2.1.1.228 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=187335&form=6&db=m Composition, associated tissue methyltransferase activity, and catabolic end products of transfer RNA from carcinogen-induced hepatoma and normal monkey livers. ongoing research,unassigned 1,0 2.1.1.228 Vitamin A Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=831816&form=6&db=m The effect of vitamin A deficiency on testicular transfer RNA methyltransferase activity. causal interaction,ongoing research,unassigned 2,3,0 2.1.1.228 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3855480&form=6&db=m Differences in activity of N2-guanine tRNA methyltransferase II among several inbred strains of mice. diagnostic usage,ongoing research,unassigned 1,3,0 2.1.1.228 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4358158&form=6&db=m Alteration in tRNA methyltransferase activity in mengovirus infection: host range specificity. causal interaction,diagnostic usage,unassigned 1,1,0 2.1.1.228 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6722163&form=6&db=m Mature methyl-deficient tRNA isolated from a mammary adenocarcinoma. causal interaction,unassigned 4,0 2.1.1.228 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7139605&form=6&db=m Methyl-accepting RNA in 13762 mammary adenocarcinoma correlated with low adenine methyltransferase levels. causal interaction,unassigned 2,0 2.1.1.228 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7139605&form=6&db=m Methyl-accepting RNA in 13762 mammary adenocarcinoma correlated with low adenine methyltransferase levels. causal interaction,unassigned 2,0 2.1.1.228 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17440925&form=6&db=m Chromosome 8 BAC array comparative genomic hybridization and expression analysis identify amplification and overexpression of TRMT12 in breast cancer. unassigned - 2.1.1.228 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21670254&form=6&db=m Retrograde nuclear import of tRNA precursors is required for modified base biogenesis in yeast. causal interaction,unassigned 1,0 2.1.1.228 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23381944&form=6&db=m A human tRNA methyltransferase 9-like protein prevents tumour growth by regulating LIN9 and HIF1-?. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0 2.1.1.228 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23381944&form=6&db=m A human tRNA methyltransferase 9-like protein prevents tumour growth by regulating LIN9 and HIF1-?. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0 2.1.1.228 Microcephaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24204302&form=6&db=m tRNA methyltransferase homolog gene TRMT10A mutation in young onset diabetes and primary microcephaly in humans. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.1.1.228 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24422464&form=6&db=m A system of RNA modifications and biased codon use controls cellular stress response at the level of translation. unassigned - 2.1.1.228 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25747896&form=6&db=m Somatic cancer mutations in the DNMT2 tRNA methyltransferase alter its catalytic properties. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 2.1.1.228 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26526202&form=6&db=m tRNA methyltransferase homologue gene TRMT10A mutation in young adult-onset diabetes with intellectual disability, microcephaly and epilepsy. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0 2.1.1.228 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26526202&form=6&db=m tRNA methyltransferase homologue gene TRMT10A mutation in young adult-onset diabetes with intellectual disability, microcephaly and epilepsy. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0 2.1.1.228 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26526202&form=6&db=m tRNA methyltransferase homologue gene TRMT10A mutation in young adult-onset diabetes with intellectual disability, microcephaly and epilepsy. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0 2.1.1.228 Microcephaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26526202&form=6&db=m tRNA methyltransferase homologue gene TRMT10A mutation in young adult-onset diabetes with intellectual disability, microcephaly and epilepsy. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0 2.1.1.228 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28784718&form=6&db=m TRMT1-catalyzed tRNA modifications are required for redox homeostasis to ensure proper cellular proliferation and oxidative stress survival. causal interaction,unassigned 3,0 2.1.1.228 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28829218&form=6&db=m Association of tRNA methyltransferase NSUN2/IGF-II molecular signature with ovarian cancer survival. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,2,0 2.1.1.228 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29085442&form=6&db=m Ovarian cancer proliferation and apoptosis are regulated by human transfer RNA methyltransferase 9-likevia LIN9. unassigned - 2.1.1.228 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29085442&form=6&db=m Ovarian cancer proliferation and apoptosis are regulated by human transfer RNA methyltransferase 9-likevia LIN9. unassigned - 2.1.1.228 Microcephaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30247717&form=6&db=m Pancreatic ?-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes. causal interaction,ongoing research,unassigned 4,2,0 2.1.1.228 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30289604&form=6&db=m Mutations in the tRNA methyltransferase 1 gene TRMT1 cause congenital microcephaly, isolated inferior vermian hypoplasia and cystic leukomalacia in addition to intellectual disability. unassigned - 2.1.1.228 Microcephaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30289604&form=6&db=m Mutations in the tRNA methyltransferase 1 gene TRMT1 cause congenital microcephaly, isolated inferior vermian hypoplasia and cystic leukomalacia in addition to intellectual disability. unassigned - 2.1.1.228 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30415557&form=6&db=m tRNA Methyltransferase Defects and Intellectual Disability. diagnostic usage,ongoing research,therapeutic application,unassigned 2,1,1,0 2.1.1.228 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30415557&form=6&db=m tRNA Methyltransferase Defects and Intellectual Disability. diagnostic usage,ongoing research,therapeutic application,unassigned 2,1,1,0 2.1.1.228 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30415557&form=6&db=m tRNA Methyltransferase Defects and Intellectual Disability. diagnostic usage,ongoing research,therapeutic application,unassigned 2,1,1,0 2.1.1.228 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33067246&form=6&db=m tRNA methyltransferase 10 homologue A (TRMT10A) mutation in a Chinese patient with diabetes, insulin resistance, intellectual deficiency and microcephaly. causal interaction,ongoing research,unassigned 4,1,0 2.1.1.228 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33067246&form=6&db=m tRNA methyltransferase 10 homologue A (TRMT10A) mutation in a Chinese patient with diabetes, insulin resistance, intellectual deficiency and microcephaly. causal interaction,ongoing research,unassigned 4,1,0 2.1.1.228 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33067246&form=6&db=m tRNA methyltransferase 10 homologue A (TRMT10A) mutation in a Chinese patient with diabetes, insulin resistance, intellectual deficiency and microcephaly. causal interaction,ongoing research,unassigned 4,1,0 2.1.1.228 Microcephaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33067246&form=6&db=m tRNA methyltransferase 10 homologue A (TRMT10A) mutation in a Chinese patient with diabetes, insulin resistance, intellectual deficiency and microcephaly. causal interaction,ongoing research,unassigned 4,1,0 2.1.1.228 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33448213&form=6&db=m TRMT10A mutation in a child with diabetes, short stature, microcephaly and hypoplastic kidneys. causal interaction,unassigned 3,0 2.1.1.228 Microcephaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33448213&form=6&db=m TRMT10A mutation in a child with diabetes, short stature, microcephaly and hypoplastic kidneys. causal interaction,unassigned 3,0 2.1.1.228 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34541035&form=6&db=m Expanding the Phenotype of TRMT10A Mutations: Case Report and a Review of the Existing Cases. causal interaction,unassigned 4,0 2.1.1.228 Microcephaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34541035&form=6&db=m Expanding the Phenotype of TRMT10A Mutations: Case Report and a Review of the Existing Cases. causal interaction,unassigned 4,0