2.1.1.251 corrinoid the enzyme obligately requires the bound methylated corrinoid cofactor for activity. Corrinoid-dependent methyltransferases cycle between methylated corrinoid in the Co(III) redox state and the highly nucleophilic, reducing, and oxygen-sensitive Co(I) state. In the Co(II) form, these methyltransferase is inactive 727732 2.1.1.251 additional information no corrinoid cofactor bound to the enzyme 717763