3.4.25.1 additional information - additional information cell growth inhibition activities, overview 707667 3.4.25.1 0.00000865 - N2-(decylcarbamoyl)-N-[(3E,5S,8S,9E)-2,7-dioxo-5-(propan-2-yl)-1,6-diazacyclododeca-3,9-dien-8-yl]-L-valinamide for the chymotrypsin-like activity, pH not specified in the publication, temperature not specified in the publication 713407 3.4.25.1 0.0000373 - MG-132 in 10 mM HEPES (pH 7.6), at 37°C 733663 3.4.25.1 0.000049 - glidobactin A for the chymotrypsin-like activity, pH not specified in the publication, temperature not specified in the publication 713407 3.4.25.1 0.0000796 - N2-(decylcarbamoyl)-N-[(3E,5S,8S,9E)-2,7-dioxo-5-(propan-2-yl)-1,6-diazacyclododeca-3,9-dien-8-yl]-L-valinamide for the trypsin-like activity, pH not specified in the publication, temperature not specified in the publication 713407 3.4.25.1 0.000086 0.000194 (-)-epigallocatechin-3-gallate inhibition of the chymotrypsin-like activity of the proteasome in vitro, pH not specified in the publication, temperature not specified in the publication 702678 3.4.25.1 0.00022 - 1-[1-(1-[(2,4-dioxoimidazolidin-1-ylimino)-methyl]-2-phenyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-2-(1H-indol) pH 7.5, 30°C 711621 3.4.25.1 0.00028 - N-(tert-butoxycarbonyl)glycyl-N5-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-N1-(naphthalen-2-ylmethyl)-L-glutamamide chymotrypsin-like, b5 activity of 20S proteasome, pH not specified in the publication, temperature not specified in the publication 707667 3.4.25.1 0.00054 - N-(tert-butoxycarbonyl)glycyl-N1-benzyl-N5-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-L-glutamamide chymotrypsin-like, b5 activity of 20S proteasome, pH not specified in the publication, temperature not specified in the publication 707667 3.4.25.1 0.00068 - N2-(tert-butoxycarbonyl)-N6-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-N-(naphthalen-2-ylmethyl)-6-oxo-L-lysinamide caspase-like, b1 activity of 20S proteasome, pH not specified in the publication, temperature not specified in the publication 707667 3.4.25.1 0.000757 - syringolin A methyl ester for the chymotrypsin-like activity, pH not specified in the publication, temperature not specified in the publication 713407 3.4.25.1 0.00084 - N-(tert-butoxycarbonyl)-L-alanyl-N5-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-N1-(naphthalen-2-ylmethyl)-L-glutamamide chymotrypsin-like, b5 activity of 20S proteasome, pH not specified in the publication, temperature not specified in the publication 707667 3.4.25.1 0.00102 - syringolin A for the chymotrypsin-like activity, pH not specified in the publication, temperature not specified in the publication 713407 3.4.25.1 0.00147 - N-(tert-butoxycarbonyl)-L-phenylalanyl-N5-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-N1-(naphthalen-2-ylmethyl)-L-glutamamide chymotrypsin-like, b5 activity of 20S proteasome, pH not specified in the publication, temperature not specified in the publication 707667 3.4.25.1 0.0015 - N-(tert-butoxycarbonyl)-L-isoleucyl-N5-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-N1-(naphthalen-2-ylmethyl)-L-glutamamide chymotrypsin-like, b5 activity of 20S proteasome, pH not specified in the publication, temperature not specified in the publication 707667 3.4.25.1 0.00164 - N-(tert-butoxycarbonyl)-O-methyl-L-tyrosyl-N-[(2S)-1-(furan-2-yl)-4-methyl-1-oxopentan-2-yl]-L-tyrosinamide in 10 mM HEPES (pH 7.6), at 37°C 733663 3.4.25.1 0.002 - glidobactin A for the trypsin-like activity, pH not specified in the publication, temperature not specified in the publication 713407 3.4.25.1 0.00262 - N-[(benzyloxy)carbonyl]-L-phenylalanyl-N-[(2S)-1-(furan-2-yl)-4-methyl-1-oxopentan-2-yl]-O-methyl-L-tyrosinamide in 10 mM HEPES (pH 7.6), at 37°C 733663 3.4.25.1 0.00274 - N-(tert-butoxycarbonyl)glycyl-N6-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-N-(naphthalen-2-ylmethyl)-6-oxo-L-lysinamide chymotrypsin-like, b5 activity of 20S proteasome, pH not specified in the publication, temperature not specified in the publication 707667 3.4.25.1 0.00327 - Nalpha-[(2S)-2-[[(benzyloxy)carbonyl]amino]-4-(4-methoxyphenyl)butanoyl]-N-[(2S)-1-(furan-2-yl)-4-methyl-1-oxopentan-2-yl]-L-tyrosinamide in 10 mM HEPES (pH 7.6), at 37°C 733663 3.4.25.1 0.00412 - N2-(tert-butoxycarbonyl)-N6-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-N-(naphthalen-2-ylmethyl)-6-oxo-L-lysinamide chymotrypsin-like, b5 activity of 20S proteasome, pH not specified in the publication, temperature not specified in the publication 707667 3.4.25.1 0.00428 - N-(tert-butoxycarbonyl)-L-alanyl-N6-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-N-(naphthalen-2-ylmethyl)-6-oxo-L-lysinamide chymotrypsin-like, b5 activity of 20S proteasome, pH not specified in the publication, temperature not specified in the publication 707667 3.4.25.1 0.00451 - N2-(tert-butoxycarbonyl)-N-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-3-[(naphthalen-2-ylmethyl)amino]-3-oxo-D-alaninamide chymotrypsin-like, b5 activity of 20S proteasome, pH not specified in the publication, temperature not specified in the publication 707667 3.4.25.1 0.00585 - N-[(benzyloxy)carbonyl]-L-leucyl-N-[(2S)-1-(furan-2-yl)-4-methyl-1-oxopentan-2-yl]-O-methyl-L-tyrosinamide in 10 mM HEPES (pH 7.6), at 37°C 733663 3.4.25.1 0.00601 - Nalpha-[(benzyloxy)carbonyl]-N-[(2S)-1-[[(2S)-1-(furan-2-yl)-4-methyl-1-oxopentan-2-yl]amino]-3-(4-methoxyphenyl)-1-oxopropan-2-yl]-O-methyl-L-tyrosinamide in 10 mM HEPES (pH 7.6), at 37°C 733663 3.4.25.1 0.00642 - Nalpha-[(2S)-2-[[(benzyloxy)carbonyl]amino]-4-phenylbutanoyl]-N-[(2S)-1-(furan-2-yl)-4-methyl-1-oxopentan-2-yl]-L-tyrosinamide in 10 mM HEPES (pH 7.6), at 37°C 733663 3.4.25.1 0.00682 - Nalpha-(tert-butoxycarbonyl)-N-[(2S)-1-[[(2S)-1-(furan-2-yl)-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-O-methyl-L-tyrosinamide in 10 mM HEPES (pH 7.6), at 37°C 733663 3.4.25.1 0.007 - NPLLLVS IC50: 0.04 mM, inhibition of hydrolysis of Gly-Gly-Arg-7-amido-4-methylcoumarin. IC50: 0.007 mM, inhibition of hydrolysis of succinyl-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin, most potent inhibitor for hydrolysis of succinyl-Leu-Leu-Val-Tyr-7-amido-4-meth 652378 3.4.25.1 0.00723 - N2-(tert-butoxycarbonyl)-N5-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-N1-(naphthalen-2-ylmethyl)-L-glutamamide caspase-like, b1 activity of 20S proteasome, pH not specified in the publication, temperature not specified in the publication 707667 3.4.25.1 0.0074 - dibromo[(dimethylamino)methanedithiolato(2-)-kappa2S1,S1]aurate(3-) inhibition of the chymotrypsin-like activity of the 20S proteasome 685936 3.4.25.1 0.00756 - N-[(benzyloxy)carbonyl]-L-leucyl-N-[(2S)-1-(furan-2-yl)-4-methyl-1-oxopentan-2-yl]-L-phenylalaninamide in 10 mM HEPES (pH 7.6), at 37°C 733663 3.4.25.1 0.00778 - syringolin B for the chymotrypsin-like activity, pH not specified in the publication, temperature not specified in the publication 713407 3.4.25.1 0.00785 - N-[(1S)-1-benzyl-2-[[(1S)-1-(furan-2-ylcarbonyl)-3-methylbutyl]amino]-2-oxoethyl]-Na-(tert-butoxycarbonyl)-L-phenylalaninamide - 685565 3.4.25.1 0.00785 - Nalpha-[(2S)-2-[2-(tert-butoxycarbonyl)hydrazinyl]-4-phenylbutanoyl]-N-[(2S)-1-(furan-2-yl)-4-methyl-1-oxopentan-2-yl]-L-phenylalaninamide in 10 mM HEPES (pH 7.6), at 37°C 733663 3.4.25.1 0.00815 - N-(tert-butoxycarbonyl)-O-methyl-L-tyrosyl-N-[(2S)-1-(furan-2-yl)-4-methyl-1-oxopentan-2-yl]-O-methyl-L-tyrosinamide in 10 mM HEPES (pH 7.6), at 37°C 733663 3.4.25.1 0.00839 - Nalpha-[(2S)-2-[[(benzyloxy)carbonyl]amino]-4-phenylbutanoyl]-N-[(2S)-1-(furan-2-yl)-4-methyl-1-oxopentan-2-yl]-L-phenylalaninamide in 10 mM HEPES (pH 7.6), at 37°C 733663 3.4.25.1 0.00854 - N-(tert-butoxycarbonyl)glycyl-N5-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-N1-(naphthalen-2-ylmethyl)-L-glutamamide caspase-like, b1 activity of 20S proteasome, pH not specified in the publication, temperature not specified in the publication 707667 3.4.25.1 0.0089 - benzyloxycarbonyl-Phe-Ser-Arg IC50: 0.0089 mM for chymotrypsin-like activity, 0.002 mM for trypsin-like activity 650902 3.4.25.1 0.00942 - N-(tert-butoxycarbonyl)-L-phenylalanyl-N-[(2S)-1-(furan-2-yl)-4-methyl-1-oxopentan-2-yl]-O-methyl-L-tyrosinamide in 10 mM HEPES (pH 7.6), at 37°C 733663 3.4.25.1 0.00984 - N-(tert-butoxycarbonyl)glycyl-N1-benzyl-N5-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-L-glutamamide caspase-like, b1 activity of 20S proteasome, pH not specified in the publication, temperature not specified in the publication 707667 3.4.25.1 0.01 - N-(tert-butoxycarbonyl)-L-alanyl-N5-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-N1-(naphthalen-2-ylmethyl)-L-glutamamide above, caspase-like, b1 activity of 20S proteasome, pH not specified in the publication, temperature not specified in the publication 707667 3.4.25.1 0.01 - N-(tert-butoxycarbonyl)-L-alanyl-N5-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-N1-(naphthalen-2-ylmethyl)-L-glutamamide above, trypsin-like, b1 activity of 20S proteasome, pH not specified in the publication, temperature not specified in the publication 707667 3.4.25.1 0.01 - N-(tert-butoxycarbonyl)-L-alanyl-N6-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-N-(naphthalen-2-ylmethyl)-6-oxo-L-lysinamide above, caspase-like, b1 activity of 20S proteasome, pH not specified in the publication, temperature not specified in the publication 707667 3.4.25.1 0.01 - N-(tert-butoxycarbonyl)-L-alanyl-N6-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-N-(naphthalen-2-ylmethyl)-6-oxo-L-lysinamide above, trypsin-like, b1 activity of 20S proteasome, pH not specified in the publication, temperature not specified in the publication 707667 3.4.25.1 0.01 - N-(tert-butoxycarbonyl)-L-isoleucyl-N5-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-N1-(naphthalen-2-ylmethyl)-L-glutamamide above, caspase-like, b1 activity of 20S proteasome, pH not specified in the publication, temperature not specified in the publication 707667 3.4.25.1 0.01 - N-(tert-butoxycarbonyl)-L-isoleucyl-N5-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-N1-(naphthalen-2-ylmethyl)-L-glutamamide above, trypsin-like, b1 activity of 20S proteasome, pH not specified in the publication, temperature not specified in the publication 707667 3.4.25.1 0.01 - N-(tert-butoxycarbonyl)-L-phenylalanyl-N5-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-N1-(naphthalen-2-ylmethyl)-L-glutamamide above, caspase-like, b1 activity of 20S proteasome, pH not specified in the publication, temperature not specified in the publication 707667 3.4.25.1 0.01 - N-(tert-butoxycarbonyl)-L-phenylalanyl-N5-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-N1-(naphthalen-2-ylmethyl)-L-glutamamide above, trypsin-like, b1 activity of 20S proteasome, pH not specified in the publication, temperature not specified in the publication 707667 3.4.25.1 0.01 - N-(tert-butoxycarbonyl)glycyl-N1-benzyl-N5-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-L-glutamamide above, trypsin-like, b1 activity of 20S proteasome, pH not specified in the publication, temperature not specified in the publication 707667 3.4.25.1 0.01 - N-(tert-butoxycarbonyl)glycyl-N5-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-N1-(naphthalen-2-ylmethyl)-L-glutamamide above, trypsin-like, b1 activity of 20S proteasome, pH not specified in the publication, temperature not specified in the publication 707667 3.4.25.1 0.01 - N-(tert-butoxycarbonyl)glycyl-N6-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-N-(naphthalen-2-ylmethyl)-6-oxo-L-lysinamide above, caspase-like, b1 activity of 20S proteasome, pH not specified in the publication, temperature not specified in the publication 707667 3.4.25.1 0.01 - N-(tert-butoxycarbonyl)glycyl-N6-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-N-(naphthalen-2-ylmethyl)-6-oxo-L-lysinamide above, trypsin-like, b1 activity of 20S proteasome, pH not specified in the publication, temperature not specified in the publication 707667 3.4.25.1 0.01 - N2-(tert-butoxycarbonyl)-N-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-3-[(naphthalen-2-ylmethyl)amino]-3-oxo-D-alaninamide above, caspase-like, b1 activity of 20S proteasome, pH not specified in the publication, temperature not specified in the publication 707667 3.4.25.1 0.01 - N2-(tert-butoxycarbonyl)-N-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-3-[(naphthalen-2-ylmethyl)amino]-3-oxo-D-alaninamide above, trypsin-like, b1 activity of 20S proteasome, pH not specified in the publication, temperature not specified in the publication 707667 3.4.25.1 0.01 - N2-(tert-butoxycarbonyl)-N5-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-N1-(naphthalen-2-ylmethyl)-L-glutamamide above, chymotrypsin-like, b5 activity of 20S proteasome, pH not specified in the publication, temperature not specified in the publication 707667 3.4.25.1 0.01 - N2-(tert-butoxycarbonyl)-N5-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-N1-(naphthalen-2-ylmethyl)-L-glutamamide above, trypsin-like, b1 activity of 20S proteasome, pH not specified in the publication, temperature not specified in the publication 707667 3.4.25.1 0.01 - N2-(tert-butoxycarbonyl)-N6-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-N-(naphthalen-2-ylmethyl)-6-oxo-L-lysinamide above, trypsin-like, b1 activity of 20S proteasome, pH not specified in the publication, temperature not specified in the publication 707667 3.4.25.1 0.01 - Nalpha-(tert-butoxycarbonyl)-N-[(2S)-1-(furan-2-yl)-4-methyl-1-oxopentan-2-yl]-L-phenylalaninamide IC50 above 0.01 mM, in 10 mM HEPES (pH 7.6), at 37°C 733663 3.4.25.1 0.01 - Nalpha-(tert-butoxycarbonyl)-N-[(2S)-1-(furan-2-yl)-4-methyl-1-oxopentan-2-yl]-L-tyrosinamide IC50 above 0.01 mM, in 10 mM HEPES (pH 7.6), at 37°C 733663 3.4.25.1 0.01 - Nalpha-[(2S)-2-[[(benzyloxy)carbonyl]amino]-4-phenylbutanoyl]-N-[(2S)-1-(furan-2-yl)-4-methyl-1-oxopentan-2-yl]-O-methyl-L-tyrosinamide IC50 above 0.01 mM, in 10 mM HEPES (pH 7.6), at 37°C 733663 3.4.25.1 0.01 - Nalpha-[(benzyloxy)carbonyl]-N-[(2S)-1-(furan-2-yl)-4-methyl-1-oxopentan-2-yl]-L-phenylalaninamide IC50 above 0.01 mM, in 10 mM HEPES (pH 7.6), at 37°C 733663 3.4.25.1 0.01 - Nalpha-[(benzyloxy)carbonyl]-N-[(2S)-1-(furan-2-yl)-4-methyl-1-oxopentan-2-yl]-L-tyrosinamide IC50 above 0.01 mM, in 10 mM HEPES (pH 7.6), at 37°C 733663 3.4.25.1 0.01 - Nalpha-[(benzyloxy)carbonyl]-N-[(2S)-1-[[(2S)-1-(furan-2-yl)-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-O-methyl-L-tyrosinamide IC50 above 0.01 mM, in 10 mM HEPES (pH 7.6), at 37°C 733663 3.4.25.1 0.0103 - syringolin A for the trypsin-like activity, pH not specified in the publication, temperature not specified in the publication 713407 3.4.25.1 0.017 - benzyloxycarbonyl-Leu-Ser-Arg IC50: 0.017 mM for chymotrypsin-like activity, 0.0017 mM for trypsin-like activity 650902 3.4.25.1 0.0187 - syringolin A methyl ester for the trypsin-like activity, pH not specified in the publication, temperature not specified in the publication 713407 3.4.25.1 0.019 - (2R,3S)-1,2,3,4-tetrahydronaphthalene-2,3-diyl bis(3,4,5-trihydroxybenzoate) for the chymotrypsin-like activity, pH 7.5, 37°C 702678 3.4.25.1 0.029 - (2R,3S)-1,2,3,4-tetrahydronaphthalene-2,3-diyl bis(3,5-dihydroxybenzoate) for the chymotrypsin-like activity, pH 7.5, 37°C 702678 3.4.25.1 0.033 - YLLLVS IC50: 0.048 mM, inhibition of hydrolysis of Gly-Gly-Arg-7-amido-4-methylcoumarin. IC50: 0.033 mM, inhibition of hydrolysis of succinyl-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin 652378 3.4.25.1 0.0347 - KAuBr4 - 685936 3.4.25.1 0.056 - Benzyloxycarbonyl-Leu-Leu-Arg IC50: 0.056 mM for chymotrypsin-like activity, 0.0014 mM for trypsin-like activity 650902 3.4.25.1 0.065 - benzyloxycarbonyl-Leu-Thr-Arg IC50: 0.065 mM for chymotrypsin-like activity, 0.0021 mM for trypsin-like activity 650902 3.4.25.1 0.077 - NPLLNVS IC50: 0.063 mM, inhibition of hydrolysis of Gly-Gly-Arg-7-amido-4-carbamoylcoumarin. IC50: 0.077 mM, inhibition of hydrolysis of succinyl-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin 652378 3.4.25.1 0.1 - leupeptin IC50: 0.0015 mM, inhibition of hydrolysis of Gly-Gly-Arg-7-amido-4-methylcoumarin, most potent inhibitor for hydrolysis of Gly-Gly-Arg-7-amido-4-methylcoumarin. IC50: 0.1 mM, inhibition of hydrolysis of succinyl-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin 652378 3.4.25.1 0.1078 - syringolin B for the trypsin-like activity, pH not specified in the publication, temperature not specified in the publication 713407 3.4.25.1 0.11 - benzyloxycarbonyl-Leu-Gly-Arg IC50: 0.11 mM for chymotrypsin-like activity, 0.0066 mM for trypsin-like activity 650902 3.4.25.1 0.85 - acetyl-Leu-Leu-Arg IC50: 0.85 mM for chymotrypsin-like activity, 0.0056 mM for trypsin-like activity 650902