3.5.1.98 0.0000002 - N-hydroxy-6-[(2S,5S,8S,11S)-8-(1H-indol-3-ylmethyl)-2-methyl-11-(2-methylpropyl)-3,6,9,13-tetraoxo-1,4,7,10-tetraazacyclotridecan-5-yl]hexanamide HDAC10 698491 3.5.1.98 0.00000032 - (5R,8S,11S)-5-methyl-8-(1-methylethyl)-11-[(1E)-4-sulfanylbut-1-en-1-yl]-10-oxa-3-thia-7,14,20,21-tetraazatricyclo[14.3.1.1-2,5]henicosa-1(20),2(21),16,18-tetraene-6,9,13-trione - 700547 3.5.1.98 0.0000006 - N-hydroxy-6-[(2S,5S,8S,11S)-8-(1H-indol-3-ylmethyl)-2-methyl-11-(2-methylpropyl)-3,6,9,13-tetraoxo-1,4,7,10-tetraazacyclotridecan-5-yl]hexanamide HDAC9 698491 3.5.1.98 0.0000006 - N-hydroxy-6-[(3S,6S,9S,15aS)-6-(1H-indol-3-ylmethyl)-9-(2-methylpropyl)-1,4,7,11-tetraoxotetradecahydro-1H-pyrrolo[1,2-a][1,4,7,10]tetraazacyclotridecin-3-yl]hexanamide HDAC1 698491 3.5.1.98 0.0000006 - trichostatin A - 699458 3.5.1.98 0.0000006 - trichostatin A isoform HDAC3 682501 3.5.1.98 0.00000069 - (5S,8S,11S,5'S,8'S,11'S)-11,11'-[disulfanediyldi(1E)but-1-ene-4,1-diyl]bis[5-methyl-8-(1-methylethyl)-3,10,17-trioxa-7,14,19,20-tetraazatricyclo[14.2.1.1-2,5]icosa-1(18),2(20),16(19)-triene-6,9,13-trione] - 700547 3.5.1.98 0.0000007 - apicidin isoform HDAC3 682501 3.5.1.98 0.00000086 - (5R,8S,11S)-5-methyl-8-(1-methylethyl)-11-[(1E)-4-sulfanylbut-1-en-1-yl]-10-oxa-3-thia-7,14,20,21-tetraazatricyclo[14.3.1.1-2,5]henicosa-1(20),2(21),16,18-tetraene-6,9,13-trione - 700547 3.5.1.98 0.000001 - apicidin - 699458 3.5.1.98 0.0000011 - (5R,8S,11S)-5-methyl-8-(1-methylethyl)-11-[(1E)-4-sulfanylbut-1-en-1-yl]-10-oxa-3-thia-7,14,20,21-tetraazatricyclo[14.3.1.1-2,5]henicosa-1(20),2(21),16,18-tetraene-6,9,13-trione - 700547 3.5.1.98 0.0000012 - (5R,8S,11S)-5-methyl-8-(1-methylethyl)-11-[(1E)-4-sulfanylbut-1-en-1-yl]-10-oxa-3,17-dithia-7,14,19,20-tetraazatricyclo[14.2.1.1-2,5]icosa-1(18),2(20),16(19)-triene-6,9,13-trione - 700547 3.5.1.98 0.0000015 - (5S,8S,11S,5'S,8'S,11'S)-11,11'-[disulfanediyldi(1E)but-1-ene-4,1-diyl]bis[5-methyl-8-(1-methylethyl)-3,10,17-trioxa-7,14,19,20-tetraazatricyclo[14.2.1.1-2,5]icosa-1(18),2(20),16(19)-triene-6,9,13-trione] - 700547 3.5.1.98 0.0000015 - N-hydroxy-6-[(2S,5S,8S,11S)-8-(1H-indol-3-ylmethyl)-2-methyl-11-(2-methylpropyl)-3,6,9,13-tetraoxo-1,4,7,10-tetraazacyclotridecan-5-yl]hexanamide HDAC1 698491 3.5.1.98 0.0000015 - trichostatin A isoform HDAC1 682501 3.5.1.98 0.0000017 - (5S,8S,11S,5'S,8'S,11'S)-11,11'-[disulfanediyldi(1E)but-1-ene-4,1-diyl]bis[5-methyl-8-(1-methylethyl)-3,10,17-trioxa-7,14,19,20-tetraazatricyclo[14.2.1.1-2,5]icosa-1(18),2(20),16(19)-triene-6,9,13-trione] - 700547 3.5.1.98 0.0000018 - LBH-589 - 699458 3.5.1.98 0.0000018 - N-hydroxy-6-[4-(6-methoxynaphthalen-2-yl)-1H-1,2,3-triazol-1-yl]hexanamide - 696716 3.5.1.98 0.0000019 - (5R,8S,11S)-8-(1-methylethyl)-11-[(1E)-4-sulfanylbut-1-en-1-yl]-10-oxa-3,17-dithia-7,14,19,20-tetraazatricyclo[14.2.1.1-2,5]icosa-1(18),2(20),16(19)-triene-6,9,13-trione - 700547 3.5.1.98 0.0000019 - 6-[4-(biphenyl-3-yl)-1H-1,2,3-triazol-1-yl]-N-hydroxyhexanamide - 696716 3.5.1.98 0.000002 - apicidin isoform HDAC1 682501 3.5.1.98 0.0000021 - N-hydroxy-6-[4-(4-methoxyphenyl)-1H-1,2,3-triazol-1-yl]hexanamide - 696716 3.5.1.98 0.0000021 - N-hydroxy-6-[4-(quinolin-2-yl)-1H-1,2,3-triazol-1-yl]hexanamide - 696716 3.5.1.98 0.0000023 - N-hydroxy-6-{4-[4-(pyridin-4-yl)phenyl]-1H-1,2,3-triazol-1-yl}hexanamide - 696716 3.5.1.98 0.0000025 - N-hydroxy-6-[(2S,5S,8S,11S)-8-(1H-indol-3-ylmethyl)-2-methyl-11-(2-methylpropyl)-3,6,9,13-tetraoxo-1,4,7,10-tetraazacyclotridecan-5-yl]hexanamide HDAC5 698491 3.5.1.98 0.0000028 - trichostatin A pH 8.0, 37°C, recombinant enzyme 733817 3.5.1.98 0.000003 - trichostatin A pH 8.0 678021 3.5.1.98 0.0000034 - (5R,8S,11S)-5-methyl-8-(1-methylethyl)-11-[(1E)-4-sulfanylbut-1-en-1-yl]-10-oxa-3,17-dithia-7,14,19,20-tetraazatricyclo[14.2.1.1-2,5]icosa-1(18),2(20),16(19)-triene-6,9,13-trione - 700547 3.5.1.98 0.0000035 - (5R,8S,11S)-5-methyl-8-(1-methylethyl)-11-[(1E)-4-sulfanylbut-1-en-1-yl]-10-oxa-3,17-dithia-7,14,19,20-tetraazatricyclo[14.2.1.1-2,5]icosa-1(18),2(20),16(19)-triene-6,9,13-trione - 700547 3.5.1.98 0.0000035 - N-hydroxy-6-[(3S,6S,9S,15aS)-6-(1H-indol-3-ylmethyl)-9-(2-methylpropyl)-1,4,7,11-tetraoxotetradecahydro-1H-pyrrolo[1,2-a][1,4,7,10]tetraazacyclotridecin-3-yl]hexanamide HDAC2 698491 3.5.1.98 0.0000038 - (5R,8S,11S)-8-(1-methylethyl)-11-[(1E)-4-sulfanylbut-1-en-1-yl]-10-oxa-3,17-dithia-7,14,19,20-tetraazatricyclo[14.2.1.1-2,5]icosa-1(18),2(20),16(19)-triene-6,9,13-trione - 700547 3.5.1.98 0.0000043 - 6-{4-[4-(dimethylamino)phenyl]-1H-1,2,3-triazol-1-yl}-N-hydroxyhexanamide - 696716 3.5.1.98 0.0000048 - (5R,8S,11S)-8-(1-methylethyl)-11-[(1E)-4-sulfanylbut-1-en-1-yl]-10-oxa-3,17-dithia-7,14,19,20-tetraazatricyclo[14.2.1.1-2,5]icosa-1(18),2(20),16(19)-triene-6,9,13-trione - 700547 3.5.1.98 0.000005 - N-hydroxy-6-[(2S,5S,8S,11S)-8-(1H-indol-3-ylmethyl)-2-methyl-11-(2-methylpropyl)-3,6,9,13-tetraoxo-1,4,7,10-tetraazacyclotridecan-5-yl]hexanamide HDAC2 698491 3.5.1.98 0.000005 - trichostatin A - 696716 3.5.1.98 0.0000054 - 7-[4-(biphenyl-3-yl)-1H-1,2,3-triazol-1-yl]-N-hydroxyheptanamide - 696716 3.5.1.98 0.0000096 - N-hydroxy-7-(4-phenyl-1H-1,2,3-triazol-1-yl)heptanamide - 696716 3.5.1.98 0.0000097 - N-(8,8,8-trifluoro-7-oxooctyl)benzamide pH and temperature not specified in the publication 756043 3.5.1.98 0.00001 - suberoylanilide hydroxamic acid - 700547 3.5.1.98 0.000012 - (3S,6S,9S,15aS)-6-(1H-indol-3-ylmethyl)-9-(2-methylpropyl)-3-(6-oxooctyl)decahydro-1H-pyrrolo[1,2-a][1,4,7,10]tetraazacyclotridecine-1,4,7,11(8H)-tetrone HDAC1 698491 3.5.1.98 0.000013 - suberoylanilide hydroxamic acid - 700547 3.5.1.98 0.0000139 - N-hydroxy-6-[4-(3-methoxyphenyl)-1H-1,2,3-triazol-1-yl]hexanamide - 696716 3.5.1.98 0.0000142 - N-hydroxy-6-(4-phenyl-1H-1,2,3-triazol-1-yl)hexanamide - 696716 3.5.1.98 0.000015 - (3S,6S,9S,15aS)-6-(1H-indol-3-ylmethyl)-9-(2-methylpropyl)-3-(6-oxooctyl)decahydro-1H-pyrrolo[1,2-a][1,4,7,10]tetraazacyclotridecine-1,4,7,11(8H)-tetrone HDAC10 698491 3.5.1.98 0.000015 - 2,2,2-trifluoro-1-[5-(quinoxalin-6-yl)thiophen-2-yl]ethanone HDAC6, pH and temperature not specified in the publication 712691 3.5.1.98 0.000015 - apicidin HDAC9 698491 3.5.1.98 0.000015 - N-hydroxy-7-[(2E)-2-[[4-(1H-imidazol-1-yl)phenyl]methylidene]hydrazino]-7-oxoheptanamide - 699458 3.5.1.98 0.0000153 - N-hydroxy-7-[4-(6-methoxynaphthalen-2-yl)-1H-1,2,3-triazol-1-yl]heptanamide - 696716 3.5.1.98 0.000016 - (2E)-N-hydroxy-3-[2-[2-(1H-indol-3-yl)ethyl]-2,3-dihydro-1H-isoindol-5-yl]prop-2-enamide isoform HDAC1, pH not specified in the publication, temperature not specified in the publication 719058 3.5.1.98 0.0000166 - N-hydroxy-7-{4-[4-(pyridin-4-yl)phenyl]-1H-1,2,3-triazol-1-yl}heptanamide - 696716 3.5.1.98 0.000017 - suberoylanilide hydroxamic acid - 700547 3.5.1.98 0.0000174 - N-hydroxy-6-[4-(3-methylphenyl)-1H-1,2,3-triazol-1-yl]hexanamide - 696716 3.5.1.98 0.000018 - apicidin HDAC1 698491 3.5.1.98 0.00002 - (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide mutant H843Y 698743 3.5.1.98 0.00002 - (3S,6S,9S,13S)-3-(1H-indol-3-ylmethyl)-9-methyl-13-(2-methylpropyl)-6-(6-oxooctyl)-1,4,7,10-tetraazacyclotridecane-2,5,8,11-tetrone HDAC10 698491 3.5.1.98 0.00002 - 7-[(2E)-2-[(6-bromo-1,3-benzodioxol-5-yl)methylidene]hydrazino]-N-hydroxy-7-oxoheptanamide - 699458 3.5.1.98 0.00002 - N-(4-amino-4'-fluoro[1,1'-biphenyl]-3-yl)oxane-4-carboxamide pH 7.4, 22°C, HDAC1 isozyme 756174 3.5.1.98 0.00002 - N-hydroxy-3-[2-[(2-methyl-1H-indol-3-yl)acetyl]-2,3-dihydro-1H-isoindol-5-yl]propanamide isoform HDAC1, pH not specified in the publication, temperature not specified in the publication 719058 3.5.1.98 0.000022 - (3S,6S,9S,15aS)-6-(1H-indol-3-ylmethyl)-9-(2-methylpropyl)-3-(6-oxooctyl)decahydro-1H-pyrrolo[1,2-a][1,4,7,10]tetraazacyclotridecine-1,4,7,11(8H)-tetrone HDAC9 698491 3.5.1.98 0.000022 - 7-[(2E)-2-[(2-bromo-5-methoxyphenyl)methylidene]hydrazino]-N-hydroxy-7-oxoheptanamide - 699458 3.5.1.98 0.000022 - trichostatin A HDAC activity in HeLa nuclear cell extracts, 25°C, pH 8.0 719304 3.5.1.98 0.0000239 - N-hydroxy-7-[4-(pyridin-2-yl)-1H-1,2,3-triazol-1-yl]heptanamide - 696716 3.5.1.98 0.000024 - 2,2,2-trifluoro-1-(5-[3-[(methylsulfonyl)methyl]-1,2,4-oxadiazol-5-yl]thiophen-2-yl)ethanone HDAC4, pH and temperature not specified in the publication 712691 3.5.1.98 0.000025 - (3S,6S,9S,13S)-3-(1H-indol-3-ylmethyl)-9,10-dimethyl-13-(2-methylpropyl)-6-(6-oxooctyl)-1,4,7,10-tetraazacyclotridecane-2,5,8,11-tetrone HDAC9 698491 3.5.1.98 0.000025 - N-hydroxy-6-[(2S,5S,8S,11S)-8-(1H-indol-3-ylmethyl)-2-methyl-11-(2-methylpropyl)-3,6,9,13-tetraoxo-1,4,7,10-tetraazacyclotridecan-5-yl]hexanamide HDAC3 698491 3.5.1.98 0.000026 - (2E)-N-hydroxy-3-[2-(2-phenylethyl)-1-(2-piperidin-1-ylethyl)-1H-benzimidazol-5-yl]prop-2-enamide - 696662 3.5.1.98 0.000026 - (2E)-N-hydroxy-3-[2-[2-(2-methyl-1H-indol-3-yl)ethyl]-2,3-dihydro-1H-isoindol-5-yl]prop-2-enamide isoform HDAC1, pH not specified in the publication, temperature not specified in the publication 719058 3.5.1.98 0.000026 - 2-(5-methoxy-2-methyl-1H-indol-3-yl)-N-[(1S)-7-oxo-1-(5-phenyl-1H-imidazol-2-yl)nonyl]acetamide HDAC1 699429 3.5.1.98 0.000026 - suberoylanilide hydroxamic acid - 700547 3.5.1.98 0.000027 - 4-[5-(trifluoroacetyl)thiophen-2-yl]benzoic acid HDAC6, pH and temperature not specified in the publication 712691 3.5.1.98 0.000028 - (3S,6S,9S,13S)-3-(1H-indol-3-ylmethyl)-9,10-dimethyl-13-(2-methylpropyl)-6-(6-oxooctyl)-1,4,7,10-tetraazacyclotridecane-2,5,8,11-tetrone HDAC10 698491 3.5.1.98 0.000029 - (5R,8S,11S)-5-methyl-8-(1-methylethyl)-11-[(1E)-4-sulfanylbut-1-en-1-yl]-10-oxa-3-thia-7,14,20,21-tetraazatricyclo[14.3.1.1-2,5]henicosa-1(20),2(21),16,18-tetraene-6,9,13-trione - 700547 3.5.1.98 0.000029 - 1-[5-(4-acetylphenyl)thiophen-2-yl]-2,2,2-trifluoroethanone HDAC6, pH and temperature not specified in the publication 712691 3.5.1.98 0.00003 - (3S,6S,9S,13S)-3-(1H-indol-3-ylmethyl)-9-methyl-13-(2-methylpropyl)-6-(6-oxooctyl)-1,4,7,10-tetraazacyclotridecane-2,5,8,11-tetrone HDAC2 698491 3.5.1.98 0.00003 - (3S,6S,9S,13S)-3-(1H-indol-3-ylmethyl)-9-methyl-13-(2-methylpropyl)-6-(6-oxooctyl)-1,4,7,10-tetraazacyclotridecane-2,5,8,11-tetrone HDAC9 698491 3.5.1.98 0.00003 - 2,2,2-trifluoro-1-(5-[3-[(propylsulfonyl)methyl]-1,2,4-oxadiazol-5-yl]thiophen-2-yl)ethanone HDAC4, pH and temperature not specified in the publication 712691 3.5.1.98 0.00003 - apicidin HDAC10 698491 3.5.1.98 0.00003 - N-hydroxy-6-[(2S,5S,8S,11S)-8-(1H-indol-3-ylmethyl)-2-methyl-11-(2-methylpropyl)-3,6,9,13-tetraoxo-1,4,7,10-tetraazacyclotridecan-5-yl]hexanamide HDAC6 698491 3.5.1.98 0.00003 - vorinostat HDAC1 699429 3.5.1.98 0.0000317 - N-hydroxy-6-[4-(thiophen-2-yl)-1H-1,2,3-triazol-1-yl]hexanamide - 696716 3.5.1.98 0.0000319 - N-hydroxy-6-[4-(3-methylphenyl)-1H-1,2,3-triazol-1-yl]hexanamide - 696716 3.5.1.98 0.000035 - (2E)-N-hydroxy-3-[2-(2-phenylethyl)-1-(2-pyrrolidin-1-ylethyl)-1H-benzimidazol-5-yl]prop-2-enamide - 696662 3.5.1.98 0.000035 - (3S,6S,9S,13S)-3-(1H-indol-3-ylmethyl)-9-methyl-13-(2-methylpropyl)-6-(6-oxooctyl)-1,4,7,10-tetraazacyclotridecane-2,5,8,11-tetrone HDAC1 698491 3.5.1.98 0.000035 - (E)-3-[3-[4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl]phenyl]-N-hydroxyacrylamide recombinant HDAC3, pH not specified in the publication, temperature not specified in the publication 720187 3.5.1.98 0.000035 - 2,2,2-trifluoro-1-(5-[3-[(thiophen-2-ylsulfonyl)methyl]-1,2,4-oxadiazol-5-yl]thiophen-2-yl)ethanone HDAC4, pH and temperature not specified in the publication 712691 3.5.1.98 0.000035 - apicidin HDAC2 698491 3.5.1.98 0.000035 - N-hydroxy-6-[(3S,6S,9S,15aS)-6-(1H-indol-3-ylmethyl)-9-(2-methylpropyl)-1,4,7,11-tetraoxotetradecahydro-1H-pyrrolo[1,2-a][1,4,7,10]tetraazacyclotridecin-3-yl]hexanamide HDAC3 698491 3.5.1.98 0.000035 - N-hydroxy-6-[(3S,6S,9S,15aS)-6-(1H-indol-3-ylmethyl)-9-(2-methylpropyl)-1,4,7,11-tetraoxotetradecahydro-1H-pyrrolo[1,2-a][1,4,7,10]tetraazacyclotridecin-3-yl]hexanamide HDAC6 698491 3.5.1.98 0.000036 - 7-[(2E)-2-[(2-bromopyridin-3-yl)methylidene]hydrazino]-N-hydroxy-7-oxoheptanamide - 699458 3.5.1.98 0.000037 - 1-[5-(2,3-dihydro-1,4-benzodioxin-6-yl)thiophen-2-yl]-2,2,2-trifluoroethanone HDAC6, pH and temperature not specified in the publication 712691 3.5.1.98 0.000037 - 7-[(2E)-2-[(2-bromophenyl)methylidene]hydrazino]-N-hydroxy-7-oxoheptanamide - 699458 3.5.1.98 0.000037 - 7-[(2E)-2-[[4-(dimethylamino)-2-hydroxyphenyl]methylidene]hydrazino]-N-hydroxy-7-oxoheptanamide - 699458 3.5.1.98 0.00004 - (3S,6S,9S,13S)-3-(1H-indol-3-ylmethyl)-9,10-dimethyl-13-(2-methylpropyl)-6-(6-oxooctyl)-1,4,7,10-tetraazacyclotridecane-2,5,8,11-tetrone HDAC2 698491 3.5.1.98 0.00004 - (3S,6S,9S,15aS)-6-(1H-indol-3-ylmethyl)-9-(2-methylpropyl)-3-(6-oxooctyl)decahydro-1H-pyrrolo[1,2-a][1,4,7,10]tetraazacyclotridecine-1,4,7,11(8H)-tetrone HDAC2 698491 3.5.1.98 0.00004 - trichostatin A isoform HDAC8 681304 3.5.1.98 0.00004 - trichostatin A mutant H843Y 698743 3.5.1.98 0.000041 - (2E)-3-[1-[3-(dimethylamino)-2,2-dimethylpropyl]-2-(2-phenylethyl)-1H-benzimidazol-5-yl]-N-hydroxyprop-2-enamide - 696662 3.5.1.98 0.000041 - 4-[5-(trifluoroacetyl)thiophen-2-yl]benzonitrile HDAC6, pH and temperature not specified in the publication 712691 3.5.1.98 0.000041 - N-hydroxy-7-[(2E)-2-[(2-hydroxynaphthalen-1-yl)methylidene]hydrazino]-7-oxoheptanamide - 699458 3.5.1.98 0.000041 - trichostatin A HeLa cell nuclear extract 681304 3.5.1.98 0.000043 - N-hydroxy-8-oxo-8-[(2E)-2-[(2,4,6-trihydroxyphenyl)methylidene]hydrazino]octanamide - 699458 3.5.1.98 0.000043 - vorinostat HDAC6 699429 3.5.1.98 0.0000434 - N-hydroxy-6-[4-(4-methylphenyl)-1H-1,2,3-triazol-1-yl]hexanamide - 696716 3.5.1.98 0.000044 - apicidin HDAC1 699429 3.5.1.98 0.000044 - N-hydroxy-4-(methyl[(5-pyridin-2-yl-2-thienyl)sulfonyl]amino)benzamide isoform HDAC3 682501 3.5.1.98 0.000045 - (2E)-3-[4-([[2-(3a,7a-dihydro-1H-indol-3-yl)ethyl](2-hydroxyethyl)amino]methyl)phenyl]-N-hydroxyprop-2-enamide pH and temperature not specified in the publication 711416 3.5.1.98 0.000045 - (5S,8S,11S,5'S,8'S,11'S)-11,11'-[disulfanediyldi(1E)but-1-ene-4,1-diyl]bis[5-methyl-8-(1-methylethyl)-3,10,17-trioxa-7,14,19,20-tetraazatricyclo[14.2.1.1-2,5]icosa-1(18),2(20),16(19)-triene-6,9,13-trione] - 700547 3.5.1.98 0.000045 - MS-275 - 700547 3.5.1.98 0.000045 - N-(4-amino-4'-fluoro[1,1'-biphenyl]-3-yl)-3,4-dihydro-1H-2-benzopyran-3-carboxamide pH 7.4, 22°C, HDAC1 isozyme 756174 3.5.1.98 0.000045 - [4-[(E)-[[6-(hydroxyamino)-6-oxohexanoyl]hydrazono]methyl]phenyl]boronic acid - 699458 3.5.1.98 0.000046 - methyl (3R,6R,9R)-9-(acetylamino)-6-[6-(hydroxyamino)-6-oxohexyl]-5,8-dioxo-4,7-diazabicyclo[9.3.1]pentadeca-1(15),11,13-triene-3-carboxylate HeLa cell nuclear extract 681304 3.5.1.98 0.000047 - (2E)-N-hydroxy-3-[2-(2-phenylethyl)-1-(3,4,5-trimethoxybenzyl)-1H-benzimidazol-5-yl]prop-2-enamide - 696662 3.5.1.98 0.000047 - (E)-3-[3-[4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl]phenyl]-N-hydroxyacrylamide recombinant HDAC1, pH not specified in the publication, temperature not specified in the publication 720187 3.5.1.98 0.000048 - 2-(5-methoxy-2-methyl-1H-indol-3-yl)-N-[(1S)-7-oxo-1-(5-phenyl-1H-imidazol-2-yl)nonyl]acetamide HDAC3 699429 3.5.1.98 0.000049 - (5R,8S,11S)-5-methyl-8-(1-methylethyl)-11-[(1E)-4-sulfanylbut-1-en-1-yl]-10-oxa-3,17-dithia-7,14,19,20-tetraazatricyclo[14.2.1.1-2,5]icosa-1(18),2(20),16(19)-triene-6,9,13-trione - 700547 3.5.1.98 0.000049 - 7-[(2E)-2-[(2-bromo-5-hydroxyphenyl)methylidene]hydrazino]-N-hydroxy-7-oxoheptanamide - 699458 3.5.1.98 0.00005 - (3S,6S,9S,13S)-3-(1H-indol-3-ylmethyl)-9,10-dimethyl-13-(2-methylpropyl)-6-(6-oxooctyl)-1,4,7,10-tetraazacyclotridecane-2,5,8,11-tetrone HDAC1 698491 3.5.1.98 0.00005 - (3S,6S,9S,15aS)-6-(1H-indol-3-ylmethyl)-9-(2-methylpropyl)-3-(6-oxooctyl)decahydro-1H-pyrrolo[1,2-a][1,4,7,10]tetraazacyclotridecine-1,4,7,11(8H)-tetrone HDAC5 698491 3.5.1.98 0.000052 - (2E)-3-[1-[2-(diethylamino)ethyl]-2-(2-phenylethyl)-1H-benzimidazol-5-yl]-N-hydroxyprop-2-enamide - 696662 3.5.1.98 0.0000524 - 6-[4-(biphenyl-4-yl)-1H-1,2,3-triazol-1-yl]-N-hydroxyhexanamide - 696716 3.5.1.98 0.000055 - 1-methyl-N-[(1S)-7-oxo-1-[(4-phenyl-1,3-thiazol-2-yl)carbamoyl]octyl]piperidine-2-carboxamide HDAC1 699429 3.5.1.98 0.000057 - methyl (3R,6R,9R)-9-(acetylamino)-6-[6-(hydroxyamino)-6-oxohexyl]-5,8-dioxo-4,7-diazabicyclo[9.3.1]pentadeca-1(15),11,13-triene-3-carboxylate isoform HDAC1 681304 3.5.1.98 0.000057 - vorinostat HDAC3 699429 3.5.1.98 0.000059 - 2-(5-methoxy-2-methyl-1H-indol-3-yl)-N-[(1S)-7-oxo-1-(5-phenyl-1H-imidazol-2-yl)nonyl]acetamide HDAC2 699429 3.5.1.98 0.000059 - 2-(5-methoxy-2-methyl-1H-indol-3-yl)-N-[(1S)-7-oxo-1-(5-phenyl-1H-imidazol-2-yl)octyl]acetamide HDAC1 699429 3.5.1.98 0.000059 - 6-[(2E)-2-[(2-bromo-4-hydroxy-5-methoxyphenyl)methylidene]hydrazino]-N-hydroxy-6-oxohexanamide - 699458 3.5.1.98 0.000059 - 7-[(2E)-2-[(2-bromo-4-hydroxy-5-methoxyphenyl)methylidene]hydrazino]-N-hydroxy-7-oxoheptanamide - 699458 3.5.1.98 0.000059 - N-hydroxy-7-[(2E)-2-[(3-hydroxyphenyl)methylidene]hydrazino]-7-oxoheptanamide - 699458 3.5.1.98 0.000059 - suberoylanilide hydroxamic acid - 699458 3.5.1.98 0.00006 - (3S,6S,9S,13S)-3-(1H-indol-3-ylmethyl)-9,10-dimethyl-13-(2-methylpropyl)-6-(6-oxooctyl)-1,4,7,10-tetraazacyclotridecane-2,5,8,11-tetrone HDAC5 698491 3.5.1.98 0.00006 - 2,2,2-trifluoro-1-[5-(3-[[(4-fluorobenzyl)sulfonyl]methyl]-1,2,4-oxadiazol-5-yl)thiophen-2-yl]ethanone HDAC4, pH and temperature not specified in the publication 712691 3.5.1.98 0.00006 - trichostatin A isoform HDAC1 681304 3.5.1.98 0.000062 - N-(4-amino-4'-fluoro[1,1'-biphenyl]-3-yl)oxane-4-carboxamide pH 7.4, 22°C, HDAC2 isozyme 756174 3.5.1.98 0.0000621 - N-[1,1,2,2,3,3,4,4,5,5,6,6-dodecafluoro-7-(hydroxyamino)-7-oxoheptyl]benzamide pH and temperature not specified in the publication 756043 3.5.1.98 0.000065 - suberoylanilide hydroxamic acid - 696716 3.5.1.98 0.000065 - suberoylanilide hydroxamic acid pH 8.0, 37°C, recombinant enzyme 733817 3.5.1.98 0.000066 - (E)-3-[3-[4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl]phenyl]-N-hydroxyacrylamide recombinant HDAC6, pH not specified in the publication, temperature not specified in the publication 720187 3.5.1.98 0.0000676 - N-hydroxy-6-[4-(pyridin-2-yl)-1H-1,2,3-triazol-1-yl]hexanamide - 696716 3.5.1.98 0.00007 - (3S,6S,9S,13S)-3-(1H-indol-3-ylmethyl)-9-methyl-13-(2-methylpropyl)-6-(6-oxooctyl)-1,4,7,10-tetraazacyclotridecane-2,5,8,11-tetrone HDAC5 698491 3.5.1.98 0.00007 - 3-[5-(trifluoroacetyl)thiophen-2-yl]benzoic acid HDAC6, pH and temperature not specified in the publication 712691 3.5.1.98 0.00007 - 6-[(9H-fluoren-3-ylmethyl)(3-phenoxybenzyl)amino]-N-hydroxyhexanamide HDAC activity in HeLa nuclear cell extracts, 25°C, pH 8.0 719304 3.5.1.98 0.000072 - 7-mercapto-N-quinolin-3-ylheptanamide 37°C 681276 3.5.1.98 0.000072 - N-(4-amino-4'-fluoro[1,1'-biphenyl]-3-yl)-3,4-dihydro-2H-1-benzopyran-3-carboxamide pH 7.4, 22°C, HDAC1 isozyme 756174 3.5.1.98 0.000075 - N-biphenyl-3-yl-7-mercaptoheptanamide 37°C 681276 3.5.1.98 0.000076 - N-hydroxy-6-[4-(2-methoxyphenyl)-1H-1,2,3-triazol-1-yl]hexanamide - 696716 3.5.1.98 0.000077 - (8S,11S)-8-(1-methylethyl)-11-[(1E)-4-sulfanylbut-1-en-1-yl]-10-oxa-3,17-dithia-7,14,19,20-tetraazatricyclo[14.2.1.1-2,5]icosa-1(18),2(20),4,16(19)-tetraene-6,9,13-trione - 700547 3.5.1.98 0.000078 - (2E)-N-hydroxy-3-[2-[2-(pyrazolo[1,5-a]pyridin-3-yl)ethyl]-2,3-dihydro-1H-isoindol-5-yl]prop-2-enamide isoform HDAC1, pH not specified in the publication, temperature not specified in the publication 719058 3.5.1.98 0.000079 - N-(6-mercaptohexyl)-1-benzofuran-2-carboxamide 37°C 681276 3.5.1.98 0.00008 - (2E)-N-hydroxy-3-[1-(3-hydroxypropyl)-2-(2-phenylpropyl)-1H-benzimidazol-5-yl]prop-2-enamide - 696662 3.5.1.98 0.00008 - apicidin HDAC5 698491 3.5.1.98 0.000082 - vorinostat HDAC2 699429 3.5.1.98 0.000085 - (8S,11S)-8-(1-methylethyl)-11-[(1E)-4-sulfanylbut-1-en-1-yl]-10-oxa-3,17-dithia-7,14,19,20-tetraazatricyclo[14.2.1.1-2,5]icosa-1(18),2(20),4,16(19)-tetraene-6,9,13-trione - 700547 3.5.1.98 0.000085 - N-(6-mercaptohexyl)-2-naphthamide 37°C 681276 3.5.1.98 0.000086 - (E)-3-[3-[4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl]phenyl]-N-hydroxyacrylamide recombinant HDAC8, pH not specified in the publication, temperature not specified in the publication 720187 3.5.1.98 0.000086 - N-hydroxy-4-(methyl[(5-pyridin-2-yl-2-thienyl)sulfonyl]amino)benzamide isoform HDAC1 682501 3.5.1.98 0.000089 - 6-[(2E)-2-[(2-bromo-5-hydroxyphenyl)methylidene]hydrazino]-N-hydroxy-6-oxohexanamide - 699458 3.5.1.98 0.000089 - N-methyl-N-(quinoxalin-6-ylmethyl)-5-(trifluoroacetyl)thiophene-2-carboxamide HDAC6, pH and temperature not specified in the publication 712691 3.5.1.98 0.000089 - N1-hydroxy-N7-(5-phenyl-1,3,4-thiadiazol-2-yl)heptanediamide HDAC from HeLa cell nucleus extracts, mainly including HDAC1 and HDAC2, 37°C, pH not specified in the publication 719092 3.5.1.98 0.00009 - 7-[(2E)-2-[(2-chlorophenyl)methylidene]hydrazino]-N-hydroxy-7-oxoheptanamide - 699458 3.5.1.98 0.000098 - N-methyl-N-(quinoxalin-6-ylmethyl)-5-(trifluoroacetyl)thiophene-2-carboxamide HDAC4, pH and temperature not specified in the publication 712691 3.5.1.98 0.0001 - (2E)-N-hydroxy-3-[1-(3-hydroxypropyl)-2-(2-methylpropyl)-1H-benzimidazol-5-yl]prop-2-enamide - 696662 3.5.1.98 0.0001 - 6-[(2S,5S,8S,11S)-8-(1H-indol-3-ylmethyl)-2-methyl-11-(2-methylpropyl)-3,6,9,13-tetraoxo-1,4,7,10-tetraazacyclotridecan-5-yl]hexanoic acid HDAC1 698491 3.5.1.98 0.0001 - apicidin HDAC3 698491 3.5.1.98 0.0001 - N-(6-mercaptohexyl)-1H-indole-2-carboxamide 37°C 681276 3.5.1.98 0.000106 - 6-[(2E)-2-[(2-bromo-4-hydroxyphenyl)methylidene]hydrazino]-N-hydroxy-6-oxohexanamide - 699458 3.5.1.98 0.000106 - suberoylanilide hydroxamic acid isoform HDAC3 682501 3.5.1.98 0.0001061 - 7-{4-[4-(dimethylamino)phenyl]-1H-1,2,3-triazol-1-yl}-N-hydroxyheptanamide - 696716 3.5.1.98 0.00011 - (3S,15R,20aS)-15-methyl-3-[(1E)-4-sulfanylbut-1-en-1-yl]-3,4,6,7,14,15,18,19,20,20a-decahydro-1H,5H,16H-11,8:15,12-di(azeno)pyrrolo[2,1-c][1,8,12,4,15]oxadithiadiazacyclooctadecine-1,5,16-trione - 700547 3.5.1.98 0.00011 - 2,2,2-trifluoro-1-[5-(4-methoxyphenyl)thiophen-2-yl]ethanone HDAC4, pH and temperature not specified in the publication 712691 3.5.1.98 0.00011 - 2-(5-methoxy-2-methyl-1H-indol-3-yl)-N-[(1S)-7-oxo-1-(5-phenyl-1H-imidazol-2-yl)octyl]acetamide HDAC2 699429 3.5.1.98 0.00011 - 7-mercapto-N-pyridin-3-ylheptanamide 37°C 681276 3.5.1.98 0.00011 - 8-[(2E)-2-[(2,5-dihydroxyphenyl)methylidene]hydrazino]-N-hydroxy-8-oxooctanamide - 699458 3.5.1.98 0.00011 - N-hydroxy-5-(4-phenyl-1H-1,2,3-triazol-1-yl)pentanamide - 696716 3.5.1.98 0.00011 - suberoylanilide hydroxamic acid HeLa cell nuclear extract 681304 3.5.1.98 0.000112 - suberoylanilide hydroxamic acid isoform HDAC1 681304 3.5.1.98 0.0001125 - N-hydroxy-6-[4-(pyridin-4-yl)-1H-1,2,3-triazol-1-yl]hexanamide - 696716 3.5.1.98 0.000119 - N-(4-amino-4'-fluoro[1,1'-biphenyl]-3-yl)-3,4-dihydro-1H-2-benzopyran-3-carboxamide pH 7.4, 22°C, HDAC2 isozyme 756174 3.5.1.98 0.000119 - N-(4-amino[1,1'-biphenyl]-3-yl)oxane-4-carboxamide pH 7.4, 22°C, HDAC1 isozyme 756174 3.5.1.98 0.000119 - suberoylanilide hydroxamic acid isoform HDAC1 682501 3.5.1.98 0.00012 - (8S,11S)-8-(1-methylethyl)-11-[(1E)-4-sulfanylbut-1-en-1-yl]-10-oxa-3,17-dithia-7,14,19,20-tetraazatricyclo[14.2.1.1-2,5]icosa-1(18),2(20),4,16(19)-tetraene-6,9,13-trione - 700547 3.5.1.98 0.00012 - 2-(5-methoxy-2-methyl-1H-indol-3-yl)-N-[(1S)-7-oxo-1-(5-phenyl-1H-imidazol-2-yl)octyl]acetamide HDAC3 699429 3.5.1.98 0.00012 - MS-275 HDAC1 699429 3.5.1.98 0.00012 - N-hydroxy-6-[(2S,5S,8S,11S)-8-(1H-indol-3-ylmethyl)-2-methyl-11-(2-methylpropyl)-3,6,9,13-tetraoxo-1,4,7,10-tetraazacyclotridecan-5-yl]hexanamide HDAC8 698491 3.5.1.98 0.000123 - N-(4-amino-4'-fluoro[1,1'-biphenyl]-3-yl)-3-oxabicyclo[3.1.0]hexane-6-carboxamide pH 7.4, 22°C, HDAC1 isozyme 756174 3.5.1.98 0.00013 - (5R,8S,11S)-8-(1-methylethyl)-11-[(1E)-4-sulfanylbut-1-en-1-yl]-10-oxa-3,17-dithia-7,14,19,20-tetraazatricyclo[14.2.1.1-2,5]icosa-1(18),2(20),16(19)-triene-6,9,13-trione - 700547 3.5.1.98 0.00013 - 2,2,2-trifluoro-1-(2-phenyl-1,3-thiazol-5-yl)ethanone HDAC4, pH and temperature not specified in the publication 712691 3.5.1.98 0.00013 - LBH589 mutant H843Y 698743 3.5.1.98 0.00013 - MS-275 - 700547 3.5.1.98 0.00014 - (2S)-8-oxo-2-[(3-piperidin-1-ylpropanoyl)amino]-N-quinolin-3-ylnonanamide HDAC1 699429 3.5.1.98 0.00015 - (3S,6S,9S,13S)-3-(1H-indol-3-ylmethyl)-9-methyl-13-(2-methylpropyl)-6-(6-oxooctyl)-1,4,7,10-tetraazacyclotridecane-2,5,8,11-tetrone HDAC3 698491 3.5.1.98 0.00015 - suberoylanilide hydroxamic acid HDAC from HeLa cell nucleus extracts, mainly including HDAC1 and HDAC2, 37°C, pH not specified in the publication 719092 3.5.1.98 0.0001515 - N-hydroxy-6-[4-(quinolin-7-yl)-1H-1,2,3-triazol-1-yl]hexanamide - 696716 3.5.1.98 0.000156 - N-(4-amino-4'-fluoro[1,1'-biphenyl]-3-yl)-3,4-dihydro-2H-1-benzopyran-3-carboxamide pH 7.4, 22°C, HDAC2 isozyme 756174 3.5.1.98 0.00016 - (2E)-3-[1-[4-(dimethylamino)butyl]-2-(2-phenylethyl)-1H-benzimidazol-5-yl]-N-hydroxyprop-2-enamide - 696662 3.5.1.98 0.00016 - (2E)-N-hydroxy-3-[1-[3-(1H-imidazol-1-yl)propyl]-2-(2-phenylethyl)-1H-benzimidazol-5-yl]prop-2-enamide - 696662 3.5.1.98 0.00016 - (E)-N1-hydroxy-N5-(5-styryl-1,3,4-thiadiazol-2-yl)glutaramide HDAC from HeLa cell nucleus extracts, mainly including HDAC1 and HDAC2, 37°C, pH not specified in the publication 719092 3.5.1.98 0.00016 - 2,2,2-trifluoro-1-[5-(quinoxalin-6-yl)thiophen-2-yl]ethanone HDAC4, pH and temperature not specified in the publication 712691 3.5.1.98 0.00016 - 4-[5-(trifluoroacetyl)thiophen-2-yl]benzonitrile HDAC4, pH and temperature not specified in the publication 712691 3.5.1.98 0.0001626 - 6-[4-(biphenyl-2-yl)-1H-1,2,3-triazol-1-yl]-N-hydroxyhexanamide - 696716 3.5.1.98 0.000167 - methyl N-[(2S)-2-[(N-acetyl-L-alanyl)amino]-7-(hydroxyamino)-7-oxoheptanoyl]-L-phenylalaninate HeLa cell nuclear extract 681304 3.5.1.98 0.000168 - (1R,5S)-N-(4-amino-4'-fluoro[1,1'-biphenyl]-3-yl)-6-oxabicyclo[3.1.1]heptane-3-carboxamide pH 7.4, 22°C, HDAC2 isozyme 756174 3.5.1.98 0.00017 - (2E)-3-[2-[(benzyloxy)methyl]-1-(3-hydroxypropyl)-1H-benzimidazol-5-yl]-N-hydroxyprop-2-enamide - 696662 3.5.1.98 0.00017 - (2E)-N-hydroxy-3-[1-(3-hydroxypropyl)-2-(2-phenylethyl)-1H-benzimidazol-5-yl]prop-2-enamide - 696662 3.5.1.98 0.00017 - (2E)-N-hydroxy-3-[2-(2-phenylethyl)-1-propyl-1H-benzimidazol-5-yl]prop-2-enamide - 696662 3.5.1.98 0.00017 - (2E)-N-hydroxy-3-[2-(2-phenylethyl)-1H-benzimidazol-5-yl]prop-2-enamide - 696662 3.5.1.98 0.00017 - 2,2,2-trifluoro-1-(5-phenylthiophen-2-yl)ethanone HDAC6, pH and temperature not specified in the publication 712691 3.5.1.98 0.00017 - 6-[(biphenyl-4-ylmethyl)[4-[(4-bromobenzyl)oxy]benzyl]amino]-N-hydroxyhexanamide HDAC activity in HeLa nuclear cell extracts, 25°C, pH 8.0 719304 3.5.1.98 0.00017 - 7-mercapto-N-(2-phenyl-1,3-thiazol-5-yl)heptanamide 37°C 681276 3.5.1.98 0.00017 - MS-275 - 700547 3.5.1.98 0.00017 - N-hydroxy-3-[2-(2-phenylethyl)-1-(3,4,5-trimethoxybenzyl)-1H-benzimidazol-5-yl]propanamide - 696662 3.5.1.98 0.000174 - methyl N-[(2S)-2-[(N-acetyl-L-alanyl)amino]-7-(hydroxyamino)-7-oxoheptanoyl]-L-phenylalaninate isoform HDAC1 681304 3.5.1.98 0.000175 - N-hydroxy-4-(methyl[(5-pyridin-2-yl-2-thienyl)sulfonyl]amino)benzamide isoform HDAC8 682501 3.5.1.98 0.00018 - 6-[[4-[(4-bromobenzyl)oxy]benzyl](9H-fluoren-3-ylmethyl)amino]-N-hydroxyhexanamide HDAC activity in HeLa nuclear cell extracts, 25°C, pH 8.0 719304 3.5.1.98 0.00018 - N-hydroxy-6-[(3S,6S,9S,15aS)-6-(1H-indol-3-ylmethyl)-9-(2-methylpropyl)-1,4,7,11-tetraoxotetradecahydro-1H-pyrrolo[1,2-a][1,4,7,10]tetraazacyclotridecin-3-yl]hexanamide HDAC8 698491 3.5.1.98 0.000185 - pyridin-3-ylmethyl (4-[[(2-aminophenyl)amino]carbonyl]benzyl)carbamate isoform HDAC1 682501 3.5.1.98 0.00019 - (2E)-3-[1-[3-(dimethylamino)propyl]-2-(2-phenylethyl)-1H-benzimidazol-5-yl]-N-hydroxyprop-2-enamide - 696662 3.5.1.98 0.000192 - (1R,5S)-N-(4-amino-4'-fluoro[1,1'-biphenyl]-3-yl)-6-oxabicyclo[3.1.1]heptane-3-carboxamide pH 7.4, 22°C, HDAC1 isozyme 756174 3.5.1.98 0.0002 - (2E)-N-hydroxy-3-[1-[3-(2-oxopyrrolidin-1-yl)propyl]-2-(2-phenylethyl)-1H-benzimidazol-5-yl]prop-2-enamide - 696662 3.5.1.98 0.0002 - 6-[(2S,5S,8S,11S)-8-(1H-indol-3-ylmethyl)-2-methyl-11-(2-methylpropyl)-3,6,9,13-tetraoxo-1,4,7,10-tetraazacyclotridecan-5-yl]hexanoic acid HDAC2 698491 3.5.1.98 0.000201 - pyridin-3-ylmethyl (4-[[(2-aminophenyl)amino]carbonyl]benzyl)carbamate isoform HDAC3 682501 3.5.1.98 0.00021 - (2E)-N-hydroxy-3-[1-(3-methoxypropyl)-2-(2-phenylethyl)-1H-benzimidazol-5-yl]prop-2-enamide - 696662 3.5.1.98 0.00021 - 2,2,2-trifluoro-1-(2-phenyl-1,3-thiazol-5-yl)ethanone HDAC6 pH and temperature not specified in the publication 712691 3.5.1.98 0.00021 - 7-mercapto-N-(3-phenoxyphenyl)heptanamide 37°C 681276 3.5.1.98 0.00021 - 7-mercapto-N-phenylheptanamide 37°C 681276 3.5.1.98 0.000219 - N-(4-amino-4'-fluoro[1,1'-biphenyl]-3-yl)-3-oxabicyclo[3.1.0]hexane-6-carboxamide pH 7.4, 22°C, HDAC2 isozyme 756174 3.5.1.98 0.00022 - (2E)-3-[1-ethyl-2-(2-phenylethyl)-1H-benzimidazol-5-yl]-N-hydroxyprop-2-enamide - 696662 3.5.1.98 0.00022 - N1-(5-benzyl-1,3,4-thiadiazol-2-yl)-N7-hydroxyheptanediamide HDAC from HeLa cell nucleus extracts, mainly including HDAC1 and HDAC2, 37°C, pH not specified in the publication 719092 3.5.1.98 0.00023 - 2,2,2-trifluoro-1-(5-[3-[(methylsulfonyl)methyl]-1,2,4-oxadiazol-5-yl]thiophen-2-yl)ethanone HDAC6, pH and temperature not specified in the publication 712691 3.5.1.98 0.00023 - 3-[5-[4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl]furan-2-yl]-N-hydroxy-acrylamide recombinant HDAC8, pH not specified in the publication, temperature not specified in the publication 720187 3.5.1.98 0.00024 - 2,2,2-trifluoro-1-(5-[3-[(propylsulfonyl)methyl]-1,2,4-oxadiazol-5-yl]thiophen-2-yl)ethanone HDAC6, pH and temperature not specified in the publication 712691 3.5.1.98 0.00024 - N-[(3E)-4-[(5R,8S,11S)-5-methyl-8-(1-methylethyl)-6,9,13-trioxo-10-oxa-3,17-dithia-7,14,19,20-tetraazatricyclo[14.2.1.1-2,5]icosa-1(18),2(20),16(19)-trien-11-yl]but-3-en-1-yl]-2-sulfanylacetamide - 700547 3.5.1.98 0.00025 - (2E)-N-hydroxy-3-[1-(3-morpholin-4-ylpropyl)-2-(2-phenylethyl)-1H-benzimidazol-5-yl]prop-2-enamide - 696662 3.5.1.98 0.00025 - (2E)-N-hydroxy-3-[2-(2-phenylethyl)-1-(pyridin-2-ylmethyl)-1H-benzimidazol-5-yl]prop-2-enamide - 696662 3.5.1.98 0.00025 - MS-275 HDAC2 699429 3.5.1.98 0.00026 - (2E)-N-hydroxy-3-[1-methyl-2-(2-phenylethyl)-1H-benzimidazol-5-yl]prop-2-enamide - 696662 3.5.1.98 0.00026 - N1-(5-benzyl-1,3,4-thiadiazol-2-yl)-N8-hydroxyoctanediamide HDAC from HeLa cell nucleus extracts, mainly including HDAC1 and HDAC2, 37°C, pH not specified in the publication 719092 3.5.1.98 0.00027 - (2E)-N-hydroxy-3-[1-(2-morpholin-4-ylethyl)-2-(2-phenylethyl)-1H-benzimidazol-5-yl]prop-2-enamide - 696662 3.5.1.98 0.00027 - (4E)-N-(2-aminophenyl)-5-[(5R,8S,11S)-5-methyl-8-(1-methylethyl)-6,9,13-trioxo-10-oxa-3,17-dithia-7,14,19,20-tetraazatricyclo[14.2.1.1-2,5]icosa-1(18),2(20),16(19)-trien-11-yl]pent-4-enamide - 700547 3.5.1.98 0.00027 - N1-hydroxy-N8-(5-phenyl-1,3,4-thiadiazol-2-yl)octanediamide HDAC from HeLa cell nucleus extracts, mainly including HDAC1 and HDAC2, 37°C, pH not specified in the publication 719092 3.5.1.98 0.00027 - suberoylanilide hydroxamic acid isoform HDAC8 681304 3.5.1.98 0.00028 - (3S,6S,9S,15aS)-6-(1H-indol-3-ylmethyl)-9-(2-methylpropyl)-3-(6-oxooctyl)decahydro-1H-pyrrolo[1,2-a][1,4,7,10]tetraazacyclotridecine-1,4,7,11(8H)-tetrone HDAC3 698491 3.5.1.98 0.00028 - 6-[(2S,5S,8S,11S)-8-(1H-indol-3-ylmethyl)-2-methyl-11-(2-methylpropyl)-3,6,9,13-tetraoxo-1,4,7,10-tetraazacyclotridecan-5-yl]hexanoic acid HDAC10 698491 3.5.1.98 0.00028 - suberoylanilide hydroxamic acid 37°C 681276 3.5.1.98 0.0002872 - N-hydroxy-6-[4-(pyridin-3-yl)-1H-1,2,3-triazol-1-yl]hexanamide - 696716 3.5.1.98 0.0003 - (3S,6S,10S,14S)-3-(1H-indol-3-ylmethyl)-10-methyl-14-(2-methylpropyl)-6-(6-oxooctyl)-1,4,7,11-tetraazacyclotetradecane-2,5,8,12-tetrone HDAC1 698491 3.5.1.98 0.0003 - suberoylanilide hydroxamic acid mutant H843Y 698743 3.5.1.98 0.0003 - trichostatin A wild type 698743 3.5.1.98 0.00031 - (2E)-N-hydroxy-3-[2-(2-phenylethyl)-1-(3-pyrrolidin-1-ylpropyl)-1H-benzimidazol-5-yl]prop-2-enamide - 696662 3.5.1.98 0.00031 - 3-[5-(trifluoroacetyl)thiophen-2-yl]benzoic acid HDAC4, pH and temperature not specified in the publication 712691 3.5.1.98 0.000312 - N-(4-amino[1,1'-biphenyl]-3-yl)oxane-4-carboxamide pH 7.4, 22°C, HDAC2 isozyme 756174 3.5.1.98 0.0003159 - 6-[4-(2,6-dimethoxyphenyl)-1H-1,2,3-triazol-1-yl]-N-hydroxyhexanamide - 696716 3.5.1.98 0.00034 - 2-(5-methoxy-2-methyl-1H-indol-3-yl)-N-[(1S)-7-oxo-1-(5-phenyl-1H-imidazol-2-yl)octyl]acetamide HDAC6 699429 3.5.1.98 0.00034 - N1-methyl-2-oxo-N9-phenylnonanediamide 37°C 681276 3.5.1.98 0.00036 - N-(6-mercaptohexyl)benzamide 37°C 681276 3.5.1.98 0.00037 - 6-mercapto-N-phenylhexanamide 37°C 681276 3.5.1.98 0.00039 - 6-[(1-(mercaptomethyl)vinyl)amino]-N-phenylhexanamide 37°C 681276 3.5.1.98 0.0004 - (3S,6S,10S,14S)-3-(1H-indol-3-ylmethyl)-10-methyl-14-(2-methylpropyl)-6-(6-oxooctyl)-1,4,7,11-tetraazacyclotetradecane-2,5,8,12-tetrone HDAC10 698491 3.5.1.98 0.0004 - (3S,6S,10S,14S)-3-(1H-indol-3-ylmethyl)-10-methyl-14-(2-methylpropyl)-6-(6-oxooctyl)-1,4,7,11-tetraazacyclotetradecane-2,5,8,12-tetrone HDAC2 698491 3.5.1.98 0.0004 - (3S,6S,10S,14S)-3-(1H-indol-3-ylmethyl)-10-methyl-14-(2-methylpropyl)-6-(6-oxooctyl)-1,4,7,11-tetraazacyclotetradecane-2,5,8,12-tetrone HDAC9 698491 3.5.1.98 0.0004 - MS-275 HDAC3 699429 3.5.1.98 0.00041 - (2E)-3-[1-benzyl-2-(2-phenylethyl)-1H-benzimidazol-5-yl]-N-hydroxyprop-2-enamide - 696662 3.5.1.98 0.00045 - 5-(4-hydroxyphenyl)-3H-1,2-dithiol-3-thione ADTOH 696610 3.5.1.98 0.000467 - (2R)-N-(4-amino-4'-fluoro[1,1'-biphenyl]-3-yl)oxane-2-carboxamide pH 7.4, 22°C, HDAC1 isozyme 756174 3.5.1.98 0.00049 - trichostatin A isoform HDAC8 682501 3.5.1.98 0.00052 - 2,2,2-trifluoro-1-(5-[3-[(thiophen-2-ylsulfonyl)methyl]-1,2,4-oxadiazol-5-yl]thiophen-2-yl)ethanone HDAC6, pH and temperature not specified in the publication 712691 3.5.1.98 0.00053 - (2E)-N-hydroxy-3-[1-(3-hydroxypropyl)-2-octyl-1H-benzimidazol-5-yl]prop-2-enamide - 696662 3.5.1.98 0.00054 - 2,2,2-trifluoro-1-[5-(pyridin-2-yl)thiophen-2-yl]ethanone HDAC4, pH and temperature not specified in the publication 712691 3.5.1.98 0.00055 - (3S,6S,9S,13S)-3-(1H-indol-3-ylmethyl)-9,10-dimethyl-13-(2-methylpropyl)-6-(6-oxooctyl)-1,4,7,10-tetraazacyclotridecane-2,5,8,11-tetrone HDAC3 698491 3.5.1.98 0.00055 - 6-[(2S,5S,8S,11S)-8-(1H-indol-3-ylmethyl)-2-methyl-11-(2-methylpropyl)-3,6,9,13-tetraoxo-1,4,7,10-tetraazacyclotridecan-5-yl]hexanoic acid HDAC9 698491 3.5.1.98 0.00058 - (3S,15R,20aS)-15-methyl-3-[(1E)-4-sulfanylbut-1-en-1-yl]-3,4,6,7,14,15,18,19,20,20a-decahydro-1H,5H,16H-11,8:15,12-di(azeno)pyrrolo[2,1-c][1,8,12,4,15]oxadithiadiazacyclooctadecine-1,5,16-trione - 700547 3.5.1.98 0.00058 - (S)-benzyl 7-(2-(hydroxyamino)-2-oxoethoxy)-3-(phenethylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate in 15 mM Tris-HCl, pH 8.0, at 37°C 711451 3.5.1.98 0.00058 - N-methyl-N-(quinoxalin-6-ylmethyl)-5-(trifluoroacetyl)thiophene-2-carboxamide HDAC1, pH and temperature not specified in the publication 712691 3.5.1.98 0.0006 - 6-[(2S,5S,8S,11S)-8-(1H-indol-3-ylmethyl)-2-methyl-11-(2-methylpropyl)-3,6,9,13-tetraoxo-1,4,7,10-tetraazacyclotridecan-5-yl]hexanoic acid HDAC3 698491 3.5.1.98 0.00061 - 3-[5-[4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl]furan-2-yl]-N-hydroxy-acrylamide recombinant HDAC3, pH not specified in the publication, temperature not specified in the publication 720187 3.5.1.98 0.00063 - 3-[5-[4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl]furan-2-yl]-N-hydroxy-acrylamide recombinant HDAC1, pH not specified in the publication, temperature not specified in the publication 720187 3.5.1.98 0.00067 - N-[(1S)-1-(6-chloro-1H-benzimidazol-2-yl)-7-oxooctyl]-2-(5-methoxy-2-methyl-1H-indol-3-yl)acetamide HDAC1 699429 3.5.1.98 0.00067 - N-[(2E)-3-[(5R,8S,11S)-5-methyl-8-(1-methylethyl)-6,9,13-trioxo-10-oxa-3,17-dithia-7,14,19,20-tetraazatricyclo[14.2.1.1-2,5]icosa-1(18),2(20),16(19)-trien-11-yl]prop-2-en-1-yl]-2-sulfanylacetamide - 700547 3.5.1.98 0.0007 - 2,2,2-trifluoro-1-[5-(3-[[(4-fluorobenzyl)sulfonyl]methyl]-1,2,4-oxadiazol-5-yl)thiophen-2-yl]ethanone HDAC6, pH and temperature not specified in the publication 712691 3.5.1.98 0.0007 - 6-[(2S,5S,8S,11S)-8-(1H-indol-3-ylmethyl)-2-methyl-11-(2-methylpropyl)-3,6,9,13-tetraoxo-1,4,7,10-tetraazacyclotridecan-5-yl]hexanoic acid HDAC5 698491 3.5.1.98 0.0007 - N-[(2E)-3-[(5R,8S,11S)-5-methyl-8-(1-methylethyl)-6,9,13-trioxo-10-oxa-3,17-dithia-7,14,19,20-tetraazatricyclo[14.2.1.1-2,5]icosa-1(18),2(20),16(19)-trien-11-yl]prop-2-en-1-yl]-2-sulfanylacetamide - 700547 3.5.1.98 0.00075 - apicidin HDAC8 698491 3.5.1.98 0.0008 - (3S,15R,20aS)-15-methyl-3-[(1E)-4-sulfanylbut-1-en-1-yl]-3,4,6,7,14,15,18,19,20,20a-decahydro-1H,5H,16H-11,8:15,12-di(azeno)pyrrolo[2,1-c][1,8,12,4,15]oxadithiadiazacyclooctadecine-1,5,16-trione - 700547 3.5.1.98 0.0008 - tubacin mutant H843Y 698743 3.5.1.98 0.00088 - (2E)-3-[1,2-bis(2-phenylethyl)-1H-benzimidazol-5-yl]-N-hydroxyprop-2-enamide - 696662 3.5.1.98 0.00088 - N-[(1S)-1-(6-chloro-1H-benzimidazol-2-yl)-7-oxooctyl]-2-(5-methoxy-2-methyl-1H-indol-3-yl)acetamide HDAC2 699429 3.5.1.98 0.00091 - 2,2,2-trifluoro-1-[5-(quinoxalin-6-yl)thiophen-2-yl]ethanone HDAC1, pH and temperature not specified in the publication 712691 3.5.1.98 0.00093 - (2E)-N-hydroxy-3-[2-[(4-methoxyphenyl)sulfonyl]-2,3-dihydro-1H-isoindol-5-yl]prop-2-enamide isoform HDAC1, pH not specified in the publication, temperature not specified in the publication 719058 3.5.1.98 0.00094 - MS-275 - 699458 3.5.1.98 0.00096 - N-[(2E)-3-[(5R,8S,11S)-5-methyl-8-(1-methylethyl)-6,9,13-trioxo-10-oxa-3,17-dithia-7,14,19,20-tetraazatricyclo[14.2.1.1-2,5]icosa-1(18),2(20),16(19)-trien-11-yl]prop-2-en-1-yl]-2-sulfanylacetamide - 700547 3.5.1.98 0.00097 - N-[(1S)-1-(6-chloro-1H-benzimidazol-2-yl)-7-oxooctyl]-2-(5-methoxy-2-methyl-1H-indol-3-yl)acetamide HDAC6 699429 3.5.1.98 0.001 - (S)-tert-butyl 7-(2-(hydroxyamino)-2-oxoethoxy)-3-(4-methoxyphenylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate in 15 mM Tris-HCl, pH 8.0, at 37°C 711451 3.5.1.98 0.001 - 2,2,2-trifluoro-1-[5-(4-methoxyphenyl)thiophen-2-yl]ethanone IC50 above 0.001 mM, HDAC1, pH and temperature not specified in the publication 712691 3.5.1.98 0.001 - 2,2,2-trifluoro-1-[5-(4-methoxyphenyl)thiophen-2-yl]ethanone IC50 above 0.001 mM, HDAC6, pH and temperature not specified in the publication 712691 3.5.1.98 0.001 - 2,2,2-trifluoro-1-[5-(pyridin-2-yl)thiophen-2-yl]ethanone IC50 above 0.001 mM, HDAC1, pH and temperature not specified in the publication 712691 3.5.1.98 0.001 - 2,2,2-trifluoro-1-[5-(pyridin-2-yl)thiophen-2-yl]ethanone IC50 above 0.001 mM, HDAC6, pH and temperature not specified in the publication 712691 3.5.1.98 0.001 - apicidin isoform HDAC8 682501 3.5.1.98 0.001 - N-[(1S)-1-(6-chloro-1H-benzimidazol-2-yl)-7-oxooctyl]-2-(5-methoxy-2-methyl-1H-indol-3-yl)acetamide HDAC3 699429 3.5.1.98 0.001 - N-[(3E)-4-[(5R,8S,11S)-5-methyl-8-(1-methylethyl)-6,9,13-trioxo-10-oxa-3,17-dithia-7,14,19,20-tetraazatricyclo[14.2.1.1-2,5]icosa-1(18),2(20),16(19)-trien-11-yl]but-3-en-1-yl]-2-sulfanylacetamide - 700547 3.5.1.98 0.00106 - (S)-7-(2-(hydroxyamino)-2-oxoethoxy)-N-(naphthalen-1-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide in 15 mM Tris-HCl, pH 8.0, at 37°C 711451 3.5.1.98 0.00109 - N-(4-amino-4'-fluoro[1,1'-biphenyl]-3-yl)oxane-4-carboxamide pH 7.4, 22°C, HDAC3 isozyme 756174 3.5.1.98 0.0011 - (2E)-N-hydroxy-3-[1-(3-hydroxypropyl)-1H-benzimidazol-5-yl]prop-2-enamide - 696662 3.5.1.98 0.00117 - (S)-tert-butyl 3-(3-chlorophenylcarbamoyl)-7-(2-(hydroxyamino)-2-oxoethoxy)-3,4-dihydroisoquinoline-2(1H)-carboxylate in 15 mM Tris-HCl, pH 8.0, at 37°C 711451 3.5.1.98 0.0012 - (2E)-3-[1-benzyl-2-(2-phenylethyl)-1H-benzimidazol-6-yl]-N-hydroxyprop-2-enamide - 696662 3.5.1.98 0.0012 - (5S,8R,11R)-5-methyl-8-(1-methylethyl)-11-[(1E)-4-sulfanylbut-1-en-1-yl]-10-oxa-3,17-dithia-7,14,19,20-tetraazatricyclo[14.2.1.1-2,5]icosa-1(18),2(20),16(19)-triene-6,9,13-trione - 700547 3.5.1.98 0.00122 - N-(4-amino-4'-fluoro[1,1'-biphenyl]-3-yl)oxane-3-carboxamide pH 7.4, 22°C, HDAC1 isozyme 756174 3.5.1.98 0.00129 - (2R)-N-(4-amino-4'-fluoro[1,1'-biphenyl]-3-yl)oxane-2-carboxamide pH 7.4, 22°C, HDAC2 isozyme 756174 3.5.1.98 0.00129 - (S)-tert-butyl 7-(2-(hydroxyamino)-2-oxoethoxy)-3-(phenylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate in 15 mM Tris-HCl, pH 8.0, at 37°C 711451 3.5.1.98 0.0013 - N-hydroxy-2-[1-methyl-2-(2-phenylethyl)-1H-benzimidazol-5-yl]cyclopropanecarboxamide - 696662 3.5.1.98 0.00142 - N-[2-amino-5-(pyridin-4-yl)phenyl]oxane-4-carboxamide pH 7.4, 22°C, HDAC2 isozyme 756174 3.5.1.98 0.00143 - (2S)-N-(4-amino-4'-fluoro[1,1'-biphenyl]-3-yl)oxane-2-carboxamide pH 7.4, 22°C, HDAC1 isozyme 756174 3.5.1.98 0.00145 - (1R,5S)-N-(4-amino-4'-fluoro[1,1'-biphenyl]-3-yl)-6-oxabicyclo[3.1.1]heptane-3-carboxamide pH 7.4, 22°C, HDAC1 isozyme 756174 3.5.1.98 0.00145 - (2S)-N-(4-amino-4'-fluoro[1,1'-biphenyl]-3-yl)oxane-2-carboxamide pH 7.4, 22°C, HDAC2 isozyme 756174 3.5.1.98 0.00149 - N-(4-amino-4'-fluoro[1,1'-biphenyl]-3-yl)-3-oxabicyclo[3.1.0]hexane-6-carboxamide pH 7.4, 22°C, HDAC3 isozyme 756174 3.5.1.98 0.0015 - (3S,6S,10S,14S)-3-(1H-indol-3-ylmethyl)-10-methyl-14-(2-methylpropyl)-6-(6-oxooctyl)-1,4,7,11-tetraazacyclotetradecane-2,5,8,12-tetrone HDAC3 698491 3.5.1.98 0.0015 - (3S,6S,9S,15aS)-6-(1H-indol-3-ylmethyl)-9-(2-methylpropyl)-3-(6-oxooctyl)decahydro-1H-pyrrolo[1,2-a][1,4,7,10]tetraazacyclotridecine-1,4,7,11(8H)-tetrone HDAC8 698491 3.5.1.98 0.0015 - N-[(3E)-4-[(5R,8S,11S)-5-methyl-8-(1-methylethyl)-6,9,13-trioxo-10-oxa-3,17-dithia-7,14,19,20-tetraazatricyclo[14.2.1.1-2,5]icosa-1(18),2(20),16(19)-trien-11-yl]but-3-en-1-yl]-2-sulfanylacetamide - 700547 3.5.1.98 0.00152 - N-(4-amino-4'-chloro[1,1'-biphenyl]-3-yl)oxane-4-carboxamide pH 7.4, 22°C, HDAC1 isozyme 756174 3.5.1.98 0.00155 - (S)-tert-butyl 3-(3-chloro-4-fluorophenylcarbamoyl)-7-(2-(hydroxyamino)-2-oxoethoxy)-3,4-dihydroisoquinoline-2(1H)-carboxylate in 15 mM Tris-HCl, pH 8.0, at 37°C 711451 3.5.1.98 0.00159 - (1R,5S)-N-(4-amino-4'-fluoro[1,1'-biphenyl]-3-yl)-6-oxabicyclo[3.1.1]heptane-3-carboxamide pH 7.4, 22°C, HDAC2 isozyme 756174 3.5.1.98 0.0016 - N-[(2E)-3-[(5R,8S,11S)-5-methyl-8-(1-methylethyl)-6,9,13-trioxo-10-oxa-3,17-dithia-7,14,19,20-tetraazatricyclo[14.2.1.1-2,5]icosa-1(18),2(20),16(19)-trien-11-yl]prop-2-en-1-yl]-2-sulfanylacetamide - 700547 3.5.1.98 0.00165 - (S)-tert-butyl 7-(2-(hydroxyamino)-2-oxoethoxy)-3-(p-tolylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate in 15 mM Tris-HCl, pH 8.0, at 37°C 711451 3.5.1.98 0.0017 - (2E)-N-hydroxy-3-[1-(3-hydroxypropyl)-2-(1-methylethyl)-1H-benzimidazol-5-yl]prop-2-enamide - 696662 3.5.1.98 0.0017 - vorinostat HDAC8 699429 3.5.1.98 0.00177 - (S)-tert-butyl 7-(2-(hydroxyamino)-2-oxoethoxy)-3-(mtolylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate in 15 mM Tris-HCl, pH 8.0, at 37°C 711451 3.5.1.98 0.0019 - (2E)-N-hydroxy-3-[1-(3-hydroxypropyl)-2-thiophen-3-yl-1H-benzimidazol-5-yl]prop-2-enamide - 696662 3.5.1.98 0.0019 - (5S,8R,11R)-5-methyl-8-(1-methylethyl)-11-[(1E)-4-sulfanylbut-1-en-1-yl]-10-oxa-3,17-dithia-7,14,19,20-tetraazatricyclo[14.2.1.1-2,5]icosa-1(18),2(20),16(19)-triene-6,9,13-trione - 700547 3.5.1.98 0.0019 - 2,2,2-trifluoro-1-(4-phenylthiophen-2-yl)ethanone HDAC6, pH and temperature not specified in the publication 712691 3.5.1.98 0.0019 - N-[(3E)-4-[(5R,8S,11S)-5-methyl-8-(1-methylethyl)-6,9,13-trioxo-10-oxa-3,17-dithia-7,14,19,20-tetraazatricyclo[14.2.1.1-2,5]icosa-1(18),2(20),16(19)-trien-11-yl]but-3-en-1-yl]-2-sulfanylacetamide - 700547 3.5.1.98 0.00198 - (S)-tert-butyl 3-(biphenyl-4-ylcarbamoyl)-7-(2-(hydroxyamino)-2-oxoethoxy)-3,4-dihydroisoquinoline-2(1H)-carboxylate in 15 mM Tris-HCl, pH 8.0, at 37°C 711451 3.5.1.98 0.002 - (3S,6S,9S,13S)-3-(1H-indol-3-ylmethyl)-9,10-dimethyl-13-(2-methylpropyl)-6-(6-oxooctyl)-1,4,7,10-tetraazacyclotridecane-2,5,8,11-tetrone HDAC8 698491 3.5.1.98 0.0022 - (3S,6S,9S,13S)-3-(1H-indol-3-ylmethyl)-9-methyl-13-(2-methylpropyl)-6-(6-oxooctyl)-1,4,7,10-tetraazacyclotridecane-2,5,8,11-tetrone HDAC8 698491 3.5.1.98 0.0022 - (5S,8R,11R)-5-methyl-8-(1-methylethyl)-11-[(1E)-4-sulfanylbut-1-en-1-yl]-10-oxa-3,17-dithia-7,14,19,20-tetraazatricyclo[14.2.1.1-2,5]icosa-1(18),2(20),16(19)-triene-6,9,13-trione - 700547 3.5.1.98 0.0022 - 2,2,2-trifluoro-1-(5-[3-[(propylsulfonyl)methyl]-1,2,4-oxadiazol-5-yl]thiophen-2-yl)ethanone HDAC1, pH and temperature not specified in the publication 712691 3.5.1.98 0.00221 - (S)-N-(biphenyl-4-yl)-7-(2-(hydroxyamino)-2-oxoethoxy)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide in 15 mM Tris-HCl, pH 8.0, at 37°C 711451 3.5.1.98 0.00228 - (1R,5S)-N-(4-amino-4'-fluoro[1,1'-biphenyl]-3-yl)-6-oxabicyclo[3.1.1]heptane-3-carboxamide pH 7.4, 22°C, HDAC3 isozyme 756174 3.5.1.98 0.0023 - 3-[5-[(1E)-3-(hydroxyamino)-3-oxoprop-1-en-1-yl]-2-(2-phenylethyl)-1H-benzimidazol-1-yl]propanoic acid - 696662 3.5.1.98 0.0023 - 6-[(2S,5S,8S,11S)-8-(1H-indol-3-ylmethyl)-2-methyl-11-(2-methylpropyl)-3,6,9,13-tetraoxo-1,4,7,10-tetraazacyclotridecan-5-yl]hexanoic acid HDAC6 698491 3.5.1.98 0.0023 - 6-[(2S,5S,8S,11S)-8-(1H-indol-3-ylmethyl)-2-methyl-11-(2-methylpropyl)-3,6,9,13-tetraoxo-1,4,7,10-tetraazacyclotridecan-5-yl]hexanoic acid HDAC8 698491 3.5.1.98 0.00235 - N-[2-amino-5-(pyridin-4-yl)phenyl]oxane-4-carboxamide pH 7.4, 22°C, HDAC1 isozyme 756174 3.5.1.98 0.0025 - 4-[5-(trifluoroacetyl)thiophen-2-yl]benzoic acid HDAC1, pH and temperature not specified in the publication 712691 3.5.1.98 0.00253 - N-(4-amino-4'-chloro[1,1'-biphenyl]-3-yl)oxane-4-carboxamide pH 7.4, 22°C, HDAC2 isozyme 756174 3.5.1.98 0.00256 - (S)-tert-butyl 3-(4-fluorophenylcarbamoyl)-7-(2-(hydroxyamino)-2-oxoethoxy)-3,4-dihydroisoquinoline-2(1H)-carboxylate in 15 mM Tris-HCl, pH 8.0, at 37°C 711451 3.5.1.98 0.0026 - oxamflatin mutant H843Y 698743 3.5.1.98 0.00267 - (S)-tert-butyl 7-(2-(hydroxyamino)-2-oxoethoxy)-3-(phenethylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate in 15 mM Tris-HCl, pH 8.0, at 37°C 711451 3.5.1.98 0.0027 - 2,2,2-trifluoro-1-(5-[3-[(methylsulfonyl)methyl]-1,2,4-oxadiazol-5-yl]thiophen-2-yl)ethanone HDAC1, pH and temperature not specified in the publication 712691 3.5.1.98 0.0027 - 4-[5-(trifluoroacetyl)thiophen-2-yl]benzonitrile HDAC1, pH and temperature not specified in the publication 712691 3.5.1.98 0.0028 - (3S,6S,10S,14S)-3-(1H-indol-3-ylmethyl)-10-methyl-14-(2-methylpropyl)-6-(6-oxooctyl)-1,4,7,11-tetraazacyclotetradecane-2,5,8,12-tetrone HDAC5 698491 3.5.1.98 0.0028 - 2,2,2-trifluoro-1-(5-phenylthiophen-2-yl)ethanone HDAC4, pH and temperature not specified in the publication 712691 3.5.1.98 0.00302 - (S)-tert-butyl 7-(2-(hydroxyamino)-2-oxoethoxy)-3-(pentylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate in 15 mM Tris-HCl, pH 8.0, at 37°C 711451 3.5.1.98 0.0031 - (5S,8R,11R)-5-methyl-8-(1-methylethyl)-11-[(1E)-4-sulfanylbut-1-en-1-yl]-10-oxa-3,17-dithia-7,14,19,20-tetraazatricyclo[14.2.1.1-2,5]icosa-1(18),2(20),16(19)-triene-6,9,13-trione - 700547 3.5.1.98 0.0031 - 2,2,2-trifluoro-1-[5-(3-methoxyphenyl)thiophen-2-yl]ethanone HDAC6, pH and temperature not specified in the publication 712691 3.5.1.98 0.0032 - (2E)-3-[2-cyclohexyl-1-(3-hydroxypropyl)-1H-benzimidazol-5-yl]-N-hydroxyprop-2-enamide - 696662 3.5.1.98 0.0032 - (S)-N-(3-chlorophenyl)-7-(2-(hydroxyamino)-2-oxoethoxy)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide in 15 mM Tris-HCl, pH 8.0, at 37°C 711451 3.5.1.98 0.0032 - 2,2,2-trifluoro-1-(4-phenylthiophen-2-yl)ethanone HDAC4, pH and temperature not specified in the publication 712691 3.5.1.98 0.00323 - (S)-N-(4-fluorophenyl)-7-(2-(hydroxyamino)-2-oxoethoxy)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide in 15 mM Tris-HCl, pH 8.0, at 37°C 711451 3.5.1.98 0.0033 - N-hydroxy-1-(3-hydroxypropyl)-2-(2-phenylethyl)-1H-benzimidazole-5-carboxamide - 696662 3.5.1.98 0.00334 - (S)-N-(3-chloro-4-fluorophenyl)-7-(2-(hydroxyamino)-2-oxoethoxy)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide in 15 mM Tris-HCl, pH 8.0, at 37°C 711451 3.5.1.98 0.00339 - (S)-N-(2,4-dimethylphenyl)-7-(2-(hydroxyamino)-2-oxoethoxy)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide in 15 mM Tris-HCl, pH 8.0, at 37°C 711451 3.5.1.98 0.00341 - (S)-tert-butyl 3-(benzylcarbamoyl)-7-(2-(hydroxyamino)-2-oxoethoxy)-3,4-dihydroisoquinoline-2(1H)-carboxylate in 15 mM Tris-HCl, pH 8.0, at 37°C 711451 3.5.1.98 0.00354 - (S)-7-(2-(hydroxyamino)-2-oxoethoxy)-N-pentyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide in 15 mM Tris-HCl, pH 8.0, at 37°C 711451 3.5.1.98 0.0036 - LAQ824 mutant H843Y 698743 3.5.1.98 0.00362 - (S)-7-(2-(hydroxyamino)-2-oxoethoxy)-N-m-tolyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide in 15 mM Tris-HCl, pH 8.0, at 37°C 711451 3.5.1.98 0.0037 - 2,2,2-trifluoro-1-(2-phenyl-1,3-thiazol-5-yl)ethanone HDAC1, pH and temperature not specified in the publication 712691 3.5.1.98 0.00378 - (S)-tert-butyl 3-(2,4-dimethylphenylcarbamoyl)-7-(2-(hydroxyamino)-2-oxoethoxy)-3,4-dihydroisoquinoline-2(1H)-carboxylate in 15 mM Tris-HCl, pH 8.0, at 37°C 711451 3.5.1.98 0.0038 - 2,2,2-trifluoro-1-[5-(3-methoxyphenyl)thiophen-2-yl]ethanone HDAC4, pH and temperature not specified in the publication 712691 3.5.1.98 0.00382 - (S)-7-(2-(hydroxyamino)-2-oxoethoxy)-N-p-tolyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide in 15 mM Tris-HCl, pH 8.0, at 37°C 711451 3.5.1.98 0.00385 - N-(4-amino[1,1'-biphenyl]-3-yl)oxane-4-carboxamide pH 7.4, 22°C, HDAC3 isozyme 756174 3.5.1.98 0.0039 - 2,2,2-trifluoro-1-(5-[3-[(thiophen-2-ylsulfonyl)methyl]-1,2,4-oxadiazol-5-yl]thiophen-2-yl)ethanone HDAC1, pH and temperature not specified in the publication 712691 3.5.1.98 0.004 - (S)-tert-butyl 7-(2-(hydroxyamino)-2-oxoethoxy)-3-(o-tolylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate in 15 mM Tris-HCl, pH 8.0, at 37°C 711451 3.5.1.98 0.004 - suberoylanilide hydroxamic acid isoform HDAC8 682501 3.5.1.98 0.00407 - (S)-7-(2-(hydroxyamino)-2-oxoethoxy)-N-phenethyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide in 15 mM Tris-HCl, pH 8.0, at 37°C 711451 3.5.1.98 0.0041 - (4E)-N-(2-aminophenyl)-5-[(5R,8S,11S)-5-methyl-8-(1-methylethyl)-6,9,13-trioxo-10-oxa-3,17-dithia-7,14,19,20-tetraazatricyclo[14.2.1.1-2,5]icosa-1(18),2(20),16(19)-trien-11-yl]pent-4-enamide - 700547 3.5.1.98 0.00413 - (S)-7-(2-(hydroxyamino)-2-oxoethoxy)-N-o-tolyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide in 15 mM Tris-HCl, pH 8.0, at 37°C 711451 3.5.1.98 0.00425 - (S)-tert-butyl 7-(2-(hydroxyamino)-2-oxoethoxy)-3-(naphthalen-1-ylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate in 15 mM Tris-HCl, pH 8.0, at 37°C 711451 3.5.1.98 0.0043 - (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide wild type 698743 3.5.1.98 0.00442 - (S)-tert-butyl 3-(hexylcarbamoyl)-7-(2-(hydroxyamino)-2-oxoethoxy)-3,4-dihydroisoquinoline-2(1H)-carboxylate in 15 mM Tris-HCl, pH 8.0, at 37°C 711451 3.5.1.98 0.00458 - (S)-tert-butyl 3-(tert-butylcarbamoyl)-7-(2-(hydroxyamino)-2-oxoethoxy)-3,4-dihydroisoquinoline-2(1H)-carboxylate in 15 mM Tris-HCl, pH 8.0, at 37°C 711451 3.5.1.98 0.00473 - N-(4-amino-4'-fluoro[1,1'-biphenyl]-3-yl)oxane-3-carboxamide pH 7.4, 22°C, HDAC2 isozyme 756174 3.5.1.98 0.005 - 2,2,2-trifluoro-1-[5-(1H-indol-5-yl)thiophen-2-yl]ethanone IC50 above 0.005 mM, HDAC6, pH and temperature not specified in the publication 712691 3.5.1.98 0.005 - 2-(5-methoxy-2-methyl-1H-indol-3-yl)-N-[(1S)-7-oxo-1-(5-phenyl-1H-imidazol-2-yl)octyl]acetamide HDAC8, larger than 0.005 699429 3.5.1.98 0.005 - 5-phenylvaleric hydroxamic acid - 699231 3.5.1.98 0.0051 - (S)-N-benzyl-7-(2-(hydroxyamino)-2-oxoethoxy)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide hydrochloride in 15 mM Tris-HCl, pH 8.0, at 37°C 711451 3.5.1.98 0.00557 - (S)-7-(2-(hydroxyamino)-2-oxoethoxy)-N-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide in 15 mM Tris-HCl, pH 8.0, at 37°C 711451 3.5.1.98 0.00559 - N-(4-amino-4'-fluoro[1,1'-biphenyl]-3-yl)oxane-3-carboxamide pH 7.4, 22°C, HDAC1 isozyme 756174 3.5.1.98 0.00573 - (2R)-N-(4-amino-4'-fluoro[1,1'-biphenyl]-3-yl)oxane-2-carboxamide pH 7.4, 22°C, HDAC3 isozyme 756174 3.5.1.98 0.00577 - (S)-N-hexyl-7-(2-(hydroxyamino)-2-oxoethoxy)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide in 15 mM Tris-HCl, pH 8.0, at 37°C 711451 3.5.1.98 0.00595 - (2S)-N-(4-amino-4'-fluoro[1,1'-biphenyl]-3-yl)oxane-2-carboxamide pH 7.4, 22°C, HDAC3 isozyme 756174 3.5.1.98 0.00626 - N-(4-amino-4'-fluoro[1,1'-biphenyl]-3-yl)oxane-3-carboxamide pH 7.4, 22°C, HDAC3 isozyme 756174 3.5.1.98 0.0063 - 2,2,2-trifluoro-1-[5-(2-methoxyphenyl)thiophen-2-yl]ethanone HDAC6, pH and temperature not specified in the publication 712691 3.5.1.98 0.0063 - 3-[5-[4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl]furan-2-yl]-N-hydroxy-acrylamide recombinant HDAC6, pH not specified in the publication, temperature not specified in the publication 720187 3.5.1.98 0.00645 - N-[2-amino-5-(pyridin-3-yl)phenyl]oxane-4-carboxamide pH 7.4, 22°C, HDAC1 isozyme 756174 3.5.1.98 0.00656 - N-(4-amino-4'-fluoro[1,1'-biphenyl]-3-yl)oxane-3-carboxamide pH 7.4, 22°C, HDAC2 isozyme 756174 3.5.1.98 0.0066 - 2,2,2-trifluoro-1-[5-(3-[[(4-fluorobenzyl)sulfonyl]methyl]-1,2,4-oxadiazol-5-yl)thiophen-2-yl]ethanone HDAC1, pH and temperature not specified in the publication 712691 3.5.1.98 0.00732 - N-[2-amino-5-(pyridin-3-yl)phenyl]oxane-4-carboxamide pH 7.4, 22°C, HDAC2 isozyme 756174 3.5.1.98 0.008 - trichostatin A recombinant HDAC3 in complex with CoR1, pH and temperature not specified in the publication 712434 3.5.1.98 0.00821 - (S)-7-(2-(hydroxyamino)-2-oxoethoxy)-N-phenyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide hydrochloride in 15 mM Tris-HCl, pH 8.0, at 37°C 711451 3.5.1.98 0.0096 - 2-[(methylsulfonyl)sulfanyl]ethyl 2-propylpentanoate - 696610 3.5.1.98 0.00967 - N-(4-amino-3'-fluoro[1,1'-biphenyl]-3-yl)oxane-4-carboxamide pH 7.4, 22°C, HDAC1 isozyme 756174 3.5.1.98 0.01 - (3S,6S,10S,14S)-3-(1H-indol-3-ylmethyl)-10-methyl-14-(2-methylpropyl)-6-(6-oxooctyl)-1,4,7,11-tetraazacyclotetradecane-2,5,8,12-tetrone HDAC4, larger than 0.010 698491 3.5.1.98 0.01 - (3S,6S,10S,14S)-3-(1H-indol-3-ylmethyl)-10-methyl-14-(2-methylpropyl)-6-(6-oxooctyl)-1,4,7,11-tetraazacyclotetradecane-2,5,8,12-tetrone HDAC6, larger than 0.010 698491 3.5.1.98 0.01 - (3S,6S,10S,14S)-3-(1H-indol-3-ylmethyl)-10-methyl-14-(2-methylpropyl)-6-(6-oxooctyl)-1,4,7,11-tetraazacyclotetradecane-2,5,8,12-tetrone HDAC7, larger than 0.010 698491 3.5.1.98 0.01 - (3S,6S,10S,14S)-3-(1H-indol-3-ylmethyl)-10-methyl-14-(2-methylpropyl)-6-(6-oxooctyl)-1,4,7,11-tetraazacyclotetradecane-2,5,8,12-tetrone HDAC8, larger than 0.010 698491 3.5.1.98 0.01 - (3S,6S,9S,13S)-3-(1H-indol-3-ylmethyl)-9,10-dimethyl-13-(2-methylpropyl)-6-(6-oxooctyl)-1,4,7,10-tetraazacyclotridecane-2,5,8,11-tetrone HDAC4, larger than 0.010 698491 3.5.1.98 0.01 - (3S,6S,9S,13S)-3-(1H-indol-3-ylmethyl)-9,10-dimethyl-13-(2-methylpropyl)-6-(6-oxooctyl)-1,4,7,10-tetraazacyclotridecane-2,5,8,11-tetrone HDAC6, larger than 0.010 698491 3.5.1.98 0.01 - (3S,6S,9S,13S)-3-(1H-indol-3-ylmethyl)-9,10-dimethyl-13-(2-methylpropyl)-6-(6-oxooctyl)-1,4,7,10-tetraazacyclotridecane-2,5,8,11-tetrone HDAC7, larger than 0.010 698491 3.5.1.98 0.01 - (3S,6S,9S,13S)-3-(1H-indol-3-ylmethyl)-9-methyl-13-(2-methylpropyl)-6-(6-oxooctyl)-1,4,7,10-tetraazacyclotridecane-2,5,8,11-tetrone HDAC4, larger than 0.010 698491 3.5.1.98 0.01 - (3S,6S,9S,13S)-3-(1H-indol-3-ylmethyl)-9-methyl-13-(2-methylpropyl)-6-(6-oxooctyl)-1,4,7,10-tetraazacyclotridecane-2,5,8,11-tetrone HDAC6, larger than 0.010 698491 3.5.1.98 0.01 - (3S,6S,9S,13S)-3-(1H-indol-3-ylmethyl)-9-methyl-13-(2-methylpropyl)-6-(6-oxooctyl)-1,4,7,10-tetraazacyclotridecane-2,5,8,11-tetrone HDAC7, larger than 0.010 698491 3.5.1.98 0.01 - (3S,6S,9S,15aS)-6-(1H-indol-3-ylmethyl)-9-(2-methylpropyl)-3-(6-oxooctyl)decahydro-1H-pyrrolo[1,2-a][1,4,7,10]tetraazacyclotridecine-1,4,7,11(8H)-tetrone HDAC4, larger than 0.010 698491 3.5.1.98 0.01 - (3S,6S,9S,15aS)-6-(1H-indol-3-ylmethyl)-9-(2-methylpropyl)-3-(6-oxooctyl)decahydro-1H-pyrrolo[1,2-a][1,4,7,10]tetraazacyclotridecine-1,4,7,11(8H)-tetrone HDAC6, larger than 0.010 698491 3.5.1.98 0.01 - (3S,6S,9S,15aS)-6-(1H-indol-3-ylmethyl)-9-(2-methylpropyl)-3-(6-oxooctyl)decahydro-1H-pyrrolo[1,2-a][1,4,7,10]tetraazacyclotridecine-1,4,7,11(8H)-tetrone HDAC7, larger than 0.010 698491 3.5.1.98 0.01 - 1-[5-(2,3-dihydro-1,4-benzodioxin-6-yl)thiophen-2-yl]-2,2,2-trifluoroethanone IC50 above 0.01 mM, HDAC1, pH and temperature not specified in the publication 712691 3.5.1.98 0.01 - 1-[5-(2,3-dihydro-1,4-benzodioxin-6-yl)thiophen-2-yl]-2,2,2-trifluoroethanone IC50 above 0.01 mM, HDAC4, pH and temperature not specified in the publication 712691 3.5.1.98 0.01 - 1-[5-(4-acetylphenyl)thiophen-2-yl]-2,2,2-trifluoroethanone IC50 above 0.01 mM, HDAC1, pH and temperature not specified in the publication 712691 3.5.1.98 0.01 - 2,2,2-trifluoro-1-(4-phenylthiophen-2-yl)ethanone IC50 above 0.01 mM, HDAC1, pH and temperature not specified in the publication 712691 3.5.1.98 0.01 - 2,2,2-trifluoro-1-[5-(1H-indol-5-yl)thiophen-2-yl]ethanone IC50 above 0.01 mM, HDAC1, pH and temperature not specified in the publication 712691 3.5.1.98 0.01 - 2,2,2-trifluoro-1-[5-(1H-indol-5-yl)thiophen-2-yl]ethanone IC50 above 0.01 mM, HDAC4, pH and temperature not specified in the publication 712691 3.5.1.98 0.01 - 2,2,2-trifluoro-1-[5-(2-methoxyphenyl)thiophen-2-yl]ethanone IC50 above 0.01 mM, HDAC1, pH and temperature not specified in the publication 712691 3.5.1.98 0.01 - 2,2,2-trifluoro-1-[5-(2-methoxyphenyl)thiophen-2-yl]ethanone IC50 above 0.01 mM, HDAC4, pH and temperature not specified in the publication 712691 3.5.1.98 0.01 - 2,2,2-trifluoro-1-[5-(3-methoxyphenyl)thiophen-2-yl]ethanone IC50 above 0.01 mM, HDAC1, pH and temperature not specified in the publication 712691 3.5.1.98 0.01 - 2-(5-methoxy-2-methyl-1H-indol-3-yl)-N-[(1S)-7-oxo-1-(5-phenyl-1H-imidazol-2-yl)nonyl]acetamide HDAC5, larger than 0.010 699429 3.5.1.98 0.01 - 2-(5-methoxy-2-methyl-1H-indol-3-yl)-N-[(1S)-7-oxo-1-(5-phenyl-1H-imidazol-2-yl)nonyl]acetamide HDAC7, larger than 0.010 699429 3.5.1.98 0.01 - 2-(5-methoxy-2-methyl-1H-indol-3-yl)-N-[(1S)-7-oxo-1-(5-phenyl-1H-imidazol-2-yl)octyl]acetamide HDAC5, larger than 0.010 699429 3.5.1.98 0.01 - 2-(5-methoxy-2-methyl-1H-indol-3-yl)-N-[(1S)-7-oxo-1-(5-phenyl-1H-imidazol-2-yl)octyl]acetamide HDAC7, larger than 0.010 699429 3.5.1.98 0.01 - 6-[(2S,5S,8S,11S)-8-(1H-indol-3-ylmethyl)-2-methyl-11-(2-methylpropyl)-3,6,9,13-tetraoxo-1,4,7,10-tetraazacyclotridecan-5-yl]hexanoic acid HDAC4, larger than 0.010 698491 3.5.1.98 0.01 - 6-[(2S,5S,8S,11S)-8-(1H-indol-3-ylmethyl)-2-methyl-11-(2-methylpropyl)-3,6,9,13-tetraoxo-1,4,7,10-tetraazacyclotridecan-5-yl]hexanoic acid HDAC7, larger than 0.010 698491 3.5.1.98 0.01 - apicidin HDAC4, larger than 0.010 698491 3.5.1.98 0.01 - apicidin HDAC6, larger than 0.010 698491 3.5.1.98 0.01 - apicidin HDAC7, larger than 0.010 698491 3.5.1.98 0.01 - MS-275 HDAC5, larger than 0.010 699429 3.5.1.98 0.01 - MS-275 HDAC6, larger than 0.010 699429 3.5.1.98 0.01 - MS-275 HDAC7, larger than 0.010 699429 3.5.1.98 0.01 - MS-275 HDAC8, larger than 0.010 699429 3.5.1.98 0.01 - N-hydroxy-3-[1-(3-hydroxypropyl)-2-(2-methylpropyl)-1H-benzimidazol-5-yl]propanamide larger than 0.010 696662 3.5.1.98 0.01 - N-hydroxy-6-[(2S,5S,8S,11S)-8-(1H-indol-3-ylmethyl)-2-methyl-11-(2-methylpropyl)-3,6,9,13-tetraoxo-1,4,7,10-tetraazacyclotridecan-5-yl]hexanamide HDAC4, larger than 0.010 698491 3.5.1.98 0.01 - N-hydroxy-6-[(2S,5S,8S,11S)-8-(1H-indol-3-ylmethyl)-2-methyl-11-(2-methylpropyl)-3,6,9,13-tetraoxo-1,4,7,10-tetraazacyclotridecan-5-yl]hexanamide HDAC7, larger than 0.010 698491 3.5.1.98 0.01 - N-hydroxy-6-[(3S,6S,9S,15aS)-6-(1H-indol-3-ylmethyl)-9-(2-methylpropyl)-1,4,7,11-tetraoxotetradecahydro-1H-pyrrolo[1,2-a][1,4,7,10]tetraazacyclotridecin-3-yl]hexanamide HDAC4, larger than 0.010 698491 3.5.1.98 0.01 - N-hydroxy-6-[(3S,6S,9S,15aS)-6-(1H-indol-3-ylmethyl)-9-(2-methylpropyl)-1,4,7,11-tetraoxotetradecahydro-1H-pyrrolo[1,2-a][1,4,7,10]tetraazacyclotridecin-3-yl]hexanamide HDAC7, larger than 0.010 698491 3.5.1.98 0.01 - N-[(1S)-1-(6-chloro-1H-benzimidazol-2-yl)-7-oxooctyl]-2-(5-methoxy-2-methyl-1H-indol-3-yl)acetamide HDAC5, larger than 0.010 699429 3.5.1.98 0.01 - N-[(1S)-1-(6-chloro-1H-benzimidazol-2-yl)-7-oxooctyl]-2-(5-methoxy-2-methyl-1H-indol-3-yl)acetamide HDAC7, larger than 0.010 699429 3.5.1.98 0.01 - N-[(1S)-1-(6-chloro-1H-benzimidazol-2-yl)-7-oxooctyl]-2-(5-methoxy-2-methyl-1H-indol-3-yl)acetamide HDAC8, larger than 0.010 699429 3.5.1.98 0.01 - pyridin-3-ylmethyl (4-[[(2-aminophenyl)amino]carbonyl]benzyl)carbamate isoform HDAC8 682501 3.5.1.98 0.01 - splitomicin larger than 0.01 699458 3.5.1.98 0.01 - vorinostat HDAC7, larger than 0.010 699429 3.5.1.98 0.01217 - (S)-N-tert -butyl-7-(2-(hydroxyamino)-2-oxoethoxy)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide in 15 mM Tris-HCl, pH 8.0, at 37°C 711451 3.5.1.98 0.0123 - N-(4-amino-3'-fluoro[1,1'-biphenyl]-3-yl)oxane-4-carboxamide pH 7.4, 22°C, HDAC2 isozyme 756174 3.5.1.98 0.0128 - 3-[5-(trifluoroacetyl)thiophen-2-yl]benzoic acid HDAC1, pH and temperature not specified in the publication 712691 3.5.1.98 0.013 - (3S,15R,20aS)-15-methyl-3-[(1E)-4-sulfanylbut-1-en-1-yl]-3,4,6,7,14,15,18,19,20,20a-decahydro-1H,5H,16H-11,8:15,12-di(azeno)pyrrolo[2,1-c][1,8,12,4,15]oxadithiadiazacyclooctadecine-1,5,16-trione - 700547 3.5.1.98 0.013 - sodium butyrate recombinant HDAC3 in complex with CoR1, pH and temperature not specified in the publication 712434 3.5.1.98 0.0137 - (1R,5S)-N-(4-amino-4'-fluoro[1,1'-biphenyl]-3-yl)-6-oxabicyclo[3.1.1]heptane-3-carboxamide pH 7.4, 22°C, HDAC3 isozyme 756174 3.5.1.98 0.014 - (5E)-N-(2-aminophenyl)-6-[(5R,8S,11S)-5-methyl-8-(1-methylethyl)-6,9,13-trioxo-10-oxa-3,17-dithia-7,14,19,20-tetraazatricyclo[14.2.1.1-2,5]icosa-1(18),2(20),16(19)-trien-11-yl]hex-5-enamide - 700547 3.5.1.98 0.0142 - N-(4-amino-4'-chloro[1,1'-biphenyl]-3-yl)oxane-4-carboxamide pH 7.4, 22°C, HDAC3 isozyme 756174 3.5.1.98 0.0154 - LBH589 wild type 698743 3.5.1.98 0.0175 - S-[2-[(2-propylpentanoyl)amino]ethyl]methanesulfonothioate - 696610 3.5.1.98 0.0198 - N-(4-amino-4'-fluoro[1,1'-biphenyl]-3-yl)oxane-3-carboxamide pH 7.4, 22°C, HDAC3 isozyme 756174 3.5.1.98 0.02 - 2,2,2-trifluoro-1-(5-phenylthiophen-2-yl)ethanone IC50 above 0.02 mM, HDAC1, pH and temperature not specified in the publication 712691 3.5.1.98 0.02 - beta-methylselenopyruvate HDAC8, at 37°C, pH not specified in the publication 711682 3.5.1.98 0.0208 - N-[2-amino-5-(pyridin-3-yl)phenyl]oxane-4-carboxamide pH 7.4, 22°C, HDAC3 isozyme 756174 3.5.1.98 0.021 - Butyrate isoform HD2 678018 3.5.1.98 0.023 - (5E)-N-(2-aminophenyl)-6-[(5R,8S,11S)-5-methyl-8-(1-methylethyl)-6,9,13-trioxo-10-oxa-3,17-dithia-7,14,19,20-tetraazatricyclo[14.2.1.1-2,5]icosa-1(18),2(20),16(19)-trien-11-yl]hex-5-enamide - 700547 3.5.1.98 0.0259 - N-(4-amino-4'-fluoro[1,1'-biphenyl]-3-yl)-3,4-dihydro-1H-2-benzopyran-3-carboxamide pH 7.4, 22°C, HDAC3 isozyme 756174 3.5.1.98 0.0267 - N-[4-amino-4'-(trifluoromethyl)[1,1'-biphenyl]-3-yl]oxane-4-carboxamide pH 7.4, 22°C, HDAC1 isozyme 756174 3.5.1.98 0.029 - (5E)-N-(2-aminophenyl)-6-[(5R,8S,11S)-5-methyl-8-(1-methylethyl)-6,9,13-trioxo-10-oxa-3,17-dithia-7,14,19,20-tetraazatricyclo[14.2.1.1-2,5]icosa-1(18),2(20),16(19)-trien-11-yl]hex-5-enamide - 700547 3.5.1.98 0.03 - (4E)-N-(2-aminophenyl)-5-[(5R,8S,11S)-5-methyl-8-(1-methylethyl)-6,9,13-trioxo-10-oxa-3,17-dithia-7,14,19,20-tetraazatricyclo[14.2.1.1-2,5]icosa-1(18),2(20),16(19)-trien-11-yl]pent-4-enamide larger than 0.030 700547 3.5.1.98 0.03 - (4Z)-6-[(5R,8S,11R)-5-methyl-8-(1-methylethyl)-6,9,13-trioxo-10-oxa-3,17-dithia-7,14,19,20-tetraazatricyclo[14.2.1.1-2,5]icosa-1(18),2(20),16(19)-trien-11-yl]hex-4-enoic acid larger than 0.030 700547 3.5.1.98 0.03 - (5E)-N-(2-aminophenyl)-6-[(5R,8S,11S)-5-methyl-8-(1-methylethyl)-6,9,13-trioxo-10-oxa-3,17-dithia-7,14,19,20-tetraazatricyclo[14.2.1.1-2,5]icosa-1(18),2(20),16(19)-trien-11-yl]hex-5-enamide larger than 0.030 700547 3.5.1.98 0.03 - (8S,11S)-8-(1-methylethyl)-11-[(1E)-4-sulfanylbut-1-en-1-yl]-10-oxa-3,17-dithia-7,14,19,20-tetraazatricyclo[14.2.1.1-2,5]icosa-1(18),2(20),4,16(19)-tetraene-6,9,13-trione larger than 0.030 700547 3.5.1.98 0.03 - MS-275 larger than 0.030 700547 3.5.1.98 0.033 - N-(4-amino-3'-fluoro[1,1'-biphenyl]-3-yl)oxane-4-carboxamide pH 7.4, 22°C, above, HDAC3 isozyme 756174 3.5.1.98 0.033 - N-(4-amino-4'-fluoro[1,1'-biphenyl]-3-yl)-3,4-dihydro-2H-1-benzopyran-3-carboxamide pH 7.4, 22°C, above, HDAC3 isozyme 756174 3.5.1.98 0.033 - N-[2-amino-5-(pyridin-4-yl)phenyl]oxane-4-carboxamide pH 7.4, 22°C, above, HDAC3 isozyme 756174 3.5.1.98 0.033 - N-[4-amino-4'-(trifluoromethyl)[1,1'-biphenyl]-3-yl]oxane-4-carboxamide pH 7.4, 22°C, above, HDAC2 isozyme 756174 3.5.1.98 0.033 - N-[4-amino-4'-(trifluoromethyl)[1,1'-biphenyl]-3-yl]oxane-4-carboxamide pH 7.4, 22°C, above, HDAC3 isozyme 756174 3.5.1.98 0.03367 - N-hydroxy-4-[[(2E)-2-(2-hydroxybenzylidene)hydrazinyl]carbonothioyl]piperazine-1-carboxamide pH and temperature not specified in the publication 711416 3.5.1.98 0.04316 - 4-[[(2E)-2-(4-chlorobenzylidene)hydrazinyl]carbonothioyl]-N-hydroxypiperazine-1-carboxamide pH and temperature not specified in the publication 711416 3.5.1.98 0.045 - Butyrate isoform HD1 678018 3.5.1.98 0.05 - (S)-benzyl 3-(biphenyl-4-ylcarbamoyl)-7-(2-(hydroxyamino)-2-oxoethoxy)-3,4-dihydroisoquinoline-2(1H)-carboxylate IC50 above 0.05 mM, in 15 mM Tris-HCl, pH 8.0, at 37°C 711451 3.5.1.98 0.05 - (S)-benzyl 7-(2-(hydroxyamino)-2-oxoethoxy)-3-(phenylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate IC50 above 0.05 mM, in 15 mM Tris-HCl, pH 8.0, at 37°C 711451 3.5.1.98 0.0564 - 4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl 2-propylpentanoate - 696610 3.5.1.98 0.072 - 1-[5-(4-acetylphenyl)thiophen-2-yl]-2,2,2-trifluoroethanone HDAC4, pH and temperature not specified in the publication 712691 3.5.1.98 0.074 - 4-[5-(trifluoroacetyl)thiophen-2-yl]benzoic acid HDAC4, pH and temperature not specified in the publication 712691 3.5.1.98 0.08 - Butyrate nuclear matrix form of enzyme 678018 3.5.1.98 0.098 - 15-deoxy-DELTA12,14-prostaglandin J2-biotin recombinant HDAC3 in complex with CoR1, pH and temperature not specified in the publication 712434 3.5.1.98 0.098 - oxamflatin wild type 698743 3.5.1.98 0.1 - (2E)-N-(2-aminophenyl)-3-[2-(2-phenylethyl)-1-(pyridin-2-ylmethyl)-1H-benzimidazol-5-yl]prop-2-enamide larger than 0.10 696662 3.5.1.98 0.102 - S-(2-hydroxyethyl) methanesulfonothioate - 696610 3.5.1.98 0.113 - suberoylanilide hydroxamic acid wild type 698743 3.5.1.98 0.115 - curcumin pH and temperature not specified in the publication 711439 3.5.1.98 0.133 - 4-benzoylbutyric hydroxamic acid - 699231 3.5.1.98 0.14 - 4-hydroxy-2-nonenal recombinant HDAC3 in complex with CoR1, pH and temperature not specified in the publication 712434 3.5.1.98 0.198 - 2-[(methylsulfonyl)sulfanyl]ethanaminium bromide - 696610 3.5.1.98 0.225 - tubacin wild type 698743 3.5.1.98 0.231 - methyl (3R,6R,9R)-9-(acetylamino)-6-[6-(hydroxyamino)-6-oxohexyl]-5,8-dioxo-4,7-diazabicyclo[9.3.1]pentadeca-1(15),11,13-triene-3-carboxylate isoform HDAC8 681304 3.5.1.98 0.35 - Butyrate pH 8.0 678021 3.5.1.98 0.375 - chlorogenic acid pH and temperature not specified in the publication 711439 3.5.1.98 0.4 - Valproic acid isoform HDAC1, pH 8.0, 37°C 680616 3.5.1.98 0.553 - LAQ824 wild type 698743 3.5.1.98 0.995 - Valproic acid - 696610 3.5.1.98 2.54 - caffeic acid pH and temperature not specified in the publication 711439 3.5.1.98 4 - (2S)-2-(acetylamino)-3-[3-[(2S)-2-[[(2S)-2-ammonio-7-(hydroxyamino)-7-oxoheptanoyl]amino]-3-methoxy-3-oxopropyl]phenyl]propanoate isoform HDAC1 681304 3.5.1.98 8.1 - (2S)-2-(acetylamino)-3-[3-[(2S)-2-[[(2S)-2-ammonio-7-(hydroxyamino)-7-oxoheptanoyl]amino]-3-methoxy-3-oxopropyl]phenyl]propanoate HeLa cell nuclear extract 681304 3.5.1.98 12.1 - N-hydroxy-2-(methyl((3-(1-(4-methylbenzyl)piperidin-4-yl)-1,2,4-oxadiazol-5-yl)methyl)amino)pyrimidine-5-carboxamide pH and temperature not specified in the publication 756656 3.5.1.98 22 - 2-(((3-(1-(4-fluorobenzyl)piperidin-4-yl)-1,2,4-oxadiazol-5-yl)methyl)(methyl)amino)-N-hydroxypyrimidine-5-carboxamide pH and temperature not specified in the publication 756656 3.5.1.98 27.6 - 2-(((3-(1-benzylpiperidin-4-yl)-1,2,4-oxadiazol-5-yl)methyl)(methyl)amino)-N-hydroxypyrimidine-5-carboxamide pH and temperature not specified in the publication 756656 3.5.1.98 34.3 - 2-(((3-(1-(2,4-difluorobenzyl)piperidin-4-yl)-1,2,4-oxadiazol-5-yl)methyl)(methyl)amino)-N-hydroxypyrimidine-5-carboxamide pH and temperature not specified in the publication 756656 3.5.1.98 47.3 - N-hydroxy-2-(methyl((3-(1-(3-methylbenzyl)piperidin-4-yl)-1,2,4-oxadiazol-5-yl)methyl)amino)pyrimidine-5-carboxamide pH and temperature not specified in the publication 756656 3.5.1.98 48.3 - 2-(((3-(1-(2-chlorobenzyl)piperidin-4-yl)-1,2,4-oxadiazol-5-yl)methyl)(methyl)amino)-N-hydroxypyrimidine-5-carboxamide pH and temperature not specified in the publication 756656 3.5.1.98 98.6 - 2-(((3-(1-(2-fluorobenzyl)piperidin-4-yl)-1,2,4-oxadiazol-5-yl)methyl)(methyl)amino)-N-hydroxypyrimidine-5-carboxamide pH and temperature not specified in the publication 756656 3.5.1.98 115.7 - 2-(((3-(1-(2-chloro-4-fluorobenzyl)piperidin-4-yl)-1,2,4-oxadiazol-5-yl)methyl)(methyl)amino)-N-hydroxypyrimidine-5-carboxamide pH and temperature not specified in the publication 756656 3.5.1.98 116.6 - 2-(((3-(1-(4-cyanobenzyl)piperidin-4-yl)-1,2,4-oxadiazol-5-yl)methyl)(methyl)amino)-N-hydroxypyrimidine-5-carboxamide pH and temperature not specified in the publication 756656 3.5.1.98 207 - N-hydroxy-2-(methyl((3-(1-(4-(trifluoromethyl)benzyl)piperidin-4-yl)-1,2,4-oxadiazol-5-yl)methyl)amino)pyrimidine-5-carboxamide pH and temperature not specified in the publication 756656 3.5.1.98 292.5 - (E)-N-hydroxy-3-(2-(methyl((3-(1-(4-methylbenzyl)piperidin-4-yl)-1,2,4-oxadiazol-5-yl)methyl)amino)pyrimidin-5-yl)acrylamide pH and temperature not specified in the publication 756656 3.5.1.98 547.3 - (E)-3-(2-(((3-(1-benzylpiperidin-4-yl)-1,2,4-oxadiazol-5-yl)methyl)(methyl)amino)pyrimidin-5-yl)-N-hydroxyacrylamide pH and temperature not specified in the publication 756656