1.14.15.3 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3455615&form=6&db=m Effect of dietary acid and calcium on 25-hydroxyvitamin D metabolism by chick kidney. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 1.14.15.3 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7124941&form=6&db=m Inhibition of 25-hydroxyvitamin D3-1-hydroxylase by chronic metabolic acidosis. unassigned - 1.14.15.3 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9012361&form=6&db=m Overexpression of the heme oxygenase gene in renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0 1.14.15.3 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23846787&form=6&db=m Differential Expression of Cytochrome P450 Omega-hydroxylase Isoforms and Their Association with Clinicopathological Features in Pancreatic Ductal Adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,2,0 1.14.15.3 Albuminuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19208908&form=6&db=m Mechanisms of podocyte injury in diabetes: role of cytochrome P450 and NADPH oxidases. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0 1.14.15.3 Albuminuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22874759&form=6&db=m Disorder of fatty acid metabolism in the kidney of PAN-induced nephrotic rats. causal interaction,therapeutic application,unassigned 3,3,0 1.14.15.3 alkane 1-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18385420&form=6&db=m Association of a CYP4A11 variant and blood pressure in black men. causal interaction,unassigned 4,0 1.14.15.3 alkane 1-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25064769&form=6&db=m Genetic variation in CYP4A11 and blood pressure response to mineralocorticoid receptor antagonism or ENaC inhibition: an exploratory pilot study in African Americans. causal interaction,therapeutic application,unassigned 4,1,0 1.14.15.3 Ascorbic Acid Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2830915&form=6&db=m [Effect of ascorbic acid on 25-hydroxyvitamin D3 metabolism in the kidneys and 1,25-dihydroxyvitamin D3 reception in the small intestine mucosa of guinea pigs] unassigned - 1.14.15.3 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15066132&form=6&db=m Expression of cytochrome P450 4A mRNA in mouse lung: effect of clofibrate and interleukin-1beta. causal interaction,unassigned 4,0 1.14.15.3 Bacterial Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24413902&form=6&db=m Altered Inflammatory Responses to Citrobacter rodentium Infection, but not Bacterial Lipopolysaccharide, in Mice Lacking the Cyp4a10 or Cyp4a14 Genes. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,2 1.14.15.3 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30571981&form=6&db=m Astrocytic cytochrome P450 4A/20-hydroxyeicosatetraenoic acid contributes to angiogenesis in the experimental ischemic stroke. ongoing research,therapeutic application,unassigned 1,4,0 1.14.15.3 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28481877&form=6&db=m CYP4A in tumor-associated macrophages promotes pre-metastatic niche formation and metastasis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 1.14.15.3 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32040184&form=6&db=m An evaluation of the human relevance of the liver tumors observed in female mice treated with permethrin based on mode of action. unassigned - 1.14.15.3 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24990856&form=6&db=m Combined therapy with COX-2 inhibitor and 20-HETE inhibitor reduces colon tumor growth and the adverse effects of ischemic stroke associated with COX-2 inhibition. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 1.14.15.3 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32047554&form=6&db=m Alteration of CYP4A11 expression in renal cell carcinoma: diagnostic and prognostic implications. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,4,1 1.14.15.3 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15716483&form=6&db=m Evaluation of polycyclic aromatic hydrocarbons in the activation of early growth response-1 and peroxisome proliferator activated receptors. ongoing research,unassigned 2,0 1.14.15.3 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16712844&form=6&db=m CYP4A11 is repressed by retinoic acid in human liver cells. ongoing research,unassigned 4,0 1.14.15.3 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21205922&form=6&db=m Genistein, Resveratrol, and 5-Aminoimidazole-4-carboxamide-1-{beta}-D-ribofuranoside Induce Cytochrome P450 4F2 Expression through an AMP-Activated Protein Kinase-Dependent Pathway. ongoing research,unassigned 1,0 1.14.15.3 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30069903&form=6&db=m Cytochrome P450 4A11 expression in tumor cells: A favorable prognostic factor for hepatocellular carcinoma patients. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,2,0 1.14.15.3 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32047554&form=6&db=m Alteration of CYP4A11 expression in renal cell carcinoma: diagnostic and prognostic implications. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,4,1 1.14.15.3 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19889059&form=6&db=m 3-methylcholanthrene and benzo(a)pyrene modulate cardiac cytochrome P450 gene expression and arachidonic acid metabolism in male Sprague Dawley rats. causal interaction,therapeutic application,unassigned 4,4,0 1.14.15.3 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24472606&form=6&db=m Acute mercury toxicity modulates cytochrome P450, soluble epoxide hydrolase and their associated arachidonic acid metabolites in C57Bl/6 mouse heart. causal interaction,unassigned 2,0 1.14.15.3 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15576629&form=6&db=m Constitutive expression of peroxisome proliferator-activated receptor alpha-regulated genes in dwarf mice. unassigned - 1.14.15.3 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21820496&form=6&db=m Genetic polymorphism of CYP4A11 and CYP4A22 genes and in silico insights from comparative 3D modelling in a French population. causal interaction,therapeutic application,unassigned 4,4,0 1.14.15.3 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31480463&form=6&db=m Molecular Functionality of Cytochrome P450 4 (CYP4) Genetic Polymorphisms and Their Clinical Implications. causal interaction,unassigned 3,0 1.14.15.3 Cerebral Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18484194&form=6&db=m Haplotype-based case study of human CYP4A11 gene and cerebral infarction in Japanese subject. ongoing research,unassigned 4,0 1.14.15.3 Cerebrovascular Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30132788&form=6&db=m Genetic role of CYP4A11 polymorphisms in the risk of developing cardiovascular and cerebrovascular diseases. causal interaction,diagnostic usage,unassigned 4,3,0 1.14.15.3 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30423565&form=6&db=m Mice Deficient in Cyp4a14 Have An Increased Number of Goblet Cells and Attenuated Dextran Sulfate Sodium-Induced Colitis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 1.14.15.3 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19615687&form=6&db=m CYP4A11 polymorphism correlates with coronary endothelial dysfunction in patients with coronary artery disease-The ENCORE Trials. causal interaction,unassigned 4,0 1.14.15.3 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22327816&form=6&db=m A Novel Polymorphism of the CYP4A11 Gene is Associated With Coronary Artery Disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 1.14.15.3 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23085321&form=6&db=m Haplotype study of the CYP4A11 gene and coronary artery disease in Han and Uygur populations in China. diagnostic usage,ongoing research,unassigned 1,4,0 1.14.15.3 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29484037&form=6&db=m A Novel Polymorphism in the Promoter of the causal interaction,unassigned 4,0 1.14.15.3 Craniocerebral Trauma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32320934&form=6&db=m Identification of the miRNA-3185/CYP4A11 axis in cardiac tissue as a biomarker for mechanical asphyxia. causal interaction,unassigned 1,0 1.14.15.3 Death, Sudden, Cardiac http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32320934&form=6&db=m Identification of the miRNA-3185/CYP4A11 axis in cardiac tissue as a biomarker for mechanical asphyxia. causal interaction,unassigned 1,0 1.14.15.3 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25309930&form=6&db=m Chronic treatment with Ang-(1-7) reverses abnormal reactivity in the corpus cavernosum and normalizes diabetes-induced changes in the protein levels of ACE, ACE2, ROCK1, ROCK2 and omega-hydroxylase in a rat model of type 1 diabetes. unassigned - 1.14.15.3 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15340111&form=6&db=m Altered kidney CYP2C and cyclooxygenase-2 levels are associated with obesity-related albuminuria. causal interaction,ongoing research,unassigned 4,2,0 1.14.15.3 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31966555&form=6&db=m SiRNA-Cyp4a14 and diabetic nephropathy: silencing of Cyp4a14 by siRNA inhibits proliferation and fibrosis of mesangial cells. ongoing research,unassigned 2,0 1.14.15.3 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34501433&form=6&db=m Genetics Variants in the Epoxygenase Pathway of Arachidonic Metabolism Are Associated with Eicosanoids Levels and the Risk of Diabetic Nephropathy. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 1.14.15.3 Dyslipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17405690&form=6&db=m The role of mercury and cadmium heavy metals in vascular disease, hypertension, coronary heart disease, and myocardial infarction. causal interaction,unassigned 3,0 1.14.15.3 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10454501&form=6&db=m Modulation of cytochrome P-450 gene expression in endotoxemic mice is tissue specific and peroxisome proliferator-activated receptor-alpha dependent. ongoing research,unassigned 2,0 1.14.15.3 Essential Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15611369&form=6&db=m Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 1.14.15.3 Essential Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18227405&form=6&db=m The T8590C polymorphism of CYP4A11 and 20-hydroxyeicosatetraenoic acid in essential hypertension. causal interaction,ongoing research,unassigned 2,1,0 1.14.15.3 Essential Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18300855&form=6&db=m A haplotype of the CYP4A11 gene associated with essential hypertension in Japanese men. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1 1.14.15.3 Essential Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24164311&form=6&db=m CYP4A11 gene T8590C polymorphism is associated with essential hypertension in the male western Chinese Han population. ongoing research,unassigned 3,0 1.14.15.3 Essential Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24278241&form=6&db=m Association between the CYP4A11 T8590C variant and essential hypertension: new data from han chinese and a meta-analysis. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 1.14.15.3 Essential Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28534704&form=6&db=m Associations of CYP4A11 gene-gene and gene-smoking interactions with essential hypertension in the male eastern Chinese Han population. diagnostic usage,ongoing research,unassigned 2,2,0 1.14.15.3 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11296694&form=6&db=m Etiopathogenesis of nonalcoholic steatohepatitis. unassigned - 1.14.15.3 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12829994&form=6&db=m Central role of PPARalpha-dependent hepatic lipid turnover in dietary steatohepatitis in mice. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 1.14.15.3 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18433732&form=6&db=m Cytochrome P450 omega hydroxylase (CYP4) function in fatty acid metabolism and metabolic diseases. causal interaction,ongoing research,unassigned 3,2,0 1.14.15.3 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20300478&form=6&db=m PPAR/RXR Regulation of Fatty Acid Metabolism and Fatty Acid omega-Hydroxylase (CYP4) Isozymes: Implications for Prevention of Lipotoxicity in Fatty Liver Disease. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 1.14.15.3 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26546267&form=6&db=m The direction of cross affects [corrected] obesity after puberty in male but not female offspring. unassigned - 1.14.15.3 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28270609&form=6&db=m Ablation of cytochrome P450 omega-hydroxylase 4A14 gene attenuates hepatic steatosis and fibrosis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 1.14.15.3 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33022287&form=6&db=m MEHP/ethanol co-exposure favors the death of steatotic hepatocytes, possibly through CYP4A and ADH involvement. unassigned - 1.14.15.3 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34135776&form=6&db=m Cytochrome P450 Omega-Hydroxylase 4a14 Attenuates Cholestatic Liver Fibrosis. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 1.14.15.3 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16081682&form=6&db=m Human U251 glioma cell proliferation is suppressed by HET0016 [N-hydroxy-N'-(4-butyl-2-methylphenyl)formamidine], a selective inhibitor of CYP4A. therapeutic application,unassigned 2,0 1.14.15.3 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28602979&form=6&db=m Inhibition of CYP4A by a novel flavonoid FLA-16 prolongs survival and normalizes tumor vasculature in glioma. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 1.14.15.3 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31438982&form=6&db=m Inhibition of COX-2, mPGES-1 and CYP4A by isoliquiritigenin blocks the angiogenic Akt signaling in glioma through ceRNA effect of miR-194-5p and lncRNA NEAT1. causal interaction,therapeutic application,unassigned 2,3,0 1.14.15.3 Gliosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16352703&form=6&db=m 9L gliosarcoma cell proliferation and tumor growth in rats are suppressed by N-hydroxy-N'-(4-butyl-2-methylphenol) formamidine (HET0016), a selective inhibitor of CYP4A. unassigned - 1.14.15.3 Glucose Intolerance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17405690&form=6&db=m The role of mercury and cadmium heavy metals in vascular disease, hypertension, coronary heart disease, and myocardial infarction. causal interaction,unassigned 3,0 1.14.15.3 Gout http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9598031&form=6&db=m Decreased serum concentrations of 1,25(OH)2-vitamin D3 in patients with gout. causal interaction,unassigned 3,0 1.14.15.3 Hematuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3199682&form=6&db=m Renal 25-hydroxyvitamin D3-1-hydroxylase in patients with renal disease. causal interaction,diagnostic usage,unassigned 3,1,0 1.14.15.3 Hemorrhagic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20130494&form=6&db=m Association of common variants of CYP4A11 and CYP4F2 with stroke in the Han Chinese population. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,3 1.14.15.3 Hemorrhagic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31514409&form=6&db=m Conflicting Roles of 20-HETE in Hypertension and Stroke. causal interaction,therapeutic application,unassigned 3,1,0 1.14.15.3 Hepatitis, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11992637&form=6&db=m Associations between human liver and kidney cadmium content and immunochemically detected CYP4A11 apoprotein. causal interaction,diagnostic usage,unassigned 2,1,0 1.14.15.3 Hepatomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8571391&form=6&db=m Bifonazole, but not the structurally-related clotrimazole, induces both peroxisome proliferation and members of the cytochrome P4504A sub-family in rat liver. ongoing research,unassigned 1,0 1.14.15.3 Hepatomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9007043&form=6&db=m Hepatic microsomal enzyme induction, beta-oxidation, and cell proliferation following administration of clofibrate, gemfibrozil, or bezafibrate in the CD rat. causal interaction,unassigned 1,0 1.14.15.3 Hypercalcemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8445039&form=6&db=m Parathyroid hormone-related protein (PTHrP) does not regulate 1,25-dihydroxyvitamin D serum levels in hypercalcemia of malignancy. unassigned - 1.14.15.3 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33746109&form=6&db=m Pharmacological regulation of cytochrome P450 metabolites of arachidonic acid attenuates cardiac injury in diabetic rats. causal interaction,unassigned 2,0 1.14.15.3 Hyperparathyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3563383&form=6&db=m [Serum concentrations of 1,25-dihydroxyvitamin D in cases of osteomalacia, parathyroid dysfunction and idiopathic hypercalciuria] causal interaction,unassigned 4,0 1.14.15.3 Hyperparathyroidism, Primary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3840228&form=6&db=m Substrate-product relation of 1-hydroxylase activity in primary hyperparathyroidism. diagnostic usage,therapeutic application,unassigned 3,1,0 1.14.15.3 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3800924&form=6&db=m Altered vitamin D metabolism in the kidney of the spontaneously hypertensive rat. causal interaction,unassigned 3,0 1.14.15.3 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8505111&form=6&db=m Clofibrate prevents the development of hypertension in Dahl salt-sensitive rats. ongoing research,unassigned 4,0 1.14.15.3 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9281597&form=6&db=m Developmentally regulated expression of the CYP4A genes in the spontaneously hypertensive rat kidney. causal interaction,unassigned 4,0 1.14.15.3 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10775129&form=6&db=m Contribution of cytochrome P-450 omega-hydroxylase to altered arteriolar reactivity with high-salt diet and hypertension. ongoing research,unassigned 4,0 1.14.15.3 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11781816&form=6&db=m Differential effect of cytochrome P-450 omega-hydroxylase inhibition on O2-induced constriction of arterioles in SHR with early and established hypertension. causal interaction,therapeutic application,unassigned 2,1,0 1.14.15.3 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12505434&form=6&db=m Potential for early involvement of CYP isoforms in aspects of human cadmium toxicity. causal interaction,ongoing research,unassigned 4,2,0 1.14.15.3 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15340111&form=6&db=m Altered kidney CYP2C and cyclooxygenase-2 levels are associated with obesity-related albuminuria. causal interaction,ongoing research,unassigned 4,2,0 1.14.15.3 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15611369&form=6&db=m Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 1.14.15.3 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16144986&form=6&db=m Association of the T8590C polymorphism of CYP4A11 with hypertension in the MONICA Augsburg echocardiographic substudy. causal interaction,unassigned 4,0 1.14.15.3 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16691295&form=6&db=m Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 1.14.15.3 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16957555&form=6&db=m Association of a functional polymorphism in the CYP4A11 gene with systolic blood pressure in survivors of myocardial infarction. ongoing research,unassigned 2,0 1.14.15.3 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17405690&form=6&db=m The role of mercury and cadmium heavy metals in vascular disease, hypertension, coronary heart disease, and myocardial infarction. causal interaction,unassigned 3,0 1.14.15.3 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17597703&form=6&db=m Roles of the cytochrome P450 arachidonic acid monooxygenases in the control of systemic blood pressure and experimental hypertension. ongoing research,unassigned 3,0 1.14.15.3 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17688991&form=6&db=m Lifelong inorganic arsenic compounds consumption affected blood pressure in rats. causal interaction,unassigned 3,0 1.14.15.3 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17693763&form=6&db=m Regulation of ion transport and blood pressure by cytochrome p450 monooxygenases. ongoing research,unassigned 3,0 1.14.15.3 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18227405&form=6&db=m The T8590C polymorphism of CYP4A11 and 20-hydroxyeicosatetraenoic acid in essential hypertension. causal interaction,ongoing research,unassigned 2,1,0 1.14.15.3 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18300855&form=6&db=m A haplotype of the CYP4A11 gene associated with essential hypertension in Japanese men. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1 1.14.15.3 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18356699&form=6&db=m Aging Increases Cytochrome P450 4A Modulation of alpha1-Adrenergic Vasoconstriction in Mesenteric Arteries. causal interaction,unassigned 3,0 1.14.15.3 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18385420&form=6&db=m Association of a CYP4A11 variant and blood pressure in black men. causal interaction,unassigned 4,0 1.14.15.3 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18391101&form=6&db=m A single nucleotide polymorphism in the CYP4F2 but not CYP4A11 gene is associated with increased 20-HETE excretion and blood pressure. ongoing research,unassigned 1,0 1.14.15.3 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18574070&form=6&db=m The V433M variant of the CYP4F2 is associated with ischemic stroke in male Swedes beyond its effect on blood pressure. causal interaction,diagnostic usage,therapeutic application,unassigned 2,4,1,0 1.14.15.3 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18622255&form=6&db=m The relationship between CYP4A11 and human hypertension. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,4,0 1.14.15.3 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18842817&form=6&db=m Transfer of the CYP4A region of chromosome 5 from Lewis to Dahl S rats attenuates renal injury. causal interaction,unassigned 3,0 1.14.15.3 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18936345&form=6&db=m A polymorphism regulates CYP4A11 transcriptional activity and is associated with hypertension in a Japanese population. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 1.14.15.3 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19713718&form=6&db=m Increased Renal Proximal Convoluted Tubule Transport Contributes to Hypertension in Cyp4a14 Knockout Mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1 1.14.15.3 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21326303&form=6&db=m A common polymorphism of CYP4A11 is associated with blood pressure in a Chinese population. ongoing research,therapeutic application,unassigned 4,2,0 1.14.15.3 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21617944&form=6&db=m Arachidonic acid ?-hydroxylase CYP4A11: inter-ethnic variations in the 8590T>C loss-of-function variant. causal interaction,unassigned 4,0 1.14.15.3 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21820496&form=6&db=m Genetic polymorphism of CYP4A11 and CYP4A22 genes and in silico insights from comparative 3D modelling in a French population. causal interaction,therapeutic application,unassigned 4,4,0 1.14.15.3 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21873888&form=6&db=m CYP4A11 T8590C polymorphism, salt-sensitive hypertension, and renal blood flow. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 1.14.15.3 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22173545&form=6&db=m Hypertension, cardiovascular risk and polymorphisms in genes controlling the cytochrome P450 pathway of arachidonic acid: A sex-specific relation? causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 1.14.15.3 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22190908&form=6&db=m Peroxisome Proliferator-Activated Receptor-? Activation Decreases Mean Arterial Pressure, Plasma Interleukin-6, and COX-2 While Increasing Renal CYP4A Expression in an Acute Model of DOCA-Salt Hypertension. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 1.14.15.3 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22442195&form=6&db=m Role of 20-HETE in the antihypertensive effect of transfer of chromosome 5 from Brown Norway to Dahl salt-sensitive rats. ongoing research,unassigned 3,0 1.14.15.3 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22848208&form=6&db=m Peroxisome Proliferator Activated Receptor-? Agonist Slows the Progression of Hypertension, Attenuates Plasma Interleukin-6 Levels and Renal Inflammatory Markers in Angiotensin II Infused Mice. causal interaction,therapeutic application,unassigned 4,1,0 1.14.15.3 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23438293&form=6&db=m Role of the CYP4A/20-HETE pathway in vascular dysfunction of the Dahl salt-sensitive rat. causal interaction,unassigned 2,0 1.14.15.3 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23584425&form=6&db=m 20-HETE and Blood Pressure Regulation: Clinical Implications. causal interaction,unassigned 1,0 1.14.15.3 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23859711&form=6&db=m Genetic associations with hypertension: meta-analyses of six candidate genetic variants. causal interaction,unassigned 3,0 1.14.15.3 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24405547&form=6&db=m [Altered expressions of alkane monooxygenase and hypoxia inducible factor-1? expression in lung tissue of rat hypoxic pulmonary hypertension]. causal interaction,ongoing research,unassigned 1,3,0 1.14.15.3 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24413902&form=6&db=m Altered Inflammatory Responses to Citrobacter rodentium Infection, but not Bacterial Lipopolysaccharide, in Mice Lacking the Cyp4a10 or Cyp4a14 Genes. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,2 1.14.15.3 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24535879&form=6&db=m Association of a CYP4A11 polymorphism and hypertension in the Mongolian and Han populations of China. ongoing research,unassigned 4,0 1.14.15.3 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24931260&form=6&db=m T8590C polymorphism of CYP4A11 is a risk factor for hypertension: a meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,1 1.14.15.3 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24984178&form=6&db=m The effect of a single nucleotide polymorphism of the CYP4F2 gene on blood pressure and 20-hydroxyeicosatetraenoic acid excretion after weight loss. ongoing research,therapeutic application,unassigned 2,1,0 1.14.15.3 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25064769&form=6&db=m Genetic variation in CYP4A11 and blood pressure response to mineralocorticoid receptor antagonism or ENaC inhibition: an exploratory pilot study in African Americans. causal interaction,therapeutic application,unassigned 4,1,0 1.14.15.3 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25760539&form=6&db=m Functional characterization of 10 CYP4A11 allelic variants to evaluate the effect of genotype on arachidonic acid ?-hydroxylation. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 1.14.15.3 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25986599&form=6&db=m Arachidonic acid monooxygenase: Genetic and biochemical approaches to physiological/pathophysiological relevance. diagnostic usage,ongoing research,unassigned 1,2,0 1.14.15.3 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27100515&form=6&db=m Molecular mechanisms and cell signaling of 20-hydroxyeicosatetraenoic acid in vascular pathophysiology. causal interaction,unassigned 2,0 1.14.15.3 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27298316&form=6&db=m 20-Hydroxyeicosatetraenoic Acid (HETE)-dependent Hypertension in Human Cytochrome P450 (CYP) 4A11 Transgenic Mice: NORMALIZATION OF BLOOD PRESSURE BY SODIUM RESTRICTION, HYDROCHLOROTHIAZIDE, OR BLOCKADE OF THE TYPE 1 ANGIOTENSIN II RECEPTOR. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 1.14.15.3 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30132788&form=6&db=m Genetic role of CYP4A11 polymorphisms in the risk of developing cardiovascular and cerebrovascular diseases. causal interaction,diagnostic usage,unassigned 4,3,0 1.14.15.3 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30154230&form=6&db=m The Arachidonic Acid Monooxygenase. From Biochemical Curiosity to Physiological/Pathophysiological Significance. unassigned - 1.14.15.3 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31514409&form=6&db=m Conflicting Roles of 20-HETE in Hypertension and Stroke. causal interaction,therapeutic application,unassigned 3,1,0 1.14.15.3 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32373936&form=6&db=m The role of cytochrome P450 gene rs1126742 polymorphism and risk of hypertension: a systematic review and meta-analysis. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 1.14.15.3 Hyperthyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8632760&form=6&db=m Regulation of CYP4A expression in rat by dehydroepiandrosterone and thyroid hormone. causal interaction,ongoing research,unassigned 3,2,0 1.14.15.3 Hypocalcemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2559250&form=6&db=m Effect of vitamin D3 administration on serum 25-hydroxyvitamin D3, 1,25-dihydroxyvitamin D3 and osteocalcin in vitamin D-deficient elderly people. causal interaction,therapeutic application,unassigned 3,3,0 1.14.15.3 Hypoparathyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3563383&form=6&db=m [Serum concentrations of 1,25-dihydroxyvitamin D in cases of osteomalacia, parathyroid dysfunction and idiopathic hypercalciuria] causal interaction,unassigned 4,0 1.14.15.3 Hypoparathyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6981469&form=6&db=m Vitamin D metabolism in hyperthyroidism. diagnostic usage,unassigned 2,0 1.14.15.3 Hypophosphatemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2837500&form=6&db=m Hemangiopericytoma-induced osteomalacia: tumor transplantation in nude mice causes hypophosphatemia and tumor extracts inhibit renal 25-hydroxyvitamin D 1-hydroxylase activity. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0 1.14.15.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21570957&form=6&db=m Selective role for tumor necrosis factor-?, but not interleukin-1 or Kupffer cells, in down-regulation of CYP3A11 and CYP3A25 in livers of mice infected with a noninvasive intestinal pathogen. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,2 1.14.15.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24413902&form=6&db=m Altered Inflammatory Responses to Citrobacter rodentium Infection, but not Bacterial Lipopolysaccharide, in Mice Lacking the Cyp4a10 or Cyp4a14 Genes. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,2 1.14.15.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24707356&form=6&db=m Selective effects of a therapeutic protein targeting tumor necrosis factor-alpha on cytochrome P450 regulation during infectious colitis: Implications for disease-dependent drug-drug interactions. ongoing research,therapeutic application,unassigned 4,3,0 1.14.15.3 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12130701&form=6&db=m Effect of hyperinsulinemia and type 2 diabetes-like hyperglycemia on expression of hepatic cytochrome p450 and glutathione s-transferase isoforms in a New Zealand obese-derived mouse backcross population. ongoing research,unassigned 3,0 1.14.15.3 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21894443&form=6&db=m Testosterone-dependent increase in blood pressure is mediated by elevated Cyp4A expression in fructose-fed rats. ongoing research,therapeutic application,unassigned 4,1,0 1.14.15.3 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30957185&form=6&db=m Effects of daphnetin on lipid metabolism, insulin resistance and oxidative stress in OA?treated HepG2 cells. diagnostic usage,unassigned 3,0 1.14.15.3 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20130494&form=6&db=m Association of common variants of CYP4A11 and CYP4F2 with stroke in the Han Chinese population. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,3 1.14.15.3 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25734770&form=6&db=m Cytochrome 4A11 Genetic Polymorphisms Increase Susceptibility to Ischemic Stroke and Associate with Atherothrombotic Events After Stroke in Chinese. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0 1.14.15.3 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25947240&form=6&db=m Interaction among CYP2C8, EPHX2, and CYP4A11 Gene Variants Significantly Increases the Risk for Ischemic Stroke in Chinese Populations. causal interaction,therapeutic application,unassigned 2,1,0 1.14.15.3 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27087514&form=6&db=m Interactions Among CYP2C8, EPHX2, and CYP4A11 Variants and CYP Plasma Metabolite Levels in Ischemic Stroke. diagnostic usage,ongoing research,unassigned 2,1,0 1.14.15.3 Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18385420&form=6&db=m Association of a CYP4A11 variant and blood pressure in black men. causal interaction,unassigned 4,0 1.14.15.3 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34135776&form=6&db=m Cytochrome P450 Omega-Hydroxylase 4a14 Attenuates Cholestatic Liver Fibrosis. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 1.14.15.3 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18433732&form=6&db=m Cytochrome P450 omega hydroxylase (CYP4) function in fatty acid metabolism and metabolic diseases. causal interaction,ongoing research,unassigned 3,2,0 1.14.15.3 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20300478&form=6&db=m PPAR/RXR Regulation of Fatty Acid Metabolism and Fatty Acid omega-Hydroxylase (CYP4) Isozymes: Implications for Prevention of Lipotoxicity in Fatty Liver Disease. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 1.14.15.3 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25399406&form=6&db=m Toxicogenomics directory of chemically exposed human hepatocytes. ongoing research,unassigned 3,0 1.14.15.3 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26233911&form=6&db=m Translational Implications of the Alcohol-Metabolizing Enzymes, Including Cytochrome P450-2E1, in Alcoholic and Nonalcoholic Liver Disease. unassigned - 1.14.15.3 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32124935&form=6&db=m CYP4A11 is involved in the development of nonalcoholic fatty liver disease via ROS?induced lipid peroxidation and inflammation. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 1.14.15.3 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34135776&form=6&db=m Cytochrome P450 Omega-Hydroxylase 4a14 Attenuates Cholestatic Liver Fibrosis. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 1.14.15.3 Liver Diseases, Alcoholic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16161764&form=6&db=m Influence of royal jelly on mouse hepatic gene expression and safety assessment with a DNA microarray. unassigned - 1.14.15.3 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12533745&form=6&db=m Toxicology and carcinogenesis study of chloral hydrate (ad libitum and dietary controlled) (CAS no. 302-17-0) in male B6C3F1 mice (gavage study). causal interaction,ongoing research,unassigned 1,1,0 1.14.15.3 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27931333&form=6&db=m Implication of vitamin D-associated factors in patients with non-tuberculous mycobacterial lung disease. diagnostic usage,unassigned 3,0 1.14.15.3 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33215946&form=6&db=m The role of cytochrome P450 (CYP) enzymes in hyperoxic lung injury. ongoing research,unassigned 1,0 1.14.15.3 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28481877&form=6&db=m CYP4A in tumor-associated macrophages promotes pre-metastatic niche formation and metastasis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 1.14.15.3 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18433732&form=6&db=m Cytochrome P450 omega hydroxylase (CYP4) function in fatty acid metabolism and metabolic diseases. causal interaction,ongoing research,unassigned 3,2,0 1.14.15.3 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16214838&form=6&db=m Effects of selective inhibition of cytochrome P-450 omega-hydroxylases and ischemic preconditioning in myocardial protection. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0 1.14.15.3 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16957555&form=6&db=m Association of a functional polymorphism in the CYP4A11 gene with systolic blood pressure in survivors of myocardial infarction. ongoing research,unassigned 2,0 1.14.15.3 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22804341&form=6&db=m Haplotype-based case-control study of CYP4A11 gene and myocardial infarction. ongoing research,therapeutic application,unassigned 2,1,0 1.14.15.3 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21120482&form=6&db=m Cytochrome P450 ?-hydroxylase promotes angiogenesis and metastasis by upregulation of VEGF and MMP-9 in non-small cell lung cancer. causal interaction,ongoing research,unassigned 3,2,0 1.14.15.3 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28430663&form=6&db=m Co-expression network analysis identified six hub genes in association with metastasis risk and prognosis in hepatocellular carcinoma. diagnostic usage,unassigned 3,0 1.14.15.3 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28481877&form=6&db=m CYP4A in tumor-associated macrophages promotes pre-metastatic niche formation and metastasis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 1.14.15.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1690216&form=6&db=m Tumor necrosis factor-alpha induces vitamin D-1-hydroxylase activity in normal human alveolar macrophages. unassigned - 1.14.15.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2837500&form=6&db=m Hemangiopericytoma-induced osteomalacia: tumor transplantation in nude mice causes hypophosphatemia and tumor extracts inhibit renal 25-hydroxyvitamin D 1-hydroxylase activity. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0 1.14.15.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8424651&form=6&db=m Identification of a new P450 subfamily, CYP4F1, expressed in rat hepatic tumors. diagnostic usage,ongoing research,unassigned 3,4,0 1.14.15.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8445039&form=6&db=m Parathyroid hormone-related protein (PTHrP) does not regulate 1,25-dihydroxyvitamin D serum levels in hypercalcemia of malignancy. unassigned - 1.14.15.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9012361&form=6&db=m Overexpression of the heme oxygenase gene in renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0 1.14.15.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16352703&form=6&db=m 9L gliosarcoma cell proliferation and tumor growth in rats are suppressed by N-hydroxy-N'-(4-butyl-2-methylphenol) formamidine (HET0016), a selective inhibitor of CYP4A. unassigned - 1.14.15.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16684660&form=6&db=m On the mechanism of hepatocarcinogenesis of benzodiazepines: evidence that diazepam and oxazepam are CYP2B inducers in rats, and both CYP2B and CYP4A inducers in mice. causal interaction,ongoing research,unassigned 1,3,0 1.14.15.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18957819&form=6&db=m Renoprotective effects of soy protein hydrolysates in N(omega)-nitro-L-arginine methyl ester hydrochloride-induced hypertensive rats. ongoing research,therapeutic application,unassigned 4,1,0 1.14.15.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19622001&form=6&db=m Species differences in the hepatic effects of inducers of CYP2B and CYP4A subfamily forms: relationship to rodent liver tumour formation. ongoing research,therapeutic application,unassigned 3,1,0 1.14.15.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21120482&form=6&db=m Cytochrome P450 ?-hydroxylase promotes angiogenesis and metastasis by upregulation of VEGF and MMP-9 in non-small cell lung cancer. causal interaction,ongoing research,unassigned 3,2,0 1.14.15.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22552991&form=6&db=m Chlorella pyrenoidosa ameliorated L-NAME-induced hypertension and cardiorenal remodeling in rats. diagnostic usage,unassigned 1,0 1.14.15.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22798501&form=6&db=m 20-HETE-producing enzymes are up-regulated in human cancers. causal interaction,unassigned 1,0 1.14.15.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25971253&form=6&db=m Urothelial cancer gene regulatory networks inferred from large-scale RNAseq, Bead and Oligo gene expression data. diagnostic usage,unassigned 3,0 1.14.15.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26233909&form=6&db=m Cytochrome P450 ?-Hydroxylases in Inflammation and Cancer. ongoing research,unassigned 2,0 1.14.15.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28481877&form=6&db=m CYP4A in tumor-associated macrophages promotes pre-metastatic niche formation and metastasis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 1.14.15.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28557975&form=6&db=m The differential expression of omega-3 and omega-6 fatty acid metabolising enzymes in colorectal cancer and its prognostic significance. causal interaction,diagnostic usage,unassigned 4,3,0 1.14.15.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28602979&form=6&db=m Inhibition of CYP4A by a novel flavonoid FLA-16 prolongs survival and normalizes tumor vasculature in glioma. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 1.14.15.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30069903&form=6&db=m Cytochrome P450 4A11 expression in tumor cells: A favorable prognostic factor for hepatocellular carcinoma patients. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,2,0 1.14.15.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30148168&form=6&db=m Downregulation of CYP2A6 and CYP2C8 in Tumor Tissues Is Linked to Worse Overall Survival and Recurrence-Free Survival from Hepatocellular Carcinoma. causal interaction,diagnostic usage,unassigned 4,4,0 1.14.15.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30154230&form=6&db=m The Arachidonic Acid Monooxygenase. From Biochemical Curiosity to Physiological/Pathophysiological Significance. unassigned - 1.14.15.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32040184&form=6&db=m An evaluation of the human relevance of the liver tumors observed in female mice treated with permethrin based on mode of action. unassigned - 1.14.15.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32047554&form=6&db=m Alteration of CYP4A11 expression in renal cell carcinoma: diagnostic and prognostic implications. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,4,1 1.14.15.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32124935&form=6&db=m CYP4A11 is involved in the development of nonalcoholic fatty liver disease via ROS?induced lipid peroxidation and inflammation. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 1.14.15.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33732023&form=6&db=m Integrated Proteomics and Bioinformatics to Identify Potential Prognostic Biomarkers in Hepatocellular Carcinoma. causal interaction,unassigned 1,0 1.14.15.3 Nephrosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18385420&form=6&db=m Association of a CYP4A11 variant and blood pressure in black men. causal interaction,unassigned 4,0 1.14.15.3 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10772651&form=6&db=m CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis. causal interaction,unassigned 1,0 1.14.15.3 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16161764&form=6&db=m Influence of royal jelly on mouse hepatic gene expression and safety assessment with a DNA microarray. unassigned - 1.14.15.3 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17671740&form=6&db=m Re-evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease. causal interaction,unassigned 1,0 1.14.15.3 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18433732&form=6&db=m Cytochrome P450 omega hydroxylase (CYP4) function in fatty acid metabolism and metabolic diseases. causal interaction,ongoing research,unassigned 3,2,0 1.14.15.3 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28270609&form=6&db=m Ablation of cytochrome P450 omega-hydroxylase 4A14 gene attenuates hepatic steatosis and fibrosis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 1.14.15.3 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30957185&form=6&db=m Effects of daphnetin on lipid metabolism, insulin resistance and oxidative stress in OA?treated HepG2 cells. diagnostic usage,unassigned 3,0 1.14.15.3 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31406506&form=6&db=m Targeting CYP4A attenuates hepatic steatosis in a novel multicellular organotypic liver model. causal interaction,ongoing research,unassigned 1,1,0 1.14.15.3 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32124935&form=6&db=m CYP4A11 is involved in the development of nonalcoholic fatty liver disease via ROS?induced lipid peroxidation and inflammation. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 1.14.15.3 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34135776&form=6&db=m Cytochrome P450 Omega-Hydroxylase 4a14 Attenuates Cholestatic Liver Fibrosis. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 1.14.15.3 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10049703&form=6&db=m Altered expression of hepatic CYP2E1 and CYP4A in obese, diabetic ob/ob mice, and fa/fa Zucker rats. causal interaction,ongoing research,unassigned 1,2,0 1.14.15.3 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18189363&form=6&db=m Drug-metabolizing enzyme and transporter expression in a mouse model of diabetes and obesity. ongoing research,unassigned 3,0 1.14.15.3 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26233911&form=6&db=m Translational Implications of the Alcohol-Metabolizing Enzymes, Including Cytochrome P450-2E1, in Alcoholic and Nonalcoholic Liver Disease. unassigned - 1.14.15.3 Osteomalacia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2837500&form=6&db=m Hemangiopericytoma-induced osteomalacia: tumor transplantation in nude mice causes hypophosphatemia and tumor extracts inhibit renal 25-hydroxyvitamin D 1-hydroxylase activity. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0 1.14.15.3 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29588191&form=6&db=m Arachidonic acid metabolites of CYP4A and CYP4F are altered in women with preeclampsia. causal interaction,diagnostic usage,therapeutic application,unassigned 1,2,1,0 1.14.15.3 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3199682&form=6&db=m Renal 25-hydroxyvitamin D3-1-hydroxylase in patients with renal disease. causal interaction,diagnostic usage,unassigned 3,1,0 1.14.15.3 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18385420&form=6&db=m Association of a CYP4A11 variant and blood pressure in black men. causal interaction,unassigned 4,0 1.14.15.3 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29277328&form=6&db=m Induction of cytochrome P450 4A14 contributes to angiotensin II-induced renal fibrosis in mice. causal interaction,ongoing research,unassigned 4,1,0 1.14.15.3 Pulmonary Arterial Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24405547&form=6&db=m [Altered expressions of alkane monooxygenase and hypoxia inducible factor-1? expression in lung tissue of rat hypoxic pulmonary hypertension]. causal interaction,ongoing research,unassigned 1,3,0 1.14.15.3 Renal Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3199682&form=6&db=m Renal 25-hydroxyvitamin D3-1-hydroxylase in patients with renal disease. causal interaction,diagnostic usage,unassigned 3,1,0 1.14.15.3 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16214838&form=6&db=m Effects of selective inhibition of cytochrome P-450 omega-hydroxylases and ischemic preconditioning in myocardial protection. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0 1.14.15.3 Rickets http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1520695&form=6&db=m The effects of 1,25-dihydroxyvitamin D-3 deficiency on Ca(2+)-transport and Ca(2+)-uptake into brush-border membrane vesicles from pig small intestine. ongoing research,unassigned 2,0 1.14.15.3 Rickets http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1548347&form=6&db=m Normal 24-hydroxylation of vitamin D metabolites in patients with vitamin D-dependency rickets type I. Structural implications for the vitamin D hydroxylases. causal interaction,ongoing research,unassigned 1,2,0 1.14.15.3 Rickets http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7340701&form=6&db=m [Insufficiency and excess of vitamin D activity (author's transl)] causal interaction,unassigned 3,0 1.14.15.3 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9813074&form=6&db=m Peroxisome proliferator-activated receptor alpha controls the hepatic CYP4A induction adaptive response to starvation and diabetes. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 1.14.15.3 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20130494&form=6&db=m Association of common variants of CYP4A11 and CYP4F2 with stroke in the Han Chinese population. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,3 1.14.15.3 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24984178&form=6&db=m The effect of a single nucleotide polymorphism of the CYP4F2 gene on blood pressure and 20-hydroxyeicosatetraenoic acid excretion after weight loss. ongoing research,therapeutic application,unassigned 2,1,0 1.14.15.3 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25734770&form=6&db=m Cytochrome 4A11 Genetic Polymorphisms Increase Susceptibility to Ischemic Stroke and Associate with Atherothrombotic Events After Stroke in Chinese. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0 1.14.15.3 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30571981&form=6&db=m Astrocytic cytochrome P450 4A/20-hydroxyeicosatetraenoic acid contributes to angiogenesis in the experimental ischemic stroke. ongoing research,therapeutic application,unassigned 1,4,0 1.14.15.3 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31514409&form=6&db=m Conflicting Roles of 20-HETE in Hypertension and Stroke. causal interaction,therapeutic application,unassigned 3,1,0 1.14.15.3 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11418560&form=6&db=m The alkane hydroxylase gene of Burkholderia cepacia RR10 is under catabolite repression control. unassigned - 1.14.15.3 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11872725&form=6&db=m Functional analysis of alkane hydroxylases from gram-negative and gram-positive bacteria. therapeutic application,unassigned 1,0 1.14.15.3 Uremia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19232159&form=6&db=m 1alpha(OH)D3 One-alpha-hydroxy-cholecalciferol--an active vitamin D analog. Clinical studies on prophylaxis and treatment of secondary hyperparathyroidism in uremic patients on chronic dialysis. causal interaction,diagnostic usage,unassigned 3,2,0 1.14.15.3 Varicose Veins http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15191401&form=6&db=m Cytochromes P450 are differently expressed in normal and varicose human saphenous veins: linkage with varicosis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 1.14.15.3 Vitamin B 6 Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1792751&form=6&db=m [Vitamin D and calcium metabolism in relation to different levels of vitamins B6 and D] causal interaction,diagnostic usage,ongoing research,unassigned 1,4,2,0 1.14.15.3 Vitamin D Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2011085&form=6&db=m Deficiency of vitamin D metabolites directly stimulates renal 25-hydroxyvitamin D3-1-hydroxylase activity in rats. ongoing research,unassigned 4,0 1.14.15.3 Vitamin D Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3000565&form=6&db=m Regulation of renal vitamin D hydroxylase activity in vitamin D deficient rats. ongoing research,unassigned 4,0 1.14.15.3 Vitamin D Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6956890&form=6&db=m Vitamin D deficiency in rats with normal serum calcium concentrations. ongoing research,unassigned 2,0 1.14.15.3 Vitamin D Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7626515&form=6&db=m Regulation of the ferredoxin component of renal hydroxylases at transcriptional and postranslational levels and of the protein inhibitor of cyclic AMP-dependent kinase. diagnostic usage,unassigned 3,0 1.14.15.3 Vitamin D Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31463983&form=6&db=m Vitamin D Deficiency Attenuates Acute Alcohol-Induced Hepatic Lipid Accumulation in Mice. unassigned -