1.14.16.4 Abortion, Habitual http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11576585&form=6&db=m Tryptophan hydroxylase gene polymorphism (A218C) and idiopathic recurrent miscarriage. diagnostic usage,ongoing research,unassigned 1,4,0 1.14.16.4 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17336599&form=6&db=m Changes in glucose do not alter baseline firing rate or chemosensitivity of serotonin neurons cultured from the medullary raphé. causal interaction,therapeutic application,unassigned 1,4,0 1.14.16.4 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11683520&form=6&db=m Changes in serotonin dynamics in the gastrointestinal tract of colon-26 tumour-bearing mice: effects of cisplatin treatment. causal interaction,ongoing research,unassigned 3,3,0 1.14.16.4 Alopecia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10946908&form=6&db=m Pteridin-dependent hydroxylases as autoantigens in autoimmune polyendocrine syndrome type I. unassigned - 1.14.16.4 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1707735&form=6&db=m Evidence for decreased transport of tryptophan hydroxylase in Alzheimer's disease. causal interaction,unassigned 4,0 1.14.16.4 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2879891&form=6&db=m Tyrosine hydroxylase, tryptophan hydroxylase, biopterin, and neopterin in the brains of normal controls and patients with senile dementia of Alzheimer type. diagnostic usage,ongoing research,unassigned 3,3,0 1.14.16.4 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11150890&form=6&db=m No association between tryptophan hydroxylase gene polymorphism and Alzheimer's disease. causal interaction,ongoing research,unassigned 3,2,0 1.14.16.4 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15182943&form=6&db=m Allelic variation at the A218C tryptophan hydroxylase polymorphism influences agitation and aggression in Alzheimer's disease. causal interaction,ongoing research,unassigned 3,2,0 1.14.16.4 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20721333&form=6&db=m Circulating Antibodies to IDO/THO Pathway Metabolites in Alzheimer's Disease. unassigned - 1.14.16.4 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23334703&form=6&db=m Brain-Specific Tryptophan Hydroxylase, TPH2, and 5-HTTLPR are Associated with Frontal Lobe Symptoms in Alzheimer's Disease. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,1,0 1.14.16.4 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26238767&form=6&db=m Decoy receptor 3 regulates the expression of tryptophan hydroxylase 1 in rheumatoid synovial fibroblasts. causal interaction,unassigned 2,0 1.14.16.4 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29567680&form=6&db=m Chronic Intake of the Selective Serotonin Reuptake Inhibitor Fluoxetine Enhances Atherosclerosis. therapeutic application,unassigned 1,0 1.14.16.4 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9690408&form=6&db=m Identification of tryptophan hydroxylase as an intestinal autoantigen. diagnostic usage,ongoing research,unassigned 3,2,0 1.14.16.4 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15012616&form=6&db=m Autoantibodies to human tryptophan hydroxylase and aromatic L-amino acid decarboxylase. diagnostic usage,ongoing research,unassigned 3,3,0 1.14.16.4 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19903352&form=6&db=m Altered serotonin physiology in human breast cancers favors paradoxical growth and cell survival. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 1.14.16.4 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27871326&form=6&db=m Tryptophan hydroxylase 1 and 5-HT diagnostic usage,ongoing research,unassigned 1,4,0 1.14.16.4 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8738133&form=6&db=m Immortalization of neuroendocrine pinealocytes from transgenic mice by targeted tumorigenesis using the tryptophan hydroxylase promoter. ongoing research,unassigned 4,0 1.14.16.4 Carcinoid Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16654&form=6&db=m Properties of tryptophan hydroxylase from human carcinoid tumor. ongoing research,unassigned 4,0 1.14.16.4 Carcinoid Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3974452&form=6&db=m Increased dopamine production in patients with carcinoid tumors. unassigned - 1.14.16.4 Carcinoid Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4282665&form=6&db=m [Proceedings: Tryptophan hydroxylase inhibition as therapy for carcinoid tumors] causal interaction,therapeutic application,unassigned 3,4,0 1.14.16.4 Carcinoid Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7575647&form=6&db=m Elevated aromatic-L-amino acid decarboxylase in human carcinoid tumors. unassigned - 1.14.16.4 Carcinoid Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8925846&form=6&db=m Successful and unsuccessful approaches to imaging carcinoids: comparison of a radiolabelled tryptophan hydroxylase inhibitor with a tracer of biogenic amine uptake and storage, and a somatostatin analogue. unassigned - 1.14.16.4 Carcinoid Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9840098&form=6&db=m Tryptophan hydroxylase antibodies used in the diagnosis of carcinoid. causal interaction,diagnostic usage,therapeutic application,unassigned 2,4,1,0 1.14.16.4 Carcinoid Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10953292&form=6&db=m Tryptophan hydroxylase and 5-hydroxytryptamine in carcinoids of the gastrointestinal tract. diagnostic usage,ongoing research,unassigned 4,4,0 1.14.16.4 Carcinoid Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11106255&form=6&db=m The aromatic-L-amino acid decarboxylase inhibitor carbidopa is selectively cytotoxic to human pulmonary carcinoid and small cell lung carcinoma cells. ongoing research,unassigned 2,0 1.14.16.4 Carcinoid Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12115345&form=6&db=m 7-Hydroxytryptophan, a novel, specific, cytotoxic agent for carcinoids and other serotonin-producing tumors. causal interaction,diagnostic usage,unassigned 3,3,0 1.14.16.4 Carcinoid Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12397014&form=6&db=m Cystic fibrosis transmembrane conductance regulator modulates neurosecretory function in pulmonary neuroendocrine cell-related tumor cell line models. diagnostic usage,ongoing research,unassigned 3,4,0 1.14.16.4 Carcinoid Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17717663&form=6&db=m CD8+ T cells against multiple tumor-associated antigens in peripheral blood of midgut carcinoid patients. causal interaction,unassigned 2,0 1.14.16.4 Carcinoid Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27041406&form=6&db=m Patient-Reported Symptom Experiences in Patients With Carcinoid Syndrome After Participation in a Study of Telotristat Etiprate: A Qualitative Interview Approach. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,3,0 1.14.16.4 Carcinoid Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27107003&form=6&db=m Inhibition of Peripheral Synthesis of Serotonin as a New Target in Neuroendocrine Tumors. causal interaction,therapeutic application,unassigned 1,4,0 1.14.16.4 Carcinoid Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27817224&form=6&db=m Telotristat ethyl: a new option for the management of carcinoid syndrome. therapeutic application,unassigned 4,0 1.14.16.4 Carcinoid Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27918724&form=6&db=m Telotristat Ethyl, a Tryptophan Hydroxylase Inhibitor for the Treatment of Carcinoid Syndrome. causal interaction,therapeutic application,unassigned 1,4,0 1.14.16.4 Carcinoid Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28382568&form=6&db=m Telotristat Ethyl: First Global Approval. therapeutic application,unassigned 3,0 1.14.16.4 Carcinoid Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29051994&form=6&db=m Telotristat ethyl: proof of principle and the first oral agent in the management of well-differentiated metastatic neuroendocrine tumor and carcinoid syndrome diarrhea. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,3,0 1.14.16.4 Carcinoid Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29074312&form=6&db=m Understanding the Patient Experience with Carcinoid Syndrome: Exit Interviews from a Randomized, Placebo-controlled Study of Telotristat Ethyl. therapeutic application,unassigned 4,0 1.14.16.4 Carcinoid Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29330194&form=6&db=m Telotristat ethyl in carcinoid syndrome: safety and efficacy in the TELECAST phase 3 trial. therapeutic application,unassigned 1,0 1.14.16.4 Carcinoid Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29724499&form=6&db=m Changes in Weight Associated With Telotristat Ethyl in the Treatment of Carcinoid Syndrome. therapeutic application,unassigned 3,0 1.14.16.4 Carcinoid Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29931594&form=6&db=m Telotristat Ethyl: A Review in Carcinoid Syndrome Diarrhoea. causal interaction,therapeutic application,unassigned 1,4,0 1.14.16.4 Carcinoid Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30295930&form=6&db=m Gastroenteropancreatic Neuroendocrine Tumors. causal interaction,therapeutic application,unassigned 3,4,0 1.14.16.4 Carcinoid Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30651397&form=6&db=m Long-Term Safety Experience with Telotristat Ethyl Across Five Clinical Studies in Patients with Carcinoid Syndrome. therapeutic application,unassigned 3,0 1.14.16.4 Carcinoid Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31189618&form=6&db=m TELEPRO: Patient-Reported Carcinoid Syndrome Symptom Improvement Following Initiation of Telotristat Ethyl in the Real World. therapeutic application,unassigned 4,0 1.14.16.4 Carcinoid Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32801896&form=6&db=m Antiproliferative Effects of Telotristat Ethyl in Patients with Neuroendocrine Tumors: The TELEACE Real-World Chart Review Study. unassigned - 1.14.16.4 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12115345&form=6&db=m 7-Hydroxytryptophan, a novel, specific, cytotoxic agent for carcinoids and other serotonin-producing tumors. causal interaction,diagnostic usage,unassigned 3,3,0 1.14.16.4 Cardiomyopathy, Dilated http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20828585&form=6&db=m Contribution of gene-modified mice and rats to our understanding of the cardiovascular pharmacology of serotonin. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0 1.14.16.4 Catalepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1475314&form=6&db=m Activity of tryptophan hydroxylase in brain of hereditary predisposed to catalepsy rats. diagnostic usage,ongoing research,unassigned 1,2,0 1.14.16.4 Catalepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2413649&form=6&db=m [Changes in the serotonin system of the brains of rats genetically predisposed to catalepsy] causal interaction,unassigned 1,0 1.14.16.4 Catalepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2611380&form=6&db=m [The relation of tryptophan hydroxylase activity in the brain and the manifestation of catalepsy in mice] diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 1.14.16.4 Catalepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7573174&form=6&db=m On the role of brain serotonin in expression of genetic predisposition to catalepsy in animal models. unassigned - 1.14.16.4 Catalepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7617682&form=6&db=m Correlation between tryptophan hydroxylase activity in the brain and predisposition to pinch-induced catalepsy in mice. diagnostic usage,ongoing research,unassigned 1,3,0 1.14.16.4 Catalepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=13677667&form=6&db=m Involvement of striatum serotonergic system in the expression of genetically defined catalepsy. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 1.14.16.4 Catalepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24925295&form=6&db=m Experimental studies on genetically determined predisposition to catatonia in rats as a model of schizophrenia. causal interaction,unassigned 3,0 1.14.16.4 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19010890&form=6&db=m Serotonin metabolism is dysregulated in cholangiocarcinoma, which has implications for tumor growth. causal interaction,unassigned 3,0 1.14.16.4 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33525332&form=6&db=m Serotonin Pathway in Cancer. causal interaction,therapeutic application,unassigned 3,4,0 1.14.16.4 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10340628&form=6&db=m Origin of the serotonergic innervation to the rat dorsolateral hypothalamus: retrograde transport of cholera toxin and upregulation of tryptophan hydroxylase mRNA expression following selective nerve terminals lesion. diagnostic usage,ongoing research,unassigned 1,1,0 1.14.16.4 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23562375&form=6&db=m Immunoreactivity for the NMDA NR1 subunit in bulbospinal catecholamine and serotonin neurons of rat ventral medulla. ongoing research,therapeutic application,unassigned 2,1,0 1.14.16.4 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29803764&form=6&db=m Serotonergic projections to the ventral respiratory column from raphe nuclei in rats. diagnostic usage,ongoing research,unassigned 3,3,0 1.14.16.4 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19706294&form=6&db=m Serotonin Has a Key Role in Pathogenesis of Experimental Colitis. ongoing research,therapeutic application,unassigned 3,2,0 1.14.16.4 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26206858&form=6&db=m Blocking peripheral serotonin synthesis by telotristat etiprate (LX1032/LX1606) reduces severity of both chemical- and infection-induced intestinal inflammation. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 1.14.16.4 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29447434&form=6&db=m Alterations in melatonin and 5-HT signalling in the colonic mucosa of mice with dextran-sodium sulfate-induced colitis. causal interaction,therapeutic application,unassigned 3,1,0 1.14.16.4 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15798484&form=6&db=m Nerves, reflexes, and the enteric nervous system: pathogenesis of the irritable bowel syndrome. unassigned - 1.14.16.4 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15832123&form=6&db=m Nerves, reflexes, and the enteric nervous system: pathogenesis of the irritable bowel syndrome. unassigned - 1.14.16.4 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34285037&form=6&db=m Overproduction of Gastrointestinal 5-HT Promotes Colitis-Associated Colorectal Cancer Progression via Enhancing NLRP3 Inflammasome Activation. diagnostic usage,ongoing research,unassigned 4,4,0 1.14.16.4 Cushing Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21924839&form=6&db=m Chronic non-invasive corticosterone administration abolishes the diurnal pattern of tph2 expression. ongoing research,therapeutic application,unassigned 4,1,0 1.14.16.4 Dandy-Walker Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10480208&form=6&db=m Changes of neurotransmitters in the brainstem of patients with respiratory-pattern disorders during childhood. causal interaction,diagnostic usage,unassigned 2,2,0 1.14.16.4 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23334703&form=6&db=m Brain-Specific Tryptophan Hydroxylase, TPH2, and 5-HTTLPR are Associated with Frontal Lobe Symptoms in Alzheimer's Disease. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,1,0 1.14.16.4 Depression, Postpartum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24265583&form=6&db=m Associations Between Variations in TPH1 , TPH2 and SLC6A4 Genes and Postpartum Depression: A Study in the Jordanian Population. ongoing research,unassigned 2,0 1.14.16.4 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11195179&form=6&db=m [Changes in brain serotonin biosynthesis in rats with diabetes mellitus induced by streptozocin: effect of insulin treatment] diagnostic usage,ongoing research,unassigned 1,3,0 1.14.16.4 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15909768&form=6&db=m Inhibition and kinetic changes of brain tryptophan-5-hydroxylase during insulin-dependent diabetes mellitus in the rat. ongoing research,therapeutic application,unassigned 4,2,0 1.14.16.4 Dyskinesias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20713157&form=6&db=m Morphological changes in serotoninergic neurites in the striatum and globus pallidus in levodopa primed MPTP treated common marmosets with dyskinesia. ongoing research,therapeutic application,unassigned 3,2,0 1.14.16.4 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23008335&form=6&db=m Tryptophan hydroxylase-1 regulates immune tolerance and inflammation. causal interaction,ongoing research,unassigned 4,1,0 1.14.16.4 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23008335&form=6&db=m Tryptophan hydroxylase-1 regulates immune tolerance and inflammation. causal interaction,ongoing research,unassigned 4,1,0 1.14.16.4 Enterocolitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27217698&form=6&db=m Altered tryptophan hydroxylase 2 expression in enteric serotonergic nerves in Hirschsprung's-associated enterocolitis. unassigned - 1.14.16.4 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24491795&form=6&db=m Tryptophan hydroxylase 2 (TPH2) gene polymorphisms and psychiatric comorbidities in temporal lobe epilepsy. ongoing research,unassigned 1,0 1.14.16.4 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29608654&form=6&db=m The ventrolateral medulla and medullary raphe in sudden unexpected death in epilepsy. causal interaction,diagnostic usage,unassigned 2,4,0 1.14.16.4 Epilepsy, Temporal Lobe http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24491795&form=6&db=m Tryptophan hydroxylase 2 (TPH2) gene polymorphisms and psychiatric comorbidities in temporal lobe epilepsy. ongoing research,unassigned 1,0 1.14.16.4 Epileptic Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11701285&form=6&db=m Neuropathology of early-infantile epileptic encephalopathy with suppression-bursts; comparison with those of early myoclonic encephalopathy and West syndrome. unassigned - 1.14.16.4 Familial Primary Pulmonary Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17130306&form=6&db=m Effect of tryptophan hydroxylase 1 deficiency on the development of hypoxia-induced pulmonary hypertension. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 1.14.16.4 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33417443&form=6&db=m Peripheral Selective Oxadiazolylphenyl Alanine Derivatives as Tryptophan Hydroxylase 1 Inhibitors for Obesity and Fatty Liver Disease. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0 1.14.16.4 Gastrointestinal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10470707&form=6&db=m Tryptophan hydroxylase autoantibodies and intestinal disease in autoimmune polyendocrine syndrome type 1. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 1.14.16.4 Gastrointestinal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18557609&form=6&db=m Modulation of peripheral serotonin levels by novel tryptophan hydroxylase inhibitors for the potential treatment of functional gastrointestinal disorders. causal interaction,therapeutic application,unassigned 4,4,0 1.14.16.4 Gastrointestinal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29194046&form=6&db=m Updates on the biology of serotonin and tryptophan hydroxylase. ongoing research,unassigned 1,0 1.14.16.4 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20487987&form=6&db=m Serotonin in neuroblastoma x glioma NG108-15 hybrid cells. diagnostic usage,unassigned 3,0 1.14.16.4 Glucose Intolerance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30931486&form=6&db=m Selective inhibition of intestinal 5-HT improves neurobehavioral abnormalities caused by high-fat diet mice. unassigned - 1.14.16.4 Headache Disorders, Secondary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24458851&form=6&db=m Tryptophan hydroxylase 2 gene polymorphisms in Japanese patients with medication overuse headaches. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 1.14.16.4 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9116203&form=6&db=m Superfluous expression of tryptophan hydroxylase in the zona incerta dopaminergic neurones. unassigned - 1.14.16.4 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12354289&form=6&db=m Inhibition of tryptophan hydroxylase activity and decreased 5-HT1A receptor binding in a mouse model of Huntington's disease. ongoing research,unassigned 1,0 1.14.16.4 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18411707&form=6&db=m [Descending facilitation in chronic stress and chronic pain state] causal interaction,unassigned 3,0 1.14.16.4 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20573908&form=6&db=m Molecular depletion of descending serotonin unmasks its novel facilitatory role in the development of persistent pain. unassigned - 1.14.16.4 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29720377&form=6&db=m Analgesic effects of electroacupuncture at ST25 and CV12 in a rat model of postinflammatory irritable bowel syndrome visceral pain. ongoing research,unassigned 1,0 1.14.16.4 Hyperhomocysteinemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26935476&form=6&db=m Maternal vitamin B6 deficient or supplemented diets on expression of genes related to GABAergic, serotonergic or glutamatergic pathways in hippocampus of rat dams and their offspring. unassigned - 1.14.16.4 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22323131&form=6&db=m SERT and TPH-1 mRNA expression are reduced in Irritable Bowel Syndrome patients irrespective of visceral sensitivity state in large intestine. diagnostic usage,ongoing research,unassigned 3,2,0 1.14.16.4 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24930506&form=6&db=m Exendin-4, an analogue of glucagon-like peptide-1, attenuates hyperalgesia through serotonergic pathways in rats with neonatal colonic sensitivity. causal interaction,unassigned 4,0 1.14.16.4 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17130306&form=6&db=m Effect of tryptophan hydroxylase 1 deficiency on the development of hypoxia-induced pulmonary hypertension. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 1.14.16.4 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21464983&form=6&db=m Altered gene expression in pulmonary tissue of tryptophan hydroxylase-1 knockout mice: implications for pulmonary arterial hypertension. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 1.14.16.4 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23087024&form=6&db=m Imatinib attenuates hypoxia-induced pulmonary arterial hypertension pathology via reduction in 5-hydroxytryptamine through inhibition of tryptophan hydroxylase 1 expression. causal interaction,therapeutic application,unassigned 2,4,0 1.14.16.4 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24337018&form=6&db=m 4-Chloro-DL-phenylalanine protects against monocrotaline?induced pulmonary vascular remodeling and lung inflammation. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 1.14.16.4 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17130306&form=6&db=m Effect of tryptophan hydroxylase 1 deficiency on the development of hypoxia-induced pulmonary hypertension. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 1.14.16.4 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17675372&form=6&db=m Tryptophan hydroxylase 1 knockout and tryptophan hydroxylase 2 polymorphism: effects on hypoxic pulmonary hypertension in mice. ongoing research,unassigned 4,0 1.14.16.4 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27927914&form=6&db=m Tryptophan hydroxylase 1 Inhibition Impacts Pulmonary Vascular Remodeling in Two Rat Models of Pulmonary Hypertension. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 1.14.16.4 Hyperthyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=574927&form=6&db=m Evidence that chronic apomorphine treatment enhances 5-hydroxytryptamine metabolism in brains of normal and neonatally hyperthyroid rats. unassigned - 1.14.16.4 Hyperthyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=978462&form=6&db=m Influence of neonatal and adult hyperthyroidism on behavior and biosynthetic capacity for norepinephrine, dopamine and 5-hydroxytryptamine in rat brain. causal interaction,ongoing research,unassigned 1,1,0 1.14.16.4 Hypertrophy, Right Ventricular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17130306&form=6&db=m Effect of tryptophan hydroxylase 1 deficiency on the development of hypoxia-induced pulmonary hypertension. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 1.14.16.4 Hypertrophy, Right Ventricular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24337018&form=6&db=m 4-Chloro-DL-phenylalanine protects against monocrotaline?induced pulmonary vascular remodeling and lung inflammation. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 1.14.16.4 Hypothyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=692746&form=6&db=m The effect of thyroid hormone on serotonergic neurones: depletion of serotonin in discrete brain areas of developing hypothyroid rats. unassigned - 1.14.16.4 Hypothyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6199087&form=6&db=m Effect of neonatal hypothyroidism on the serotonin system of the rat brain. unassigned - 1.14.16.4 Hypothyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10364698&form=6&db=m Effects of experimental hypothyroidism on 5-HT1A, 5-HT2A receptors, 5-HT uptake sites and tryptophan hydroxylase activity in mature rat brain1. ongoing research,unassigned 3,0 1.14.16.4 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21221921&form=6&db=m Reference gene selection for normalization of PCR analysis in chicken embryo fibroblast infected with H5N1 AIV. diagnostic usage,unassigned 3,0 1.14.16.4 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23505381&form=6&db=m RFX Transcription Factor DAF-19 Regulates 5-HT and Innate Immune Responses to Pathogenic Bacteria in Caenorhabditis elegans. ongoing research,unassigned 1,0 1.14.16.4 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29569002&form=6&db=m Mast Cells and Serotonin Synthesis Modulate Chagas Disease in the Colon: Clinical and Experimental Evidence. ongoing research,therapeutic application,unassigned 2,1,0 1.14.16.4 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30899295&form=6&db=m Expression of tryptophan hydroxylase in gastric mucosa in symptomatic and asymptomatic Helicobacter pylori infection. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 1.14.16.4 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31194165&form=6&db=m Acute nociceptive stimuli rapidly induce the activity of serotonin and noradrenalin neurons in the brain stem of awake mice. ongoing research,unassigned 4,0 1.14.16.4 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31663407&form=6&db=m Liposomes with pH responsive 'on and off' switches for targeted and intracellular delivery of antibiotics. ongoing research,unassigned 1,0 1.14.16.4 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30628490&form=6&db=m Lethal Avian Influenza A (H5N1) Virus Replicates in Pontomedullary Chemosensitive Neurons and Depresses Hypercapnic Ventilatory Response in Mice. ongoing research,therapeutic application,unassigned 3,1,0 1.14.16.4 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2109147&form=6&db=m The control of 5-hydroxytryptamine and dopamine synthesis in the brain: a theoretical approach. causal interaction,unassigned 3,0 1.14.16.4 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33679889&form=6&db=m Case Report: Whole Exome Sequencing Revealed Disease-Causing Variants in Two Genes in a Patient With Autism Spectrum Disorder, Intellectual Disability, Hyperactivity, Sleep and Gastrointestinal Disturbances. unassigned - 1.14.16.4 Intestinal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10470707&form=6&db=m Tryptophan hydroxylase autoantibodies and intestinal disease in autoimmune polyendocrine syndrome type 1. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 1.14.16.4 Irritable Bowel Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16611266&form=6&db=m Review article: intestinal serotonin signalling in irritable bowel syndrome. causal interaction,diagnostic usage,unassigned 1,3,0 1.14.16.4 Irritable Bowel Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21073637&form=6&db=m Associations of tryptophan hydroxylase gene polymorphisms with irritable bowel syndrome. causal interaction,therapeutic application,unassigned 1,1,0 1.14.16.4 Irritable Bowel Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21154152&form=6&db=m LX-1031, a tryptophan 5-hydroxylase inhibitor that reduces 5-HT levels for the potential treatment of irritable bowel syndrome. causal interaction,therapeutic application,unassigned 3,4,0 1.14.16.4 Irritable Bowel Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21684281&form=6&db=m The Tryptophan Hydroxylase Inhibitor LX1031 Shows Clinical Benefit in Patients With Nonconstipating Irritable Bowel Syndrome. causal interaction,therapeutic application,unassigned 1,2,0 1.14.16.4 Irritable Bowel Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22323131&form=6&db=m SERT and TPH-1 mRNA expression are reduced in Irritable Bowel Syndrome patients irrespective of visceral sensitivity state in large intestine. diagnostic usage,ongoing research,unassigned 3,2,0 1.14.16.4 Irritable Bowel Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23172723&form=6&db=m TPH Gene Polymorphisms Are Associated With Disease Perception and Quality of Life in Women With Irritable Bowel Syndrome. ongoing research,unassigned 2,0 1.14.16.4 Irritable Bowel Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28948742&form=6&db=m [Effects of baldrinal of Valeriana jatamansi on expression of CRF, TPH1 mRNA and 5-HT in rats with irritable bowel syndrome]. ongoing research,unassigned 3,0 1.14.16.4 Irritable Bowel Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29035515&form=6&db=m Isoform-Specific Substrate Inhibition Mechanism of Human Tryptophan Hydroxylase. causal interaction,therapeutic application,unassigned 1,1,0 1.14.16.4 Irritable Bowel Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32705826&form=6&db=m [Moxibustion relieves abdominal hypersensitivity and diarrhea by regulating colonic 5-hydroxytryptamine signaling pathway in rats with diarrhea type irritable bowel syndrome]. causal interaction,ongoing research,unassigned 1,3,0 1.14.16.4 Learning Disabilities http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14720417&form=6&db=m [Association between tryptophan hydroxylase gene polymorphisms and attention deficit hyperactivity disorder with or without learning disorder] causal interaction,unassigned 4,0 1.14.16.4 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7615072&form=6&db=m Rapid turnover of tryptophan hydroxylase in serotonin producing cells: demonstration of ATP-dependent proteolytic degradation. ongoing research,unassigned 4,0 1.14.16.4 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23158905&form=6&db=m Flavanocoumarins from Guazuma ulmifolia bark and evaluation of their affinity for STAT1. ongoing research,therapeutic application,unassigned 3,1,0 1.14.16.4 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24934683&form=6&db=m Cytotoxic compounds from the leaves of Garcinia polyantha. ongoing research,therapeutic application,unassigned 1,1,0 1.14.16.4 Leukocytosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23243271&form=6&db=m Platelet serotonin promotes the recruitment of neutrophils to sites of acute inflammation in mice. unassigned - 1.14.16.4 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33417443&form=6&db=m Peripheral Selective Oxadiazolylphenyl Alanine Derivatives as Tryptophan Hydroxylase 1 Inhibitors for Obesity and Fatty Liver Disease. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0 1.14.16.4 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18274776&form=6&db=m Sicilian family with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) and lethal lung disease in one of the affected brothers. causal interaction,unassigned 1,0 1.14.16.4 Malnutrition http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3240344&form=6&db=m [Intrauterine malnutrition. II. L-tryptophan, tryptophan-5-hydroxylase and serotonin in the brain of rats] unassigned - 1.14.16.4 Malnutrition http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7747596&form=6&db=m Early nutritional changes modify the kinetics and phosphorylation capacity of tryptophan-5-hydroxylase. causal interaction,unassigned 1,0 1.14.16.4 Malnutrition http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22819790&form=6&db=m Increased expression of tryptophan-5-hydroxylase 1, but not 2, in brainstem as a result of intrauterine malnutrition. diagnostic usage,ongoing research,unassigned 2,3,0 1.14.16.4 Mastocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1522951&form=6&db=m Inhibition of tryptophan hydroxylase by (R)- and (S)-1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolines (salsolinols). ongoing research,unassigned 2,0 1.14.16.4 Mastocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1714508&form=6&db=m Isolation and structural characterization of the murine tryptophan hydroxylase gene. ongoing research,unassigned 3,0 1.14.16.4 Mastocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2110547&form=6&db=m Characterization and chromosomal mapping of a cDNA encoding tryptophan hydroxylase from a mouse mastocytoma cell line. ongoing research,therapeutic application,unassigned 4,1,0 1.14.16.4 Mastocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3110558&form=6&db=m Tryptophan 5-monooxygenase from mouse mastocytoma: high-performance liquid chromatography assay. unassigned - 1.14.16.4 Mastocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3110559&form=6&db=m Tryptophan 5-monooxygenase from mouse mastocytoma clone P815. ongoing research,unassigned 1,0 1.14.16.4 Mastocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6809461&form=6&db=m Tryptophan 5-monooxygenase from mouse mastocytoma P815. A simple purification and general properties. ongoing research,unassigned 2,0 1.14.16.4 Mastocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6813320&form=6&db=m Tryptophan hydroxylase from mouse mastocytoma P-815. Reversible activation by ethylenediaminetetraacetate. unassigned - 1.14.16.4 Mastocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7615072&form=6&db=m Rapid turnover of tryptophan hydroxylase in serotonin producing cells: demonstration of ATP-dependent proteolytic degradation. ongoing research,unassigned 4,0 1.14.16.4 Mastocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9159879&form=6&db=m Characterization of yellowfin tuna (Thunnus albacares, Scombroidei) tryptophan hydroxylase. ongoing research,unassigned 3,0 1.14.16.4 Mastocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10421874&form=6&db=m Immunohistochemical localization of tryptophan hydroxylase in the human and rat gastrointestinal tracts. ongoing research,unassigned 4,0 1.14.16.4 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11821057&form=6&db=m Conversion of L-tryptophan to serotonin and melatonin in human melanoma cells. ongoing research,unassigned 2,0 1.14.16.4 Melanoma, Amelanotic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12406341&form=6&db=m Serotoninergic system in hamster skin. diagnostic usage,ongoing research,unassigned 1,4,0 1.14.16.4 Memory Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26013962&form=6&db=m Serotonin Transporter and Tryptophan Hydroxylase Gene Variations Mediate Working Memory Deficits of Cocaine Users. therapeutic application,unassigned 1,0 1.14.16.4 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6143470&form=6&db=m Deficiency of tyrosine hydroxylase or tryptophan hydroxylase: a possible cause of two hypothetical metabolic diseases. causal interaction,unassigned 4,0 1.14.16.4 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19125159&form=6&db=m Variations in tryptophan hydroxylase 2 linked to decreased serotonergic activity are associated with elevated risk for metabolic syndrome in depression. causal interaction,diagnostic usage,unassigned 4,4,0 1.14.16.4 Migraine Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16200390&form=6&db=m A genetic analysis of serotonergic biosynthetic and metabolic enzymes in migraine using a DNA pooling approach. diagnostic usage,ongoing research,unassigned 3,4,0 1.14.16.4 Migraine Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17194593&form=6&db=m The A218C polymorphism of tryptophan hydroxylase gene and migraine. diagnostic usage,ongoing research,unassigned 2,4,0 1.14.16.4 Migraine Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19434366&form=6&db=m Functional gene variants of the serotonin-synthesizing enzyme tryptophan hydroxylase 2 in migraine. ongoing research,unassigned 3,0 1.14.16.4 Migraine Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21631476&form=6&db=m Mechanisms of pain modulation by sex hormones in migraine. causal interaction,unassigned 3,0 1.14.16.4 Migraine Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24458851&form=6&db=m Tryptophan hydroxylase 2 gene polymorphisms in Japanese patients with medication overuse headaches. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 1.14.16.4 Mucocutaneous Lymph Node Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19763617&form=6&db=m Involvement of tryptophan hydroxylase 2 (TPH2) gene polymorphisms in susceptibility to coronary artery lesions in Korean children with Kawasaki disease. causal interaction,diagnostic usage,unassigned 4,3,0 1.14.16.4 Myoclonus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=307327&form=6&db=m Post-hypoxic intention myoclonus treated with 5-hydroxy-tryptophan and an extracerebral decarboxylase inhibitor. therapeutic application,unassigned 1,0 1.14.16.4 Myoclonus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6130489&form=6&db=m Tryptamine-induced myoclonus in guinea-pigs pretreated with a monoamine oxidase inhibitor indicates pre- and post-synaptic actions of tryptamine upon central indoleamine systems. therapeutic application,unassigned 1,0 1.14.16.4 Narcolepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11444684&form=6&db=m Serotonergic polymorphisms in patients suffering from alcoholism, anxiety disorders and narcolepsy. causal interaction,diagnostic usage,unassigned 4,2,0 1.14.16.4 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10953292&form=6&db=m Tryptophan hydroxylase and 5-hydroxytryptamine in carcinoids of the gastrointestinal tract. diagnostic usage,ongoing research,unassigned 4,4,0 1.14.16.4 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11106255&form=6&db=m The aromatic-L-amino acid decarboxylase inhibitor carbidopa is selectively cytotoxic to human pulmonary carcinoid and small cell lung carcinoma cells. ongoing research,unassigned 2,0 1.14.16.4 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=192079&form=6&db=m Gastrointestinal and metabolic function in patients with the carcinoid syndrome. causal interaction,unassigned 3,0 1.14.16.4 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=761167&form=6&db=m Malignant melanoma producing serotonin. diagnostic usage,ongoing research,unassigned 1,2,0 1.14.16.4 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6767445&form=6&db=m Comparisons of tryptophan hydroxylase from a malignant murine mast cell tumor and rat mesencephalic tegmentum. ongoing research,unassigned 4,0 1.14.16.4 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7575647&form=6&db=m Elevated aromatic-L-amino acid decarboxylase in human carcinoid tumors. unassigned - 1.14.16.4 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8925846&form=6&db=m Successful and unsuccessful approaches to imaging carcinoids: comparison of a radiolabelled tryptophan hydroxylase inhibitor with a tracer of biogenic amine uptake and storage, and a somatostatin analogue. unassigned - 1.14.16.4 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10953292&form=6&db=m Tryptophan hydroxylase and 5-hydroxytryptamine in carcinoids of the gastrointestinal tract. diagnostic usage,ongoing research,unassigned 4,4,0 1.14.16.4 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11334877&form=6&db=m Methylenedioxymethamphetamine-induced suppression of interleukin-1beta and tumour necrosis factor-alpha is not mediated by serotonin. ongoing research,therapeutic application,unassigned 3,3,0 1.14.16.4 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11683520&form=6&db=m Changes in serotonin dynamics in the gastrointestinal tract of colon-26 tumour-bearing mice: effects of cisplatin treatment. causal interaction,ongoing research,unassigned 3,3,0 1.14.16.4 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17099150&form=6&db=m Selection of reference genes for quantitative real-time PCR analysis in canine mammary tumors using the GeNorm algorithm. diagnostic usage,ongoing research,unassigned 1,1,0 1.14.16.4 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17971073&form=6&db=m Histological features and expression of enzymes implicated in melatonin synthesis in pineal parenchymal tumours and in cultured tumoural pineal cells. causal interaction,ongoing research,unassigned 1,4,0 1.14.16.4 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19050963&form=6&db=m Principal component analysis, hierarchical clustering, and decision tree assessment of plasma mRNA and hormone levels as an early detection strategy for small intestinal neuroendocrine (carcinoid) tumors. unassigned - 1.14.16.4 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23008335&form=6&db=m Tryptophan hydroxylase-1 regulates immune tolerance and inflammation. causal interaction,ongoing research,unassigned 4,1,0 1.14.16.4 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24337018&form=6&db=m 4-Chloro-DL-phenylalanine protects against monocrotaline?induced pulmonary vascular remodeling and lung inflammation. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 1.14.16.4 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27347369&form=6&db=m Update on management of midgut neuroendocrine tumors. causal interaction,therapeutic application,unassigned 3,4,0 1.14.16.4 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27871326&form=6&db=m Tryptophan hydroxylase 1 and 5-HT diagnostic usage,ongoing research,unassigned 1,4,0 1.14.16.4 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29067122&form=6&db=m Analgesic activity of cynaropicrinon on post-inflammatory irritable bowel syndrome visceral hypersensitivity in a rat model. causal interaction,unassigned 4,0 1.14.16.4 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31798304&form=6&db=m Tryptophan Metabolism as Source of New Prognostic Biomarkers for FAP Patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,1 1.14.16.4 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31997472&form=6&db=m Induction of tryptophan hydroxylase in the liver of s.c. tumor model of prostate cancer. ongoing research,unassigned 3,0 1.14.16.4 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33525332&form=6&db=m Serotonin Pathway in Cancer. causal interaction,therapeutic application,unassigned 3,4,0 1.14.16.4 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20487987&form=6&db=m Serotonin in neuroblastoma x glioma NG108-15 hybrid cells. diagnostic usage,unassigned 3,0 1.14.16.4 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21785940&form=6&db=m Transcriptional modulation of monoaminergic neurotransmission genes by the histone deacetylase inhibitor trichostatin A in neuroblastoma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 1.14.16.4 Neuroendocrine Tumors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9840098&form=6&db=m Tryptophan hydroxylase antibodies used in the diagnosis of carcinoid. causal interaction,diagnostic usage,therapeutic application,unassigned 2,4,1,0 1.14.16.4 Neuroendocrine Tumors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29724499&form=6&db=m Changes in Weight Associated With Telotristat Ethyl in the Treatment of Carcinoid Syndrome. therapeutic application,unassigned 3,0 1.14.16.4 Neuroendocrine Tumors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31319410&form=6&db=m Efficacy of the tryptophan hydroxylase inhibitor telotristat on growth and serotonin secretion in 2D and 3D cultured pancreatic neuroendocrine tumor cells. diagnostic usage,ongoing research,unassigned 3,3,0 1.14.16.4 Neuroendocrine Tumors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32801896&form=6&db=m Antiproliferative Effects of Telotristat Ethyl in Patients with Neuroendocrine Tumors: The TELEACE Real-World Chart Review Study. unassigned - 1.14.16.4 Neuroendocrine Tumors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33525332&form=6&db=m Serotonin Pathway in Cancer. causal interaction,therapeutic application,unassigned 3,4,0 1.14.16.4 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23008335&form=6&db=m Tryptophan hydroxylase-1 regulates immune tolerance and inflammation. causal interaction,ongoing research,unassigned 4,1,0 1.14.16.4 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33329133&form=6&db=m Beneficial Effects of Exercise on Depression and Anxiety During the Covid-19 Pandemic: A Narrative Review. causal interaction,unassigned 2,0 1.14.16.4 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10564740&form=6&db=m Increased binding at 5-HT(1A), 5-HT(1B), and 5-HT(2A) receptors and 5-HT transporters in diet-induced obese rats. ongoing research,unassigned 3,0 1.14.16.4 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20215417&form=6&db=m High fat diet leads to tissue specific changes reflecting risk factors for diseases in DBA/2J mice. causal interaction,ongoing research,unassigned 4,2,0 1.14.16.4 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23940384&form=6&db=m Properties of myenteric neurons and mucosal functions in the distal colon of diet-induced obese mice. ongoing research,unassigned 4,0 1.14.16.4 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26381270&form=6&db=m Altered intestinal neuroendocrine gene expression in humans with obesity. diagnostic usage,ongoing research,unassigned 3,1,0 1.14.16.4 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27126880&form=6&db=m Serotonin as a New Therapeutic Target for Diabetes Mellitus and Obesity. causal interaction,unassigned 4,0 1.14.16.4 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33417443&form=6&db=m Peripheral Selective Oxadiazolylphenyl Alanine Derivatives as Tryptophan Hydroxylase 1 Inhibitors for Obesity and Fatty Liver Disease. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0 1.14.16.4 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33427054&form=6&db=m Investigating the complex interplay between genotype and high-fat-diet feeding in the lactating mammary gland using the Tph1 and Ldlr knockout models. ongoing research,therapeutic application,unassigned 3,2,0 1.14.16.4 Osteoporosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24844139&form=6&db=m Tryptophan hydroxylase 1 (Tph-1)-targeted bone anabolic agents for osteoporosis. therapeutic application,unassigned 3,0 1.14.16.4 Osteoporosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25930119&form=6&db=m Ursolic acid derivatives as bone anabolic agents targeted to tryptophan hydroxylase 1 (Tph-1). causal interaction,diagnostic usage,therapeutic application,unassigned 2,4,4,0 1.14.16.4 Paralysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4020380&form=6&db=m Tryptophan hydroxylase activity in the brains of controls and parkinsonian patients. diagnostic usage,ongoing research,unassigned 4,4,0 1.14.16.4 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4020380&form=6&db=m Tryptophan hydroxylase activity in the brains of controls and parkinsonian patients. diagnostic usage,ongoing research,unassigned 4,4,0 1.14.16.4 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8783276&form=6&db=m Dopaminergic transplants alter in vivo activity of tryptophan hydroxylase in the striatum in a rat model of Parkinson's disease. ongoing research,unassigned 2,0 1.14.16.4 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14991820&form=6&db=m Involvement of medullary serotonergic groups in multiple system atrophy. diagnostic usage,ongoing research,unassigned 4,3,0 1.14.16.4 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21105877&form=6&db=m Tryptophan hydroxylase 2 aggregates through disulfide cross-linking upon oxidation: possible link to serotonin deficits and non-motor symptoms in Parkinson's disease. unassigned - 1.14.16.4 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27237108&form=6&db=m Tryptophan hydroxylase type 2 variants modulate severity and outcome of addictive behaviors in Parkinson's disease. causal interaction,unassigned 2,0 1.14.16.4 Phenylketonurias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1974311&form=6&db=m The effect of plasma valine, isoleucine and leucine on the control of the flux through tyrosine- and tryptophan-hydroxylase in the brain. causal interaction,unassigned 3,0 1.14.16.4 Phenylketonurias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2109147&form=6&db=m The control of 5-hydroxytryptamine and dopamine synthesis in the brain: a theoretical approach. causal interaction,unassigned 3,0 1.14.16.4 Phenylketonurias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17513427&form=6&db=m Inherited disorders affecting dopamine and serotonin: critical neurotransmitters derived from aromatic amino acids. diagnostic usage,unassigned 3,0 1.14.16.4 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1359535&form=6&db=m "7-tetrahydrobiopterin," a naturally occurring analogue of tetrahydrobiopterin, is a cofactor for and a potential inhibitor of the aromatic amino acid hydroxylases. diagnostic usage,unassigned 1,0 1.14.16.4 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3974452&form=6&db=m Increased dopamine production in patients with carcinoid tumors. unassigned - 1.14.16.4 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24337018&form=6&db=m 4-Chloro-DL-phenylalanine protects against monocrotaline?induced pulmonary vascular remodeling and lung inflammation. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 1.14.16.4 Polyendocrinopathies, Autoimmune http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18274776&form=6&db=m Sicilian family with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) and lethal lung disease in one of the affected brothers. causal interaction,unassigned 1,0 1.14.16.4 Polyendocrinopathies, Autoimmune http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19107747&form=6&db=m Autoantibodies in autoimmune polyglandular syndrome type I patients react with major brain neurotransmitter systems. unassigned - 1.14.16.4 Polyendocrinopathies, Autoimmune http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25502918&form=6&db=m APECED syndrome in childhood: clinical spectrum is enlarging. causal interaction,therapeutic application,unassigned 3,4,0 1.14.16.4 Polyendocrinopathies, Autoimmune http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25805658&form=6&db=m Gastrointestinal immunity against tryptophan hydroxylase-1, aromatic L-amino-acid decarboxylase, AIE-75, villin and Paneth cells in APECED. ongoing research,unassigned 1,0 1.14.16.4 Polyendocrinopathies, Autoimmune http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30608907&form=6&db=m Serotonin and tryptophan metabolites, autoantibodies and gut microbiome in APECED. causal interaction,diagnostic usage,unassigned 2,2,0 1.14.16.4 Premature Ejaculation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32169437&form=6&db=m Association Between Lifelong Premature Ejaculation and Polymorphism of Tryptophan Hydroxylase 2 Gene in the Han Population. unassigned - 1.14.16.4 Premenstrual Dysphoric Disorder http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17026953&form=6&db=m Serotonin transporter, tryptophan hydroxylase, and monoamine oxidase A gene polymorphisms in premenstrual dysphoric disorder. causal interaction,therapeutic application,unassigned 2,1,0 1.14.16.4 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22866066&form=6&db=m Serotonin synthesis and metabolism-related molecules in a human prostate cancer cell line. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,4,0 1.14.16.4 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31997472&form=6&db=m Induction of tryptophan hydroxylase in the liver of s.c. tumor model of prostate cancer. ongoing research,unassigned 3,0 1.14.16.4 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33087457&form=6&db=m Pancreatic Sirtuin 3 Deficiency Promotes Hepatic Steatosis by Enhancing 5-Hydroxytryptamine Synthesis in Mice With Diet-Induced Obesity. causal interaction,unassigned 4,0 1.14.16.4 Pulmonary Arterial Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17130306&form=6&db=m Effect of tryptophan hydroxylase 1 deficiency on the development of hypoxia-induced pulmonary hypertension. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 1.14.16.4 Pulmonary Arterial Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21464983&form=6&db=m Altered gene expression in pulmonary tissue of tryptophan hydroxylase-1 knockout mice: implications for pulmonary arterial hypertension. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 1.14.16.4 Pulmonary Arterial Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23087024&form=6&db=m Imatinib attenuates hypoxia-induced pulmonary arterial hypertension pathology via reduction in 5-hydroxytryptamine through inhibition of tryptophan hydroxylase 1 expression. causal interaction,therapeutic application,unassigned 2,4,0 1.14.16.4 Pulmonary Arterial Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24337018&form=6&db=m 4-Chloro-DL-phenylalanine protects against monocrotaline?induced pulmonary vascular remodeling and lung inflammation. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 1.14.16.4 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28434116&form=6&db=m Activation of the Serotonin Pathway is Associated with Poor Outcome in COPD Exacerbation: Results of a Long-Term Cohort Study. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 1.14.16.4 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31581603&form=6&db=m Dysregulation of the Tryptophan Pathway Evidences Gender Differences in COPD. causal interaction,therapeutic application,unassigned 4,1,0 1.14.16.4 Rabies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19433074&form=6&db=m Localization of Serotoninergic Neurons that Participate in Regulating Diaphragm Activity in the Cat. diagnostic usage,unassigned 3,0 1.14.16.4 Scoliosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18794762&form=6&db=m Association study of tryptophan hydroxylase 1 and arylalkylamine N-acetyltransferase polymorphisms with adolescent idiopathic scoliosis in Han Chinese. ongoing research,unassigned 1,0 1.14.16.4 Scoliosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33545939&form=6&db=m Association study of single nucleotide polymorphism in tryptophan hydroxylase 1 gene with adolescent idiopathic scoliosis: A meta-analysis. unassigned - 1.14.16.4 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22826223&form=6&db=m Macrophage migration inhibitory factor mediates the antidepressant actions of voluntary exercise. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 1.14.16.4 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24925295&form=6&db=m Experimental studies on genetically determined predisposition to catatonia in rats as a model of schizophrenia. causal interaction,unassigned 3,0 1.14.16.4 Shy-Drager Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4020380&form=6&db=m Tryptophan hydroxylase activity in the brains of controls and parkinsonian patients. diagnostic usage,ongoing research,unassigned 4,4,0 1.14.16.4 Sleep Deprivation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6204343&form=6&db=m Increased brain serotonin metabolism during rebound sleep in sleep-deprived rats. unassigned - 1.14.16.4 Sleep Initiation and Maintenance Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2527339&form=6&db=m Reversibility of para-chlorophenylalanine-induced insomnia by intrahypothalamic microinjection of L-5-hydroxytryptophan. unassigned - 1.14.16.4 Sleep Initiation and Maintenance Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29952309&form=6&db=m Association of Tryptophan Hydroxylase-2 Gene rs4290270 with Primary Insomnia and Depressive Symptoms in a Chinese Han Population. diagnostic usage,ongoing research,unassigned 3,2,0 1.14.16.4 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24068759&form=6&db=m Synthesis, transport and metabolism of serotonin formed from exogenously applied 5-HTP after spinal cord injury in rats. unassigned - 1.14.16.4 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27572262&form=6&db=m Serotonin signaling mediates protein valuation and aging. therapeutic application,unassigned 1,0 1.14.16.4 Steatorrhea http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=192079&form=6&db=m Gastrointestinal and metabolic function in patients with the carcinoid syndrome. causal interaction,unassigned 3,0 1.14.16.4 Striatonigral Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4020380&form=6&db=m Tryptophan hydroxylase activity in the brains of controls and parkinsonian patients. diagnostic usage,ongoing research,unassigned 4,4,0 1.14.16.4 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33523710&form=6&db=m LIM kinase inhibitor T56-LIMKi protects mouse brain from photothrombotic stroke. ongoing research,therapeutic application,unassigned 3,2,0 1.14.16.4 Stupor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12667915&form=6&db=m Behavioral and neurochemical effects induced by subchronic exposure to 40 ppm toluene in rats. ongoing research,unassigned 3,0 1.14.16.4 Stupor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15135026&form=6&db=m Behavioral and neurochemical effects induced by subchronic combined exposure to toluene at 40 ppm and noise at 80 dB-A in rats. ongoing research,unassigned 3,0 1.14.16.4 Supranuclear Palsy, Progressive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4020380&form=6&db=m Tryptophan hydroxylase activity in the brains of controls and parkinsonian patients. diagnostic usage,ongoing research,unassigned 4,4,0 1.14.16.4 Temporomandibular Joint Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18813430&form=6&db=m Association between tryptophan hydroxylase gene polymorphism and painful non-osseous temporomandibular disorders. ongoing research,unassigned 1,0 1.14.16.4 Teratoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1140&form=6&db=m Neurochemical studies in a mouse teratoma with neuroepithelial differentiation. Presence of cyclic AMP, serotonin and enzymes of the serotonergic, adrenergic and cholinergic systems. ongoing research,unassigned 2,0 1.14.16.4 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1993891&form=6&db=m Stereotaxic injection of tetanus toxin in rat central nervous system causes alteration in normal levels of monoamines. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 1.14.16.4 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27053202&form=6&db=m Partial Raphe Dysfunction in Neurotransmission Is Sufficient to Increase Mortality after Anoxic Exposures in Mice at a Critical Period in Postnatal Development. ongoing research,unassigned 2,0 1.14.16.4 Thromboembolism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16924415&form=6&db=m Development of antithrombotic miniribozymes that target peripheral tryptophan hydroxylase. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0 1.14.16.4 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16924415&form=6&db=m Development of antithrombotic miniribozymes that target peripheral tryptophan hydroxylase. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0 1.14.16.4 Tic Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23360517&form=6&db=m Involvement of tryptophan hydroxylase 2 gene polymorphisms in susceptibility to tic disorder in Chinese Han population. causal interaction,therapeutic application,unassigned 4,1,0 1.14.16.4 Tourette Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17592484&form=6&db=m Role of the novel tryptophan hydroxylase-2 gene in Tourette syndrome. causal interaction,ongoing research,unassigned 1,2,0 1.14.16.4 Tremor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14529803&form=6&db=m Serotonin synthesis inhibition in olivo-cerebellar system attenuates harmaline-induced tremor in Swiss albino mice. ongoing research,therapeutic application,unassigned 2,1,0 1.14.16.4 Tremor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15990178&form=6&db=m Evidence for the involvement of central serotonergic mechanisms in cholinergic tremor induced by tacrine in Balb/c mice. causal interaction,therapeutic application,unassigned 3,2,0 1.14.16.4 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27796714&form=6&db=m Up-regulation of cathepsin S expression by HSP90 and 5-HT7 receptor-dependent serotonin signaling correlates with triple negativity of human breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 1.14.16.4 tryptophan 5-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17130306&form=6&db=m Effect of tryptophan hydroxylase 1 deficiency on the development of hypoxia-induced pulmonary hypertension. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 1.14.16.4 tryptophan 5-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23008335&form=6&db=m Tryptophan hydroxylase-1 regulates immune tolerance and inflammation. causal interaction,ongoing research,unassigned 4,1,0 1.14.16.4 tryptophan 5-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24553000&form=6&db=m Role of brain cytochrome P450 (CYP2D) in the metabolism of monoaminergic neurotransmitters. causal interaction,unassigned 3,0 1.14.16.4 tryptophan 5-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30931940&form=6&db=m Identification of serum metabolites associating with chronic kidney disease progression and anti-fibrotic effect of 5-methoxytryptophan. causal interaction,unassigned 4,0 1.14.16.4 tryptophan 5-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33062239&form=6&db=m Poricoic acid A as a modulator of TPH-1 expression inhibits renal fibrosis via modulating protein stability of ?-catenin and ?-catenin-mediated transcription. unassigned - 1.14.16.4 Vitiligo http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22415302&form=6&db=m Blunted epidermal L-tryptophan metabolism in vitiligo affects immune response and ROS scavenging by Fenton chemistry, part 1: epidermal H2O2/ONOO--mediated stress abrogates tryptophan hydroxylase and dopa decarboxylase activities, leading to low serotonin and melatonin levels. unassigned -