4.1.1.22 4.5 - - 4148, 728063 4.1.1.22 4.5 7 - 651607 4.1.1.22 4.8 - - 4139, 4166 4.1.1.22 4.8 - assay at 679896 4.1.1.22 4.8 - HDC is essentially inactive at neutral and alkaline pH and active at low pH, low pH shifts HDC from the inactive, i.e. T-state, to the active, i.e. R-state 653849 4.1.1.22 4.8 - wild-type and mutant enzyme 4146 4.1.1.22 6 - - 677685, 727564 4.1.1.22 6.2 - - 4163 4.1.1.22 6.2 - assay at 682308 4.1.1.22 6.5 - - 4150, 4154, 4159, 677685, 749155