1.1.1.105 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18788756&form=6&db=m Oxidation of PAH trans-Dihydrodiols by Human Aldo-Keto Reductase AKR1B10. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 1.1.1.105 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23639973&form=6&db=m Retinoid acid receptor expression is helpful to distinguish between adenoma and well-differentiated carcinoma in the thyroid. diagnostic usage,unassigned 1,0 1.1.1.105 all-trans-retinol dehydrogenase (nad+) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23267101&form=6&db=m Retinol dehydrogenase 10 is indispensible for spermatogenesis in juvenile males. causal interaction,unassigned 1,0 1.1.1.105 all-trans-retinol dehydrogenase (nad+) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27740873&form=6&db=m Retinol Dehydrogenase-10 Regulates Pancreas Organogenesis and Endocrine Cell Differentiation via Paracrine Retinoic Acid Signaling. causal interaction,therapeutic application,unassigned 4,1,0 1.1.1.105 all-trans-retinol dehydrogenase (nad+) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31237438&form=6&db=m Development of a Gene Therapy Vector for RDH12-Associated Retinal Dystrophy. causal interaction,therapeutic application,unassigned 3,2,0 1.1.1.105 Bacteremia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33204758&form=6&db=m Trends in Bacteremia Over 2 Decades in the Top End of the Northern Territory of Australia. causal interaction,unassigned 2,0 1.1.1.105 Blindness http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15865448&form=6&db=m Biochemical properties of purified human retinol dehydrogenase 12 (RDH12): catalytic efficiency toward retinoids and C9 aldehydes and effects of cellular retinol-binding protein type I (CRBPI) and cellular retinaldehyde-binding protein (CRALBP) on the oxidation and reduction of retinoids. causal interaction,unassigned 2,0 1.1.1.105 Blindness http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16269441&form=6&db=m Retinal degeneration associated with RDH12 mutations results from decreased 11-cis retinal synthesis due to disruption of the visual cycle. causal interaction,unassigned 4,0 1.1.1.105 Blindness http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17130236&form=6&db=m Targeted disruption of the murine retinal dehydrogenase gene Rdh12 does not limit visual cycle function. causal interaction,unassigned 3,0 1.1.1.105 Blindness http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17197551&form=6&db=m RDH12 and RPE65, visual cycle genes causing leber congenital amaurosis, differ in disease expression. causal interaction,unassigned 3,0 1.1.1.105 Blindness http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17389517&form=6&db=m The phenotype of early-onset retinal degeneration in persons with RDH12 mutations. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 1.1.1.105 Blindness http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17512723&form=6&db=m RDH12, a retinol dehydrogenase causing Leber's congenital amaurosis, is also involved in steroid metabolism. causal interaction,unassigned 3,0 1.1.1.105 Blindness http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17512964&form=6&db=m Novel RDH12 mutations associated with Leber congenital amaurosis and cone-rod dystrophy: biochemical and clinical evaluations. causal interaction,ongoing research,unassigned 3,2,0 1.1.1.105 Blindness http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18326732&form=6&db=m Retinol dehydrogenases RDH11 and RDH12 in the mouse retina: expression levels during development and regulation by oxidative stress. causal interaction,unassigned 3,0 1.1.1.105 Blindness http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19686838&form=6&db=m Retinol dehydrogenase 12 detoxifies 4-hydroxynonenal in photoreceptor cells. therapeutic application,unassigned 1,0 1.1.1.105 Blindness http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19840725&form=6&db=m Which Leber congenital amaurosis patients are eligible for gene therapy trials? causal interaction,diagnostic usage,unassigned 1,1,0 1.1.1.105 Blindness http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20736127&form=6&db=m Novel RDH12 sequence variations in Leber congenital amaurosis. unassigned - 1.1.1.105 Blindness http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22621924&form=6&db=m Reduction of all-trans-retinal in vertebrate rod photoreceptors requires the combined action of RDH8 and RDH12. causal interaction,unassigned 3,0 1.1.1.105 Blindness http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25148430&form=6&db=m Genome-wide homozygosity mapping in families with leber congenital amaurosis identifies mutations in AIPL1 and RDH12 genes. diagnostic usage,unassigned 3,0 1.1.1.105 Blindness http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27809489&form=6&db=m Structural Insights into the Drosophila melanogaster Retinol Dehydrogenase, a Member of the Short-Chain Dehydrogenase/Reductase Family. ongoing research,unassigned 2,0 1.1.1.105 Blindness http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28471114&form=6&db=m Phenotype-genotype correlation with Sanger sequencing identified retinol dehydrogenase 12 (RDH12) compound heterozygous variants in a Chinese family with Leber congenital amaurosis. unassigned - 1.1.1.105 Blindness http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28513254&form=6&db=m Peripapillary sparing in RDH12-associated Leber congenital amaurosis. unassigned - 1.1.1.105 Blindness http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28540421&form=6&db=m Yeast ENV9 encodes a conserved lipid droplet (LD) short-chain dehydrogenase involved in LD morphology. causal interaction,unassigned 4,0 1.1.1.105 Blindness http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30979730&form=6&db=m Detailed clinical characterisation, unique features and natural history of autosomal recessive RDH12-associated retinal degeneration. causal interaction,ongoing research,therapeutic application,unassigned 2,1,3,0 1.1.1.105 Blindness http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31237438&form=6&db=m Development of a Gene Therapy Vector for RDH12-Associated Retinal Dystrophy. causal interaction,therapeutic application,unassigned 3,2,0 1.1.1.105 Blindness http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31424981&form=6&db=m Choroidal neovascularization in an adolescent with RDH12-associated retinal degeneration. causal interaction,unassigned 4,0 1.1.1.105 Blindness http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31505163&form=6&db=m Retinol dehydrogenase 12 (RDH12): Role in vision, retinal disease and future perspectives. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 1.1.1.105 Blindness http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32322264&form=6&db=m Novel Heterozygous Deletion in Retinol Dehydrogenase 12 (RDH12) Causes Familial Autosomal Dominant Retinitis Pigmentosa. causal interaction,unassigned 4,0 1.1.1.105 Blindness http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32855876&form=6&db=m Report from a Workshop on Accelerating the Development of Treatments for Inherited Retinal Dystrophies Associated with Mutations in the RDH12 Gene. causal interaction,unassigned 3,0 1.1.1.105 Blindness http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33928237&form=6&db=m Retinal imaging in inherited retinal diseases. causal interaction,unassigned 1,0 1.1.1.105 Blindness http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34216980&form=6&db=m Generation of two human iPSC lines from patients with autosomal dominant retinitis pigmentosa (UCLi014-A) and autosomal recessive Leber congenital amaurosis (UCLi015-A), associated with RDH12 variants. ongoing research,unassigned 3,0 1.1.1.105 Blindness http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34445569&form=6&db=m Involvement of Oxidative and Endoplasmic Reticulum Stress in RDH12-Related Retinopathies. causal interaction,unassigned 4,0 1.1.1.105 Burkitt Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16102592&form=6&db=m Biallelic deletion and loss of expression analysis of genes at FRA2G common fragile site in tumor-derived cell lines. ongoing research,unassigned 4,0 1.1.1.105 Burkitt Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17244623&form=6&db=m Epstein-Barr virus lytic infection induces retinoic acid-responsive genes through induction of a retinol-metabolizing enzyme, DHRS9. causal interaction,therapeutic application,unassigned 4,1,0 1.1.1.105 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23639973&form=6&db=m Retinoid acid receptor expression is helpful to distinguish between adenoma and well-differentiated carcinoma in the thyroid. diagnostic usage,unassigned 1,0 1.1.1.105 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30149992&form=6&db=m Downregulation of DHRS9 is associated with poor prognosis in oral squamous cell carcinoma. causal interaction,diagnostic usage,unassigned 4,4,0 1.1.1.105 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17218779&form=6&db=m Forced expression of RDH10 gene retards growth of HepG2 cells. causal interaction,therapeutic application,unassigned 1,4,0 1.1.1.105 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25627686&form=6&db=m Insulin Regulates Retinol Dehydrogenase Expression and All-trans-retinoic Acid Biosynthesis through FoxO1. diagnostic usage,ongoing research,unassigned 2,3,0 1.1.1.105 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31661588&form=6&db=m Clinical significance and function of RDH16 as a tumor-suppressing gene in hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,2 1.1.1.105 Cellulitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29115723&form=6&db=m Patterns of paediatric emergency presentations to a tertiary referral centre in the Northern Territory. causal interaction,unassigned 2,0 1.1.1.105 Choanal Atresia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28169399&form=6&db=m Rdh10 loss-of-function and perturbed retinoid signaling underlies the etiology of choanal atresia. unassigned - 1.1.1.105 Coloboma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25148430&form=6&db=m Genome-wide homozygosity mapping in families with leber congenital amaurosis identifies mutations in AIPL1 and RDH12 genes. diagnostic usage,unassigned 3,0 1.1.1.105 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26254099&form=6&db=m Downregulation of DHRS9 expression in colorectal cancer tissues and its prognostic significance. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,3 1.1.1.105 Cone-Rod Dystrophies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15322982&form=6&db=m Retinal dehydrogenase 12 (RDH12) mutations in leber congenital amaurosis. unassigned - 1.1.1.105 Cone-Rod Dystrophies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17512964&form=6&db=m Novel RDH12 mutations associated with Leber congenital amaurosis and cone-rod dystrophy: biochemical and clinical evaluations. causal interaction,ongoing research,unassigned 3,2,0 1.1.1.105 Cone-Rod Dystrophies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30134391&form=6&db=m PHENOTYPIC VARIABILITY OF RECESSIVE RDH12-ASSOCIATED RETINAL DYSTROPHY. causal interaction,diagnostic usage,unassigned 4,3,0 1.1.1.105 Cone-Rod Dystrophies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32014858&form=6&db=m Expanding the phenotypic spectrum in RDH12-associated retinal disease. causal interaction,therapeutic application,unassigned 1,1,0 1.1.1.105 Cone-Rod Dystrophies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33634125&form=6&db=m Different Phenotypes in Pseudodominant Inherited Retinal Dystrophies. unassigned - 1.1.1.105 Cone-Rod Dystrophies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33928237&form=6&db=m Retinal imaging in inherited retinal diseases. causal interaction,unassigned 1,0 1.1.1.105 Cone-Rod Dystrophies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34031043&form=6&db=m Novel disease-causing variant in RDH12 presenting with autosomal dominant retinitis pigmentosa. causal interaction,unassigned 3,0 1.1.1.105 Congenital Abnormalities http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21930923&form=6&db=m Involvement of retinol dehydrogenase 10 in embryonic patterning and rescue of its loss of function by maternal retinaldehyde treatment. causal interaction,unassigned 1,0 1.1.1.105 Congenital Abnormalities http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25198128&form=6&db=m Identification of genes related to beak deformity of chickens using digital gene expression profiling. causal interaction,unassigned 1,0 1.1.1.105 Craniocerebral Trauma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29115723&form=6&db=m Patterns of paediatric emergency presentations to a tertiary referral centre in the Northern Territory. causal interaction,unassigned 2,0 1.1.1.105 Crohn Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19592647&form=6&db=m Human CD14+ macrophages in intestinal lamina propria exhibit potent antigen-presenting ability. diagnostic usage,ongoing research,unassigned 3,1,0 1.1.1.105 Cross Infection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33204758&form=6&db=m Trends in Bacteremia Over 2 Decades in the Top End of the Northern Territory of Australia. causal interaction,unassigned 2,0 1.1.1.105 Dental Caries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27039531&form=6&db=m Rella Christensen, RDH, PhD, discusses what it takes to stop a developing carious lesion. unassigned - 1.1.1.105 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30073352&form=6&db=m Rhythmic Regulation of Photoreceptor and RPE Genes Important for Vision and Genetically Associated With Severe Retinal Diseases. unassigned - 1.1.1.105 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32752300&form=6&db=m Are Mutations in the DHRS9 Gene Causally Linked to Epilepsy? A Case Report. causal interaction,therapeutic application,unassigned 2,2,0 1.1.1.105 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33391336&form=6&db=m Identification of Critical Genes and Proteins for Stent Restenosis Induced by Esophageal Benign Hyperplasia in Esophageal Cancer. unassigned - 1.1.1.105 Essential Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17380846&form=6&db=m Clinical utility and applicability of smoothness index, normalized smoothness index and individualized RDH index during treatment of essential hypertension. therapeutic application,unassigned 1,0 1.1.1.105 Eye Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17081426&form=6&db=m [Establishing the linkage disequilibrium pattern for the all-trans-retinol dehydrogenase (RDH8) gene] diagnostic usage,unassigned 3,0 1.1.1.105 Eye Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33928237&form=6&db=m Retinal imaging in inherited retinal diseases. causal interaction,unassigned 1,0 1.1.1.105 Febrile Neutropenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11584902&form=6&db=m Retrospective review of febrile neutropenia in the Royal Darwin Hospital, 1994-99. therapeutic application,unassigned 4,0 1.1.1.105 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28394339&form=6&db=m NSPc1 promotes cancer stem cell self-renewal by repressing the synthesis of all-trans retinoic acid via targeting RDH16 in malignant glioma. causal interaction,therapeutic application,unassigned 3,4,0 1.1.1.105 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29285249&form=6&db=m Retinol dehydrogenase-10 promotes development and progression of human glioma via the TWEAK-NF-?B axis. causal interaction,ongoing research,unassigned 3,1,0 1.1.1.105 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31613821&form=6&db=m Retinol dehydrogenase 10 promotes metastasis of glioma cells via the transforming growth factor-?/SMAD signaling pathway. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 1.1.1.105 Granulomatous Disease, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18283656&form=6&db=m [Chronic granulomatous disease recognised in 42-years-old patient.] causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 1.1.1.105 Gyrate Atrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33928237&form=6&db=m Retinal imaging in inherited retinal diseases. causal interaction,unassigned 1,0 1.1.1.105 Hydrops Fetalis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27491505&form=6&db=m What are the most common first-trimester ultrasound findings in cases of Turner syndrome? unassigned - 1.1.1.105 Hyperopia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15322982&form=6&db=m Retinal dehydrogenase 12 (RDH12) mutations in leber congenital amaurosis. unassigned - 1.1.1.105 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20681461&form=6&db=m [The normalized smoothness index and parametric population RDH index of telmisartane in patients with newly diagnosed hypertension and metabolic syndrome] diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,2,0 1.1.1.105 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21137176&form=6&db=m [The normalized smoothness index and parametric population RDH index of losartan in patients with newly diagnosed hypertension and metabolic syndrome]. therapeutic application,unassigned 1,0 1.1.1.105 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2260469&form=6&db=m [Neonatal group B streptococcal pneumonia and right-sided diaphragmatic hernia: report of one case] diagnostic usage,unassigned 1,0 1.1.1.105 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17244623&form=6&db=m Epstein-Barr virus lytic infection induces retinoic acid-responsive genes through induction of a retinol-metabolizing enzyme, DHRS9. causal interaction,therapeutic application,unassigned 4,1,0 1.1.1.105 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22344199&form=6&db=m Abnormal Expression of Genes Involved in Inflammation, Lipid Metabolism, and Wnt Signaling in the Adipose Tissue of Polycystic Ovary Syndrome. causal interaction,unassigned 4,0 1.1.1.105 Leber Congenital Amaurosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16269441&form=6&db=m Retinal degeneration associated with RDH12 mutations results from decreased 11-cis retinal synthesis due to disruption of the visual cycle. causal interaction,unassigned 4,0 1.1.1.105 Leber Congenital Amaurosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17130236&form=6&db=m Targeted disruption of the murine retinal dehydrogenase gene Rdh12 does not limit visual cycle function. causal interaction,unassigned 3,0 1.1.1.105 Leber Congenital Amaurosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17197551&form=6&db=m RDH12 and RPE65, visual cycle genes causing leber congenital amaurosis, differ in disease expression. causal interaction,unassigned 3,0 1.1.1.105 Leber Congenital Amaurosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17389517&form=6&db=m The phenotype of early-onset retinal degeneration in persons with RDH12 mutations. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 1.1.1.105 Leber Congenital Amaurosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17512964&form=6&db=m Novel RDH12 mutations associated with Leber congenital amaurosis and cone-rod dystrophy: biochemical and clinical evaluations. causal interaction,ongoing research,unassigned 3,2,0 1.1.1.105 Leber Congenital Amaurosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18326732&form=6&db=m Retinol dehydrogenases RDH11 and RDH12 in the mouse retina: expression levels during development and regulation by oxidative stress. causal interaction,unassigned 3,0 1.1.1.105 Leber Congenital Amaurosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19686838&form=6&db=m Retinol dehydrogenase 12 detoxifies 4-hydroxynonenal in photoreceptor cells. therapeutic application,unassigned 1,0 1.1.1.105 Leber Congenital Amaurosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19840725&form=6&db=m Which Leber congenital amaurosis patients are eligible for gene therapy trials? causal interaction,diagnostic usage,unassigned 1,1,0 1.1.1.105 Leber Congenital Amaurosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20736127&form=6&db=m Novel RDH12 sequence variations in Leber congenital amaurosis. unassigned - 1.1.1.105 Leber Congenital Amaurosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22621924&form=6&db=m Reduction of all-trans-retinal in vertebrate rod photoreceptors requires the combined action of RDH8 and RDH12. causal interaction,unassigned 3,0 1.1.1.105 Leber Congenital Amaurosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25148430&form=6&db=m Genome-wide homozygosity mapping in families with leber congenital amaurosis identifies mutations in AIPL1 and RDH12 genes. diagnostic usage,unassigned 3,0 1.1.1.105 Leber Congenital Amaurosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27809489&form=6&db=m Structural Insights into the Drosophila melanogaster Retinol Dehydrogenase, a Member of the Short-Chain Dehydrogenase/Reductase Family. ongoing research,unassigned 2,0 1.1.1.105 Leber Congenital Amaurosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28471114&form=6&db=m Phenotype-genotype correlation with Sanger sequencing identified retinol dehydrogenase 12 (RDH12) compound heterozygous variants in a Chinese family with Leber congenital amaurosis. unassigned - 1.1.1.105 Leber Congenital Amaurosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28513254&form=6&db=m Peripapillary sparing in RDH12-associated Leber congenital amaurosis. unassigned - 1.1.1.105 Leber Congenital Amaurosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28540421&form=6&db=m Yeast ENV9 encodes a conserved lipid droplet (LD) short-chain dehydrogenase involved in LD morphology. causal interaction,unassigned 4,0 1.1.1.105 Leber Congenital Amaurosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30979730&form=6&db=m Detailed clinical characterisation, unique features and natural history of autosomal recessive RDH12-associated retinal degeneration. causal interaction,ongoing research,therapeutic application,unassigned 2,1,3,0 1.1.1.105 Leber Congenital Amaurosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31237438&form=6&db=m Development of a Gene Therapy Vector for RDH12-Associated Retinal Dystrophy. causal interaction,therapeutic application,unassigned 3,2,0 1.1.1.105 Leber Congenital Amaurosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31424981&form=6&db=m Choroidal neovascularization in an adolescent with RDH12-associated retinal degeneration. causal interaction,unassigned 4,0 1.1.1.105 Leber Congenital Amaurosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31505163&form=6&db=m Retinol dehydrogenase 12 (RDH12): Role in vision, retinal disease and future perspectives. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 1.1.1.105 Leber Congenital Amaurosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32322264&form=6&db=m Novel Heterozygous Deletion in Retinol Dehydrogenase 12 (RDH12) Causes Familial Autosomal Dominant Retinitis Pigmentosa. causal interaction,unassigned 4,0 1.1.1.105 Leber Congenital Amaurosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32855876&form=6&db=m Report from a Workshop on Accelerating the Development of Treatments for Inherited Retinal Dystrophies Associated with Mutations in the RDH12 Gene. causal interaction,unassigned 3,0 1.1.1.105 Leber Congenital Amaurosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33928237&form=6&db=m Retinal imaging in inherited retinal diseases. causal interaction,unassigned 1,0 1.1.1.105 Leber Congenital Amaurosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34216980&form=6&db=m Generation of two human iPSC lines from patients with autosomal dominant retinitis pigmentosa (UCLi014-A) and autosomal recessive Leber congenital amaurosis (UCLi015-A), associated with RDH12 variants. ongoing research,unassigned 3,0 1.1.1.105 Leber Congenital Amaurosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34445569&form=6&db=m Involvement of Oxidative and Endoplasmic Reticulum Stress in RDH12-Related Retinopathies. causal interaction,unassigned 4,0 1.1.1.105 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2818226&form=6&db=m [Markers of the hepatitis B virus in the blood serum and liver tissue in chronic diffuse diseases] causal interaction,unassigned 1,0 1.1.1.105 Liver Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30981405&form=6&db=m The Analysis of Posthepatectomy Liver Failure Incidence and Risk Factors Among Right Liver Living Donors According to International Study Group of Liver Surgery Definition. unassigned - 1.1.1.105 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26254099&form=6&db=m Downregulation of DHRS9 expression in colorectal cancer tissues and its prognostic significance. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,3 1.1.1.105 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18380700&form=6&db=m Consensus guidelines for 'rainy day' autologous stem cell harvests in New South Wales. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,1,2 1.1.1.105 Macular Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32014858&form=6&db=m Expanding the phenotypic spectrum in RDH12-associated retinal disease. causal interaction,therapeutic application,unassigned 1,1,0 1.1.1.105 Macular Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33928237&form=6&db=m Retinal imaging in inherited retinal diseases. causal interaction,unassigned 1,0 1.1.1.105 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20681461&form=6&db=m [The normalized smoothness index and parametric population RDH index of telmisartane in patients with newly diagnosed hypertension and metabolic syndrome] diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,2,0 1.1.1.105 Microcephaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22291023&form=6&db=m Short-chain dehydrogenase/reductase rdhe2 is a novel retinol dehydrogenase essential for frog embryonic development. causal interaction,therapeutic application,unassigned 4,1,0 1.1.1.105 Microphthalmos http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25148430&form=6&db=m Genome-wide homozygosity mapping in families with leber congenital amaurosis identifies mutations in AIPL1 and RDH12 genes. diagnostic usage,unassigned 3,0 1.1.1.105 Mite Infestations http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10640375&form=6&db=m Flexible spatial organization of urban foxes, Vulpes vulpes, before and during an outbreak of sarcoptic mange. unassigned - 1.1.1.105 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18380700&form=6&db=m Consensus guidelines for 'rainy day' autologous stem cell harvests in New South Wales. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,1,2 1.1.1.105 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30695588&form=6&db=m [Gene expression of key enzymes for all-trans- retinoic acid biosynthesis - ALDHJAI and RDH10: relationship with co-expression of nuclear receptors RAR? and PPAR?/? genes and some clinical characteristics in multiple myeloma. diagnostic usage,ongoing research,unassigned 3,4,0 1.1.1.105 Myopia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17081426&form=6&db=m [Establishing the linkage disequilibrium pattern for the all-trans-retinol dehydrogenase (RDH8) gene] diagnostic usage,unassigned 3,0 1.1.1.105 Myopia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21043051&form=6&db=m Investigation of the association between all-trans-retinol dehydrogenase (RDH8) polymorphisms and high myopia in Chinese. causal interaction,diagnostic usage,unassigned 2,1,0 1.1.1.105 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26254099&form=6&db=m Downregulation of DHRS9 expression in colorectal cancer tissues and its prognostic significance. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,3 1.1.1.105 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31613821&form=6&db=m Retinol dehydrogenase 10 promotes metastasis of glioma cells via the transforming growth factor-?/SMAD signaling pathway. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 1.1.1.105 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=271419&form=6&db=m [Cellular immunity indices in osteogenic sarcoma] diagnostic usage,therapeutic application,unassigned 1,1,0 1.1.1.105 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11584902&form=6&db=m Retrospective review of febrile neutropenia in the Royal Darwin Hospital, 1994-99. therapeutic application,unassigned 4,0 1.1.1.105 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19473719&form=6&db=m Identification of genes associated with non-small-cell lung cancer promotion and progression. causal interaction,unassigned 3,0 1.1.1.105 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25586346&form=6&db=m Transcriptome profiling of the cancer and adjacent nontumor tissues from cervical squamous cell carcinoma patients by RNA sequencing. causal interaction,unassigned 3,0 1.1.1.105 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26254099&form=6&db=m Downregulation of DHRS9 expression in colorectal cancer tissues and its prognostic significance. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,3 1.1.1.105 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28394339&form=6&db=m NSPc1 promotes cancer stem cell self-renewal by repressing the synthesis of all-trans retinoic acid via targeting RDH16 in malignant glioma. causal interaction,therapeutic application,unassigned 3,4,0 1.1.1.105 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29285249&form=6&db=m Retinol dehydrogenase-10 promotes development and progression of human glioma via the TWEAK-NF-?B axis. causal interaction,ongoing research,unassigned 3,1,0 1.1.1.105 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30149992&form=6&db=m Downregulation of DHRS9 is associated with poor prognosis in oral squamous cell carcinoma. causal interaction,diagnostic usage,unassigned 4,4,0 1.1.1.105 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31661588&form=6&db=m Clinical significance and function of RDH16 as a tumor-suppressing gene in hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,2 1.1.1.105 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32216644&form=6&db=m Bioinformatic Analysis Suggests That Three Hub Genes May Be a Vital Prognostic Biomarker in Pancreatic Ductal Adenocarcinoma. unassigned - 1.1.1.105 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32367068&form=6&db=m CDK11 is required for transcription of replication-dependent histone genes. causal interaction,unassigned 3,0 1.1.1.105 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32765099&form=6&db=m Prognostic Impact of DHRS9 Overexpression in Pancreatic Cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 1.1.1.105 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32788868&form=6&db=m Retinal dehydrogenase 5 (RHD5) attenuates metastasis via regulating HIPPO/YAP signaling pathway in Hepatocellular Carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,2,0 1.1.1.105 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32856362&form=6&db=m Redox Dyshomeostasis Strategy for Hypoxic Tumor Therapy Based on DNAzyme-Loaded Electrophilic ZIFs. causal interaction,therapeutic application,unassigned 2,4,0 1.1.1.105 Night Blindness http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18048336&form=6&db=m Redundant and unique roles of retinol dehydrogenases in the mouse retina. causal interaction,unassigned 1,0 1.1.1.105 Night Blindness http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33928237&form=6&db=m Retinal imaging in inherited retinal diseases. causal interaction,unassigned 1,0 1.1.1.105 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30415504&form=6&db=m HSD17B13 is a Hepatic Retinol Dehydrogenase Associated with Histological Features of Non-Alcoholic Fatty Liver Disease. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 1.1.1.105 Obesity, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29520627&form=6&db=m Gene expression profile following an oral unsaturated fat load in abdominal obese subjects. unassigned - 1.1.1.105 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=271419&form=6&db=m [Cellular immunity indices in osteogenic sarcoma] diagnostic usage,therapeutic application,unassigned 1,1,0 1.1.1.105 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32765099&form=6&db=m Prognostic Impact of DHRS9 Overexpression in Pancreatic Cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 1.1.1.105 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33815409&form=6&db=m TSPAN1, TMPRSS4, SDR16C5, and CTSE as Novel Panel for Pancreatic Cancer: A Bioinformatics Analysis and Experiments Validation. unassigned - 1.1.1.105 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16102592&form=6&db=m Biallelic deletion and loss of expression analysis of genes at FRA2G common fragile site in tumor-derived cell lines. ongoing research,unassigned 4,0 1.1.1.105 Prostatic Hyperplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18060684&form=6&db=m Pre-receptor regulation of the androgen receptor. causal interaction,therapeutic application,unassigned 4,1,0 1.1.1.105 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18926804&form=6&db=m Biochemical characterization of human epidermal retinol dehydrogenase 2. causal interaction,unassigned 3,0 1.1.1.105 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34277700&form=6&db=m Identification of Proteomic Signatures in Chronic Obstructive Pulmonary Disease Emphysematous Phenotype. causal interaction,unassigned 4,0 1.1.1.105 Retinal Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16269441&form=6&db=m Retinal degeneration associated with RDH12 mutations results from decreased 11-cis retinal synthesis due to disruption of the visual cycle. causal interaction,unassigned 4,0 1.1.1.105 Retinal Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16617060&form=6&db=m Retinal degeneration associated with RDH12 mutations results from decreased 11-cis retinal synthesis due to disruption of the visual cycle. causal interaction,unassigned 3,0 1.1.1.105 Retinal Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17197551&form=6&db=m RDH12 and RPE65, visual cycle genes causing leber congenital amaurosis, differ in disease expression. causal interaction,unassigned 3,0 1.1.1.105 Retinal Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17389517&form=6&db=m The phenotype of early-onset retinal degeneration in persons with RDH12 mutations. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 1.1.1.105 Retinal Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17512723&form=6&db=m RDH12, a retinol dehydrogenase causing Leber's congenital amaurosis, is also involved in steroid metabolism. causal interaction,unassigned 3,0 1.1.1.105 Retinal Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17925390&form=6&db=m Overproduction of bioactive retinoic acid in cells expressing disease-associated mutants of retinol dehydrogenase 12. causal interaction,therapeutic application,unassigned 3,1,0 1.1.1.105 Retinal Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19011012&form=6&db=m Complexity of phenotype-genotype correlations in Spanish patients with RDH12 mutations. causal interaction,unassigned 3,0 1.1.1.105 Retinal Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20006610&form=6&db=m Disease-associated variants of microsomal retinol dehydrogenase 12 (RDH12) are degraded at mutant-specific rates. causal interaction,unassigned 2,0 1.1.1.105 Retinal Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20045325&form=6&db=m Requirement for an enzymatic visual cycle in Drosophila. diagnostic usage,therapeutic application,unassigned 3,2,0 1.1.1.105 Retinal Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21232531&form=6&db=m Evidence that proteosome inhibitors and chemical chaperones can rescue the activity of retinol dehydrogenase 12 mutant T49M. causal interaction,unassigned 2,0 1.1.1.105 Retinal Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22621924&form=6&db=m Reduction of all-trans-retinal in vertebrate rod photoreceptors requires the combined action of RDH8 and RDH12. causal interaction,unassigned 3,0 1.1.1.105 Retinal Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26992781&form=6&db=m Molecular genetics of cone-rod dystrophy in Chinese patients: new data from 61 probands and mutation overview of 163 probands. unassigned - 1.1.1.105 Retinal Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30372751&form=6&db=m RDH12 Mutations Cause a Severe Retinal Degeneration With Relatively Spared Rod Function. causal interaction,unassigned 3,0 1.1.1.105 Retinal Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30979730&form=6&db=m Detailed clinical characterisation, unique features and natural history of autosomal recessive RDH12-associated retinal degeneration. causal interaction,ongoing research,therapeutic application,unassigned 2,1,3,0 1.1.1.105 Retinal Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31237438&form=6&db=m Development of a Gene Therapy Vector for RDH12-Associated Retinal Dystrophy. causal interaction,therapeutic application,unassigned 3,2,0 1.1.1.105 Retinal Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31884613&form=6&db=m Natural History and Genotype-Phenotype Correlations in RDH12-Associated Retinal Degeneration. causal interaction,therapeutic application,unassigned 3,4,0 1.1.1.105 Retinal Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34429587&form=6&db=m Gene Therapy for Rdh12-Associated Retinal Diseases Helps to Delay Retinal Degeneration and Vision Loss. causal interaction,unassigned 1,0 1.1.1.105 Retinal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17197551&form=6&db=m RDH12 and RPE65, visual cycle genes causing leber congenital amaurosis, differ in disease expression. causal interaction,unassigned 3,0 1.1.1.105 Retinal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17389517&form=6&db=m The phenotype of early-onset retinal degeneration in persons with RDH12 mutations. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 1.1.1.105 Retinal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31505163&form=6&db=m Retinol dehydrogenase 12 (RDH12): Role in vision, retinal disease and future perspectives. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 1.1.1.105 Retinal Dystrophies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7028497&form=6&db=m Retinal reductase activity in rats with and without inherited retinal dystrophy. ongoing research,unassigned 2,0 1.1.1.105 Retinal Dystrophies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15258582&form=6&db=m Mutations in RDH12 encoding a photoreceptor cell retinol dehydrogenase cause childhood-onset severe retinal dystrophy. causal interaction,unassigned 4,0 1.1.1.105 Retinal Dystrophies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16269441&form=6&db=m Retinal degeneration associated with RDH12 mutations results from decreased 11-cis retinal synthesis due to disruption of the visual cycle. causal interaction,unassigned 4,0 1.1.1.105 Retinal Dystrophies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17011878&form=6&db=m Screening genes of the retinoid metabolism: novel LRAT mutation in leber congenital amaurosis. ongoing research,therapeutic application,unassigned 2,1,0 1.1.1.105 Retinal Dystrophies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17032653&form=6&db=m Retinol dehydrogenase (RDH12) protects photoreceptors from light-induced degeneration in mice. causal interaction,unassigned 3,0 1.1.1.105 Retinal Dystrophies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17130236&form=6&db=m Targeted disruption of the murine retinal dehydrogenase gene Rdh12 does not limit visual cycle function. causal interaction,unassigned 3,0 1.1.1.105 Retinal Dystrophies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17389517&form=6&db=m The phenotype of early-onset retinal degeneration in persons with RDH12 mutations. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 1.1.1.105 Retinal Dystrophies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17925390&form=6&db=m Overproduction of bioactive retinoic acid in cells expressing disease-associated mutants of retinol dehydrogenase 12. causal interaction,therapeutic application,unassigned 3,1,0 1.1.1.105 Retinal Dystrophies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18048336&form=6&db=m Redundant and unique roles of retinol dehydrogenases in the mouse retina. causal interaction,unassigned 1,0 1.1.1.105 Retinal Dystrophies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18326732&form=6&db=m Retinol dehydrogenases RDH11 and RDH12 in the mouse retina: expression levels during development and regulation by oxidative stress. causal interaction,unassigned 3,0 1.1.1.105 Retinal Dystrophies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19506076&form=6&db=m Rdh12 activity and effects on retinoid processing in the murine retina. causal interaction,ongoing research,unassigned 3,2,0 1.1.1.105 Retinal Dystrophies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19686838&form=6&db=m Retinol dehydrogenase 12 detoxifies 4-hydroxynonenal in photoreceptor cells. therapeutic application,unassigned 1,0 1.1.1.105 Retinal Dystrophies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24625443&form=6&db=m Identity-by-descent-guided mutation analysis and exome sequencing in consanguineous families reveals unusual clinical and molecular findings in retinal dystrophy. causal interaction,diagnostic usage,unassigned 1,3,0 1.1.1.105 Retinal Dystrophies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24752437&form=6&db=m Longitudinal clinical course of three Japanese patients with Leber congenital amaurosis/early-onset retinal dystrophy with RDH12 mutation. causal interaction,unassigned 3,0 1.1.1.105 Retinal Dystrophies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30134391&form=6&db=m PHENOTYPIC VARIABILITY OF RECESSIVE RDH12-ASSOCIATED RETINAL DYSTROPHY. causal interaction,diagnostic usage,unassigned 4,3,0 1.1.1.105 Retinal Dystrophies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30979730&form=6&db=m Detailed clinical characterisation, unique features and natural history of autosomal recessive RDH12-associated retinal degeneration. causal interaction,ongoing research,therapeutic application,unassigned 2,1,3,0 1.1.1.105 Retinal Dystrophies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31424981&form=6&db=m Choroidal neovascularization in an adolescent with RDH12-associated retinal degeneration. causal interaction,unassigned 4,0 1.1.1.105 Retinal Dystrophies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31505163&form=6&db=m Retinol dehydrogenase 12 (RDH12): Role in vision, retinal disease and future perspectives. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 1.1.1.105 Retinal Dystrophies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32014858&form=6&db=m Expanding the phenotypic spectrum in RDH12-associated retinal disease. causal interaction,therapeutic application,unassigned 1,1,0 1.1.1.105 Retinal Dystrophies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32322264&form=6&db=m Novel Heterozygous Deletion in Retinol Dehydrogenase 12 (RDH12) Causes Familial Autosomal Dominant Retinitis Pigmentosa. causal interaction,unassigned 4,0 1.1.1.105 Retinal Dystrophies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32790509&form=6&db=m Macula-predominant retinopathy associated with biallelic variants in RDH12. causal interaction,therapeutic application,unassigned 2,1,0 1.1.1.105 Retinal Dystrophies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32855876&form=6&db=m Report from a Workshop on Accelerating the Development of Treatments for Inherited Retinal Dystrophies Associated with Mutations in the RDH12 Gene. causal interaction,unassigned 3,0 1.1.1.105 Retinitis Pigmentosa http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17011878&form=6&db=m Screening genes of the retinoid metabolism: novel LRAT mutation in leber congenital amaurosis. ongoing research,therapeutic application,unassigned 2,1,0 1.1.1.105 Retinitis Pigmentosa http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17389517&form=6&db=m The phenotype of early-onset retinal degeneration in persons with RDH12 mutations. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 1.1.1.105 Retinitis Pigmentosa http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17512964&form=6&db=m Novel RDH12 mutations associated with Leber congenital amaurosis and cone-rod dystrophy: biochemical and clinical evaluations. causal interaction,ongoing research,unassigned 3,2,0 1.1.1.105 Retinitis Pigmentosa http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18779497&form=6&db=m Association of a novel mutation in the retinol dehydrogenase 12 (RDH12) gene with autosomal dominant retinitis pigmentosa. causal interaction,unassigned 2,0 1.1.1.105 Retinitis Pigmentosa http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19753312&form=6&db=m Mutations that are a common cause of Leber congenital amaurosis in northern America are rare in Southern India. unassigned - 1.1.1.105 Retinitis Pigmentosa http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23900199&form=6&db=m Exome sequencing identifies RDH12 compound heterozygous mutations in a family with severe retinitis pigmentosa. causal interaction,unassigned 2,0 1.1.1.105 Retinitis Pigmentosa http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26124963&form=6&db=m Exome Sequencing Identified a Recessive RDH12 Mutation in a Family with Severe Early-Onset Retinitis Pigmentosa. causal interaction,unassigned 3,0 1.1.1.105 Retinitis Pigmentosa http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31505163&form=6&db=m Retinol dehydrogenase 12 (RDH12): Role in vision, retinal disease and future perspectives. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 1.1.1.105 Retinitis Pigmentosa http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31801355&form=6&db=m Large choroidal excavation in retinitis pigmentosa: A case report. unassigned - 1.1.1.105 Retinitis Pigmentosa http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32014858&form=6&db=m Expanding the phenotypic spectrum in RDH12-associated retinal disease. causal interaction,therapeutic application,unassigned 1,1,0 1.1.1.105 Retinitis Pigmentosa http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32322264&form=6&db=m Novel Heterozygous Deletion in Retinol Dehydrogenase 12 (RDH12) Causes Familial Autosomal Dominant Retinitis Pigmentosa. causal interaction,unassigned 4,0 1.1.1.105 Retinitis Pigmentosa http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34031043&form=6&db=m Novel disease-causing variant in RDH12 presenting with autosomal dominant retinitis pigmentosa. causal interaction,unassigned 3,0 1.1.1.105 Retinitis Pigmentosa http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34216980&form=6&db=m Generation of two human iPSC lines from patients with autosomal dominant retinitis pigmentosa (UCLi014-A) and autosomal recessive Leber congenital amaurosis (UCLi015-A), associated with RDH12 variants. ongoing research,unassigned 3,0 1.1.1.105 Retinoschisis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33928237&form=6&db=m Retinal imaging in inherited retinal diseases. causal interaction,unassigned 1,0 1.1.1.105 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26073183&form=6&db=m High frequency oscillations are less frequent but more specific to epileptogenicity during rapid eye movement sleep. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,1,0 1.1.1.105 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30149992&form=6&db=m Downregulation of DHRS9 is associated with poor prognosis in oral squamous cell carcinoma. causal interaction,diagnostic usage,unassigned 4,4,0 1.1.1.105 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33277966&form=6&db=m Prognostic value of lipid metabolism-related genes in head and neck squamous cell carcinoma. diagnostic usage,ongoing research,unassigned 3,1,0 1.1.1.105 Stargardt Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8035984&form=6&db=m Histopathology and immunocytochemistry of the neurosensory retina in fundus flavimaculatus. therapeutic application,unassigned 1,0 1.1.1.105 Stargardt Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24707049&form=6&db=m ATP-binding cassette transporter ABCA4 and chemical isomerization protect photoreceptor cells from the toxic accumulation of excess 11-cis-retinal. ongoing research,unassigned 1,0 1.1.1.105 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31661588&form=6&db=m Clinical significance and function of RDH16 as a tumor-suppressing gene in hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,2 1.1.1.105 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33879671&form=6&db=m In silico screening using bulk and single-cell RNA-seq data identifies RIMS2 as a prognostic marker in basal-like breast cancer: A retrospective study. unassigned - 1.1.1.105 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17244623&form=6&db=m Epstein-Barr virus lytic infection induces retinoic acid-responsive genes through induction of a retinol-metabolizing enzyme, DHRS9. causal interaction,therapeutic application,unassigned 4,1,0 1.1.1.105 Vision Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15258582&form=6&db=m Mutations in RDH12 encoding a photoreceptor cell retinol dehydrogenase cause childhood-onset severe retinal dystrophy. causal interaction,unassigned 4,0 1.1.1.105 Vision Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17032653&form=6&db=m Retinol dehydrogenase (RDH12) protects photoreceptors from light-induced degeneration in mice. causal interaction,unassigned 3,0 1.1.1.105 Vitelliform Macular Dystrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33928237&form=6&db=m Retinal imaging in inherited retinal diseases. causal interaction,unassigned 1,0