m Intramuscular triglyceride and muscle insulin sensitivity: evidence for a relationship in nondiabetic subjects. ongoing research,therapeutic application,unassigned 3,2,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8860096&form=6&db=m Glycogen synthase polymorphism, insulin resistance and hypertension. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8891456&form=6&db=m Intracellular glucose and fat metabolism in identical twins discordant for non-insulin-dependent diabetes mellitus (NIDDM): acquired versus genetic metabolic defects? causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8960833&form=6&db=m UKPDS 19: heterogeneity in NIDDM: separate contributions of IRS-1 and beta 3-adrenergic-receptor mutations to insulin resistance and obesity respectively with no evidence for glycogen synthase gene mutations. UK Prospective Diabetes Study. unassigned - 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8967027&form=6&db=m [Amylin as an additional possible pathogenic factor in NIDDM and the insulin resistance syndrome] ongoing research,unassigned 2,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9113484&form=6&db=m Post-marathon paradox in IDDM: unchanged insulin sensitivity in spite of glycogen depletion. unassigned - 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9162607&form=6&db=m Fetal growth and insulin resistance in adult life: relationship between glycogen synthase activity in adult skeletal muscle and birthweight. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,4,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9240761&form=6&db=m Analysis of candidate genes for insulin resistance in essential hypertension. unassigned - 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9243486&form=6&db=m Blood flow, lipid oxidation, and muscle glycogen synthesis after glycogen depletion by strenuous exercise. unassigned - 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9267990&form=6&db=m A missense mutation of the muscle glycogen synthase gene (M416V) is associated with insulin resistance in the Japanese population. causal interaction,therapeutic application,unassigned 3,1,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9389424&form=6&db=m New variants in the glycogen synthase gene (Gln71His, Met416Val) in patients with NIDDM from eastern Finland. therapeutic application,unassigned 1,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9493493&form=6&db=m Mechanisms of insulin resistance and new pharmacological approaches to metabolism and diabetic complications. causal interaction,unassigned 3,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9566643&form=6&db=m Muscle fibre composition and glycogen synthase activity in hypertension-prone men. ongoing research,unassigned 1,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9589675&form=6&db=m Defects of insulin action and skeletal muscle glucose metabolism in growth hormone-deficient adults persist after 24 months of recombinant human growth hormone therapy. causal interaction,ongoing research,unassigned 4,1,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9593781&form=6&db=m Postabsorptive respiratory quotient and insulin-stimulated glucose storage rate in nondiabetic pima indians are related To glycogen synthase fractional activity in cultured myoblasts. causal interaction,unassigned 4,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9657106&form=6&db=m Insulin resistance in cirrhosis: prolonged reduction of hyperinsulinemia normalizes insulin sensitivity. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9696698&form=6&db=m Lack of defect in insulin action on hepatic glycogen synthase and phosphorylase in insulin-resistant monkeys. causal interaction,ongoing research,unassigned 4,2,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9821177&form=6&db=m The intracellular mechanism of insulin resistance in the hamster pancreatic ductal adenocarcinoma model. causal interaction,unassigned 3,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10212838&form=6&db=m Mechanisms of insulin resistance in non-oxidative glucose metabolism: the role of glycogen synthase. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10331416&form=6&db=m Allosteric regulation of glycogen synthase and hexokinase by glucosamine-6-phosphate during glucosamine-induced insulin resistance in skeletal muscle and heart. ongoing research,therapeutic application,unassigned 2,1,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10421979&form=6&db=m On the pathophysiology of late onset non-insulin dependent diabetes mellitus. Current controversies and new insights. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10442567&form=6&db=m Insulin sensitivity in growth hormone (GH)-deficient adults and effect of GH replacement therapy. causal interaction,therapeutic application,unassigned 4,4,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10484052&form=6&db=m Intracellular skeletal muscle glucose metabolism is differentially altered by dexamethasone treatment of normoglycemic relatives of type 2 diabetic patients. causal interaction,therapeutic application,unassigned 4,1,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10488084&form=6&db=m The role of glucose metabolites in the activation and translocation of glycogen synthase by insulin in 3T3-L1 adipocytes. unassigned - 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10610074&form=6&db=m Interaction of physical activity and diet: implications for insulin-glucose dynamics. diagnostic usage,ongoing research,unassigned 1,2,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10634968&form=6&db=m Neuroendocrine perturbations as a cause of insulin resistance. causal interaction,ongoing research,unassigned 1,4,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10919262&form=6&db=m Protein kinase Ctheta expression is increased upon differentiation of human skeletal muscle cells: dysregulation in type 2 diabetic patients and a possible role for protein kinase Ctheta in insulin-stimulated glycogen synthase activity. causal interaction,unassigned 4,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10950823&form=6&db=m Palmitate oxidation rate and action on glycogen synthase in myoblasts from insulin-resistant subjects. ongoing research,unassigned 2,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10954011&form=6&db=m Induction of insulin resistance in human skeletal muscle cells by downregulation of glycogen synthase protein expression. causal interaction,ongoing research,unassigned 1,4,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11110507&form=6&db=m Impact of the Xba1-polymorphism of the human muscle glycogen synthase gene on parameters of the insulin resistance syndrome in a Danish twin population. ongoing research,therapeutic application,unassigned 4,1,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11147787&form=6&db=m The stimulation-induced increase in skeletal muscle glycogen synthase content is impaired in carriers of the glycogen synthase XbaI gene polymorphism. unassigned - 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11274905&form=6&db=m Glucose-induced insulin resistance of phosphatidylinositol 3'-OH kinase and AKT/PKB is mediated by the hexosamine biosynthesis pathway. unassigned - 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11408400&form=6&db=m A defect in glycogen synthesis characterizes insulin resistance in hypertensive patients with type 2 diabetes. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12171564&form=6&db=m Prospects for kinase activity modulators in the treatment of diabetes and diabetic complications. therapeutic application,unassigned 4,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12231074&form=6&db=m Pathogenesis of skeletal muscle insulin resistance in type 2 diabetes mellitus. causal interaction,unassigned 4,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12386964&form=6&db=m [Diagnostic use of gene polymorphism for type 2 diabetes] causal interaction,unassigned 1,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12387679&form=6&db=m The role of glycogen synthase kinase-3 in insulin resistance and type 2 diabetes. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12510058&form=6&db=m Insulin resistance of glycogen synthase mediated by o-linked N-acetylglucosamine. causal interaction,therapeutic application,unassigned 1,1,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12864742&form=6&db=m The role of intramuscular lipid in insulin resistance. ongoing research,therapeutic application,unassigned 1,1,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12870167&form=6&db=m Association of muscle glycogen synthase polymorphism with insulin resistance in type 2 diabetic patients. causal interaction,ongoing research,unassigned 2,2,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12893722&form=6&db=m Effect of testosterone and endurance training on glycogen metabolism in skeletal muscle of chronic hyperglycaemic female rats. causal interaction,therapeutic application,unassigned 3,1,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12962696&form=6&db=m Metabolic and genetic influence on glucose metabolism in type 2 diabetic subjects--experiences from relatives and twin studies. causal interaction,unassigned 3,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14693981&form=6&db=m Effects of troglitazone in young first-degree relatives of patients with type 2 diabetes. ongoing research,therapeutic application,unassigned 4,1,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15014073&form=6&db=m Hyperglycemia and inhibition of glycogen synthase in streptozotocin-treated mice: role of O-linked N-acetylglucosamine. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15166226&form=6&db=m Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease. therapeutic application,unassigned 2,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15181086&form=6&db=m Association of the (AU)AT-rich element polymorphism in PPP1R3 with hormonal and metabolic features of polycystic ovary syndrome. causal interaction,unassigned 4,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15741240&form=6&db=m Contraction activates glucose uptake and glycogen synthase normally in muscles from dexamethasone-treated rats. unassigned - 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16567381&form=6&db=m Effects of an ad libitum, high carbohydrate diet and aerobic exercise training on insulin action and muscle metabolism in older men and women. therapeutic application,unassigned 1,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16761106&form=6&db=m Partial rescue of in vivo insulin signalling in skeletal muscle by impaired insulin clearance in heterozygous carriers of a mutation in the insulin receptor gene. causal interaction,ongoing research,unassigned 3,1,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17402423&form=6&db=m Effects of short-term training on insulin sensitivity and skeletal muscle glucose metabolism in standardbred horses. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,1 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17509520&form=6&db=m Regulation of glycogen concentration and glycogen synthase activity in skeletal muscle of insulin-resistant rats. diagnostic usage,ongoing research,unassigned 2,4,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17569761&form=6&db=m Role of glycogen synthase kinase-3 alpha in insulin action in cultured human skeletal muscle cells. causal interaction,ongoing research,unassigned 4,1,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17585040&form=6&db=m Time course of insulin sensitivity and skeletal muscle glycogen synthase activity after a single bout of exercise in horses. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,2,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18167087&form=6&db=m Effects of dexamethasone administration on insulin resistance and components of insulin signaling and glucose metabolism in equine skeletal muscle. therapeutic application,unassigned 4,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18220643&form=6&db=m Impaired glycogen synthase activity and mitochondrial dysfunction in skeletal muscle: markers or mediators of insulin resistance in type 2 diabetes? causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19267278&form=6&db=m Regulation of muscle glycogen synthase phosphorylation and kinetic properties by insulin, exercise, adrenaline and role in insulin resistance. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19434737&form=6&db=m Apolipoprotein B100 acts as a molecular link between lipid-induced endoplasmic reticulum stress and hepatic insulin resistance. unassigned - 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19685889&form=6&db=m Effects of caffeic acid and cinnamic acid on glucose uptake in insulin-resistant mouse hepatocytes. causal interaction,therapeutic application,unassigned 3,1,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20938636&form=6&db=m Impaired insulin-induced site-specific phosphorylation of TBC1 domain family, member 4 (TBC1D4) in skeletal muscle of type 2 diabetes patients is restored by endurance exercise-training. causal interaction,therapeutic application,unassigned 1,1,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21059030&form=6&db=m Dietary energy source and physical conditioning affect insulin sensitivity and skeletal muscle glucose metabolism in horses. ongoing research,therapeutic application,unassigned 4,1,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22008454&form=6&db=m Exercise with calorie restriction improves insulin sensitivity and glycogen synthase activity in obese postmenopausal women with impaired glucose tolerance. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,2,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22403297&form=6&db=m GLUT4 and Glycogen Synthase Are Key Players in Bed Rest-Induced Insulin Resistance. therapeutic application,unassigned 1,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22851577&form=6&db=m Exercise Alleviates Lipid-Induced Insulin Resistance in Human Skeletal Muscle-Signaling Interaction at the Level of TBC1 Domain Family Member 4. causal interaction,therapeutic application,unassigned 4,1,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23206309&form=6&db=m Exercise training-induced adaptations associated with increases in skeletal muscle glycogen content. unassigned - 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24120122&form=6&db=m Dietary Salba (Salvia hispanica L) seed rich in ?-linolenic acid improves adipose tissue dysfunction and the altered skeletal muscle glucose and lipid metabolism in dyslipidemic insulin-resistant rats. unassigned - 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24349472&form=6&db=m Cinnamon counteracts the negative effects of a high fat/high fructose diet on behavior, brain insulin signaling and Alzheimer-associated changes. unassigned - 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24357038&form=6&db=m Aerobic Exercise Plus Weight Loss Improves Insulin Sensitivity and Increases Skeletal Muscle Glycogen Synthase Activity in Older Men. ongoing research,therapeutic application,unassigned 2,1,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25802191&form=6&db=m Anti-diabetic efficacy of KICG1338, a novel glycogen synthase kinase-3? inhibitor, and its molecular characterization in animal models of type 2 diabetes and insulin resistance. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26977394&form=6&db=m Impaired glucose metabolism and exercise capacity with muscle-specific glycogen synthase 1 (gys1) deletion in adult mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27308892&form=6&db=m Cognition enhancing effect of the aqueous extract of Cinnamomum zeylanicum on non-transgenic Alzheimer's disease rat model: Biochemical, histological, and behavioural studies. causal interaction,therapeutic application,unassigned 1,2,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27797909&form=6&db=m Enhanced Muscle Insulin Sensitivity After Contraction/Exercise Is Mediated by AMPK. ongoing research,therapeutic application,unassigned 3,1,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28953212&form=6&db=m Effects of menopause and high-intensity training on insulin sensitivity and muscle metabolism. unassigned - 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30851367&form=6&db=m Cocoa intake attenuates renal injury in Zucker Diabetic fatty rats by improving glucose homeostasis. unassigned - 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31049543&form=6&db=m Structure and in vitro hypoglycemic activity of a homogenous polysaccharide purified from Sargassum pallidum. therapeutic application,unassigned 1,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32003703&form=6&db=m Mitigating Perspectives of Asiatic acid in the Renal derangements of Streptozotocin-Nicotinamide induced Diabetic Rats. ongoing research,unassigned 2,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32088151&form=6&db=m Caulerpa okamurae extract attenuates inflammatory interaction, regulates glucose metabolism and increases insulin sensitivity in 3T3-L1 adipocytes and RAW 264.7 macrophages. unassigned - 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32198054&form=6&db=m Dietary calcium regulates the insulin sensitivity by altering the adipokine secretion in high fat diet induced obese rats. unassigned - 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32249934&form=6&db=m Beneficial effects of Aronia melanocarpa berry extract on hepatic insulin resistance in type 2 diabetes mellitus rats. ongoing research,therapeutic application,unassigned 1,1,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34470562&form=6&db=m Chebulagic acid attenuates HFD/Streptozotocin induced impaired glucose metabolism and insulin resistance via up regulations of PPAR ? and GLUT 4 in type 2 diabetic rats. ongoing research,unassigned 3,0 2.4.1.11 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34538494&form=6&db=m Reducing hepatic endoplasmic reticulum stress ameliorates the impairment in insulin signaling induced by high levels of ?-hydroxybutyrate in bovine hepatocytes. unassigned - 2.4.1.11 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23943518&form=6&db=m Glycogen Synthase Kinase-3? Is Involved in Electroacupuncture Pretreatment via the Cannabinoid CB1 Receptor in Ischemic Stroke. causal interaction,unassigned 2,0 2.4.1.11 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32595496&form=6&db=m Inhibition of GSK3? and RIP1K Attenuates Glial Scar Formation Induced by Ischemic Stroke via Reduction of Inflammatory Cytokine Production. therapeutic application,unassigned 1,0 2.4.1.11 Ketosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11483824&form=6&db=m Case report: liver glycogen synthase deficiency--a cause of ketotic hypoglycemia. causal interaction,unassigned 3,0 2.4.1.11 Ketosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11592574&form=6&db=m Effect of growth hormone treatment on hypoglycemia in a patient with both hepatic glycogen synthase and isolated growth hormone deficiencies. causal interaction,therapeutic application,unassigned 3,2,0 2.4.1.11 Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25284613&form=6&db=m Enhanced glycogen synthase kinase-3? activity mediates podocyte apoptosis under diabetic conditions. causal interaction,unassigned 3,0 2.4.1.11 Kidney Failure, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2555996&form=6&db=m Activity of insulin receptor kinase and glycogen synthase in skeletal muscle from patients with chronic renal failure. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.4.1.11 Kidney Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20889919&form=6&db=m Glycogen Synthase Kinase-3{beta}: A Prognostic Marker and a Potential Therapeutic Target in Human Bladder Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.4.1.11 Lafora Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21077101&form=6&db=m Glycogen hyperphosphorylation underlies lafora body formation. causal interaction,unassigned 3,0 2.4.1.11 Lafora Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21882344&form=6&db=m Neurodegeneration and functional impairments associated with glycogen synthase accumulation in a mouse model of Lafora disease. causal interaction,ongoing research,unassigned 3,1,0 2.4.1.11 Lafora Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22248338&form=6&db=m Glycogen and its metabolism: some new developments and old themes. therapeutic application,unassigned 1,0 2.4.1.11 Lafora Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33822008&form=6&db=m Astrocytic glycogen accumulation drives the pathophysiology of neurodegeneration in Lafora disease. ongoing research,unassigned 3,0 2.4.1.11 Lafora Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33830476&form=6&db=m Targeting Gys1 with AAV-SaCas9 Decreases Pathogenic Polyglucosan Bodies and Neuroinflammation in Adult Polyglucosan Body and Lafora Disease Mouse Models. ongoing research,unassigned 3,0 2.4.1.11 Leiomyoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19240153&form=6&db=m Progestins activate the AKT pathway in leiomyoma cells and promote survival. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.4.1.11 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16925830&form=6&db=m Response variability in Attention-Deficit Hyperactivity Disorder: A neuronal and glial energetics hypothesis. therapeutic application,unassigned 1,0 2.4.1.11 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20540984&form=6&db=m Glycogen synthase kinase--3? inhibitors suppress leukemia cell growth. diagnostic usage,ongoing research,unassigned 4,4,0 2.4.1.11 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21110852&form=6&db=m Glycogen synthase kinase-3? inhibition induces nuclear factor-?B-mediated apoptosis in pediatric acute lymphocyte leukemia cells. causal interaction,therapeutic application,unassigned 1,3,0 2.4.1.11 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26648536&form=6&db=m Calcineurin and GSK-3 inhibition sensitizes T-cell acute lymphoblastic leukemia cells to apoptosis through X-linked inhibitor of apoptosis protein degradation. causal interaction,therapeutic application,unassigned 4,4,0 2.4.1.11 Leukemia, Myelogenous, Chronic, BCR-ABL Positive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21705667&form=6&db=m Glucosylceramide synthase inhibitor PDMP sensitizes chronic myeloid leukemia T315I mutant to Bcr-Abl inhibitor and cooperatively induces glycogen synthase kinase-3-regulated apoptosis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 2.4.1.11 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25703587&form=6&db=m Pathological glycogenesis through glycogen synthase 1 and suppression of excessive AMP kinase activity in myeloid leukemia cells. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0 2.4.1.11 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26496242&form=6&db=m Evaluation of Improved Glycogen Synthase Kinase-3? Inhibitors in Models of Acute Myeloid Leukemia. causal interaction,therapeutic application,unassigned 2,4,0 2.4.1.11 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30925338&form=6&db=m Discovery of novel glycogen synthase kinase-3? inhibitors: Structure-based virtual screening, preliminary SAR and biological evaluation for treatment of acute myeloid leukemia. causal interaction,therapeutic application,unassigned 3,4,0 2.4.1.11 Lipodystrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16306364&form=6&db=m Skeletal Muscle Insulin Signaling Defects Downstream of Phosphatidylinositol 3-Kinase at the Level of Akt Are Associated With Impaired Nonoxidative Glucose Disposal in HIV Lipodystrophy. causal interaction,diagnostic usage,unassigned 3,2,0 2.4.1.11 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29529390&form=6&db=m Inhibition of GSK-3? induces AP-1-mediated osteopontin expression to promote cholestatic liver fibrosis. unassigned - 2.4.1.11 Liver Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27470624&form=6&db=m [Role of glycogen synthase kinase-3? in development of severe hepatitis liver failure caused by hepatitis B virus]. causal interaction,unassigned 4,0 2.4.1.11 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23325562&form=6&db=m Activation of AMP-activated Protein Kinase and Phosphorylation of Glycogen Synthase Kinase3 ? Mediate Ursolic Acid Induced Apoptosis in HepG2 Liver Cancer Cells. ongoing research,unassigned 4,0 2.4.1.11 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32633356&form=6&db=m MiR-129-2 weakens proliferation and promotes apoptosis of liver cancer cells by suppressing the Wnt signaling pathway. ongoing research,unassigned 3,0 2.4.1.11 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31471107&form=6&db=m Targeting Degradation of the Transcription Factor C/EBP? Reduces Lung Fibrosis by Restoring Activity of the Ubiquitin-Editing Enzyme A20 in Macrophages. causal interaction,unassigned 2,0 2.4.1.11 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29877972&form=6&db=m Effects of Glycogen Synthase Kinase-3? Inhibitor TWS119 on Proliferation and Cytokine Production of TILs From Human Lung Cancer. ongoing research,therapeutic application,unassigned 4,1,0 2.4.1.11 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28742189&form=6&db=m Novel endogenous negative modulators of platelet function as potential anti-thrombotic targets. ongoing research,unassigned 2,0 2.4.1.11 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24425042&form=6&db=m ?-eleostearic acid inhibits growth and induces apoptosis in breast cancer cells via HER2/HER3 signaling. diagnostic usage,ongoing research,unassigned 3,4,0 2.4.1.11 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26170971&form=6&db=m SGK3 (CISK) may induce tumor angiogenesis (Hypothesis). causal interaction,therapeutic application,unassigned 3,1,0 2.4.1.11 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26246283&form=6&db=m Enhancement of paclitaxel-induced breast cancer cell death via the glycogen synthase kinase-3?-mediated B-cell lymphoma 2 regulation. causal interaction,therapeutic application,unassigned 3,1,0 2.4.1.11 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29260360&form=6&db=m Neonatal hyperglycemia induces cell death in the rat brain. diagnostic usage,ongoing research,unassigned 1,2,0 2.4.1.11 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33277170&form=6&db=m Methane supplementation improves graft function in experimental heart transplantation. diagnostic usage,ongoing research,unassigned 1,2,0 2.4.1.11 Lymphoma, T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30405828&form=6&db=m Dihydroartemisinin triggers c-Myc proteolysis and inhibits protein kinase B/glycogen synthase kinase 3? pathway in T-cell lymphoma cells. therapeutic application,unassigned 3,0 2.4.1.11 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25111632&form=6&db=m Chemical interrogation of the malaria kinome. causal interaction,therapeutic application,unassigned 1,1,0 2.4.1.11 Malnutrition http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8344107&form=6&db=m Maternal malnutrition does not affect fetal hepatic glycogen synthase ontogeny. ongoing research,unassigned 4,0 2.4.1.11 Mania http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23076832&form=6&db=m Lithium and tamoxifen modulate cellular plasticity cascades in animal model of mania. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.4.1.11 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21628472&form=6&db=m Neural Cell Adhesion Molecule Potentiates the Growth of Murine Melanoma via {beta}-Catenin Signaling by Association with Fibroblast Growth Factor Receptor and Glycogen Synthase Kinase-3{beta}. ongoing research,unassigned 2,0 2.4.1.11 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21829575&form=6&db=m Silymarin Targets ?-Catenin Signaling in Blocking Migration/Invasion of Human Melanoma Cells. ongoing research,therapeutic application,unassigned 2,1,0 2.4.1.11 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21896753&form=6&db=m MicroRNA-149*, a p53-responsive microRNA, functions as an oncogenic regulator in human melanoma. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 2.4.1.11 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29028954&form=6&db=m 1-Benzyl-indole-3-carbinol is a highly potent new small molecule inhibitor of Wnt/?-catenin signaling in melanoma cells that coordinately inhibits cell proliferation and disrupts expression of microphthalmia-associated transcription factor isoform-M. causal interaction,unassigned 1,0 2.4.1.11 Melioidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32321878&form=6&db=m Is GSK3? a molecular target of chloroquine treatment against COVID-19? causal interaction,unassigned 1,0 2.4.1.11 Memory Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20659131&form=6&db=m Protective effects of lithium treatment for spatial memory deficits induced by tau hyperphosphorylation in splenectomized rats. ongoing research,unassigned 4,0 2.4.1.11 Memory Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21689104&form=6&db=m Acetyl-L-Carnitine ameliorates spatial memory deficits induced by inhibition of phosphoinositol-3 kinase and protein kinase C. causal interaction,therapeutic application,unassigned 1,1,0 2.4.1.11 Memory Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21929538&form=6&db=m Val97Leu mutant presenilin-1 induces tau hyperphosphorylation and spatial memory deficit in mice and the underlying mechanisms. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.4.1.11 Memory Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23402899&form=6&db=m Disease-modified glycogen synthase kinase-3? intervention by melatonin arrests the pathology and memory deficits in an Alzheimer's animal model. ongoing research,unassigned 1,0 2.4.1.11 Memory Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23948897&form=6&db=m Lithium Attenuates Scopolamine-Induced Memory Deficits with Inhibition of GSK-3? and Preservation of Postsynaptic Components. therapeutic application,unassigned 4,0 2.4.1.11 Memory Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25367884&form=6&db=m Activation of Glycogen Synthase Kinase-3 Mediates the Olfactory Deficit-Induced Hippocampal Impairments. therapeutic application,unassigned 1,0 2.4.1.11 Memory Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28536070&form=6&db=m Cotinine improves visual recognition memory and decreases cortical Tau phosphorylation in the Tg6799 mice. unassigned - 2.4.1.11 Memory Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30789100&form=6&db=m Crocin-protected malathion-induced spatial memory deficits by inhibiting TAU protein hyperphosphorylation and antiapoptotic effects. causal interaction,unassigned 1,0 2.4.1.11 Memory Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31453129&form=6&db=m Orengedokuto and san'oshashinto improve memory deficits by inhibiting aging-dependent activation of glycogen synthase kinase-3?. causal interaction,therapeutic application,unassigned 3,1,0 2.4.1.11 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24969542&form=6&db=m Incorporating covalent and allosteric effects into rate equations: the case of muscle glycogen synthase. unassigned - 2.4.1.11 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10889791&form=6&db=m Genetics of the metabolic syndrome. unassigned - 2.4.1.11 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11965829&form=6&db=m Pathogenesis of type 2 diabetes: the relative contribution of insulin resistance and impaired insulin secretion. causal interaction,unassigned 1,0 2.4.1.11 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17356695&form=6&db=m Variation in GYS1 interacts with exercise and gender to predict cardiovascular mortality. unassigned - 2.4.1.11 Muscular Atrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21106911&form=6&db=m Electrostimulation during hindlimb unloading modulates PI3K-AKT downstream targets without preventing soleus atrophy and restores slow phenotype through ERK. causal interaction,unassigned 1,0 2.4.1.11 Muscular Atrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21832246&form=6&db=m GLYCOGEN SYNTHASE KINASE-3{beta} IS REQUIRED FOR THE INDUCTION OF SKELETAL MUSCLE ATROPHY. causal interaction,therapeutic application,unassigned 2,2,0 2.4.1.11 Muscular Atrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32531667&form=6&db=m Curcumin ameliorates CKD-induced mitochondrial dysfunction and oxidative stress through inhibiting GSK-3? activity. diagnostic usage,ongoing research,unassigned 2,4,0 2.4.1.11 Muscular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18691366&form=6&db=m Glycogen synthase 1 (GYS1) mutation in diverse breeds with polysaccharide storage myopathy. causal interaction,unassigned 2,0 2.4.1.11 Muscular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19056269&form=6&db=m Polysaccharide storage myopathy phenotype in quarter horse-related breeds is modified by the presence of an RYR1 mutation. ongoing research,unassigned 3,0 2.4.1.11 Muscular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19803057&form=6&db=m A glycogen synthase 1 mutation associated with equine polysaccharide storage myopathy and exertional rhabdomyolysis occurs in a variety of UK breeds. causal interaction,unassigned 3,0 2.4.1.11 Muscular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20644724&form=6&db=m Epidemiology of exertional rhabdomyolysis susceptibility in standardbred horses reveals associated risk factors and underlying enhanced performance. unassigned - 2.4.1.11 Muscular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21262610&form=6&db=m Presence of the glycogen synthase 1 (GYS1) mutation causing type 1 polysaccharide storage myopathy in continental European draught horse breeds. unassigned - 2.4.1.11 Muscular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21949056&form=6&db=m Estimated prevalence of the GYS-1 mutation in healthy Austrian Haflingers. ongoing research,unassigned 3,0 2.4.1.11 Muscular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22860112&form=6&db=m Allele Copy Number and Underlying Pathology Are Associated with Subclinical Severity in Equine Type 1 Polysaccharide Storage Myopathy (PSSM1). unassigned - 2.4.1.11 Muscular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22978303&form=6&db=m Evaluation of Cardiac Phenotype in Horses with Type 1 Polysaccharide Storage Myopathy. causal interaction,unassigned 3,0 2.4.1.11 Muscular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24265594&form=6&db=m Role of autophagy in glycogen breakdown and its relevance to chloroquine myopathy. therapeutic application,unassigned 2,0 2.4.1.11 Muscular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27476720&form=6&db=m Association between population structure and allele frequencies of the glycogen synthase 1 mutation in the Austrian Noriker draft horse. ongoing research,unassigned 3,0 2.4.1.11 Muscular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27592162&form=6&db=m A highly prevalent equine glycogen storage disease is explained by constitutive activation of a mutant glycogen synthase. causal interaction,unassigned 1,0 2.4.1.11 Muscular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29076373&form=6&db=m Clinical characteristics and muscle glycogen concentrations in warmblood horses with polysaccharide storage myopathy. unassigned - 2.4.1.11 Muscular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33609063&form=6&db=m Comparison of gluteus medius muscle activity in Haflinger and Noriker horses with polysaccharide storage myopathy. causal interaction,unassigned 3,0 2.4.1.11 Muscular Dystrophies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6245356&form=6&db=m Glycogen cycle enzymes and cyclic nucleotides in avian muscular dystrophy. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.1.11 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17356695&form=6&db=m Variation in GYS1 interacts with exercise and gender to predict cardiovascular mortality. unassigned - 2.4.1.11 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26468894&form=6&db=m Remifentanil Preconditioning Reduces Postischemic Myocardial Infarction and Improves Left Ventricular Performance via Activation of the Janus Activated Kinase-2/Signal Transducers and Activators of Transcription-3 Signal Pathway and Subsequent Inhibition of Glycogen Synthase Kinase-3? in Rats. causal interaction,therapeutic application,unassigned 2,3,0 2.4.1.11 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26591365&form=6&db=m [Protective Effects of Cornus Officinalis Total Glycosides and Cornus Polysaccharides on Myocardial Mitochondria of Acute Myocardial Infarction Rats: an Experimental Study]. diagnostic usage,unassigned 1,0 2.4.1.11 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32991876&form=6&db=m Glycogen synthase kinase-3? inhibition alleviates activation of the NLRP3 inflammasome in myocardial infarction. causal interaction,therapeutic application,unassigned 4,2,0 2.4.1.11 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22113201&form=6&db=m Glycogen synthase kinase-3? controls autophagy during myocardial ischemia and reperfusion. causal interaction,unassigned 1,0 2.4.1.11 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26468894&form=6&db=m Remifentanil Preconditioning Reduces Postischemic Myocardial Infarction and Improves Left Ventricular Performance via Activation of the Janus Activated Kinase-2/Signal Transducers and Activators of Transcription-3 Signal Pathway and Subsequent Inhibition of Glycogen Synthase Kinase-3? in Rats. causal interaction,therapeutic application,unassigned 2,3,0 2.4.1.11 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28153944&form=6&db=m Involvement of Glycogen Synthase Kinase-3? in Liver Ischemic Conditioning Induced Cardioprotection against Myocardial Ischemia and Reperfusion Injury in Rats. causal interaction,unassigned 2,0 2.4.1.11 Myotonic Dystrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4208152&form=6&db=m The glycogen synthase system in skeletal muscle of normal humans and patients with myotonic dystrophy: effect of glucose and insulin administration. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.4.1.11 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21571466&form=6&db=m Expression of mismatch repair gene PMS2 in nasopharyngeal carcinoma and regulation by glycogen synthase kinase-3? in vivo and in vitro. ongoing research,unassigned 4,0 2.4.1.11 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29516971&form=6&db=m miR-150 contributes to the radioresistance in nasopharyngeal carcinoma cells by targeting glycogen synthase kinase-3?. unassigned - 2.4.1.11 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26707073&form=6&db=m CD151 knockdown inhibits osteosarcoma metastasis through the GSK-3?/?-catenin/MMP9 pathway. causal interaction,unassigned 1,0 2.4.1.11 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30556279&form=6&db=m FAM134B induces tumorigenesis and epithelial-to-mesenchymal transition via Akt signaling in hepatocellular carcinoma. causal interaction,unassigned 3,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3099747&form=6&db=m Mechanism of hepatic glycogen synthase inactivation induced by Ca2+-mobilizing hormones. Studies using phospholipase C and phorbol myristate acetate. ongoing research,unassigned 2,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=5047713&form=6&db=m Inactivation of glycogen synthase by the tumor inhibitor vernolepin. causal interaction,unassigned 3,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6265468&form=6&db=m Role of nuclear glycogen synthase and cytoplasmic UDP glucose pyrophosphorylase in the biosynthesis of nuclear glycogen in HD33 Ehrlich-Lettré ascites tumor cells. ongoing research,unassigned 2,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6417664&form=6&db=m Modification of glycogen synthase activity in isolated rat hepatocytes by tumor-promoting phorbol esters: evidence for differential regulation of glycogen synthase and phosphorylase. therapeutic application,unassigned 1,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6418376&form=6&db=m Growth-related enzymatic control of glycogen metabolism in cultured human tumor cells. causal interaction,ongoing research,unassigned 1,4,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6698292&form=6&db=m Activity of enzymes related to carbohydrate metabolism in the HT 29 colon adenocarcinoma cell line and tumor. causal interaction,ongoing research,unassigned 1,3,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6816629&form=6&db=m Nuclear glycogen synthase--fact or artifact? therapeutic application,unassigned 1,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9326333&form=6&db=m Recessive inheritance of obesity in familial non-insulin-dependent diabetes mellitus, and lack of linkage to nine candidate genes. ongoing research,unassigned 2,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9832415&form=6&db=m Effects of tumor necrosis factor-alpha on glucose metabolism in cultured human muscle cells from nondiabetic and type 2 diabetic subjects. ongoing research,unassigned 4,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15012593&form=6&db=m Cell signalling of glucagon-like peptide-1 action in rat skeletal muscle. therapeutic application,unassigned 1,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16322264&form=6&db=m Cancer cells become susceptible to natural killer cell killing after exposure to histone deacetylase inhibitors due to glycogen synthase kinase-3-dependent expression of MHC class I-related chain A and B. ongoing research,unassigned 2,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20823143&form=6&db=m Inhibitory effect of silibinin against azoxymethane-induced colon tumorigenesis in A/J mice. causal interaction,unassigned 1,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20854473&form=6&db=m Glycogen synthase kinase-3? does not correlate with the expression and activity of ?-catenin in gastric cancer. diagnostic usage,unassigned 1,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20934407&form=6&db=m The anti-tumoral drug enzastaurin inhibits natural killer cell cytotoxicity via activation of glycogen synthase kinase-3? causal interaction,therapeutic application,unassigned 4,3,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21194439&form=6&db=m Glycogen synthase kinase-3? inactivation inhibits tumor necrosis factor-? production in microglia by modulating nuclear factor ?B and MLK3/JNK signaling cascades. therapeutic application,unassigned 1,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21303975&form=6&db=m Raf kinase inhibitor protein RKIP enhances signaling by glycogen synthase kinase-3?. causal interaction,therapeutic application,unassigned 4,1,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21443429&form=6&db=m Citrus flavonoids luteolin, apigenin, and quercetin inhibit glycogen synthase kinase-3? enzymatic activity by lowering the interaction energy within the binding cavity. causal interaction,unassigned 1,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21880954&form=6&db=m Whole blueberry powder modulates the growth and metastasis of MDA-MB-231 triple negative breast tumors in nude mice. causal interaction,ongoing research,unassigned 1,3,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22023517&form=6&db=m Protein phosphatase-2A activation is a critical step for enzastaurin activity in chronic lymphoid leukemia cells. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22397759&form=6&db=m Role of Sulindac and Celecoxib in the regulation of angiogenesis during the early neoplasm of colon: Exploring PI3-K/PTEN/Akt pathway to the canonical Wnt/?-catenin signaling. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22534782&form=6&db=m Glycogen synthase kinase-3?, NF-?B signaling, and tumorigenesis of human osteosarcoma. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23509364&form=6&db=m Epithelial-Mesenchymal Transition Induces an Antitumor Immune Response Mediated by NKG2D Receptor. causal interaction,ongoing research,unassigned 4,3,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23715499&form=6&db=m Glycogen synthase kinase 3? inhibition sensitizes human glioblastoma cells to temozolomide by affecting O6-methylguanine DNA methyltransferase promoter methylation via c-Myc signaling. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23751897&form=6&db=m Puerarin, isolated from Kudzu root (Willd.), attenuates hepatocellular cytotoxicity and regulates the GSK-3?/NF-?B pathway for exerting the hepatoprotection against chronic alcohol-induced liver injury in rats. causal interaction,diagnostic usage,unassigned 1,3,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23846217&form=6&db=m ER stress-mediated apoptosis induced by celastrol in cancer cells and important role of glycogen synthase kinase-3? in the signal network. causal interaction,ongoing research,unassigned 1,1,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24116170&form=6&db=m Membrane-to-nucleus signaling links insulin-like growth factor-1- and stem cell factor-activated pathways. ongoing research,unassigned 3,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24302615&form=6&db=m Suppressing N-Myc downstream regulated gene 1 reactivates senescence signaling and inhibits tumor growth in hepatocellular carcinoma. causal interaction,therapeutic application,unassigned 4,4,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24618834&form=6&db=m New methods to control neuroblastoma growth. unassigned - 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24768446&form=6&db=m Coumestrol suppresses hypoxia inducible factor 1? by inhibiting ROS mediated sphingosine kinase 1 in hypoxic PC-3 prostate cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25002914&form=6&db=m Lithium chloride suppresses colorectal cancer cell survival and proliferation through ROS/GSK-3?/NF-?B signaling pathway. causal interaction,therapeutic application,unassigned 3,4,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25157753&form=6&db=m Glycogen synthase kinase-3? is associated with the prognosis of hepatocellular carcinoma and may mediate the influence of type 2 diabetes mellitus on hepatocellular carcinoma. causal interaction,diagnostic usage,unassigned 4,1,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25504636&form=6&db=m Glycogen Synthase Kinase 3? Sustains Invasion of Glioblastoma via the Focal Adhesion Kinase, Rac1, and c-Jun N-Terminal Kinase-Mediated Pathway. causal interaction,therapeutic application,unassigned 3,1,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25814664&form=6&db=m Glycogen Synthase Kinase-3? (GSK-3?) Inhibition Enhances Dendritic Cell-based Cancer Vaccine Potency via Suppression of Interferon-?-induced Indoleamine 2,3-Dioxygenase Expression. unassigned - 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25937997&form=6&db=m Modulation of deoxycytidine kinase (dCK) and glycogen synthase kinase (GSK-3?) by anti-CD20 (rituximab) and 2-chlorodeoxyadenosine (2-CdA) in human lymphoid malignancies. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26104971&form=6&db=m Salidroside Mitigates Sepsis-Induced Myocarditis in Rats by Regulating IGF-1/PI3K/Akt/GSK-3? Signaling. diagnostic usage,unassigned 2,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26116771&form=6&db=m Inhibition of invasion by glycogen synthase kinase-3 beta inhibitors through dysregulation of actin re-organisation via down-regulation of WAVE2. unassigned - 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26170971&form=6&db=m SGK3 (CISK) may induce tumor angiogenesis (Hypothesis). causal interaction,therapeutic application,unassigned 3,1,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26224641&form=6&db=m PTEN Overexpression Cooperates With Lithium to Reduce the Malignancy and to Increase Cell Death by Apoptosis via PI3K/Akt Suppression in Colorectal Cancer Cells. causal interaction,therapeutic application,unassigned 3,1,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26246283&form=6&db=m Enhancement of paclitaxel-induced breast cancer cell death via the glycogen synthase kinase-3?-mediated B-cell lymphoma 2 regulation. causal interaction,therapeutic application,unassigned 3,1,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26315788&form=6&db=m miRNA-99b-3p functions as a potential tumor suppressor by targeting glycogen synthase kinase-3? in oral squamous cell carcinoma Tca-8113 cells. causal interaction,therapeutic application,unassigned 2,3,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26788169&form=6&db=m Glycogen synthase kinase-3? regulates tumor necrosis factor-related apoptosis inducing ligand (TRAIL)-induced apoptosis via the NF-?B pathway in hepatocellular carcinoma. therapeutic application,unassigned 1,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26902162&form=6&db=m Nimbolide, a neem limonoid inhibits Phosphatidyl Inositol-3 Kinase to activate Glycogen Synthase Kinase-3? in a hamster model of oral oncogenesis. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27050373&form=6&db=m The role of glycogen synthase kinase-3? (GSK-3?) in endometrial carcinoma: A carcinogenesis, progression, prognosis, and target therapy marker. causal interaction,therapeutic application,unassigned 3,3,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27051274&form=6&db=m Role of glycogen synthase kinase-3? inhibitor AZD1080 in ovarian cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27221474&form=6&db=m Glycogen synthase kinase-3? antagonizes ROS-induced hepatocellular carcinoma cell death through suppression of the apoptosis signal-regulating kinase 1. diagnostic usage,therapeutic application,unassigned 1,1,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27365055&form=6&db=m Hypoxic inactivation of glycogen synthase kinase-3? promotes gastric tumor growth and angiogenesis by facilitating hypoxia-inducible factor-1 signaling. causal interaction,ongoing research,unassigned 4,2,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27486911&form=6&db=m Glycogen synthase kinase-3? is a pivotal mediator of cancer invasion and resistance to therapy. causal interaction,therapeutic application,unassigned 3,4,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27599658&form=6&db=m GSK-3?-mediated fatty acid synthesis enhances epithelial to mesenchymal transition of TLR4-activated colorectal cancer cells through regulation of TAp63. causal interaction,unassigned 1,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27602497&form=6&db=m Modulation of glycogen synthase kinase-3? following TRAIL combinatorial treatment in cancer cells. causal interaction,therapeutic application,unassigned 2,4,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27780915&form=6&db=m Efficacy of glycogen synthase kinase-3? targeting against osteosarcoma via activation of ?-catenin. causal interaction,therapeutic application,unassigned 1,3,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27876112&form=6&db=m Antioxidant defense of Nrf2 vs pro-inflammatory system of NF-?B during the amoebic liver infection in hamster. unassigned - 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28053024&form=6&db=m Molecular Pathways: Revisiting Glycogen Synthase Kinase-3? as a Target for the Treatment of Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28057765&form=6&db=m Insulin signaling regulates a functional interaction between adenomatous polyposis coli and cytoplasmic dynein. ongoing research,therapeutic application,unassigned 2,1,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28672195&form=6&db=m Combination Treatment with the GSK-3 Inhibitor 9-ING-41 and CCNU Cures Orthotopic Chemoresistant Glioblastoma in Patient-Derived Xenograft Models. therapeutic application,unassigned 4,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28731148&form=6&db=m Molecular genetics and targeted therapy of WNT-related human diseases (Review). causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,2,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28743492&form=6&db=m 5-Bromoindirubin 3'-(O-oxiran-2-ylmethyl)oxime: A long-acting anticancer agent and a suicide inhibitor for epoxide hydrolase. therapeutic application,unassigned 1,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29028954&form=6&db=m 1-Benzyl-indole-3-carbinol is a highly potent new small molecule inhibitor of Wnt/?-catenin signaling in melanoma cells that coordinately inhibits cell proliferation and disrupts expression of microphthalmia-associated transcription factor isoform-M. causal interaction,unassigned 1,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29120752&form=6&db=m The Glycogen Shunt Maintains Glycolytic Homeostasis and the Warburg Effect in Cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29208522&form=6&db=m Discovery of new GSK-3? inhibitors through structure-based virtual screening. causal interaction,therapeutic application,unassigned 3,3,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29309927&form=6&db=m Glycogen synthase kinases: Moonlighting proteins with theranostic potential in cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29516284&form=6&db=m Stimulation of ACE2/ANG(1-7)/Mas Axis by Diminazene Ameliorates Alzheimer's Disease in the D-Galactose-Ovariectomized Rat Model: Role of PI3K/Akt Pathway. unassigned - 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29708074&form=6&db=m The Relationship Between Lithium and Cancer Proliferation: A Case-Based Review of the Literature. causal interaction,unassigned 1,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29863246&form=6&db=m Target inhibition on GSK-3? by miR-9 to modulate proliferation and apoptosis of bladder cancer cells. unassigned - 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30405781&form=6&db=m Aberrant expression of glycogen synthase kinase-3? in human breast and head and neck cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30556279&form=6&db=m FAM134B induces tumorigenesis and epithelial-to-mesenchymal transition via Akt signaling in hepatocellular carcinoma. causal interaction,unassigned 3,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30584071&form=6&db=m A GYS2/p53 Negative Feedback Loop Restricts Tumor Growth in HBV-Related Hepatocellular Carcinoma. causal interaction,unassigned 3,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31026007&form=6&db=m ?-Thujaplicin inhibits basal-like mammary tumor growth by regulating glycogen synthase kinase-3?/?-catenin signaling. ongoing research,therapeutic application,unassigned 4,1,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31175888&form=6&db=m Vinpocetine mitigates aluminum-induced cognitive impairment in socially isolated rats. therapeutic application,unassigned 1,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31289467&form=6&db=m Expression levels of MRP1, GST-?, and GSK3? in ovarian cancer and the relationship with drug resistance and prognosis of patients. diagnostic usage,ongoing research,unassigned 4,4,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31750236&form=6&db=m The Role of Lithium in Management of Endocrine Tumors-A Comprehensive Review. causal interaction,unassigned 1,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31894292&form=6&db=m Clinically relevant GSK?3? inhibitor 9?ING?41 is active as a single agent and in combination with other antitumor therapies in human renal cancer. therapeutic application,unassigned 1,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32253536&form=6&db=m Why do anti-inflammatory signals of bone marrow-derived stromal cells improve neurodegenerative conditions where anti-inflammatory drugs fail? causal interaction,diagnostic usage,unassigned 3,4,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32364921&form=6&db=m Effects of Yixintai Pills on Myocardial Cell Apoptosis in Rats With Adriamycin-Induced Heart Failure. diagnostic usage,ongoing research,unassigned 4,2,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32802186&form=6&db=m GYS1 induces glycogen accumulation and promotes tumor progression via the NF-?B pathway in Clear Cell Renal Carcinoma. ongoing research,unassigned 3,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32936609&form=6&db=m Ameliorative Effect of Necrosulfonamide in a Rat Model of Alzheimer's Disease: Targeting Mixed Lineage Kinase Domain-like Protein-Mediated Necroptosis. ongoing research,unassigned 2,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33087512&form=6&db=m The Landscape of Glycogen Synthase Kinase-3 Beta Genomic Alterations in Cancer. causal interaction,diagnostic usage,unassigned 4,3,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33110096&form=6&db=m Structural modeling of GSK3? implicates the inactive (DFG-out) conformation as the target bound by TDZD analogs. causal interaction,unassigned 3,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33492962&form=6&db=m Novel 18F-Labeled Isonicotinamide-Based Radioligands for Positron Emission Tomography Imaging of Glycogen Synthase Kinase-3?. causal interaction,unassigned 4,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33503871&form=6&db=m Design and Synthesis of Novel Imidazole Derivatives Possessing Triazole Pharmacophore with Potent Anticancer Activity, and In Silico ADMET with GSK-3? Molecular Docking Investigations. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33786620&form=6&db=m Role of C14orf166 in viral infection and RNA metabolism and its relationship with cancer (Review). causal interaction,therapeutic application,unassigned 3,1,0 2.4.1.11 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34391818&form=6&db=m Empagliflozin nanoparticles attenuates type2 diabetes induced cognitive impairment via oxidative stress and inflammatory pathway in high fructose diet induced hyperglycemic mice. unassigned - 2.4.1.11 Nephrotic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33362958&form=6&db=m Dysregulated levels of glycogen synthase kinase-3? (GSK-3?) and miR-135 in peripheral blood samples of cases with nephrotic syndrome. diagnostic usage,therapeutic application,unassigned 3,1,0 2.4.1.11 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32483472&form=6&db=m The Potential Role of Glycogen Synthase Kinase-3? in Neuropathy-Induced Apoptosis in Spinal Cord. causal interaction,unassigned 3,0 2.4.1.11 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12091467&form=6&db=m BDNF-mediated signal transduction is modulated by GSK3beta and mood stabilizing agents. ongoing research,therapeutic application,unassigned 4,1,0 2.4.1.11 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21161565&form=6&db=m GSK-3? inhibition promotes cell death, apoptosis, and in vivo tumor growth delay in neuroblastoma Neuro-2A cell line. ongoing research,therapeutic application,unassigned 3,4,0 2.4.1.11 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25079798&form=6&db=m Helicobacter pylori filtrate induces Alzheimer-like tau hyperphosphorylation by activating glycogen synthase kinase-3?. causal interaction,unassigned 1,0 2.4.1.11 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25371750&form=6&db=m Brain-derived neurotrophic factor exerts neuroprotective actions against amyloid ?-induced apoptosis in neuroblastoma cells. causal interaction,unassigned 1,0 2.4.1.11 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29846250&form=6&db=m 9-ING-41, a small-molecule glycogen synthase kinase-3 inhibitor, is active in neuroblastoma. causal interaction,therapeutic application,unassigned 3,4,0 2.4.1.11 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32574796&form=6&db=m The miR-455-5p/ER?36 axis regulates mammalian neuronal viability and axonal regeneration. causal interaction,unassigned 3,0 2.4.1.11 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23099099&form=6&db=m Identification of novel scaffold of benzothiazepinones as non-ATP competitive glycogen synthase kinase-3? inhibitors through virtual screening. causal interaction,therapeutic application,unassigned 4,4,0 2.4.1.11 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23533250&form=6&db=m Role of glycogen synthase kinase-3? in ketamine-induced developmental neuroapoptosis in rats. causal interaction,therapeutic application,unassigned 4,2,0 2.4.1.11 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23951236&form=6&db=m GSK3B and MAPT Polymorphisms Are Associated with Grey Matter and Intracranial Volume in Healthy Individuals. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,1 2.4.1.11 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29208522&form=6&db=m Discovery of new GSK-3? inhibitors through structure-based virtual screening. causal interaction,therapeutic application,unassigned 3,3,0 2.4.1.11 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32232872&form=6&db=m Wnt signalling pathway and tau phosphorylation: A comprehensive study on known connections. unassigned - 2.4.1.11 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32483472&form=6&db=m The Potential Role of Glycogen Synthase Kinase-3? in Neuropathy-Induced Apoptosis in Spinal Cord. causal interaction,unassigned 3,0 2.4.1.11 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21629736&form=6&db=m Glycogen synthase kinase-3?: a mediator of inflammation in Alzheimer's disease? causal interaction,unassigned 1,0 2.4.1.11 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23904373&form=6&db=m Role of GSK-3? in isoflurane-induced neuroinflammation and cognitive dysfunction in aged rats. ongoing research,unassigned 4,0 2.4.1.11 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27566245&form=6&db=m The glucagon-like peptide-1 receptor agonist exendin-4 ameliorates warfarin-associated hemorrhagic transformation after cerebral ischemia. therapeutic application,unassigned 1,0 2.4.1.11 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29782959&form=6&db=m Targeting central ?2 receptors ameliorates streptozotocin-induced neuroinflammation via inhibition of glycogen synthase kinase3 pathway in mice. therapeutic application,unassigned 2,0 2.4.1.11 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30548443&form=6&db=m A Triazolotriazine-Based Dual GSK-3?/CK-1? Ligand as a Potential Neuroprotective Agent Presenting Two Different Mechanisms of Enzymatic Inhibition. therapeutic application,unassigned 3,0 2.4.1.11 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31332763&form=6&db=m Avenanthramide-C Restores Impaired Plasticity and Cognition in Alzheimer's Disease Model Mice. causal interaction,unassigned 1,0 2.4.1.11 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32673674&form=6&db=m Discovery of a novel small molecule PT109 with multi-targeted effects against Alzheimer's disease in vitro and in vivo. causal interaction,therapeutic application,unassigned 3,1,0 2.4.1.11 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33417987&form=6&db=m Cognitive effects of the GSK-3 inhibitor "lithium" in LPS/chronic mild stress rat model of depression: Hippocampal and cortical neuroinflammation and tauopathy. ongoing research,unassigned 3,0 2.4.1.11 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30616587&form=6&db=m The traditional Chinese formulae Ling-gui-zhu-gan decoction alleviated non-alcoholic fatty liver disease via inhibiting PPP1R3C mediated molecules. ongoing research,unassigned 1,0 2.4.1.11 o-acetyl-adp-ribose deacetylase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32257385&form=6&db=m MACROD2 deficiency promotes hepatocellular carcinoma growth and metastasis by activating GSK-3?/?-catenin signaling. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0 2.4.1.11 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1900343&form=6&db=m Impaired activation of skeletal muscle glycogen synthase in non-insulin-dependent diabetes mellitus is unrelated to the degree of obesity. causal interaction,ongoing research,unassigned 1,3,0 2.4.1.11 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3061759&form=6&db=m Obesity and insulin resistance: lessons learned from the Pima Indians. causal interaction,unassigned 4,0 2.4.1.11 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3094377&form=6&db=m Adipocyte glycogen synthase and pyruvate dehydrogenase in obese and type II diabetic subjects. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,4,0 2.4.1.11 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3138128&form=6&db=m Glycogen and lactate synthetic pathways in human skeletal muscle in relation to obesity, weight reduction and physical training. diagnostic usage,ongoing research,unassigned 2,3,0 2.4.1.11 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7812417&form=6&db=m Changes in glycogen metabolism in liver of gold thioglucose injected mice during the development of obesity. causal interaction,unassigned 4,0 2.4.1.11 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8960833&form=6&db=m UKPDS 19: heterogeneity in NIDDM: separate contributions of IRS-1 and beta 3-adrenergic-receptor mutations to insulin resistance and obesity respectively with no evidence for glycogen synthase gene mutations. UK Prospective Diabetes Study. unassigned - 2.4.1.11 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9326333&form=6&db=m Recessive inheritance of obesity in familial non-insulin-dependent diabetes mellitus, and lack of linkage to nine candidate genes. ongoing research,unassigned 2,0 2.4.1.11 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9593781&form=6&db=m Postabsorptive respiratory quotient and insulin-stimulated glucose storage rate in nondiabetic pima indians are related To glycogen synthase fractional activity in cultured myoblasts. causal interaction,unassigned 4,0 2.4.1.11 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11979384&form=6&db=m Progressive defect of insulin action on glycogen synthase in obesity and diabetes. causal interaction,ongoing research,unassigned 1,4,0 2.4.1.11 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17100583&form=6&db=m Role of glycogen synthase kinase-3 in insulin resistance and type 2 diabetes. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.4.1.11 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19837931&form=6&db=m Dysregulation of Glycogen Synthase COOH- and NH2-Terminal Phosphorylation by Insulin in Obesity and Type 2 Diabetes Mellitus. causal interaction,ongoing research,unassigned 3,1,0 2.4.1.11 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24854430&form=6&db=m Phosphorylation of glycogen synthase kinase-3? in metabolically abnormal obesity affects immune stimulation-induced cytokine production. unassigned - 2.4.1.11 Obesity, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10442567&form=6&db=m Insulin sensitivity in growth hormone (GH)-deficient adults and effect of GH replacement therapy. causal interaction,therapeutic application,unassigned 4,4,0 2.4.1.11 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22534782&form=6&db=m Glycogen synthase kinase-3?, NF-?B signaling, and tumorigenesis of human osteosarcoma. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.4.1.11 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23164673&form=6&db=m The glycogen synthase kinase-3?/nuclear factor-kappa B pathway is involved in cinobufagin-induced apoptosis in cultured osteosarcoma cells. causal interaction,unassigned 1,0 2.4.1.11 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27780915&form=6&db=m Efficacy of glycogen synthase kinase-3? targeting against osteosarcoma via activation of ?-catenin. causal interaction,therapeutic application,unassigned 1,3,0 2.4.1.11 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27051274&form=6&db=m Role of glycogen synthase kinase-3? inhibitor AZD1080 in ovarian cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.4.1.11 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31289467&form=6&db=m Expression levels of MRP1, GST-?, and GSK3? in ovarian cancer and the relationship with drug resistance and prognosis of patients. diagnostic usage,ongoing research,unassigned 4,4,0 2.4.1.11 Overnutrition http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3080654&form=6&db=m Overnutrition induced decrease in insulin action for glucose storage: in vivo and in vitro in man. causal interaction,therapeutic application,unassigned 1,1,0 2.4.1.11 Overweight http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8412779&form=6&db=m The impact of metformin therapy on hepatic glucose production and skeletal muscle glycogen synthase activity in overweight type II diabetic patients. causal interaction,ongoing research,therapeutic application,unassigned 1,2,2,0 2.4.1.11 Overweight http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15334390&form=6&db=m Exercise training increases glycogen synthase activity and GLUT4 expression but not insulin signaling in overweight nondiabetic and type 2 diabetic subjects. unassigned - 2.4.1.11 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9821177&form=6&db=m The intracellular mechanism of insulin resistance in the hamster pancreatic ductal adenocarcinoma model. causal interaction,unassigned 3,0 2.4.1.11 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10720068&form=6&db=m The intracellular mechanism of insulin resistance in pancreatic cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,3,1 2.4.1.11 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18829575&form=6&db=m Maintenance of constitutive IkappaB kinase activity by glycogen synthase kinase-3alpha/beta in pancreatic cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,4 2.4.1.11 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21443429&form=6&db=m Citrus flavonoids luteolin, apigenin, and quercetin inhibit glycogen synthase kinase-3? enzymatic activity by lowering the interaction energy within the binding cavity. causal interaction,unassigned 1,0 2.4.1.11 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23943362&form=6&db=m Flavonoid apigenin modified gene expression associated with inflammation and cancer and induced apoptosis in human pancreatic cancer cells through inhibition of GSK-3?/NF-?B signaling cascade. ongoing research,unassigned 3,0 2.4.1.11 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25145299&form=6&db=m CXCR4 promotes GSK3? expression in pancreatic cancer cells via the Akt pathway. causal interaction,unassigned 2,0 2.4.1.11 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26213494&form=6&db=m GSK3? mediates pancreatic cancer cell invasion in vitro via the CXCR4/MMP-2 Pathway. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,1,0 2.4.1.11 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29863120&form=6&db=m Glycogen synthase kinase-3? activity plays a key role in the antitumor effect of nafamostat mesilate in pancreatic cancer cells. causal interaction,therapeutic application,unassigned 1,1,0 2.4.1.11 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30226582&form=6&db=m ARHGEF4 predicts poor prognosis and promotes cell invasion by influencing ERK1/2 and GSK-3?/? signaling in pancreatic cancer. causal interaction,diagnostic usage,unassigned 2,3,0 2.4.1.11 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32178549&form=6&db=m Glycogen Synthase Kinase-3?: a novel therapeutic target for pancreatic cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.4.1.11 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32309890&form=6&db=m Synthesis, cytotoxicity, and molecular docking of substituted 3-(2-methylbenzofuran-3-yl)-5-(phenoxymethyl)-1,2,4-oxadiazoles. ongoing research,therapeutic application,unassigned 3,1,0 2.4.1.11 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32986894&form=6&db=m Glycogen synthase kinase-3? participates in acquired resistance to gemcitabine in pancreatic cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.4.1.11 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21500552&form=6&db=m [Expression of glycogen synthase kinase-3B in pancreatic tissue of acute edematous pancreatitis rats]. causal interaction,ongoing research,unassigned 2,2,0 2.4.1.11 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25323773&form=6&db=m Inhibition of glycogen synthase kinase-3? attenuates acute kidney injury in sodium taurocholate?induced severe acute pancreatitis in rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 2.4.1.11 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31315730&form=6&db=m [Experimental study on the mechanism of glycogen synthase kinase-3? inhibitor on acute kidney injury of acute necrotizing pancreatitis in rats]. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 2.4.1.11 Pancreatitis, Acute Necrotizing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31315730&form=6&db=m [Experimental study on the mechanism of glycogen synthase kinase-3? inhibitor on acute kidney injury of acute necrotizing pancreatitis in rats]. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 2.4.1.11 Paralysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12410379&form=6&db=m Glycogen synthase kinase-3 is associated with neuronal and glial hyperphosphorylated tau deposits in Alzheimer's disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration. causal interaction,unassigned 3,0 2.4.1.11 Paralysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15265592&form=6&db=m Protein levels of glycogen synthase 3 kinase are normal in progressive supranuclear palsy. causal interaction,diagnostic usage,unassigned 1,1,0 2.4.1.11 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22815195&form=6&db=m GSK3? reduces risk of sporadic Parkinson's disease in ethnic Chinese. causal interaction,unassigned 4,0 2.4.1.11 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24681994&form=6&db=m Association of glycogen synthase kinase?3? with Parkinson's disease (Review). causal interaction,unassigned 4,0 2.4.1.11 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29327199&form=6&db=m Glycogen Synthase Kinase-3? Regulates Equilibrium Between Neurogenesis and Gliogenesis in Rat Model of Parkinson's Disease: a Crosstalk with Wnt and Notch Signaling. ongoing research,unassigned 2,0 2.4.1.11 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30548443&form=6&db=m A Triazolotriazine-Based Dual GSK-3?/CK-1? Ligand as a Potential Neuroprotective Agent Presenting Two Different Mechanisms of Enzymatic Inhibition. therapeutic application,unassigned 3,0 2.4.1.11 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31325476&form=6&db=m Phytic acid attenuates upregulation of GSK-3? and disturbance of synaptic vesicle recycling in MPTP-induced Parkinson's disease models. causal interaction,unassigned 1,0 2.4.1.11 Perinatal Death http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33219378&form=6&db=m Pulmonary glycogen deficiency as a new potential cause of respiratory distress syndrome. causal interaction,therapeutic application,unassigned 4,1,0 2.4.1.11 Peritoneal Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24756461&form=6&db=m Small interfering RNA targeting ILK inhibits EMT in human peritoneal mesothelial cells through phosphorylation of GSK?3?. ongoing research,unassigned 1,0 2.4.1.11 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24722055&form=6&db=m Extracellular ?-Synuclein Leads to Microtubule Destabilization via GSK-3?-Dependent Tau Phosphorylation in PC12 Cells. ongoing research,unassigned 4,0 2.4.1.11 Pick Disease of the Brain http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12410379&form=6&db=m Glycogen synthase kinase-3 is associated with neuronal and glial hyperphosphorylated tau deposits in Alzheimer's disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration. causal interaction,unassigned 3,0 2.4.1.11 Polycystic Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25629553&form=6&db=m Glycogen synthase kinase-3? promotes cyst expansion in polycystic kidney disease. unassigned - 2.4.1.11 Polycystic Ovary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15181086&form=6&db=m Association of the (AU)AT-rich element polymorphism in PPP1R3 with hormonal and metabolic features of polycystic ovary syndrome. causal interaction,unassigned 4,0 2.4.1.11 Polycystic Ovary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18544618&form=6&db=m Impaired insulin activation and dephosphorylation of glycogen synthase in skeletal muscle of women with polycystic ovary syndrome is reversed by pioglitazone treatment. causal interaction,therapeutic application,unassigned 1,4,0 2.4.1.11 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8514882&form=6&db=m Pre-eclampsia is associated with an increase in trophoblast glycogen content and glycogen synthase activity, similar to that found in hydatidiform moles. unassigned - 2.4.1.11 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28028966&form=6&db=m Glycogen Synthase Kinase-3? (GSK-3?) and Nuclear Factor Kappa-B (NFKB) in Childhood Acute Lymphoblastic Leukemia. causal interaction,diagnostic usage,unassigned 1,1,0 2.4.1.11 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16053514&form=6&db=m HIV-1 protease inhibitor induces growth arrest and apoptosis of human prostate cancer LNCaP cells in vitro and in vivo in conjunction with blockade of androgen receptor STAT3 and AKT signaling. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.4.1.11 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21980429&form=6&db=m Inhibition of glycogen synthase kinase-3? counteracts ligand-independent activity of the androgen receptor in castration resistant prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,1,0 2.4.1.11 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23408470&form=6&db=m Combined Treatment of Androgen-Independent Prostate Cancer Cell Line DU145 with Chemotherapeutic Agents and Lithium Chloride: Effect on Growth Arrest and/or Apoptosis. ongoing research,therapeutic application,unassigned 4,4,0 2.4.1.11 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25344861&form=6&db=m Glycogen synthase kinase-3? inhibition depletes the population of prostate cancer stem/progenitor-like cells and attenuates metastatic growth. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,1,0 2.4.1.11 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27599661&form=6&db=m Frequently rearranged in advanced T?cell lymphomas?1 demonstrates oncogenic properties in prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,1 2.4.1.11 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26320152&form=6&db=m Glycogen synthase kinase-3? modulation of glucocorticoid responsiveness in COPD. unassigned - 2.4.1.11 Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31831767&form=6&db=m Glycogen Synthase Kinase-3? Inhibition with 9-ING-41 Attenuates the Progression of Pulmonary Fibrosis. causal interaction,therapeutic application,unassigned 4,2,0 2.4.1.11 Renal Insufficiency, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32531667&form=6&db=m Curcumin ameliorates CKD-induced mitochondrial dysfunction and oxidative stress through inhibiting GSK-3? activity. diagnostic usage,ongoing research,unassigned 2,4,0 2.4.1.11 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21939667&form=6&db=m Transgenic over expression of ectonucleotide triphosphate diphosphohydrolase-1 protects against murine myocardial ischemic injury. causal interaction,unassigned 1,0 2.4.1.11 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23417421&form=6&db=m GH-Releasing Hormone Induces Cardioprotection in Isolated Male Rat Heart via Activation of RISK and SAFE Pathways. therapeutic application,unassigned 1,0 2.4.1.11 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24184997&form=6&db=m Zinc plays a critical role in the cardioprotective effect of postconditioning by enhancing the activation of the RISK pathway in rat hearts. causal interaction,unassigned 2,0 2.4.1.11 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26206086&form=6&db=m The SR/ER-mitochondria calcium crosstalk is regulated by GSK3? during reperfusion injury. causal interaction,therapeutic application,unassigned 4,2,0 2.4.1.11 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26468894&form=6&db=m Remifentanil Preconditioning Reduces Postischemic Myocardial Infarction and Improves Left Ventricular Performance via Activation of the Janus Activated Kinase-2/Signal Transducers and Activators of Transcription-3 Signal Pathway and Subsequent Inhibition of Glycogen Synthase Kinase-3? in Rats. causal interaction,therapeutic application,unassigned 2,3,0 2.4.1.11 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26572069&form=6&db=m Combination of remote ischemic perconditioning and remote ischemic postconditioning fails to increase protection against myocardial ischemia/reperfusion injury, compared with either alone. causal interaction,therapeutic application,unassigned 1,1,0 2.4.1.11 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26748398&form=6&db=m Long-term insulin treatment restores cardioprotection induced by sufentanil postconditioning in diabetic rat heart. therapeutic application,unassigned 2,0 2.4.1.11 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27580017&form=6&db=m Rosuvastatin postconditioning protects isolated hearts against ischemia-reperfusion injury: the role of radical oxygen species, PI3K-Akt-GSK-3? pathway and mitochondrial permeability transition pore. unassigned - 2.4.1.11 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28153944&form=6&db=m Involvement of Glycogen Synthase Kinase-3? in Liver Ischemic Conditioning Induced Cardioprotection against Myocardial Ischemia and Reperfusion Injury in Rats. causal interaction,unassigned 2,0 2.4.1.11 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28282906&form=6&db=m GSK3? and VDAC Involvement in ER Stress and Apoptosis Modulation during Orthotopic Liver Transplantation. ongoing research,unassigned 2,0 2.4.1.11 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31933870&form=6&db=m GSK-3? mediates ischemia-reperfusion injury by regulating autophagy in DCD liver allografts. ongoing research,unassigned 3,0 2.4.1.11 Respiratory Distress Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33219378&form=6&db=m Pulmonary glycogen deficiency as a new potential cause of respiratory distress syndrome. causal interaction,therapeutic application,unassigned 4,1,0 2.4.1.11 Retinal Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28929374&form=6&db=m Inhibition of GSK-3? Activation Protects SD Rat Retina Against N-Methyl-N-Nitrosourea-Induced Degeneration by Modulating the Wnt/?-Catenin Signaling Pathway. diagnostic usage,ongoing research,unassigned 1,1,0 2.4.1.11 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21945811&form=6&db=m Ceramide 1-phosphate stimulates proliferation of C2C12 myoblasts. causal interaction,unassigned 1,0 2.4.1.11 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33786620&form=6&db=m Role of C14orf166 in viral infection and RNA metabolism and its relationship with cancer (Review). causal interaction,therapeutic application,unassigned 3,1,0 2.4.1.11 Rhabdomyolysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19803057&form=6&db=m A glycogen synthase 1 mutation associated with equine polysaccharide storage myopathy and exertional rhabdomyolysis occurs in a variety of UK breeds. causal interaction,unassigned 3,0 2.4.1.11 Rhabdomyolysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30143916&form=6&db=m Altered mitochondrial oxidative phosphorylation capacity in horses suffering from polysaccharide storage myopathy. diagnostic usage,ongoing research,unassigned 3,2,0 2.4.1.11 Rhabdomyosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17308356&form=6&db=m Phosphoinositide-3-kinase/akt survival signal pathways are implicated in neuronal survival after stroke. unassigned - 2.4.1.11 Rhabdomyosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17488246&form=6&db=m Increased fat oxidation and regulation of metabolic genes with ultraendurance exercise. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0 2.4.1.11 Rhabdomyosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28968964&form=6&db=m Preclinical testing of the glycogen synthase kinase-3? inhibitor tideglusib for rhabdomyosarcoma. therapeutic application,unassigned 3,0 2.4.1.11 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27656241&form=6&db=m Diosgenin and 5-Methoxypsoralen Ameliorate Insulin Resistance through ER-?/PI3K/Akt-Signaling Pathways in HepG2 Cells. therapeutic application,unassigned 1,0 2.4.1.11 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11483824&form=6&db=m Case report: liver glycogen synthase deficiency--a cause of ketotic hypoglycemia. causal interaction,unassigned 3,0 2.4.1.11 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3105561&form=6&db=m Liver glycogen metabolism in endotoxin shock. I. Endotoxin administration decreases glycogen synthase activities in dog livers. causal interaction,unassigned 1,0 2.4.1.11 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17224784&form=6&db=m Glycogen synthase kinase 3beta as a target for the therapy of shock and inflammation. causal interaction,therapeutic application,unassigned 3,4,0 2.4.1.11 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21515258&form=6&db=m GSK-3?-induced ASK1 stabilization is crucial in LPS-induced endotoxin shock. therapeutic application,unassigned 2,0 2.4.1.11 Sleep Deprivation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12383246&form=6&db=m Sleep deprivation modulates brain mRNAs encoding genes of glycogen metabolism. therapeutic application,unassigned 1,0 2.4.1.11 Sleep Initiation and Maintenance Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30081294&form=6&db=m Glycogen synthase kinase-3? genetic polymorphisms and insomnia in depressed patients: A prospective study. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,2,4 2.4.1.11 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28123427&form=6&db=m Methylprednisolone promotes recovery of neurological function after spinal cord injury: association with Wnt/?-catenin signaling pathway activation. causal interaction,unassigned 4,0 2.4.1.11 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29043099&form=6&db=m Lithium ameliorates rat spinal cord injury by suppressing glycogen synthase kinase-3? and activating heme oxygenase-1. unassigned - 2.4.1.11 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32251100&form=6&db=m Neuroprotection of netrin-1 on neurological recovery via Wnt/?-catenin signaling pathway after spinal cord injury. therapeutic application,unassigned 1,0 2.4.1.11 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26315788&form=6&db=m miRNA-99b-3p functions as a potential tumor suppressor by targeting glycogen synthase kinase-3? in oral squamous cell carcinoma Tca-8113 cells. causal interaction,therapeutic application,unassigned 2,3,0 2.4.1.11 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29134466&form=6&db=m Glycogen synthase kinase-3? mediated regulation of matrix metalloproteinase-9 and its involvement in oral squamous cell carcinoma progression and invasion. causal interaction,ongoing research,unassigned 4,3,0 2.4.1.11 starch synthase (glycosyl-transferring) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17586688&form=6&db=m Characterization of SSIIIa-deficient mutants of rice: the function of SSIIIa and pleiotropic effects by SSIIIa deficiency in the rice endosperm. causal interaction,unassigned 1,0 2.4.1.11 starch synthase (glycosyl-transferring) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27523327&form=6&db=m Morphological, Thermal, and Rheological Properties of Starches from Maize Mutants Deficient in Starch Synthase III. causal interaction,unassigned 4,0 2.4.1.11 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=109607&form=6&db=m Glycogen synthase of Hymenolepis diminuta. II. Nutritional state, interconversion of forms, and primer glycogen molecular weight as control factors. unassigned - 2.4.1.11 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=203823&form=6&db=m Effect of starvation on hepatic glycogen metabolism and glucose homeostasis. ongoing research,unassigned 3,0 2.4.1.11 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=221217&form=6&db=m Regulation of glycogen synthase activity in choriocarcinoma cells. Effect of glucose starvation on the conversion of synthase D to synthase I and the kinetic properties of the enzyme. ongoing research,unassigned 3,0 2.4.1.11 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1446241&form=6&db=m Effect of starvation on glycogen and glucose metabolism in different areas of the rat brain. ongoing research,unassigned 2,0 2.4.1.11 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1471995&form=6&db=m Glutamine is a good substrate for glycogen synthesis in isolated hepatocytes from 72 h-starved rats, but not from 24 h- or 48 h-starved rats. unassigned - 2.4.1.11 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6092585&form=6&db=m Effect of prolonged starvation on glycogen synthase and glycogen synthase phosphatase activity in rat heart. ongoing research,unassigned 4,0 2.4.1.11 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6262625&form=6&db=m Effect of starvation and insulin treatment on glycogen synthase D and synthase D phosphatase activity in rat heart. diagnostic usage,ongoing research,unassigned 3,3,0 2.4.1.11 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6411070&form=6&db=m The effects of starvation and re-feeding on glycogen metabolism in mouse tail skin. ongoing research,unassigned 3,0 2.4.1.11 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6727072&form=6&db=m Metabolic alterations in normal and streptozotocin-diabetic rats in vivo: influence of prolonged starvation. causal interaction,ongoing research,unassigned 1,1,0 2.4.1.11 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6777220&form=6&db=m Insulin stimulation of glycogen synthase in cultured human diploid fibroblasts. ongoing research,unassigned 1,0 2.4.1.11 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6790684&form=6&db=m Effect of adrenalectomy on the diurnal variation in glycogen metabolism in starved-refed rats. ongoing research,unassigned 2,0 2.4.1.11 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6790691&form=6&db=m Activity of enzymes regulating glycogen metabolism in perfused muscle-cuticle sections of Ascaris suum (Nematoda). ongoing research,unassigned 3,0 2.4.1.11 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7562079&form=6&db=m Starvation and refeeding regulate glycogen synthase gene expression in rat liver at the posttranscriptional level. diagnostic usage,ongoing research,unassigned 1,4,0 2.4.1.11 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8503877&form=6&db=m Changes in rates of glucose utilization and regulation of glucose disposal by fast-twitch skeletal muscles in late pregnancy. ongoing research,unassigned 2,0 2.4.1.11 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10440121&form=6&db=m In late pregnancy insulin-dependent glucose transport/phosphorylation is selectively impaired and activation of glycogen synthase by insulin facilitated in skeletal muscles of 24-h starved rats. causal interaction,therapeutic application,unassigned 3,1,0 2.4.1.11 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11976968&form=6&db=m Molecular and biochemical characterization of the Neurospora crassa glycogen synthase encoded by the gsn cDNA. ongoing research,unassigned 2,0 2.4.1.11 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15111133&form=6&db=m Glucose starvation results in UDP-glucose deficiency and inactivation of glycogen synthase. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 2.4.1.11 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20733003&form=6&db=m Loss of Par-1a/MARK3/C-TAK1 kinase leads to reduced adiposity, resistance to hepatic steatosis, and defective gluconeogenesis. unassigned - 2.4.1.11 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22550018&form=6&db=m Sequencing and characterization of glycogen synthase and glycogen phosphorylase genes from Spodoptera exigua and analysis of their function in starvation and excessive sugar intake. ongoing research,unassigned 3,0 2.4.1.11 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23607684&form=6&db=m Polyglucosan neurotoxicity caused by glycogen branching enzyme deficiency can be reversed by inhibition of glycogen synthase. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,4 2.4.1.11 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28606937&form=6&db=m Effects of starvation on the carbohydrate metabolism in Harmonia axyridis (Pallas). causal interaction,unassigned 3,0 2.4.1.11 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33717266&form=6&db=m SOX2 enhances cell survival and induces resistance to apoptosis under serum starvation conditions through the AKT/GSK-3? signaling pathway in esophageal squamous cell carcinoma. causal interaction,diagnostic usage,unassigned 1,1,0 2.4.1.11 Status Epilepticus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22761705&form=6&db=m Lovastatin modulates glycogen synthase kinase-3? pathway and inhibits mossy fiber sprouting after pilocarpine-induced status epilepticus. therapeutic application,unassigned 1,0 2.4.1.11 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20854473&form=6&db=m Glycogen synthase kinase-3? does not correlate with the expression and activity of ?-catenin in gastric cancer. diagnostic usage,unassigned 1,0 2.4.1.11 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25846563&form=6&db=m Signal transducers and activators of transcription 3-induced metastatic potential in gastric cancer cells is enhanced by glycogen synthase kinase-3?. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1 2.4.1.11 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26077686&form=6&db=m Inhibition of glycogen synthase kinase-3? enhances cognitive recovery after stroke: the role of TAK1. therapeutic application,unassigned 2,0 2.4.1.11 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27378458&form=6&db=m Tideglusib, a chemical inhibitor of GSK3?, attenuates hypoxic-ischemic brain injury in neonatal mice. unassigned - 2.4.1.11 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30336136&form=6&db=m The neuroprotective effect of lithium chloride on cognitive impairment through glycogen synthase kinase-3? inhibition in intracerebral hemorrhage rats. causal interaction,therapeutic application,unassigned 4,4,0 2.4.1.11 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30981804&form=6&db=m OCT4B-190 protects against ischemic stroke by modulating GSK-3?/HDAC6. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.4.1.11 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31226691&form=6&db=m BIO alleviates inflammation through inhibition of GSK-3? in a rat model of intracerebral hemorrhage. causal interaction,unassigned 2,0 2.4.1.11 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32968615&form=6&db=m Insight into glycogen synthase kinase-3? inhibitory activity of phyto-constituents from Melissa officinalis: in silico studies. causal interaction,therapeutic application,unassigned 1,1,0 2.4.1.11 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33375333&form=6&db=m Insulin Resistance in Skeletal Muscle of Chronic Stroke. ongoing research,unassigned 4,0 2.4.1.11 Supranuclear Palsy, Progressive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12410379&form=6&db=m Glycogen synthase kinase-3 is associated with neuronal and glial hyperphosphorylated tau deposits in Alzheimer's disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration. causal interaction,unassigned 3,0 2.4.1.11 Supranuclear Palsy, Progressive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15265592&form=6&db=m Protein levels of glycogen synthase 3 kinase are normal in progressive supranuclear palsy. causal interaction,diagnostic usage,unassigned 1,1,0 2.4.1.11 Tauopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12581337&form=6&db=m Tau phosphorylation and kinase activation in familial tauopathy linked to deln296 mutation. causal interaction,therapeutic application,unassigned 1,1,0 2.4.1.11 Tauopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23410232&form=6&db=m AZD1080, a novel GSK3 inhibitor, rescues synaptic plasticity deficits in rodent brain and exhibits peripheral target engagement in humans. causal interaction,therapeutic application,unassigned 4,4,0 2.4.1.11 Tauopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24880087&form=6&db=m Temsirolimus attenuates tauopathy in vitro and in vivo by targeting tau hyperphosphorylation and autophagic clearance. causal interaction,unassigned 3,0 2.4.1.11 Tauopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26328540&form=6&db=m Combination of PKC? Activation and PTP1B Inhibition Effectively Suppresses A?-Induced GSK-3? Activation and Tau Phosphorylation. causal interaction,unassigned 2,0 2.4.1.11 Teratocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17961225&form=6&db=m Phosphoprotein phosphatase-2A docks to Dishevelled and counterregulates Wnt3a/beta-catenin signaling. causal interaction,unassigned 1,0 2.4.1.11 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=983652&form=6&db=m Skeletal muscle metabolism in two Pavulon treated tetanus patients. diagnostic usage,ongoing research,unassigned 2,3,0 2.4.1.11 Thrombocytopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19417015&form=6&db=m A Phase I Trial of Enzastaurin in Patients with Recurrent Gliomas. diagnostic usage,unassigned 2,0 2.4.1.11 Thymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19533653&form=6&db=m Atrogin-1, MuRF1, and FoXO, as well as phosphorylated GSK-3beta and 4E-BP1 are reduced in skeletal muscle of chronic spinal cord-injured patients. ongoing research,unassigned 2,0 2.4.1.11 Thymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20112301&form=6&db=m Green tea polyphenols improve cardiac muscle mRNA and protein levels of signal pathways related to insulin and lipid metabolism and inflammation in insulin-resistant rats. ongoing research,unassigned 1,0 2.4.1.11 Thymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23708325&form=6&db=m Genome-wide analysis of murine bone marrow?derived very small embryonic-like stem cells reveals that mitogenic growth factor signaling pathways play a crucial role in the quiescence and ageing of these cells. unassigned - 2.4.1.11 Thymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24603331&form=6&db=m Enhanced myeloid differentiation factor 88 promotes tumor metastasis via induction of epithelial-mesenchymal transition in human hepatocellular carcinoma. unassigned - 2.4.1.11 Thymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26170971&form=6&db=m SGK3 (CISK) may induce tumor angiogenesis (Hypothesis). causal interaction,therapeutic application,unassigned 3,1,0 2.4.1.11 Thymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27854077&form=6&db=m Prohibitin confers cytoprotection against ISO-induced hypertrophy in H9c2 cells via attenuation of oxidative stress and modulation of Akt/Gsk-3? signaling. causal interaction,unassigned 3,0 2.4.1.11 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31750236&form=6&db=m The Role of Lithium in Management of Endocrine Tumors-A Comprehensive Review. causal interaction,unassigned 1,0 2.4.1.11 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25277548&form=6&db=m Allosteric regulation of the partitioning of glucose-1-phosphate between glycogen and trehalose biosynthesis in Mycobacterium tuberculosis. ongoing research,unassigned 4,0 2.4.1.11 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33007281&form=6&db=m Sirtuin inhibits M. tuberculosis -induced apoptosis in macrophage through glycogen synthase kinase-3?. causal interaction,therapeutic application,unassigned 3,4,0 2.4.1.11 Tuberous Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26646023&form=6&db=m Insulin Signaling in Bupivacaine-induced Cardiac Toxicity: Sensitization during Recovery and Potentiation by Lipid Emulsion. causal interaction,therapeutic application,unassigned 2,3,0 2.4.1.11 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20889919&form=6&db=m Glycogen Synthase Kinase-3{beta}: A Prognostic Marker and a Potential Therapeutic Target in Human Bladder Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.4.1.11 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31114749&form=6&db=m Clinicohistopathological implications of phosphoserine 9 glycogen synthase kinase-3?/ ?-catenin in urinary bladder cancer patients. causal interaction,therapeutic application,unassigned 2,1,0 2.4.1.11 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7744767&form=6&db=m Ras-independent and wortmannin-sensitive activation of glycogen synthase by insulin in Chinese hamster ovary cells. ongoing research,unassigned 3,0 2.4.1.11 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26838475&form=6&db=m Role of brassinosteroid signaling in modulating Tobacco mosaic virus resistance in Nicotiana benthamiana. therapeutic application,unassigned 1,0