1.3.1.70 ? x * 50000, SDS-PAGE 1.3.1.70 ? x * 46600, mutant TM7SF2 1.3.1.70 ? x * 370000, SDS-PAGE 1.3.1.70 dimer 2 * 38000, two equally-sized subunits, SDS-PAGE 1.3.1.70 additional information the enzyme contains ten transmembrane segments (TM1-10). Its catalytic domain comprises the carboxy-terminal half (containing TM6-10) and envelops two interconnected pockets, one of which faces the cytoplasm and houses NADPH, while the other one is accessible from the lipid bilayer